Abstract：
:High-resolution positron emission tomography (microPET) allows for repeated observations of brain function in the same animal. In a previous study, using [(18)F] fluorodeoxyglucose (FDG) microPET, we demonstrated diminished glucose metabolism and subsequent recovery in the Neostriatum and thalamus ipsilateral to cortical aspiration (ASP) lesions. Thermocoagulation (TCL) of pial vessels has been shown to result in the same degree of cortical injury but induce more compensatory re-organization than ASP. In the present work, FDG microPET was used to compare glucose metabolism following both TCL and ASP lesions in order to determine whether metabolic differences correlate with the previously described anatomical and functional changes in the two lesion models. Animals were scanned 3-day, 10-day and 1-month post-injury. Estimated cortical lesion size did not differ between the two models at 1 month following injury. Both lesions induced ipsilateral neostriatal and thalamic hypometabolism 3-day post-injury, with subsequent metabolic improvement over time. However, complete recovery was not observed by 1 month in either group. ASP lesions resulted in an overall greater metabolic deficit in the subcortical structures and a greater cortical deficit 1 month following injury when compared to the TCL. Contralateral cortical glucose metabolism at 3 days following injury was not different in the two lesions. These data demonstrate that the two lesions differ somewhat in their metabolic response to injury, and that the relative hypometabolism observed following ASP may be a reflection of the diminished capacity of the contralateral cortex to compensate for ASP as compared to TCL.
journal_name
Brain Resjournal_title
Brain researchauthors
Mir HM,Tatsukawa KJ,Carmichael ST,Chesselet MF,Kornblum HIdoi
10.1016/j.brainres.2003.12.006subject
Has Abstractpub_date
2004-03-26 00:00:00pages
28-34issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899303041829journal_volume
1002pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain areas of adult brains for replenishing damaged differentiated cells. The loss of the balance between NSC self-renewal and differentiation could lead to tumor formation such as the occurrence of glioblastoma (GBM), the most co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.018
更新日期：2019-02-01 00:00:00
abstract：:Early brain injury (EBI) refers to the direct injury to the brain during the first 72 h after subarachnoid hemorrhage (SAH), which is one of the major causes for the poor clinical outcome after SAH. In this study, we investigated the effect and the related mechanism of Salvinorin A (SA), a selective kappa opioid recep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.026
更新日期：2019-09-15 00:00:00
abstract：:The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.146798
更新日期：2020-07-01 00:00:00
abstract：:In most vertebrates and several insects, melatonin (N-acetyl-5-methoxytryptamine) is synthesized enzymatically from serotonin (5-hydroxytryptamine) by the sequential action of arylalkylamine N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). In the freshwater planarian Dugesia japonica, which bel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01418-3
更新日期：1999-05-29 00:00:00
abstract：:Oligodendrocytes (OLs), the predominant cell type found in cerebral white matter, are essential for structural integrity and proper neural signaling. Very little is known concerning stroke-induced OL dysfunction. Our laboratory has shown that infusion of human umbilical cord blood (HUCB) cells protects striatal white ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.078
更新日期：2010-12-17 00:00:00
abstract：:The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91256-g
更新日期：1990-01-08 00:00:00
abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.056
更新日期：2015-01-30 00:00:00
abstract：:Atropine (5 nM to 5 muM), but not D-tubocurarine or hexamethonium, enhanced the release of acetylcholine (ACh) from rat brain cortical slices exposed to high K+. The enhancement was dose-dependent, and it could be partially antagonized by oxotremorine (50-500 muM) or by dibutyryl or 8-bromo-cyclic GMP (1 mM), but not ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90836-7
更新日期：1980-01-20 00:00:00
abstract：:Reverse transcription-polymerase chain reaction demonstrated the expression of heme oxygenase-1 and heme oxygenase-2 (HO-2) mRNA in the cochlea, but the former was considered to be much lower than the latter. The HO-2-like immunoreactivity was observed mainly in supporting cells in the organ of Corti and in the spiral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04209-9
更新日期：2003-03-14 00:00:00
abstract：:In decerebrate dogs, stimulation of pelvic afferent fibres and distension of the rectum, vagina and urinary bladder brought about a sustained postural change and rhythmic abdominal compression. The posture, which resulted from flexion of the back and stifle joints, extension of the hip joints and lifting of the tail, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90223-4
更新日期：1986-08-20 00:00:00
abstract：:Serotonin transporter (5-HTT) mRNA and 5-HTT sites were measured 3 days after treatment with p-chlorophenylalanine, a tryptophan hydroxylase inhibitor. While 5-HTT mRNA levels decreased (P < 0.001) in the dorsal raphe nucleus, 5-HTT binding sites remained unchanged, suggesting that an acute depletion of 5-HT may induc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00539-3
更新日期：1995-08-07 00:00:00
abstract：:In a recent study in the tiger salamander, Ambystoma tigrinum, were demonstrated topographic patterns of responsivity across the olfactory epithelium which were characteristic for each odorant. The present study was initiated to investigate whether these patterns remain constant when odorant concentration is varied. O...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90562-6
更新日期：1984-04-16 00:00:00
abstract：:The mechanism of the antinociceptive effect of the tricyclic antidepressant imipramine was investigated in mice. Intrathecal (i.t.) administration of imipramine produced dose-dependent antinociception in the tail-pinch and tail-flick tests with ED50 values (95% confidence limit) of 27.5 (17.0-43.9) and 20.2 (12.6-32.2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90344-9
更新日期：1992-05-22 00:00:00
abstract：:Electrophysiological studies using rats were performed to examine the influence of locus coeruleus (LC) on nucleus accumbens (Acc) neurons. Spike generation by hippocampal stimulation was inhibited by both LC conditioning stimulation and iontophoretic application of noradrenaline, but spikes elicited by stimulation of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90172-6
更新日期：1985-07-15 00:00:00
abstract：:Previous studies have shown that within 24 h after ischemic insult, gerbils exhibit an increase in locomotor activity. Because activity gradually diminishes to normal levels with repeated testing, it has been argued that this behavior represents a reversible or transient effect of ischemia. The present study challenge...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91081-3
更新日期：1993-10-22 00:00:00
abstract：:Sensory fibers trapped in nerve-end neuromas become abnormally excitable, and produce an ectopic discharge which is believed to contribute to paresthesias and pain associated with chronic nerve injury in man. Here we report that stimulation of injured nerves can alter this discharge, directly by antidromic invasion of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90275-7
更新日期：1987-07-07 00:00:00
abstract：:The present study was undertaken to explore the neuronal mechanisms of hypocretin actions on neurons in the nucleus pontis oralis (NPO), a nucleus which plays a key role in the generation of active (REM) sleep. Specifically, we sought to determine whether excitatory postsynaptic potentials (EPSPs) evoked by stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02566-6
更新日期：2003-06-27 00:00:00
abstract：:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.12.017
更新日期：2005-02-28 00:00:00
abstract：:The effect of 4% ethanol on pacemaker currents of Aplysia neurons was studied under voltage clamp. In normal seawater the n-shape in the I-V disappeared and outward current increased. Ion substitution and drug blocking experiments determined that leakage current and the slow inward calcium current were decreased and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90268-8
更新日期：1983-11-14 00:00:00
abstract：:Abdominal musculature participates in generating a large number of behaviors and protective reflexes, although each abdominal muscle is frequently activated differentially during particular motor responses. For example, rectus abdominis has been reported to play less of a role in respiration than other abdominal muscl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02597-5
更新日期：2001-08-31 00:00:00
abstract：:Immunohistochemical studies have suggested that corticotropin-releasing factor (CRF) was a transmitter of the olivocerebellar projection. We used in situ hybridization histochemistry with a 35S-labeled oligodeoxyribonucleotide probe for CRF mRNA to show that inferior olivary neurons of rats, baboons, and humans synthe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(86)90010-0
更新日期：1986-11-01 00:00:00
abstract：:Blockade of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors with 6-nitro-7-sulfamoyl-benzo-[f]quinoxaline-2,3(1H,4H)-dione (NBQX) activates tuberoinfundibular (TIDA) and periventricular-hypophysial dopaminergic (PHDA) neurons suggesting that these neurons are tonically inhibited by endogenous...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91305-6
更新日期：1994-10-17 00:00:00
abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90556-3
更新日期：1993-10-29 00:00:00
abstract：:Endothelin-1 (ET-1) has been implicated in hematoma-induced cerebral vasoconstriction and modification of cerebral microvascular reactivity, particularly attenuation of vasodilation to cAMP-dependent dilators and enhanced vasoconstriction to ET-1. We examined effects of the ET-1 antagonist, BQ-123, on hematoma-induced...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1996-09-23 00:00:00
abstract：:Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00253-3
更新日期：1996-06-03 00:00:00
abstract：:Cell death was due to activation of the receptor responsive to N-methyl-D-aspartate (NMDA). Even during a 30-min incubation, glutamate toxicity was unaffected by 5 microM CNQX and was greater than 90% blocked by 160 nM MK-801, a specific antagonist of the NMDA receptor. The extent of toxicity was dependent on the age ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91244-u
更新日期：1991-09-27 00:00:00
abstract：:While trophic support from targets depends on innervation, recent evidence suggests that local VIP promotes survival of sympathetic neuroblasts prior to target interactions, during the period of neurogenesis. Developmental studies now indicate that VIP expression peaks at embryonic day 15.5 (E15.5) in sympathetic gang...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90461-8
更新日期：1994-11-07 00:00:00
abstract：:Obesity and related metabolic disorders are important side effects of some antipsychotic drugs (APs). The currently available animal model of AP-induced bodyweight gain (BWG) in rats is based on administration of sulpiride (SUL). However, this model has important limitations. For example, SUL is a pure dopamine antago...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03616-8
更新日期：2002-12-06 00:00:00
abstract：:Brain oscillations provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as they represent important correlates of human information processing and are associated with fundamental processes from perception to cognition. These oscillations are highly heritable, a...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.06.053
更新日期：2008-10-15 00:00:00
abstract：:The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91593-6
更新日期：1990-07-02 00:00:00
