Abstract：
:This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. Oral phenidone (200 mg/kg) significantly suppressed the incidence and clinical severity of EAE paralysis. Western blot analysis showed that phenidone significantly inhibited the increases in COX-1/-2 and 5-LOX in the spinal cords of rats with EAE. This finding was paralleled by immunohistochemical observations. Overall, these findings suggest that COX-1/-2 and 5-LOX are important inflammatory mediators in the pathogenesis of EAE, and that the inhibition of both COX and LOX ameliorates the autoimmune disorder of the central nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Moon C,Ahn M,Wie MB,Kim HM,Koh CS,Hong SC,Kim MD,Tanuma N,Matsumoto Y,Shin Tdoi
10.1016/j.brainres.2004.12.017subject
Has Abstractpub_date
2005-02-28 00:00:00pages
206-10issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(04)01928-6journal_volume
1035pub_type
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