Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract.


:The suprachiasmatic nuclei (SCN) contain the major pacemaker for mammalian circadian rhythms. The SCN receive photic input both directly, via the retinohypothalamic tract (RHT), and indirectly, via the geniculohypothalamic tract (GHT), which originates in cells in the intergeniculate leaflet (IGL) and anterior portions of the ventral lateral geniculate nucleus (vLGN). We tested whether electrical stimulation of the GHT would induce phase shifts in wheel-running activity rhythms of Syrian hamsters housed in continuous darkness or continuous illumination. In both lighting conditions, electrical stimulation of the GHT induced mainly phase advances when given during the late subjective day and small phase delays when given during the late subjective night and early subjective day. Stimulation in the thalamus outside the GHT failed to produce similar phase shifts. Repeated daily stimulation had only a weak entraining effect on the activity rhythm. Activation of GHT neurons appears to influence the pacemaker for activity rhythms in a phase-dependent manner.


Brain Res


Brain research


Rusak B,Meijer JH,Harrington ME




Has Abstract


1989-07-31 00:00:00














  • Electron microscopic localization of acetylcholinesterase in the dentate gyrus of young and adult rats.

    abstract::Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Seress L,Robertson RT,Ribak CE

    更新日期:1987-11-01 00:00:00

  • Do two models of acute and chronic stress stimulation influence the amount of nerve growth factor (NGF) and its receptor TrkA in the hippocampal neurons of middle aged rats?

    abstract::Our study aimed to explore the influence of two different stressors: acute (once for 15 min) and chronic (15 min daily for 21 days) exposure to high light open field (HL-OF) or forced swim (FS) on the density of nerve growth factor (NGF) and tyrosine kinase A (TrkA) immunoreactive neurons in the hippocampal CA1 and CA...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Badowska-Szalewska E,Spodnik E,Klejbor I,Ludkiewicz B,Moryś J

    更新日期:2011-04-12 00:00:00

  • Trigeminal modulation of gustatory neurons in the nucleus of the solitary tract.

    abstract::Electrophysiological methods were used to investigate the effects of trigeminal nerve stimulation or transection on responses of single gustatory neurons in the nucleus of the solitary tract (NTS) to tastants (NaCl, sucrose, citric acid, monosodium glutamate) in pentobarbital-anesthetized rats. Unilateral transection ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Boucher Y,Simons CT,Faurion A,Azérad J,Carstens E

    更新日期:2003-05-30 00:00:00

  • Dopamine uptake by mouse neuroblastoma N1E-115 cells stably expressing human dopamine transporter is differentially inhibited by anti-idiotypic ab2beta antibodies mimicking the configuration of cocaine.

    abstract::We have successfully constructed a mouse neuronal N1E-115 cell line stably expressing a fully functional human dopamine transporter (hDAT). Previous studies in our laboratory have produced several anti-idiotypic Ab2beta antibodies that mimic the configuration of the cocaine molecule at their antigen-combining site. In...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ho M,Segre M

    更新日期:2000-07-28 00:00:00

  • Mesenchymal stem cells as cellular vectors for pediatric neurological disorders.

    abstract::Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Phinney DG,Isakova IA

    更新日期:2014-07-21 00:00:00

  • Minocycline treatment reduces white matter damage after excitotoxic striatal injury.

    abstract::We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/macrophage activation. The excitotoxic lesion both damaged oligodendrocy...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Guimarães JS,Freire MA,Lima RR,Picanço-Diniz CW,Pereira A,Gomes-Leal W

    更新日期:2010-05-06 00:00:00

  • Differential modulation of the glutamate transporters GLT1, GLAST and EAAC1 by docosahexaenoic acid.

    abstract::At present, the ability of polyunsaturated fatty acids (PUFAs) to regulate individual glutamate transporter subtypes is poorly understood and very little information exists on the mechanism(s) by which PUFAs achieve their effects on the transport process. Here we investigate the effect of cis-4,7,10,13,16,19-docosahex...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Berry CB,Hayes D,Murphy A,Wiessner M,Rauen T,McBean GJ

    更新日期:2005-03-10 00:00:00

  • Electrolytic lesions to the ventromedial hypothalamus abolish receptivity in female whiptail lizards, Cnemidophorus uniparens.

    abstract::Lesions to the ventromedial hypothalamus (VMH) inhibit receptive sexual behavior in the whiptail lizard, Cnemidophorus uniparens, an all-female species. All lesions to the VMH that effectively abolished receptivity specifically damaged the dorsal lateral VMH, an area containing high concentrations of estrogen receptor...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kendrick AM,Rand MS,Crews D

    更新日期:1995-05-22 00:00:00

  • Neuroprotective effect of astaxanthin on H(2)O(2)-induced neurotoxicity in vitro and on focal cerebral ischemia in vivo.

    abstract::Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Much experimental evidence has proved that AST has the function of eliminating oxygen free radicals and can protect organisms from oxidative damage. The present study was carried out to further investigate the neur...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lu YP,Liu SY,Sun H,Wu XM,Li JJ,Zhu L

    更新日期:2010-11-11 00:00:00

  • The preconditioning modified neuronal expression of apoptosis-related proteins of Bcl-2 superfamily following severe hypobaric hypoxia in rats.

    abstract::The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hy...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rybnikova E,Sitnik N,Gluschenko T,Tjulkova E,Samoilov MO

    更新日期:2006-05-17 00:00:00

  • Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease.

    abstract::In the quinolinic acid (QA)-rat model of Huntington's disease (HD), 15 days after QA injection, striatal glutamate, measured by in vivo microdialysis, was unchanged while a significant decrease in adenosine occurred. The decrease in adenosine may depend on QA-induced striatal cell loss. Probe perfusion of the adenosin...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gianfriddo M,Corsi C,Melani A,Pèzzola A,Reggio R,Popoli P,Pedata F

    更新日期:2003-07-25 00:00:00

  • Calcitonin gene-related peptide and substance P immunoreactivity in the monkey trigeminal ganglion, an electron microscopic study.

    abstract::Calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity was examined in neurons of the monkey trigeminal ganglion. Moreover, CGRP- and SP-positive varicose nerve fibers were found, occasionally forming pericellular arborizations around trigeminal somata, which, at light microscopic level, suggeste...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Prins M,van der Werf F,Baljet B,Otto JA

    更新日期:1993-12-03 00:00:00

  • Membrane-bound S-100 protein on nerve cells and its distribution.

    abstract::In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence u...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hydén H,Rönnbäck L

    更新日期:1975-12-26 00:00:00

  • Purine modulation of cholinomimetic responses in the rat hippocampal slice.

    abstract::Iontophoretic application of carbachol caused excitation of CA1 neurones and decreased the amplitude of antidromic CA1 population spikes recorded extracellularly. Adenosine, adenosine triphosphate (ATP) and the purine analogues N-ethylcarboxamide adenosine (NECA) and R- and S-phenylisopropyladenosine (PIA) reduced the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Brooks PA,Stone TW

    更新日期:1988-08-16 00:00:00

  • Hydroxy-safflor yellow A attenuates Aβ₁₋₄₂-induced inflammation by modulating the JAK2/STAT3/NF-κB pathway.

    abstract::Beta-amyloid (Aβ)-mediated inflammation plays a critical role in the initiation and progression of Alzheimer׳s disease (AD). Anti-inflammatory treatment may provide therapeutic benefits. In this study, the effect of hydroxy-safflor yellow A (HSYA) on Aβ1-42-induced inflammation in AD mice was investigated and the unde...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang ZH,Yu LJ,Hui XC,Wu ZZ,Yin KL,Yang H,Xu Y

    更新日期:2014-05-14 00:00:00

  • The neurotoxicity of intrahippocampal kainic acid injection in rats is not accompanied by a reduction of Timm stain.

    abstract::Histopathological changes induced by intrahippocampal injections of low doses of kainic acid (17.5 ng/site) were investigated in rats. Kainic acid produced a selective loss of CA3 pyramidal and hilar neurons. The development of kainic acid-induced neuronal injury was not accompanied by any detectable loss of histologi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Théorêt Y,Earnhardt TS,Bouldin TW,Krigman MR

    更新日期:1988-05-24 00:00:00

  • The effects of electrical stimulation on neurite outgrowth of goldfish retinal explants.

    abstract::The central nervous system (CNS) in adult mammals loses the ability to regenerate after injury. Although electrical stimulation (ES) has been shown to promote neural regeneration, the underlying mechanisms by which ES enhances CNS regeneration remain elusive. The aim of the present study was to investigate the effect ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ou YT,Lu MS,Chiao CC

    更新日期:2012-10-22 00:00:00

  • Thalamo-striatal projections in the hedgehog tenrec.

    abstract::Unlike the basal ganglia input from the midline and intralaminar nuclei, the origin and prominence of striatal projections arising in the lateral thalamus varies considerably among mammals being most restricted in the opossum and monkey, most extensive in the rat. To get further insight into the evolution of thalamo-s...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Künzle H

    更新日期:2006-07-19 00:00:00

  • Methyl-beta-carbolinium analogs of MPP+ cause nigrostriatal toxicity after substantia nigra injections in rats.

    abstract::Eleven beta-carbolinium compounds (beta C+s) and MPP+ were stereotaxically injected (40-200 nmol in 5 microliter of vehicle) unilaterally into the substantia nigra of anesthetized adult male Sprague-Dawley rats. The rats were sacrificed after three weeks. The ipsilateral striatum was analyzed for dopamine and DOPAC le...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Neafsey EJ,Albores R,Gearhart D,Kindel G,Raikoff K,Tamayo F,Collins MA

    更新日期:1995-03-27 00:00:00

  • Effects of nerve growth factor on TTX- and capsaicin-sensitivity in adult rat sensory neurons.

    abstract::We have investigated the effects of nerve growth factor (NGF, 2.5 ng/ml for 1-2 weeks) on enriched adult rat dorsal root ganglion (DRG) neurons maintained in cell culture in defined media. Whole-cell recordings in cells cultured in the absence and presence of NGF revealed no significant difference in resting membrane ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Aguayo LG,White G

    更新日期:1992-01-20 00:00:00

  • Distribution of glutamine synthetase and glial fibrillary acidic protein and correlation of glutamine synthetase with glutamate decarboxylase in different regions of the rat central nervous system.

    abstract::The concentration of soluble glial fibrillary acidic (GFA) protein and the specific activity of glutamine synthetase (GS) were estimated in 11 central nervous system (CNS) regions of the 90-day-old rat. Marked differences were observed in the regional distribution of these astrocyte marker proteins. The striatum and s...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Patel AJ,Weir MD,Hunt A,Tahourdin CS,Thomas DG

    更新日期:1985-04-01 00:00:00

  • Sensory experience determines enrichment-induced plasticity in rat auditory cortex.

    abstract::Our previous studies demonstrated that only a few days of housing in an enriched environment increases response strength and paired-pulse depression in the auditory cortex of awake and anesthetized rats [Engineer, N.D., Percaccio, C.R., Pandya, P.K., Moucha, R., Rathbun, D.L., Kilgard, M.P., 2004. Environmental enrich...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Percaccio CR,Pruette AL,Mistry ST,Chen YH,Kilgard MP

    更新日期:2007-10-12 00:00:00

  • Early changes in protein synthesis following spinal cord hemisection in the Cebus monkey (Cebus apella).

    abstract::The short term effects of spinal cord hemisection on protein synthesis in the Cebus monkey were studied by measuring the uptake of [3H]lysine into the trichloroacetic acid (TCA) precipitable and non-precipitable fractions of spinal cord. Animals were sacrificed 3, 6, or 13 days after hemisection. Two normal animals an...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wells MR,Bernstein JJ

    更新日期:1976-07-23 00:00:00

  • Barbiturate tolerance: effects on GABA-operated chloride channel function.

    abstract::Male ICR mice were fed powdered laboratory chow containing phenobarbital for 7 days to induce tolerance. Mice were sacrificed and brains assayed for changes in GABA-mediated chloride flux into brain membrane vesicles (microsacs). Concentration-dependent stimulation of chloride flux by GABA alone was not affected by th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Allan AM,Zhang X,Baier LD

    更新日期:1992-08-21 00:00:00

  • Central terminals of orofacial primary afferents and NADPH-diaphorase activity in the trigemino-solitary complex of rats.

    abstract::Nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity and the central terminal fields of branches of the mandibular and chorda tympani nerves were visualized histochemically at the same time using transganglionic transport of wheat germ agglutinin conjugated with horseradish peroxidase. The blue NA...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Takemura M,Tsujio A,Iwase K,Shimada T,Shigenaga Y

    更新日期:1998-01-19 00:00:00

  • Modification of the circadian body temperature rhythm of the spontaneously hypertensive rat during and following cessation of continuous clonidine infusion.

    abstract::The effects of continuous clonidine infusion (10 micrograms/kg/h for 10 days) and the cessation of this infusion on the circadian body temperature rhythm of the spontaneously hypertensive (SH) rat were examined. This circadian rhythm was blunted significantly during the infusion of clonidine. The fall in body temperat...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lewis SJ,Maccarrone C,Jarrott B

    更新日期:1986-10-22 00:00:00

  • Mitochondrial energy metabolism and apoptosis regulation in glioblastoma.

    abstract::Glioblastoma is the most aggressive form of gliomas and is associated with short survival. Recent advancements in molecular genetics resulted in the identification of glioma genomic, epigenomic and transcriptomic hallmarks, and multidimensional data allowed clustering of glioblastomas into molecular subtypes. Parallel...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Nagy A,Eder K,Selak MA,Kalman B

    更新日期:2015-01-21 00:00:00

  • Changes in neuropeptide Y immunoreactivity in the arcuate nucleus during and after food restriction in lactating rats.

    abstract::Previous studies have demonstrated that food restriction during lactation extends the length of lactational infertility in rats. In order to determine whether Neuropeptide Y (NPY) plays a role in the increased length of lactational infertility seen in food-restricted rats, NPY immunoreactivity in the arcuate nucleus o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Abizaid A,Walker CD,Woodside B

    更新日期:1997-07-04 00:00:00

  • Serotonin increases the frequency of light-elicited discrete waves in type-B photoreceptors of Hermissenda.

    abstract::Serotonin (5-HT) produces both short- and long-term enhancement of generator potentials in identified type B-photoreceptors of Hermissenda. The actions of 5-HT have been shown to modulate both light- and voltage-dependent conductances. To further examine light-dependent processes we studied spontaneous and light-elici...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Crow T,Pengidore T

    更新日期:1993-11-19 00:00:00

  • Enkephalins, substance P, bradykinin and angiotensin II: differential sites of action on the hypothalamo-neurohypophysial system.

    abstract::To test the hypothesis that enkephalins, substance P, bradykinin and angiotensin II could act as neurohumoral modulators of hypothalamic function, these peptides (0.01-20 microgram) were injected into the general circulation of anesthetized rats, and changes in hypothalamo-neurohypophysial activity were determined by ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baertschi AJ,Zingg HH,Dreifuss JJ

    更新日期:1981-09-07 00:00:00