Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract.

Abstract:

:The suprachiasmatic nuclei (SCN) contain the major pacemaker for mammalian circadian rhythms. The SCN receive photic input both directly, via the retinohypothalamic tract (RHT), and indirectly, via the geniculohypothalamic tract (GHT), which originates in cells in the intergeniculate leaflet (IGL) and anterior portions of the ventral lateral geniculate nucleus (vLGN). We tested whether electrical stimulation of the GHT would induce phase shifts in wheel-running activity rhythms of Syrian hamsters housed in continuous darkness or continuous illumination. In both lighting conditions, electrical stimulation of the GHT induced mainly phase advances when given during the late subjective day and small phase delays when given during the late subjective night and early subjective day. Stimulation in the thalamus outside the GHT failed to produce similar phase shifts. Repeated daily stimulation had only a weak entraining effect on the activity rhythm. Activation of GHT neurons appears to influence the pacemaker for activity rhythms in a phase-dependent manner.

journal_name

Brain Res

journal_title

Brain research

authors

Rusak B,Meijer JH,Harrington ME

doi

10.1016/0006-8993(89)91163-3

subject

Has Abstract

pub_date

1989-07-31 00:00:00

pages

283-91

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)91163-3

journal_volume

493

pub_type

杂志文章
  • Lentiviral-mediated overexpression of nerve growth factor (NGF) prevents beta-amyloid [25-35]-induced long term potentiation (LTP) decline in the rat hippocampus.

    abstract::We have explored the potential neuroprotective effect of local lentiviraly-mediated overexpression of nerve growth factor (NGF) on in vivo long-term potentiation (LTP) in the rat hippocampus under pathological conditions. The suspension of lentiviral particles was prepared using a genetic construct containing the huma...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.07.051

    authors: Uzakov SS,Ivanov AD,Salozhin SV,Markevich VA,Gulyaeva NV

    更新日期:2015-10-22 00:00:00

  • Neuroglial activation and Cx43 expression are reduced upon transplantation of human umbilical cord blood cells after perinatal hypoxic-ischemic injury.

    abstract::Glial cells play a crucial role in the pathomechanism of perinatal hypoxic-ischemic brain injury (HI) and are involved in the maintenance of a chronic state of inflammation that causes delayed neuronal damage. Activation of astrocytes is one factor prolonging brain damage and contributing to the formation of a glial s...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.05.066

    authors: Wasielewski B,Jensen A,Roth-Härer A,Dermietzel R,Meier C

    更新日期:2012-12-03 00:00:00

  • Effects of acute and repeated restraint stress on GABA efflux in the rat basolateral and central amygdala.

    abstract::Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.12.022

    authors: Reznikov LR,Reagan LP,Fadel JR

    更新日期:2009-02-23 00:00:00

  • Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat.

    abstract::Zinc was measured in whole hippocampus and in hippocampal sub-regions by stable-isotope dilution mass spectrometry. In both man and the rat, the most zinc (102-145 ppm, dry weight) was found in the hilar region, the least (27-35) in the fimbria. The amount of zinc directly associated with mossy-fiber axons was estimat...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90858-2

    authors: Frederickson CJ,Klitenick MA,Manton WI,Kirkpatrick JB

    更新日期:1983-08-29 00:00:00

  • Stress-induced analgesia prevents the development of the tonic, late phase of pain produced by subcutaneous formalin.

    abstract::Subcutaneous injection of formalin produces a biphasic pain response: a transient early phase followed by a tonic late phase. It has recently been suggested that development of the late phase depends upon the presence of the early one. In support of this suggestion, we now demonstrate that blocking the early phase by ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90478-r

    authors: Vaccarino AL,Marek P,Liebeskind JC

    更新日期:1992-02-14 00:00:00

  • Chemosensitivity of non-respiratory rat CNS neurons in tissue culture.

    abstract::Neurons from many brainstem nuclei involved in respiratory control increase their firing rate in response to acidosis in vitro, suggesting that they are central chemoreceptors. This property has been considered to be either unique to neurons involved in respiratory control, or at least very unusual for non-respiratory...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02033-3

    authors: Wang W,Richerson GB

    更新日期:2000-03-31 00:00:00

  • Altered activity patterns following neonatal 6-hydroxydopamine lesions to dopaminergic neurons: effect of SKF-38393.

    abstract::The effects of neonatal dopamine depletion on activity levels and locomotor patterns were tested in rats at 4 months of age. Measurements were taken using an activity pattern monitor. The lesioned group was significantly hypoactive in comparison to the control animals during the initial exposures to the monitor. Exami...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91637-3

    authors: Moy SS,Breese GR,Eckerman DA

    更新日期:1994-05-09 00:00:00

  • Regional preferences of AMPA receptor modulators determined through agonist binding autoradiography.

    abstract::Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01315-2

    authors: Kessler M,Mutneja MS,Rogers G,Lynch G

    更新日期:1998-02-02 00:00:00

  • Prenatal exposure to diazepam and alprazolam, but not to zolpidem, affects behavioural stress reactivity in handling-naïve and handling-habituated adult male rat progeny.

    abstract::A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03282-1

    authors: Cannizzaro C,Martire M,Steardo L,Cannizzaro E,Gagliano M,Mineo A,Provenzano G

    更新日期:2002-10-25 00:00:00

  • Central action of nitric oxide in the saltwater-acclimated duck: modulation of extrarenal sodium excretion and vasotocin release.

    abstract::Hypothalamic nuclei close to the third ventricle (VIII) represent key structures in avian osmoregulation concerned with the control of salt gland activity and release of the antidiuretic hormone [Arg8]vasotocin (AVT). Nitric oxide (NO) acting as a paracrine transmitter in the hypothalamus has been shown to contribute ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01205-6

    authors: Hübschle T,Küchenmeister I,Gerstberger R

    更新日期:1999-04-17 00:00:00

  • Muramyl dipeptide potentiates cytokine-induced activation of inducible nitric oxide synthase in rat astrocytes.

    abstract::We investigated the influence of muramyl dipeptide (MDP), a cell wall component of Gram-positive bacteria, on cytokine-induced nitric oxide (NO) production in rat primary astrocytes. MDP alone did not induce NO release in astrocyte cultures. However, MDP increased astrocyte NO production and subsequent nitrite accumul...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02920-6

    authors: Trajkovic V,Samardzic T,Stosic-Grujicic S,Ramic Z,Mostarica Stojkovic M

    更新日期:2000-11-10 00:00:00

  • Bcl-2 overexpression disrupts the morphology of PC12 cells through reduced ERK activation.

    abstract::Bcl-2 has been hypothesized to regulate many cellular functions in addition to its well-characterized role in the prevention of programmed cell death. To understand the role of Bcl-2 in regulating cell morphology and to explore the mechanism of this effect, we examined the effects of Bcl-2 overexpression on the morpho...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.07.017

    authors: Mi Z,Mirnics ZK,Schor NF

    更新日期:2006-09-27 00:00:00

  • Characterization of mineralocorticoid and glucocorticoid receptors in primate brain.

    abstract::Characteristics of neural corticosteroid receptors were studied in 51 adrenally-intact macaque monkeys using a modification of a corticosteroid receptor assay developed in this laboratory for rodent studies. Using cortisol as a ligand, two receptor subtypes could be distinguished and with similar Kd's to those observe...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91249-1

    authors: Brooke SM,de Haas-Johnson AM,Kaplan JR,Sapolsky RM

    更新日期:1994-02-21 00:00:00

  • Effects of palatability-induced hyperphagia and food restriction on mRNA levels of neuropeptide-Y in the arcuate nucleus.

    abstract::This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00755-0

    authors: Kim EM,Welch CC,Grace MK,Billington CJ,Levine AS

    更新日期:1998-09-21 00:00:00

  • Three-dimensional mapping of norepinephrine and serotonin in human thalamus.

    abstract::Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00404-6

    authors: Oke AF,Carver LA,Gouvion CM,Adams RN

    更新日期:1997-07-18 00:00:00

  • Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci.

    abstract::Experiments were carried out in rats to (1) elaborate upon the sepcificity of drug action in the periaqueductal gray matter (PAG), and (2) to evaluate the posible congruence of PAG sites of morphine-induced and stimulation-produced analgesis (SPA) applied at virtually identical PAG loci. It was demonstrated that the e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90886-1

    authors: Lewis VA,Gebhart GF

    更新日期:1977-03-25 00:00:00

  • Effect of early unilateral visual deprivation on cholinergic muscarinic receptors and acetylcholinesterase in chick optic lobe.

    abstract::Chicks of 1-8 days after hatching were submitted to unilateral visual deprivation and, in both optic lobes, muscarinic receptors, labeled with L-[3H]quinuclidinyl benzylate [( 3H]L-QNB) and acetylcholinesterase (AChE) were assayed. Between 1 and 6 days the number of [3H]L-QNB binding sites was lower in the contralater...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(84)90313-4

    authors: Jerusalinsky DA,De Robertis E

    更新日期:1984-06-01 00:00:00

  • In vivo measurement of a diurnal variation in vasopressin release in the rat suprachiasmatic nucleus.

    abstract::Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00324-j

    authors: Kalsbeek A,Buijs RM,Engelmann M,Wotjak CT,Landgraf R

    更新日期:1995-06-05 00:00:00

  • Vagally mediated insulin secretion by stimulation of brain cholinergic neurons with neostigmine in bilateral adrenalectomized rats.

    abstract::This study investigated the relationship between central cholinergic neurons and insulin secretion in bilateral adrenalectomized fed rats. Neostigmine (a cholinesterase inhibitor, 5 x 10(-8) mol) administered into the third cerebral ventricle produced significant increases in hepatic venous plasma insulin and glucose ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91003-2

    authors: Gotoh M,Iguchi A,Yatomi A,Uemura K,Miura H,Futenma A,Kato K,Sakamoto N

    更新日期:1989-07-24 00:00:00

  • Mitochondrial toxins in models of neurodegenerative diseases. I: In vivo brain hydroxyl radical production during systemic MPTP treatment or following microdialysis infusion of methylpyridinium or azide ions.

    abstract::Mitochondrial electron transport chain (ETC) function is selectively reduced in multiple tissues, including brain, from patients with Parkinson's disease (PD) and Alzheimer's disease (AD). The ETC defects are specific to each illness, involve complex I in PD and complex IV in AD, are transferable with mitochondrial DN...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00429-0

    authors: Smith TS,Bennett JP Jr

    更新日期:1997-08-15 00:00:00

  • Age-related increase in oxidized proteins in mouse synaptic mitochondria.

    abstract::Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated their contents in synaptic mitochondria from five age groups of mice. Protein carbonyl content in synaptic mitochondria showed a significant positive correlation with age (r = 0.95, P = 0.01). A lin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00708-1

    authors: Martinez M,Hernández AI,Martínez N,Ferrándiz ML

    更新日期:1996-08-26 00:00:00

  • Short photoperiod and testosterone-induced modification of GnRH release from the hypothalamus of Peromyscus maniculatus.

    abstract::Seasonally breeding animals undergo numerous physiological changes in response to changes in the length of the photoperiod. In most warm-weather breeding rodents, these changes result in reproductive quiescence during short photoperiods. It has been hypothesized that this change is mediated by changes in the activity ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.08.083

    authors: Mintz EM,Lavenburg KR,Blank JL

    更新日期:2007-11-14 00:00:00

  • Musical scale properties are automatically processed in the human auditory cortex.

    abstract::While listening to music, we immediately detect 'wrong' tones that do not match our expectations based on the prior context. This study aimed to determine whether such expectations can occur preattentively, as indexed by event-related potentials (ERPs), and whether these are modulated by attentional processes. To this...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.08.023

    authors: Brattico E,Tervaniemi M,Näätänen R,Peretz I

    更新日期:2006-10-30 00:00:00

  • Progesterone stimulates sexual behaviour in female rats by increasing 5-HT activity on 5-HT2 receptors.

    abstract::We have investigated the possibility that there is a correlation between female sexual receptivity and CNS serotonergic activity. In ovariectomized rats primed with a submaximal steroid regime of 2 micrograms oestradiol benzoate (OB) plus 0.2 mg progesterone (P), so that only a proportion were receptive, the 5-hydroxy...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91575-6

    authors: Wilson CA,Hunter AJ

    更新日期:1985-05-06 00:00:00

  • Presynaptic tyrosine availability in the phenylketonuric brain: a hypothetical evaluation.

    abstract::From measured effects of amino acids on synaptosomal tyrosine uptake and from published data on human CNS levels of amino acids hypothetical calculations were made to compare CNS tyrosine availability for catecholamine synthesis in the hyperphenylalaninemic and non-hyperphenylalaninemic condition. These calculations i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90380-3

    authors: Peterson NA,Shah SN,Raghupathy E,Rhoads DE

    更新日期:1983-08-01 00:00:00

  • Expression of metallothionein-III induced by hypoxia attenuates hypoxia-induced cell death in vitro.

    abstract::Metallothioneins (MTs) are metal-binding proteins that are expressed in many tissues including brain. MTs protect cells and organs against metal toxicity and oxidants. Among MTs, a brain-predominant subtype MT-III has prominent neuroprotective activity against various types of damage. Here we show that the expression ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02633-7

    authors: Tanji K,Irie Y,Uchida Y,Mori F,Satoh K,Mizushima Y,Wakabayashi K

    更新日期:2003-06-20 00:00:00

  • Identification of opioid peptides regulating proliferation of neurons and glia in the developing nervous system.

    abstract::Endogenous opioid systems (i.e. opioids and opioid receptors) play a role in regulating neural development. Using the cerebellar cortex of 6-day-old rats, the most potent opioid peptides involved with cell proliferation were assessed. In both the external germinal (granule) layer (EGL), a germinative matrix giving ris...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91585-o

    authors: Zagon IS,McLaughlin PJ

    更新日期:1991-03-01 00:00:00

  • Microinjection of bicuculline into the central nucleus of the amygdala alters gustatory responses of the rat parabrachial nucleus.

    abstract::The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the GABA receptors within the CeA are involved in this m...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2004.08.068

    authors: Kang Y,Yan J,Huang T

    更新日期:2004-11-26 00:00:00

  • The effects of selective blockade of delta and mu opiate receptors on ethanol consumption by C57BL/6 mice in a restricted access paradigm.

    abstract::The effects of naltrexone, naltrindole (a selective delta opiate receptor antagonist) and beta-funaltrexamine (beta-FNA; a selective mu opiate receptor antagonist) on alcohol intake by C57BL/6 mice in a restricted access paradigm were examined. During the pretreatment baseline phase, mice consumed an average of 1.3 g/...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90672-a

    authors: Lê AD,Poulos CX,Quan B,Chow S

    更新日期:1993-12-10 00:00:00

  • The protective role of mild acidic pH shifts on synaptic NMDA current in hippocampal slices.

    abstract::Glutamate is a major neurotransmitter in the CNS. Its release activates NMDA and non-NMDA receptors on the postsynaptic membrane. NMDA receptor activation is shown to be important in physiological and pathological events. The modulatory sites on the NMDA receptor-channel ionophore complex are important in the regulati...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01461-3

    authors: Saybasili H

    更新日期:1998-03-09 00:00:00