Out with the old and in with the new: Synaptic mechanisms of extinction in the amygdala.

Abstract:

:Considerable research indicates that long-term synaptic plasticity in the amygdala underlies the acquisition of emotional memories, including those learned during Pavlovian fear conditioning. Much less is known about the synaptic mechanisms involved in other forms of associative learning, including extinction, that update fear memories. Extinction learning might reverse conditioning-related changes (e.g., depotentiation) or induce plasticity at inhibitory synapses (e.g., long-term potentiation) to suppress conditioned fear responses. Either mechanism must account for fear recovery phenomena after extinction, as well as savings of extinction after fear recovery. This article is part of a Special Issue entitled SI: Brain and Memory.

journal_name

Brain Res

journal_title

Brain research

authors

Maren S

doi

10.1016/j.brainres.2014.10.010

subject

Has Abstract

pub_date

2015-09-24 00:00:00

pages

231-8

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(14)01362-6

journal_volume

1621

pub_type

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