Abstract:
:When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.
journal_name
Brain Resjournal_title
Brain researchauthors
Close JM,Neil JJ,Loewy ADdoi
10.1016/0006-8993(82)90076-2subject
Has Abstractpub_date
1982-10-14 00:00:00pages
393-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(82)90076-2journal_volume
249pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.07.022
更新日期:2010-09-24 00:00:00
abstract::Postsynaptic potentials were evoked in neostriatal neurons by stimulation of the ipsilateral and contralateral medial agranular frontal cortical field (AGm) in the rat. This cortical region is known to project bilaterally to the dorsal lateral head of the caudate-putamen of rats. Ipsilateral stimulation of AGm should ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91593-3
更新日期:1986-03-05 00:00:00
abstract::The glutamate analogue 2-amino-4-phosphonobutyric acid (AP4) is a potent antagonist at several synapses where an excitatory amino acid appears to be the neurotransmitter. Previous studies identified a Cl-/Ca2+ dependent [3H]glutamate binding site in synaptic plasma membrane (SPM) preparations that was also labeled by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90977-7
更新日期:1986-06-04 00:00:00
abstract::Auditory transients (such as sound onset or a frequency transition within a continuous sound) are assumed to parse the auditory input into smaller units enabling the formation of unitary sound representations separately for each segment. This was discovered by using the mismatch negativity (MMN) component of the event...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.046
更新日期:2012-06-29 00:00:00
abstract::Presumptive neurons, immature neurons and degenerating structures were found in the intermediate and deep layers of the superior colliculus of normal cats over the age range 7-45 days postnatal. Electron microscopical analysis revealed these structures to be unexpectedly frequent in the early postnatal period. There w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90013-0
更新日期:1984-05-01 00:00:00
abstract::Gamma-hydroxybutyrate (GHB) has been shown to have therapeutical properties in various psychiatric disorders, especially in alcohol abuse, and to mimic different actions of ethanol at the cellular and system level. Using whole-cell patch-clamp recordings on brain slices of 21- to 25-day-old rats, the present study inv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.10.046
更新日期:2004-01-30 00:00:00
abstract::The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01457-s
更新日期:1995-03-13 00:00:00
abstract::Defeat stress in mice, a model of social stress, increases benzodiazepine receptor binding as measured by specific [3H]Ro15-1788 binding in vivo, but not by [3H]flunitrazepam binding in vitro. This increase occurs rapidly, by 20 min following exposure to stress, and resolves by 60 min. Increased benzodiazepine recepto...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90023-0
更新日期:1987-06-30 00:00:00
abstract::Previous examination of binge cocaine self-administration and 2 week withdrawal from cocaine self-administration on ionotropic glutamate receptor subunit (iGluRs) protein levels revealed significant alterations in iGluR protein levels that differed between the mesocorticolimbic and nigrostriatal pathways. The present ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.051
更新日期:2005-12-07 00:00:00
abstract::The distribution of neurocalcin-immunoreactive (NC-ir) primary sensory neurons was examined in the trigeminal ganglion (TG), mesencephalic trigeminal tract nucleus (Mes5) and intraoral structures. NC-ir primary sensory neurons were located in the TG but not the Mes5. The coexpression study demonstrated that virtually ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02175-2
更新日期:2000-05-02 00:00:00
abstract::This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00249-2
更新日期:1998-06-08 00:00:00
abstract::Previous reports from this laboratory have indicated that fetal rat striatal grafts have the major types of neuronal and glial components known to be involved in Huntington's chorea. In this study a number of major afferent and efferent innervations seen in normal striatum were examined in the striatal grafts and were...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91592-8
更新日期:1989-12-11 00:00:00
abstract::Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no signif...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90949-6
更新日期:1983-10-31 00:00:00
abstract::The neuropathological consequences of acute exposure to the neurotoxicants ammonia and octanoic acid were investigated with the isolated, perfused canine brain preparation. After 1 h of combined hyperammonemia and octanoic acidemia, ultrastructural changes were apparent in all brain regions examined. The cell bodies o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90916-3
更新日期:1985-08-12 00:00:00
abstract::Previous work has suggested that the rewarding effect of hippocampal stimulation develops only as a consequence of neuroplastic change resulting from repeated stimulation experience: naive rats will not initiate self-stimulation for several days, but a prior program of hippocampal kindling greatly facilitates acquisit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91706-m
更新日期:1990-06-18 00:00:00
abstract::The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01234-6
更新日期:1997-01-16 00:00:00
abstract::(1) After inoculation of the pseudorabies virus in the anterior chamber of the eye of the rat, virions can be found only in the neurons of the superior cervical sympathetic ganglion and in the sensory ganglion of the fifth nerve on the inoculated side. Other nervous structures--central or peripheral--are not infected....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(78)90241-x
更新日期:1978-01-20 00:00:00
abstract::The effect of chronic administration of morphine to rats on the N-methyl-D-aspartate (NMDA) receptors labeled with [3H]MK-801, a non-competitive antagonist, was determined in brain regions and spinal cord. Male Sprague-Dawley rats were rendered tolerant to and physically dependent on morphine by subcutaneous implantat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91740-x
更新日期:1994-03-14 00:00:00
abstract::In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90353-8
更新日期:1988-07-19 00:00:00
abstract::To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)91044-8
更新日期:1984-03-05 00:00:00
abstract::Potassium-evoked cholecystokinin (CCK) release from slices of caudate-putamen and cerebral cortex, but not hippocampus incubated in vitro was increased by 152-175% by preincubation for 40 min with 10 mM lithium. These results and previous studies suggest that although different physiological agents regulate CCK releas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91030-4
更新日期:1987-06-16 00:00:00
abstract::Norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MOPEG) were determined in medio-basal hypothalamus of adult male rats using high-performance liquid chromatography to study nutritional modulation of noradrenergic turnover. Acute starvation, as well as 3 weeks of semistarvation with a low-protein high-carbohydr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90471-8
更新日期:1985-06-03 00:00:00
abstract::The mechanisms responsible for the rate of rise (RR) of cumulative depolarization induced by dorsal root stimulus trains were investigated with intracellular recordings from motoneurones of the rat isolated spinal cord. The NMDA receptor antagonists CPP or APV depressed the cumulative depolarization but not its RR whi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00997-3
更新日期:1996-11-04 00:00:00
abstract::Pharmacological studies using an in vitro model system were carried out to determine if naloxone, an opiate receptor antagonist, could have effects on neuronal membranes which were unrelated to its action as an opiate receptor antagonist. Intracellular recordings were made from cultured mammalian spinal cord neurons. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90747-7
更新日期:1980-10-06 00:00:00
abstract::Spinally-projecting A5 neurons were studied with anatomical and electrophysiological techniques in the rat. A detailed study of the number and distribution of spinally-projecting catecholaminergic (CA) and non-catecholaminergic neurons present in a defined area of ventrolateral pontine reticular formation was performe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90206-3
更新日期:1984-06-11 00:00:00
abstract::In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(83)90018-4
更新日期:1983-06-01 00:00:00
abstract::The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02659-2
更新日期:2001-08-10 00:00:00
abstract::The terminal areas and cells of origin of the projection from the dorsal column nuclei to the mesencephalon were investigated by the intra-axonal transport method. Following injection of wheat germ agglutinin-horseradish peroxidase conjugate into the dorsal column nuclei, anterograde labeling was observed in several r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90086-6
更新日期:1984-10-08 00:00:00
abstract::Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91651-9
更新日期:1994-05-09 00:00:00
abstract::The aim of this study was to investigate the relationship between serum metabolomic biomarkers and brain in vivo magnetic resonance spectroscopy (MRS) biomarkers in patients with Parkinson's disease (PD) as well as to investigate compound concentration changes by comparing the results with healthy control subjects. Un...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147118
更新日期:2020-12-01 00:00:00