Actions of N-methyl aspartate and its antagonist aminophosphonovalerate on the A5 catecholamine cell group in rat.

Abstract:

:When N-methyl-D,L-aspartic acid was injected into the A5 catecholamine cell group of the rat, a dose-dependent decrease in blood pressure and heart rate was obtained. These cardiovascular changes were subsequently blocked by the (-) and (+) isomers of the aspartate receptor blocker 2-amino-5-phosphonovalerate (2-amino-5-phosphonopentanoic acid). The (-) isomer was 2-4 times more potent than the (+) form.

journal_name

Brain Res

journal_title

Brain research

authors

Close JM,Neil JJ,Loewy AD

doi

10.1016/0006-8993(82)90076-2

subject

Has Abstract

pub_date

1982-10-14 00:00:00

pages

393-6

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(82)90076-2

journal_volume

249

pub_type

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