Abstract:
:In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in microglia. The LPS-inducible IL-1β was significantly suppressed by pretreatment with the NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide, but not by pretreatment with the O2(-) scavenger N-acetyl cysteine, suggesting the close association of NO with IL-1β induction. The pretreatment of microglia with the inducible NO synthase inhibitor 1400W prior to LPS stimulation significantly reduced the production of IL-1β, and the addition of the NO donor S-nitroso-N-acetyl-DL-penicillamine (SNAP) into microglia led to the induction of IL-1β. These results suggested that NO induces IL-1β through a specific signaling cascade. LPS-dependent IL-1β induction was significantly suppressed by inhibitors of extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and nuclear factor kappaB (NFκB), indicating that ERK/JNK and NFκB serve in the cascade of IL-1β induction. As expected, ERK/JNK and NFκB were all activated in the SNAP-stimulated microglia. Taken together, these results indicate that NO is an important signaling molecule for the ERK/JNK and NFκB activations, which are requisite to the induction of IL-1β in microglia.
journal_name
Brain Resjournal_title
Brain researchauthors
Sudo K,Takezawa Y,Kohsaka S,Nakajima Kdoi
10.1016/j.brainres.2015.08.030subject
Has Abstractpub_date
2015-11-02 00:00:00pages
121-34eissn
0006-8993issn
1872-6240pii
S0006-8993(15)00664-2journal_volume
1625pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The retrograde transport of fluorescent substances was used in order to investigate divergent axon collaterals of neurons in the nucleus prepositus hypoglossi (Ph). Fast blue (FB) was injected into the flocculus, paraflocculus and/or the vermis, while nuclear yellow (NY) was injected into the oculomotor nucleus alone ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90150-0
更新日期:1982-08-19 00:00:00
abstract::The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17 beta-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, ce...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91057-2
更新日期:1987-01-27 00:00:00
abstract::Routine cell stains disclose abnormal, usually single, nests of ectopic neurons in neocortical layer I of New Zealand Black (NZB) and BXSB autoimmune mice. We have suggested that these anomalies represent only the most visible part of more widespread cortical disorganization. In an attempt to determine the true magnit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90828-y
更新日期:1990-10-08 00:00:00
abstract::Attack by a cat on a rat was elicited by electrical stimulation of the ventral parabrachial nucleus or the paralemniscal pontine reticular formation. The attack was quiet and it differed from similar behavior elicited at other sites in that the cat not only bit the rat but struck it with its paw. Horseradish peroxidas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90009-x
更新日期:1979-03-23 00:00:00
abstract::The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147237
更新日期:2021-01-02 00:00:00
abstract::In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.02.065
更新日期:2011-04-22 00:00:00
abstract::Opioid-binding cell adhesion molecule (OBCAM) is the member of the IgLON family, a subgroup of the immunoglobulin superfamily. In the present study, the functions and dynamics of OBCAM were investigated in hippocampal neurons in vitro. Western blotting revealed that OBCAM expression was low at early stages of culture ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.062
更新日期:2007-08-24 00:00:00
abstract::Triiodothyronine (T3) plays an important role during development of the central nervous system. T3 effects on gene expression are determined in part by the type of thyroid hormone receptors (TRs) expressed in a given cell type. Previous studies have demonstrated that thyrotropin releasing hormone (TRH) transcription i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.042
更新日期:2009-12-11 00:00:00
abstract::IgLONs are a family of four GPI-anchored cell adhesion molecules that regulate neurite outgrowth, synaptogenesis and may act as tumour suppressor genes. IgLONs are thought to function as monomers or homodimers and we have proposed that IgLONs also act as heterodimeric complexes termed Dimeric IgLONs or DIgLONs. Here w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.028
更新日期:2011-02-16 00:00:00
abstract::The short and long-term effects of systemic administration of kainic acid to immature animals were studied in rats. Kainic acid was administered systemically to rats of 1-30 days of age. The rats were monitored for both behavioral and EEG changes. To study the effects of kainic acid on seizure susceptibility, status e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90066-1
更新日期:1988-03-01 00:00:00
abstract::Subcutaneous injection of formalin produces a biphasic pain response: a transient early phase followed by a tonic late phase. It has recently been suggested that development of the late phase depends upon the presence of the early one. In support of this suggestion, we now demonstrate that blocking the early phase by ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90478-r
更新日期:1992-02-14 00:00:00
abstract::In the framework of a series of investigations concerning the neural substrate of aversion, electrophysiological methods were used in order to specify, within the rat's periaqueductal gray (PAG), functional properties, viz. conduction velocity and refractory period, of PAG neurons already assessed in previous studies ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90140-x
更新日期:1986-10-29 00:00:00
abstract::Two separate in vitro assays were used to examine the biosynthesis of the broad spectrum excitatory amino acid receptor antagonist kynurenic acid (KYNA) during the life span of the adult rat. Assessment of KYNA's anabolic enzyme kynurenine aminotransferase revealed steady increases between 3 and 24 months of age in al...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91337-e
更新日期:1992-08-14 00:00:00
abstract::Fulfilled predictions lead to neural suppression akin to repetition suppression, but it is currently unclear if such effects generalize to broader stimulus categories in the absence of exact expectations. In particular, does expecting novelty alter the way novel stimuli are processed? In the present study, the effects...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.008
更新日期:2018-09-01 00:00:00
abstract::The mammalian circadian clock located in the suprachiasmatic nuclei (SCN) continues to oscillate when isolated in a brain slice preparation, and can be phase shifted in vitro by a variety of serotonergic (5-HTergic) agents. We have previously shown that 5-HT and a 5-HT agonist, quipazine, induce phase advances in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90348-4
更新日期:1994-04-25 00:00:00
abstract::A mutation in the Vps33a gene causes Hermansky-Pudlak Syndrome (HPS)-like-symptoms in the buff (bf) mouse mutant. The encoded product, Vps33a, is a member of the Sec1 and Class C multi-protein complex that regulates vesicle trafficking to specialized lysosome-related organelles. As Sec1 signaling pathways have been im...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.035
更新日期:2009-04-17 00:00:00
abstract::Neonatal rats were given capsaicin subcutaneously. Controls received vehicle only. Six months later the nerve fiber populations in the dorsal root L4, in the inferior alveolar nerve and in mandibular molar pulps were examined by electron microscopy. The proportion of unmyelinated axons was found to be markedly decreas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91315-x
更新日期:1983-04-25 00:00:00
abstract::Several studies have demonstrated that the blood-brain barrier (BBB) (dynamic cellular complex composed by brain capillary endothelial cells (BCECs) and surrounded by astrocytic end feet and pericytes) regulates the exchanges of amyloid β (Aβ) peptide between the blood and the brain. Deregulation of these exchanges se...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.047
更新日期:2015-01-12 00:00:00
abstract::Small iontophoretic application of wheat-germ-agglutinin conjugated to horseradish peroxidase, was used to simultaneously observe, in the rat, the afferent and the efferent connections of the cuneiformis nucleus (Cnf), in the same animal. The results demonstrate that the main Cnf afferent connections originate from: (...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90449-6
更新日期:1989-06-19 00:00:00
abstract::Variations in cerebral blood flow and partial pressures of oxygen and carbon dioxide (pO2, pCO2) were studied in rabbits during short-duration (1 min) immobilization stress. The techniques used enabled us to determine these variables locally in the caudate nucleus in a continuous, simultaneous and quantitative fashion...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90927-8
更新日期:1985-08-12 00:00:00
abstract::Earlier studies in this laboratory have shown that partial serotonergic (5-HT) deafferentation from the hippocampus induced a homotypic sprouting. The 5-HT-denervated hippocampus was further found to be a favorable environment for the growth of grafted 5-HT, but not for norepinephrinergic neurons. In the current study...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90286-k
更新日期:1990-01-22 00:00:00
abstract::The aim of the present study was to investigate the anxiolytic effects of long-term treatment with fluoxetine in rats. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, are used to treat anxiety and panic disorders, in addition to treating depression. A major concern with SSRIs is a 2-3-week delay i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02289-1
更新日期:2000-02-07 00:00:00
abstract::Inoculation of the tail base of rats with Mycobacterium butyricum led to an arthritic swelling and inflammation of the limbs which displayed a hyperalgesia to noxious pressure: these effects peaked at 3 weeks postinoculation. In vitro autoradiography of coronal sections of rat brain was used for a parallel determinati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90917-6
更新日期:1987-07-28 00:00:00
abstract::Aging leads to a decrease in the number of neurons expressing vasopressin (VP) and vasoactive intestinal polypeptide (VIP) in the suprachiasmatic nucleus (SCN) of the rat. Similar results were observed following prolonged alcohol consumption and withdrawal. In the latter circumstances, the administration of nerve grow...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.04.066
更新日期:2005-06-28 00:00:00
abstract::Previous research has demonstrated that cross-language activation is present even when proficient bilinguals perform a task only in one language. The present study investigated the time-course of cross-language activation during word production in a second language (L2) by using a picture-word interference paradigm wi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.11.053
更新日期:2011-01-31 00:00:00
abstract::Excessive stimulation of neurons by glutamic acid initiates a destructive cascade of ion fluxes, cellular swelling, and death. Homeostatic mechanisms which rectify these disturbances depend largely upon transmembrane ion gradients maintained by Na+,K(+)-ATPase (NaP). We proposed that the neurotoxicity of glutamate is ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90982-f
更新日期:1992-09-18 00:00:00
abstract::Microinjections of the substance P (SP) antagonist (D-pro2,D-phe7,D-trp9)-SP, or the gamma-aminobutyric acid (GABA) agonist, muscimol, into the entopeduncular nucleus reduced muscle tone in genetically spastic rats in a dose- and time-dependent manner. Similar injections into the ventral thalamus, zona incerta or amyg...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90564-r
更新日期:1990-02-19 00:00:00
abstract::Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this techniq...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.11.020
更新日期:2017-01-15 00:00:00
abstract::Activation of microglia is a well-documented phenomenon associated with diverse pathological conditions of the central nervous system. In order to investigate the involvement of microglial cells in the neurotoxic action of the heavy metal compound trimethyltin, three-dimensional brain cell cultures were treated during...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00509-o
更新日期:1995-08-28 00:00:00
abstract::Both enkephalin and 5-hydroxytryptamine (5-HT) have been implicated in neural mechanisms underlying the central control of respiration. In view of the role of the nuclei tractus solitarii (NTS) in respiratory regulation, we carried out a study in artificially ventilated, chloralose-anaesthetized cats of the effects of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91515-x
更新日期:1985-02-18 00:00:00