Role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo.


:In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors by local administration of NMDA (1-100μM) resulted in a concentration-dependent decrease in the extracellular concentration of norepinephrine in the hippocampus of freely moving rats, whereas the blockade of these receptors with MK801 (1-100μM) induced a concentration-dependent increase in norepinephrine output. Activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptors with AMPA (1-100μM) resulted in a biphasic effect on the extracellular norepinephrine concentration, with a decrease in this parameter apparent at 10μM and an increase at 100μM. The AMPA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione had no effect on norepinephrine output. The GABA(A) receptor antagonist bicuculline (10μM) prevented the decrease in hippocampal norepinephrine output induced by either NMDA or 10μM AMPA. Our results thus implicate ionotropic glutamate receptors as key regulators of norepinephrine release in the hippocampus and may therefore provide a basis for the development of new drugs for stress-related disorders.


Brain Res


Brain research


Dazzi L,Matzeu A,Biggio G




Has Abstract


2011-04-22 00:00:00












  • Site of interaction of serotonin and desglycinamide-arginine-vasopressin in maintenance of ethanol tolerance.

    abstract::Rats trained to walk in a moving belt apparatus were subjected to a partial (fornix-fimbria (FF] or total (fornix-fimbria + cingulum bundles (FF + CB] chemical denervation of the dorsal serotonergic afferent pathways to the hippocampus. After chronic alcohol treatment that resulted in tolerance development to the moto...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Speisky MB,Kalant H

    更新日期:1985-02-11 00:00:00

  • Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP.

    abstract::To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Overstreet DH,Russell RW,Crocker AD,Schiller GD

    更新日期:1984-03-05 00:00:00

  • A quantitative study of developing axons and glia following altered gliogenesis in rat optic nerve.

    abstract::Axonal and glial cell development within rat optic nerve in which gliogenesis was altered by systemic injection of 5-azacytidine (5-AZ) was examined by quantitative electron microscopy. In neonatal (0-2 days) rat optic nerves, all fibers are premyelinated, and they exhibit a fairly uniform diameter (approximately 0.22...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Black JA,Waxman SG,Ransom BR,Feliciano MD

    更新日期:1986-08-13 00:00:00

  • Failure of deferoxamine, an iron chelator, to improve outcome after collagenase-induced intracerebral hemorrhage in rats.

    abstract::Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Warkentin LM,Auriat AM,Wowk S,Colbourne F

    更新日期:2010-01-14 00:00:00

  • Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.

    abstract::In the hippocampus, BK channels are preferentially localized in presynaptic glutamatergic terminals including mossy fibers where they are thought to play an important role regulating excessive glutamate release during hyperactive states. Large conductance calcium-activated potassium channels (BK, MaxiK, Slo) have rece...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pacheco Otalora LF,Hernandez EF,Arshadmansab MF,Francisco S,Willis M,Ermolinsky B,Zarei M,Knaus HG,Garrido-Sanabria ER

    更新日期:2008-03-20 00:00:00

  • An evaluation of the use of intraventricularly administered [3H]5-hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine.

    abstract::Following the intraventricular injection of a small amount of [3H]5-hydroxytryptamine ([3H]5-HT), the amount of radioactivity in telencephalic structures on the injected side was 6--7 times larger than that in corresponding areas on the opposite side. Moreover, a multiphasic disappearance of [3H]5-HT from whole brain ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gallager DW,Sanders-Bush E,Aghajanian GK,Sulser F

    更新日期:1975-07-25 00:00:00

  • The avian subpallium: new insights into structural and functional subdivisions occupying the lateral subpallial wall and their embryological origins.

    abstract::The subpallial region of the avian telencephalon contains neural systems whose functions are critical to the survival of individual vertebrates and their species. The subpallial neural structures can be grouped into five major functional systems, namely the dorsal somatomotor basal ganglia; ventral viscerolimbic basal...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Kuenzel WJ,Medina L,Csillag A,Perkel DJ,Reiner A

    更新日期:2011-11-18 00:00:00

  • Tetrodotoxin-sensitive and -resistant Na+ channel currents in subsets of small sensory neurons of rats.

    abstract::Voltage-activated Na+ channels in the primary sensory neurons are important for generation of action potentials and regulation of neurotransmitter release. The Na+ channels expressed in different types of dorsal root ganglion (DRG) neurons are not fully known. In this study, we determined the possible difference in te...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wu ZZ,Pan HL

    更新日期:2004-12-17 00:00:00

  • Immediate-early gene expression in cerebral cortex following exposure to chronic-intermittent hypoxia.

    abstract::Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical cir...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sica AL,Greenberg HE,Scharf SM,Ruggiero DA

    更新日期:2000-07-07 00:00:00

  • Aromatase- (estrogen synthetase) immunoreactive neurons in the rat septal area. A light and electron microscopic study.

    abstract::The aromatase enzyme (estrogen synthetase) catalyzes the conversion of testosterone to estrogen in peripheral and central nervous tissue. Light and electron microscopic immunocytochemistry was used to study the localization of this enzyme in the septal area of adult male and female albino rats. Aromatase-immunoreactiv...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jakab RL,Harada N,Naftolin F

    更新日期:1994-11-21 00:00:00

  • Effect of subacute and chronic immobilisation stress on the outcome of permanent focal cerebral ischaemia in rats.

    abstract::The aim of this study was to determine the effect of mood disorders, including psychological distress and depression, on stroke outcome. Male Fischer rats were exposed to immobilisation stress, an animal paradigm of psychological stress, major depression and post-traumatic stress disorder. Either a subacute (1 h for 7...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Madrigal JL,Caso JR,de Cristóbal J,Cárdenas A,Leza JC,Lizasoain I,Lorenzo P,Moro MA

    更新日期:2003-07-25 00:00:00

  • Cyclic nucleotides in the rat neostriatum: push-pull perfusion studies.

    abstract::A push-pull perfusion technique was employed for in vivo study of adenosine 3',5'-monophosphate (cAMP) and guanosine 3',5'-monophosphate (cGMP) in the rat caudate nucleus. Addition of dopamine to the perfusion fluid elicited dose-dependent increases of both cAMP and cGMP perfusate concentrations. In separate experimen...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schoener EP,Hager PJ,Felt BT,Schneider DR

    更新日期:1979-12-21 00:00:00

  • Hippocampal polymorph neurons are the cells of origin for ipsilateral association and commissural afferents to the dentate gyrus.

    abstract::Neurons in the polymorph layer of the hippocampal dentate hilus were found to be the cells of origin for ipsilateral association and commissural projections to the dentate gyrus. Both afferent systems terminate in the proximal one-third of the stratum moleculare. The polymorph layer is the primary target for noradrene...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Berger TW,Semple-Rowland S,Basset JL

    更新日期:1981-06-29 00:00:00

  • Increases in ribosomal RNA within the denervated neuropil of the dentate gyrus during reinnervation: evaluation by in situ hybridization using DNA probes complementary to ribosomal RNA.

    abstract::Previous studies have revealed that there are increases in the incorporation of [3H]amino acids into protein in the denervated neuropil of the dentate gyrus during periods of reactive synaptogenesis. The present study evaluates whether the increase in incorporation reflects an increase in protein synthetic machinery (...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Phillips LL,Nostrandt SJ,Chikaraishi DM,Steward O

    更新日期:1987-09-01 00:00:00

  • Synaptic glomeruli in the nucleus submedius of the rat thalamus.

    abstract::Synaptic glomeruli in the nucleus submedius of the rat are described and the source of some of the component terminals identified. The glomeruli consist of large terminals with round synaptic vesicles establishing Gray type I contacts with dendrites and surrounded by layers of astrocyte derived membranes. The astrocyt...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ma W,Ohara PT

    更新日期:1987-07-14 00:00:00

  • Studies of substrate requirements, kinetic properties, and competive inhibitors of the enzymes catabolizing TRH in rat brain.

    abstract::The enzymes catalyzing the breakdown of TRH are soluble and dependent upon active sulfhydryl groups. One of these enzymes is a pyroglutamyl aminopeptidase (EC (apparent molecular weight 60,000 daltons) with a specificity restricted to pyroglutamyl peptide bonds. The second enzyme is a prolyl endopeptidase (a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Busby WH Jr,Youngblood WW,Kizer JS

    更新日期:1982-06-24 00:00:00

  • Single unit sensory activity in free walking crabs: force sensitive mechanoreceptors of the dactyl.

    abstract::Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zill SN,Libersat F,Clarac F

    更新日期:1985-06-17 00:00:00

  • Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex.

    abstract::The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vickers JC,Huntley GW,Hof PR,Bederson J,DeFelipe J,Morrison JH

    更新日期:1995-02-06 00:00:00

  • Melanotropin receptors in the brain are differentially distributed and recognize both corticotropin and alpha-melanocyte stimulating hormone.

    abstract::Melanotropinergic neurons in the brain may mediate the known modulatory effects of alpha-melanocyte stimulating hormone (alpha-MSH) and adrenocorticotropic hormone (ACTH) on brain functions including thermoregulation, pituitary regulation, learning and behavior. To determine the distribution of brain melanotropin rece...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tatro JB

    更新日期:1990-12-17 00:00:00

  • Thalamic multiple-unit activity underlying spike-wave discharges in anesthetized rats.

    abstract::In epilept WAG/Rij rats, multiple unit activity coinciding with the occurrence of spike-wave discharges was recorded under neurolept anesthesia. Recordings were made in the frontal cortex and in various nuclei of the thalamus, in specific nuclei such as the ventroposterolateral, the ventroposteromedial and the ventrol...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Inoue M,Duysens J,Vossen JM,Coenen AM

    更新日期:1993-05-28 00:00:00

  • The influence of strongly focused visual attention on the detection of change in an auditory pattern.

    abstract::The mismatch negativity, an ERP that reflects the detection of change in the auditory environment, is considered to be a relatively automatic process. Its automaticity has by in large been studied using the oddball paradigm, in which a physical feature of a frequently presented standard stimulus is changed. In the pre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sculthorpe LD,Collin CA,Campbell KB

    更新日期:2008-10-09 00:00:00

  • Evidence for coexistence of serotonin and noradrenaline in sympathetic nerves supplying brain vessels of guinea pig.

    abstract::Nerve fibers containing 5-hydroxytryptamine (5-HT) were demonstrated immunohistochemically in the wall of pial vessels associated with the circle of Willis in the guinea pig. The fibers formed a network structure which was more dense in the rostral part of the arterial circle and its branches than in the caudal part. ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang JY,Owman C,Steinbusch HW

    更新日期:1988-01-12 00:00:00

  • Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX.

    abstract::Nuclear factor one X (NFIX) has been shown to play a pivotal role during the development of many regions of the brain, including the neocortex, the hippocampus and the cerebellum. Mechanistically, NFIX has been shown to promote neural stem cell differentiation through the activation of astrocyte-specific genes and via...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vidovic D,Harris L,Harvey TJ,Evelyn Heng YH,Smith AG,Osinski J,Hughes J,Thomas P,Gronostajski RM,Bailey TL,Piper M

    更新日期:2015-08-07 00:00:00

  • Organization of projections from the medial agranular cortex to the superior colliculus in the rat: a study using anterograde and retrograde tracing methods.

    abstract::The organization of corticotectal projections from the medial agranular cortex (AGm), which has been considered to contain rat's frontal eye field, was examined using anterograde and retrograde tracing techniques. When biotinylated dextranamine (BDA) injections were made into the rostral part of the AGm, small numbers...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tsumori T,Yokota S,Ono K,Yasui Y

    更新日期:2001-06-08 00:00:00

  • Electrophysiological correlates of the efficient detection of emotional facial expressions.

    abstract::Behavioral studies have shown that emotional facial expressions are detected more rapidly and accurately than are neutral expressions. However, the neural mechanism underlying this efficient detection has remained unclear. To investigate this mechanism, we measured event-related potentials (ERPs) during a visual searc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sawada R,Sato W,Uono S,Kochiyama T,Toichi M

    更新日期:2014-04-29 00:00:00

  • Progesterone attenuates thrombin-induced endothelial barrier disruption in the brain endothelial cell line bEnd.3: The role of tight junction proteins and the endothelial protein C receptor.

    abstract:UNLABELLED:This study examines the effects of progesterone on blood-brain barrier (BBB) integrity following thrombin administration. Thrombin is expressed in many diseases which affect neural tissue and is associated with breakdown of the BBB. Progesterone has shown protective effects on the BBB in stroke and traumatic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hun Lee J,Won S,Stein DG

    更新日期:2015-07-10 00:00:00

  • The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal cultures.

    abstract::We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gober MD,Laing JM,Thompson SM,Aurelian L

    更新日期:2006-11-13 00:00:00

  • Release of luteinizing hormone-releasing hormone: interrelations between eicosanoids and catecholamines.

    abstract::The in vitro release of luteinizing hormone-releasing hormone (LHRH), prostaglandin (PG) E2 and leukotriene (LT) C4 from male rat median eminences (ME), was estimated by radioimmunoassay (RIA) in the presence of the catecholamines (CA), norepinephrine (NE) and dopamine (DA). NE increased the release of PGE2 in the pre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Saadi M,Gerozissis K,Dray F

    更新日期:1989-05-29 00:00:00

  • The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.

    abstract::Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Czarnecka A,Konieczny J,Lenda T,Lorenc-Koci E

    更新日期:2015-11-02 00:00:00

  • Combined therapy affects outcomes differentially after mild traumatic brain injury and secondary forebrain ischemia in rats.

    abstract::Muscarinic and NMDA receptors contribute to post-traumatic hypersensitivity to secondary ischemia. However, the effect of these receptor antagonists on behavior and CA1 neuronal death after traumatic brain injury (TBI) with acute (1 h after TBI) forebrain ischemia has not been systematically assessed. We examined cogn...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jenkins LW,Lu Y,Johnston WE,Lyeth BG,Prough DS

    更新日期:1999-01-30 00:00:00