Role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo.


:In vitro evidence indicates that norepinephrine release in the mammalian hippocampus is modulated by glutamate receptors. With the use of microdialysis, we have now evaluated the role of ionotropic glutamate receptors in the regulation of hippocampal norepinephrine output in vivo. Stimulation of N-methyl-D-aspartate (NMDA)-sensitive glutamate receptors by local administration of NMDA (1-100μM) resulted in a concentration-dependent decrease in the extracellular concentration of norepinephrine in the hippocampus of freely moving rats, whereas the blockade of these receptors with MK801 (1-100μM) induced a concentration-dependent increase in norepinephrine output. Activation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA)-sensitive glutamate receptors with AMPA (1-100μM) resulted in a biphasic effect on the extracellular norepinephrine concentration, with a decrease in this parameter apparent at 10μM and an increase at 100μM. The AMPA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione had no effect on norepinephrine output. The GABA(A) receptor antagonist bicuculline (10μM) prevented the decrease in hippocampal norepinephrine output induced by either NMDA or 10μM AMPA. Our results thus implicate ionotropic glutamate receptors as key regulators of norepinephrine release in the hippocampus and may therefore provide a basis for the development of new drugs for stress-related disorders.


Brain Res


Brain research


Dazzi L,Matzeu A,Biggio G




Has Abstract


2011-04-22 00:00:00












  • Selective activation of mesolimbic and mesocortical dopamine metabolism in rat brain by infusion of a stable substance P analogue into the ventral tegmental area.

    abstract::Microinfusion of the metabolically stable substance P (SP) agonist, [pGlu5,MePhe8,Sar9]-SP5-11 (DiMe-C7), into the ventral tegmental area (VTA) of rat brain increased levels of the dopamine (DA) metabolite dihydroxyphenylacetic acid in the prefrontal cortex (+ 120%) and nucleus accumbens (+30%) but not in other region...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Elliott PJ,Alpert JE,Bannon MJ,Iversen SD

    更新日期:1986-01-15 00:00:00

  • Paeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways.

    abstract::Alzheimer׳s disease (AD) is a neurodegenerative disease with elusive pathogenesis, which accounts for most cases of dementia in the aged population. It has been reported that persistent inflammatory responses and excessive chemotaxis of microglia stimulated by beta-amyloid (Aβ) oligomers in the brain may accelerate th...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Liu H,Wang J,Wang J,Wang P,Xue Y

    更新日期:2015-08-27 00:00:00

  • Single unit response of noradrenergic, serotonergic and dopaminergic neurons in freely moving cats to simple sensory stimuli.

    abstract::The response of noradrenergic (NE), serotonergic (5-HT), and dopaminergic (DA), neurons to repeated presentations (once/2 s for 64 trials) of phasic auditory (click) and visual (flash) stimuli was examined in freely moving cats. All 3 groups of neurons displayed similar response latencies and somewhat similar duration...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rasmussen K,Strecker RE,Jacobs BL

    更新日期:1986-03-26 00:00:00

  • Analysis of anti-depressant potential of curcumin against depression induced male albino wistar rats.

    abstract::The present study investigated the antidepressant potential of curcumin in olfactory bulbectomy and forced swimming test models of depression in male albino rats under chronic treatment. The experimental animals were divided into four groups, and curcumin was administered for 45 days. Our results showed that the curcu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang XR,Wang L,Li J,Wu DS

    更新日期:2016-07-01 00:00:00

  • Reducing conditions differentially affect the functional and structural properties of group-I and -II metabotropic glutamate receptors.

    abstract::We have examined the influence of reducing conditions on the activity of group-I or -II metabotropic glutamate receptors. In cultured cerebellar granule cells or in hippocampal slices, the reducing agent dithiothreitol (DTT) inhibited the stimulation of polyphosphoinositide (PPI) hydrolysis elicited by group-I mGlu re...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Copani A,Romano C,Di Giorgi Gerevini V,Nicosia A,Casabona G,Storto M,Mutel V,Nicoletti F

    更新日期:2000-06-09 00:00:00

  • Serotonin agonists mimic the phase shifting effects of light on the melatonin rhythm in rats.

    abstract::The effect of serotonin agonists on the rhythmic excretion of the melatonin metabolite 6-sulphatoxymelatonin was examined in rats. The animals were maintained in 12L:12D and administered saline, quipazine (10 mg/kg), (+/-)-2-propylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (8-OH-DPAT, 5 mg/kg) or buspi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kennaway DJ,Rowe SA,Ferguson SA

    更新日期:1996-10-21 00:00:00

  • The electrophysiological and morphological characteristics of feline dorsal root ganglion cells.

    abstract::The electrophysiological characteristics of physiologically typed L7 and S1 dorsal root ganglion (DRG) cells have been studied in the cat by intracellular recording. The injection of the fluorescent dye Lucifer Yellow has enabled us to study the morphology of these neurons. Our results show that over the entire range ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cameron AA,Leah JD,Snow PJ

    更新日期:1986-01-01 00:00:00

  • Evaluation of the effects of testosterone and luteinizing hormone on regulation of β-amyloid in male 3xTg-AD mice.

    abstract::During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rosario ER,Carroll JC,Pike CJ

    更新日期:2012-07-23 00:00:00

  • Laminar patterns of geniculocortical projection in the cat.

    abstract::The cortical afferents from individual laminae of the dorsal lateral geniculate nucleus (LGN) were studied using both light and electron microscope autoradiography. In area 17, the A geniculate laminae (A and A1) had two main bands of projection, one extending from the bottom of IVc to the deepest cells in layer III, ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: LeVay S,Gilbert CD

    更新日期:1976-08-20 00:00:00

  • Co-localization of enkephalin and cholecystokinin in discrete areas of rat brain.

    abstract::A double-label immunofluorescence technique was used to demonstrate that immunoreactivities for the functionally antagonistic neuropeptides enkephalin and cholecystokinin octapeptide (CCK) are co-localized within individual neurons and processes in discrete areas of rat midbrain and forebrain. Coexistence was most pro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gall C,Lauterborn J,Burks D,Seroogy K

    更新日期:1987-02-17 00:00:00

  • Seizure-induced neuronal apoptosis is related to dysregulation of the RNA-edited GluR2 subunit in the developing mouse brain.

    abstract::Ca2+-permeable AMPA receptors (AMPAR) which crucially modify maturational programs of the developing brain are involved in seizure-induced glutamate excitotoxicity and apoptosis. Regulatory effects on AMPAR subunit composition and RNA-editing in the developing brain and their significance as therapeutic targets are no...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jung S,Ballheimer YE,Brackmann F,Zoglauer D,Geppert CI,Hartmann A,Trollmann R

    更新日期:2020-05-15 00:00:00

  • The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease.

    abstract::The deposition of amyloid beta-peptide (Abeta) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Beta-site APP cleaving enzyme (BACE) is the rate-limiting enzyme in the Abeta formation. BACE mutations/polymorphisms may be associated with AD. We searched the BACE coding region mutations/polymorphism...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Liu HC,Leu SJ,Chang JG,Sung SM,Hsu WC,Lee LS,Hu CJ

    更新日期:2003-01-24 00:00:00

  • Effects of cholecystokinin on sympathetic activity to interscapular brown adipose tissue.

    abstract::The effects of injecting cholecystokinin (CCK) into the third ventricle or into selected hypothalamic sites on electrical firing rate of sympathetic nerves to interscapular brown fat (IBAT) has been investigated in anesthetized rats. The hypothesis for these experiments was that there was a reciprocal relationship bet...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Yoshimatsu H,Egawa M,Bray GA

    更新日期:1992-12-04 00:00:00

  • Enkephalin-like immunoreactivity levels increase in the motor nucleus after an intramedullar axotomy of motoneurons in the adult cat spinal cord.

    abstract::Neuropeptide- and serotonin-like immunoreactivities were studied in the lumbar spinal cord of the cat after a longitudinal incision in the ventral funiculus. This lesion, which accomplishes a central axotomy of motoneurons, was accompanied by increased level of Met-enkephalin-like immunoreactivity in nerve endings in ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lindå H,Cullheim S,Risling M,Arvidsson U,Mossberg K,Ulfhake B,Terenius L,Hökfelt T

    更新日期:1990-11-26 00:00:00

  • Intra-amygdalar okadaic acid enhances conditioned taste aversion learning and CREB phosphorylation in rats.

    abstract::Protein phosphatases (PPs) regulate many substrates implicated in learning and memory. Conditioned taste aversion (CTA) learning, in which animals associate a novel taste paired with a toxin and subsequently avoid the taste, is dependent on several serine/threonine phosphatase substrates and the PP1-binding protein sp...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Oberbeck DL,McCormack S,Houpt TA

    更新日期:2010-08-12 00:00:00

  • Behavioral and electrophysiological study of cutaneous trigeminal nerves in axolotls. I. Normal innervation and reinnervation following nerve section.

    abstract::Behavioral responses to light tactile stimulation of the skin of the head of axolotls were variable in occurrence but were of a constant pattern. Retraction of the eyes and gills followed stimulation of dorsal but not ventral skin. Ventral skin yielded lowering of the head. Touching near the lips caused turning of the...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Griersmith BT,Mark RF

    更新日期:1981-09-01 00:00:00

  • Role of potassium channels in the central neurogenic neuroprotection elicited by cerebellar stimulation in rat.

    abstract::Electrical stimulation of the cerebellar fastigial nucleus (FN) in spontaneously hypertensive (SHR), Wistar-Kyoto (WKY) and Fisher rats reduced, by approximately 50%, the infarctions produced by occlusion of the middle cerebral artery. Blockade of ATP-dependent potassium (K-ATP) channels with glibenclamide (i.c.v.) ab...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Golanov EV,Christensen JD,Reis DJ

    更新日期:1999-09-25 00:00:00

  • Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area.

    abstract::High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Christie MJ,Bridge S,James LB,Beart PM

    更新日期:1985-04-29 00:00:00

  • Activation of central muscarinic receptors inhibit Ca2+/Mg2+ ATPase and ATP-dependent Ca2+ transport in synaptic membranes.

    abstract::Preparations of lysed synaptosomes exhibit a high affinity Ca2+/Mg2+ ATPase and ATP-dependent Ca2+ accumulation activity, with a Km for Ca2+ congruent to 0.5 microM, close to the cytosolic concentration of Ca2+. When these membrane suspensions were incubated with cholinergic agonists muscarine or oxotremorine (1-20 mi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ross DH,Shreeve SM,Hamilton MG

    更新日期:1985-03-11 00:00:00

  • Effects of sex steroids on beta-endorphin release from rat hypothalamus in vitro.

    abstract::The effects of sex steroids on immunoreactive beta-endorphin (EP) release from the rat hypothalamus in vitro were examined using a rat hypothalamic perifusion system and an EP RIA. Testosterone (1-100 ng/ml) and estradiol (10-100 pg/ml) stimulated EP release in a dose-dependent manner. Dehydroepiandrosterone (DHEA, 1-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nakano Y,Suda T,Sumitomo T,Tozawa F,Demura H

    更新日期:1991-07-05 00:00:00

  • Chronic inhibition of NOS does not prevent plasticity of rat somatosensory (S1) cortex following deafferentation.

    abstract::Nitric oxide (NO) has been proposed as an intercellular messenger mediating postsynaptic to presynaptic information transfer in the induction of long-term potentiation. A number of studies support the possible involvement of NO in synaptic plasticity. NO may have a role in synaptogenesis and synaptic plasticity in dev...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Won Sohn N,Greenberg JH,Hand PJ

    更新日期:1999-01-23 00:00:00

  • Development of morphine-induced changes of activity in the mouse.

    abstract::The development of spontaneous activity in response to morphine administration was studied at different postnatal ages in C57BL/6 mice. Morphine induced hyperactivity at all ages except in 3-week-old mice, in which a catatonic effect is evident. The results indicate that the neurophysiological and inhibitory systems r...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Filibeck U,Castellano C,Oliverio A

    更新日期:1981-11-01 00:00:00

  • Ultrastructural relationships between leu-enkephalin- and GABA-containing neurons differ within the hippocampal formation.

    abstract::Electrophysiological studies have suggested that the excitatory actions of opioids in the hippocampal formation are mediated by inhibition of interneurons containing GABA; however, an anatomical basis for this interaction has never been established. Thus, we sought to determine the relationship between leu-enkephalin ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Commons KG,Milner TA

    更新日期:1996-06-10 00:00:00

  • Topography of cholinergic perikarya and nerve fibres as well as cholinergic vesicles in the rat duodenum.

    abstract::Using the acetylthiocholine staining method, it was possible to visualize acetylcholinesterase (AChE)-stained neuronal cell bodies and nerve endings as well as AChE-positive vesicles in the rat duodenum. AChE-reactive perikarya were seen with certainty only in the myenteric plexus. They were 40 micron in diameter and ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wolter HJ

    更新日期:1985-07-29 00:00:00

  • Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus.

    abstract::Acute estradiol (E2) can potentiate the excitatory responses of hypothalamic ventromedial nucleus (VMN) neurons to neurotransmitters. To investigate the mechanism(s) underlying the potentiation, the whole-cell patch voltage clamp technique was used to study VMN neurons in hypothalamic slices prepared from female juven...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Kow LM,Devidze N,Pataky S,Shibuya I,Pfaff DW

    更新日期:2006-10-20 00:00:00

  • The effect of sequential lesioning in the basal forebrain on cerebral cortical glucose metabolism in rats. An animal positron emission tomography study.

    abstract::We studied the effect of the cortical projection from the basal forebrain on the cerebral cortical metabolism using positron emission tomography (PET) with [(18)F] fluorodeoxyglucose. Unilateral damage of the nucleus basalis magnocellularis (NBM) did not cause a permanent reduction of cortical metabolism: recovery was...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Katsumi Y,Hanakawa T,Fukuyama H,Hayashi T,Nagahama Y,Yamauchi H,Ouchi Y,Tsukada H,Shibasaki H

    更新日期:1999-08-07 00:00:00

  • Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures.

    abstract::The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271:2543], but its effect on microglia is not known. In addition, S100B's ability to modulate the activity of other glial activating agents has not been defi...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Petrova TV,Hu J,Van Eldik LJ

    更新日期:2000-01-17 00:00:00

  • Long-term enhancement of entorhinal-dentate evoked potentials following 'modified' ECS in the rat.

    abstract::Electroconvulsive therapy (ECT) is widely used as a treatment for drug-resistant depression. The animal analogue of ECT is electroconvulsive shock (ECS) seizures. We have recently shown that repeated ECS seizures cause a long-lasting, perhaps permanent, enhancement in entorhinal-dentate evoked potentials in the rat. O...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gombos Z,Mendonça A,Racine RJ,Cottrell GA,Burnham WM

    更新日期:1997-08-22 00:00:00

  • Hyperthermia-enhanced serotonin (5-HT) depletion resulting from D-fenfluramine (D-Fen) exposure does not evoke a glial-cell response in the central nervous system of rats.

    abstract::D-Fen-induced hyperthermia has been shown to coincide with an enhanced depletion of 5-HT and 5-hydroxyindole acetic acid (5-HIAA). Because these observations have relied on D-Fen exposure at multiple environmental temperatures, some have questioned the validity of the findings. Therefore, this experiment was designed ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Stewart CW,Slikker W Jr

    更新日期:1999-08-28 00:00:00

  • Early BBB breakdown and subacute inflammasome activation and pyroptosis as a result of cerebral venous thrombosis.

    abstract::Cerebral venous thrombosis (CVT) is a rare form of cerebral stroke that causes a variety of symptoms, ranging from mild headache to severe morbidity or death in the more severe forms. The use of anti-coagulant or thrombolytic agents is the classical treatment for CVT. However, the development of new therapies for the ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rashad S,Niizuma K,Sato-Maeda M,Fujimura M,Mansour A,Endo H,Ikawa S,Tominaga T

    更新日期:2018-11-15 00:00:00