Abstract：
:To evaluate the role of the amygdala in pain modulation and opioid-mediated antinociception, a recombinant, replication-defective herpes virus carrying the human preproenkephalin cDNA was injected bilaterally into the rat amygdala. Four days after gene delivery nociceptive behavior was assessed by the formalin test. Rats infected with the virus expressing preproenkephalin showed a selective, naloxone-reversible abolition of phase 2 flinching behavior compared to rats infected with a control virus. The results implicate the amygdala in the control of pain and in opioid analgesia and demonstrate the use of recombinant herpes viruses as tools for studying gene function in specific neural pathways of the central nervous system.
journal_name
Brain Resjournal_title
Brain researchauthors
Kang W,Wilson MA,Bender MA,Glorioso JC,Wilson SPdoi
10.1016/s0006-8993(98)00194-2subject
Has Abstractpub_date
1998-05-04 00:00:00pages
133-5issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00194-2journal_volume
792pub_type
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