Abstract：
:In adolescence, gender differences in rates of affective disorders emerge. For both adolescent boys and girls, peer relationships are the primary source of life stressors though adolescent girls are more sensitive to such stressors. Social stressors are also powerful stressors for non-human social species like rodents. In a rat model, we examined how social isolation during adolescence impacts stress reactivity and specific neural substrates in adult male and female rats. Rats were isolated during adolescence by single housing from day 30 to 50 of age and control rats were group housed. On day 50, isolated rats and control rats were re-housed in same-treatment same-sex groups. Adult female rats isolated as adolescents exhibited increased adrenal responses to acute and to repeated stress and exhibited increased hypothalamic vasopressin mRNA and BDNF mRNA in the CA3 hippocampal subfield. In contrast, adult male rats isolated as adolescents exhibited a lower corticosterone response to acute stress, exhibited a reduced state of anxiety as assessed in the elevated plus maze and reduced Orexin mRNA compared to adult males group-housed as adolescents. These data point to a markedly different impact of isolation experienced in adolescence on endocrine and behavioral endpoints in males compared to females and identify specific neural substrates that may mediate the long-lasting effects of stress in adolescence.
journal_name
Brain Resjournal_title
Brain researchauthors
Weintraub A,Singaravelu J,Bhatnagar Sdoi
10.1016/j.brainres.2010.04.068subject
Has Abstractpub_date
2010-07-09 00:00:00pages
83-92eissn
0006-8993issn
1872-6240pii
S0006-8993(10)00985-6journal_volume
1343pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Significant insights into the dynamics of neuronal populations have been gained in the olfactory system where rich spatio-temporal dynamics is observed during, and following, exposure to odours. It is now widely accepted that odour identity is represented in terms of stimulus-specific rate patterning observed in the c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.07.032
更新日期：2012-01-24 00:00:00
abstract：:Expression of the immediate-early gene c-fos, a marker of neuronal activation, was employed to localize brainstem neuronal populations functionally related to the expiration reflex (ER). Twelve spontaneously breathing, non-decerebrate, pentobarbital anesthetized cats were used. The level of Fos-like immunoreactivity (...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.09.064
更新日期：2007-12-12 00:00:00
abstract：:In this paper we report on the effects of intra-VTA infusion of opioid agonists on rat ingestive behavior in a variety of experimental contexts. When the animals were tested outside of their home cages surrounded only by food-pellets (Experiment 1), the injection of the mu-opioid agonist DAMGO, but not the kappa-opioi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01281-l
更新日期：1995-01-30 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is the predominant isoform of cyclooxygenase in brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that have many injurious effects. COX-2 transcription is induced by synaptic activity; therefore, COX-2 activity could contribute to epileptic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.038
更新日期：2005-07-19 00:00:00
abstract：:N-stearoyltyrosine (NsTyr), a synthesized anandamide (AEA) analogue, was evaluated for the first time in the present study for the neuroprotective effect in gerbils subjected to transient global cerebral ischemia reperfusion (IR). The extent of ischemia injury was assessed behaviorally by measuring neurological functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.070
更新日期：2009-09-01 00:00:00
abstract：:Semaphorins constitute a family of signaling molecules with functions in axon pathfinding and neuronal migration. Neuropilins 1 and 2 have been identified as the ligand-binding component of semaphorin receptors. Both ligands and receptors are expressed in embryonic and adult organs in complementary and sometimes redun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.028
更新日期：2006-01-05 00:00:00
abstract：:Luteinizing hormone (LH) secretion during the reproductive cycle and in ovariectomized (OVX) rats is pulsatile and this pattern of secretion is determined by intermittent discharges of LH-releasing hormone (LHRH) into the hypophysial portal vessels. LHRH secretion is probably controlled by prior pulsatile norepinephri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01548-6
更新日期：1999-06-26 00:00:00
abstract：:Instructions are an inextricable, yet poorly understood aspect of modern human life. In this paper we propose that instruction implementation and following can be understood as fast Hebbian learning in prefrontal cortex, which trains slower pathways (e.g., cortical-basal ganglia pathways). We present a computational m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.025
更新日期：2012-02-23 00:00:00
abstract：:The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.083
更新日期：2005-05-17 00:00:00
abstract：:Previously we reported that several microRNAs (miRNA) are upregulated following experimentally induced traumatic brain injury (TBI) using both in vivo and in vitro approaches. Specific miRNAs were found to be sensitive to therapeutic hypothermia and may therefore be important targets for neuroprotective strategies. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.08.011
更新日期：2013-10-02 00:00:00
abstract：:Wild red foxes, proverbially cunning carnivores, are investigated for adult hippocampal neurogenesis and morphological characteristics of the dentate gyrus. Adult red foxes harbor almost 15-times more young, doublecortin-positive neurons in their dentate gyrus than domesticated dogs. The number of doublecortin-positiv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.075
更新日期：2010-04-30 00:00:00
abstract：:Choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities were measured in various visual structures of the pigeon brain after long-term monocular deprivation followed by short-term binocular presence or absence of light stimulation. The short-term phase (45 min) was coupled with a 2-deoxygluco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91253-7
更新日期：1982-09-16 00:00:00
abstract：:In the present study, we assessed the beneficial synergistic effects of concurrent treatment with low doses of cilostazol and probucol against focal cerebral ischemic infarct in rats. The ischemic infarct induced by 2-h occlusion of middle cerebral artery (MCA) and 22-h reperfusion was significantly reduced in rat bra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.051
更新日期：2007-07-09 00:00:00
abstract：:We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced lea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.07.038
更新日期：2005-09-28 00:00:00
abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90342-7
更新日期：1992-05-22 00:00:00
abstract：:The medial nucleus of the amygdala, bed nucleus of the stria terminalis, and medial preoptic area appear to mediate steroidal regulation of mating behavior in male rodents. The mechanism of action has not been determined. One way testosterone could enhance neuronal function is by increasing neurotransmitter levels, th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91077-r
更新日期：1992-09-11 00:00:00
abstract：:Short-term potentiation of extracellular field excitatory postsynaptic potentials (EPSP's) was investigated in the stratum radiatum of CA1 of the rat hippocampal slice in vitro. A presynaptic tetanus consisting of a single train of stimuli at 250 Hz evoked short-term potentiation (STP), but not long-term potentiation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90304-6
更新日期：1988-08-30 00:00:00
abstract：:Extracellular field recordings were made in CA1 in the hippocampal explant cultures in oxygenated artificial cerebrospinal fluid. Schaffer collaterals were stimulated with 1-s trains of 60 Hz pulses every 10 min. Seizures were reliably elicited with progressive lengthening over 1-2 h. D-APV, an N-methyl-D-aspartate (N...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91171-a
更新日期：1992-08-28 00:00:00
abstract：:The effect of lowered brain glutathione content on the glutamate release following cerebral ischemia was investigated. Diethylmaleate (4 mmol/kg, i.p.), a commonly used chemical reagent for tissue glutathione depletion, significantly reduced the ischemia-induced glutamate release. The release of another excitatory ami...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00992-y
更新日期：1995-11-06 00:00:00
abstract：:Prolidase deficiency is characterized by chronic ulcerative dermatitis, mental retardation, and frequent infections. In the present study we examined the characteristics of rat brain prolidase isoenzymes. Prolidase isoenzymes (PD I and PD II) were isolated from the rat brain using DEAE cellulose column chromatography....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.09.081
更新日期：2009-12-15 00:00:00
abstract：:Intracerebroventricular (i.c.v.) infusion of sodium in rats increases cerebrospinal fluid (CSF) [Na], mimicking the effects of a high salt diet in salt-sensitive strains and causing sympathetic hyperactivity and a pressor response that are mediated via both an endogenous brain ouabainlike substance (OLS) and the brain...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.06.056
更新日期：2004-09-24 00:00:00
abstract：:Phospholipid extracts from 48 intracranial tumors were analyzed using 31P NMR. Phospholipids commonly identified in the tumor spectra included phosphatidylglycerol (PG), phosphatidic acid (PA), diphosphatidylglycerol (DPG), uncharacterized phospholipid (U), ethanolamine plasmalogen (EPLAS), phosphatidylethanolamine (P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91041-3
更新日期：1994-06-27 00:00:00
abstract：:Hydrocephalus with aqueduct stenosis was a consistent feature in mice which received a single intraperitoneal injection of 6-aminonicotinamide (6-AN) on day 5 postnatal. Chronological investigation revealed that 6-AN-treated mice had aqueductal obstruction with edematously swollen ependymal cells and spongy changes in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90180-4
更新日期：1985-10-01 00:00:00
abstract：:This work describes the change in an active electrogenesis of the command neurons responsible for defensive closure of a snail's pneumostome during elaborating, extinction and restoration of a classical conditioned defensive reflex to a tactile stimulus. Tactile stimulations applied to different parts of a snail's bod...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91453-l
更新日期：1992-11-06 00:00:00
abstract：:Stressors produce rapid activation of the hypothalamic-pituitary-adrenal axis, which typically resolves within 60-90 min following termination of the stressor. In addition, some stressors such as inescapable tailshock (IS) also produce elevated basal levels of corticosterone (CORT), and reduced serum levels of cortico...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02050-8
更新日期：1999-11-20 00:00:00
abstract：:N2O antinociception was assessed in eight inbred and two outbred mouse strains. Results indicated the following order of responsiveness among the 10 strains: A/J (most sensitive), C57BL/6ByJ, C57BL/6J, BALB/cByJ, C3H/HeJ, Swiss-Webster, CXBK/ByJ, ICR, CBA/J and DBA/2J (least sensitive). These results demonstrate signi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91017-m
更新日期：1993-06-18 00:00:00
abstract：:The taste reactivity test described in the preceding paper was used to begin determining the capacity of brain stem structures to execute and regulate ingestive behavior. Both chronic thalamic and chronic decerebrate rat preparations were examined repeatedly, and their gustatory mimetic responses compared through fram...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90569-3
更新日期：1978-03-24 00:00:00
abstract：:The effects of stimulating the reticular formation were studied during fictive locomotion in lampreys (Ichthyomyzon unicuspis). The in vitro isolated preparation of the brainstem and spinal cord was used and fictive locomotion was induced by bath application of N-methyl-D-aspartate (NMDA; 50-100 microM). During differ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00151-0
更新日期：1997-04-11 00:00:00
abstract：:The patterns of expression of the Bcl-2, Bax, and Bcl-xL proteins were examined immunocytochemically in rat hippocampus and neocortex after severe hypobaric hypoxia (180 Torr for 3 h) and severe hypoxia preconditioned by intermittent mild hypoxia (360 Torr for 2 h daily, for 3 consecutive days, 24 h prior to severe hy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.053
更新日期：2006-05-17 00:00:00
abstract：:The enhanced olfactory bulb neural response to familiar odors by young rats persists into adulthood. Ninety-day-old rats who had received neonatal odor exposure had an enhanced uptake of [14C]2-deoxyglucose (2-DG) when exposed to the familiar odor. The odor-familiar rats did not have an increased respiration rate duri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90384-7
更新日期：1986-04-23 00:00:00
