Abstract：
:Hydrocephalus with aqueduct stenosis was a consistent feature in mice which received a single intraperitoneal injection of 6-aminonicotinamide (6-AN) on day 5 postnatal. Chronological investigation revealed that 6-AN-treated mice had aqueductal obstruction with edematously swollen ependymal cells and spongy changes in the periaqueductal gray matter in the early stage (on days 5 and 7 postinjection). However, these cytoplasmic edema of the ependymal and glial cells totally subsided by day 30 postinjection, leaving an obliterated aqueduct with a few remnants of ependymal cells without reactive gliosis. This abnormality of aqueductal lesions in the chronic stage was similar to those of human congenital hydrocephalus. These findings raise the possibility that some form of human congenital hydrocephalus may result from ependymal cell degeneration due to exposure to certain noxious substances in the perinatal period.
journal_name
Brain Resjournal_title
Brain researchauthors
Aikawa H,Suzuki Kdoi
10.1016/0165-3806(85)90180-4subject
Has Abstractpub_date
1985-10-01 00:00:00pages
284-7issue
2eissn
0006-8993issn
1872-6240journal_volume
354pub_type
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