Abstract：
:The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in the frontal cortex (Fc) alone. These results suggest that the decrease in NTLI in Fc is related to the behavioral abnormalities produced by PCP.
journal_name
Brain Resjournal_title
Brain researchauthors
Wachi M,Okuda M,Togashi S,Fuwano S,Miyashita Odoi
10.1016/0006-8993(85)91601-4subject
Has Abstractpub_date
1985-05-06 00:00:00pages
393-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(85)91601-4journal_volume
333pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:After transplantation of autologous sciatic nerve segments into the retina of adult hamsters for 1-2 months, retrograde labelling with horseradish peroxidase demonstrated a population of ganglion cells situated peripheral to the graft. If an additional lesion was placed between the insertion of the graft and the optic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91203-5
更新日期：1986-07-02 00:00:00
abstract：BACKGROUND:Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder which is characterized by altered bowel habits. A growing number of studies investigate the association between IBS and cognitive impairments. Current studies report conflicting results regarding cognitive impairment in IBS patie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.05.036
更新日期：2019-09-15 00:00:00
abstract：:The blockade of central histaminergic H(2) receptors has been reported to aggravate ischemic neuronal damage. Since excess release of excitatory neurotransmitters is closely related to ischemic neuronal damage, the effects of ranitidine on ischemic release of dopamine were investigated in gerbil striatum. Changes in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03107-9
更新日期：2002-02-01 00:00:00
abstract：:We have previously demonstrated an absence of ovarian steroid negative feedback on pulsatile luteinizing hormone (LH) release between estrus and early diestrus 1 (D1) in the rat estrous cycle. The object of the present study was to determine if there was a steroid-independent endogenous opioid peptide (EOP) suppressio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90902-4
更新日期：1987-07-28 00:00:00
abstract：:Several human tumour cell lines were screened for secretion of proenkephalin-derived peptides with an antiserum directed to its N-terminus, Met-enkephalin-Arg6,Phe7 and for proopiomelanocortin-derived peptides with an antiserum to beta-endorphin. The neuroblastoma SK-N-MC cell line secreted Met-enkephalin-Arg6,Phe7-im...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90060-5
更新日期：1988-04-01 00:00:00
abstract：:A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91641-6
更新日期：1987-12-29 00:00:00
abstract：:We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00580-5
更新日期：1997-08-22 00:00:00
abstract：:The spinal nucleus of the bulbocavernosus (SNB) is a sexually dimorphic group of motoneurons in Rexed's Lamina X of the lumbosacral spinal cord of the Mongolian gerbil. The SNB innervates the perineal musculature, the bulbocavernosus (BC), levator ani (LA), and external anal sphincter (EAS). Recent studies demonstrate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02949-9
更新日期：2002-10-25 00:00:00
abstract：:Monkeys were trained to depress a hold key for a period of 2 sec. After this hold period, either a red or a green cue lamp appeared in random sequence. The red lamp required the monkey to move his hand from the hold key to a target button within 1 sec of the cue presentation. The green lamp required continued depressi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90986-0
更新日期：1976-01-09 00:00:00
abstract：:The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...
journal_title：Brain research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.brainres.2011.12.017
更新日期：2012-02-09 00:00:00
abstract：:In the present study fast axonal transport was examined in streptozotocin rats with 4 weeks duration in diabetes. Tritiated leucine and 14C-labelled glucosamine were injected into the fifth lumbar ganglion and TCA-soluble as well as insoluble activity were measured in segments of the sciatic nerve at various time inte...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90631-0
更新日期：1979-09-14 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.058
更新日期：2010-01-14 00:00:00
abstract：:The excitability of the axonal terminals of medial septal neurons projecting to the dentate gyrus has been studied in the anesthetized rat under various experimental conditions: spontaneous or drug-induced variations in neuronal soma discharge rate, conditioning stimulation of afferent pathways (perforant path, commis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90966-8
更新日期：1987-08-18 00:00:00
abstract：:Social defeat is a powerful experience that often leads to drastic physiological and behavioral changes in many animal species. An example of such a change is conditioned defeat in Syrian hamsters. The neurophysiological mechanisms that underlie such changes are not yet fully understood, however, there is evidence tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03054-2
更新日期：2001-11-30 00:00:00
abstract：:Electrophysiological characteristics were described for neurons of the parabrachial nucleus (PBN) which receive baroreceptive and somatosensory inputs in the rat. Following focal electrical stimulation in the ipsilateral caudal nucleus of the tractus solitarii (NTS), the firing rates of these neurons were increased in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91704-5
更新日期：1991-12-06 00:00:00
abstract：:Injections with [3H]leucine in the ventral parabrachial nuclei and nucleus Kölliker-Fuse of the cat revealed strong projections to the nucleus raphe magnus (NRM) and adjacent tegmentum, while similar injections in the adjacent nucleus subcoeruleus produced diffuse projections to large parts of the tegmentum, but not s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90977-8
更新日期：1988-04-26 00:00:00
abstract：:Notch signaling is a highly conserved pathway that regulates cell fate decisions during embryonic development. We have recently identified that in ischemic stroke, activity of γ-secretase and the resulting Notch activation may endanger neurons by modulating NF-κB and HIF-1α pathways. Notch signaling can also modulate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.08.054
更新日期：2014-10-24 00:00:00
abstract：:The present study examined the behavioral effects of dopamine receptor agonists, antagonists, or N-methyl-D-aspartate (NMDA) glutamate receptor antagonist in rats with a unilateral excitotoxic lesion of the globus pallidus (GP). After the unilateral GP lesions were made by injections of the ibotenic acid, drugs were s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01241-9
更新日期：1998-01-19 00:00:00
abstract：:Glioblastoma multiform is the most common malignant primary brain tumor in adults, but there remains no effective therapeutic approach. 2-methoxyestradiol (2-ME), which is a naturally occurring metabolite of 17beta-estradiol, was shown to enhance radiotherapeutic effect in certain tumors; however, whether 2-ME can als...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.092
更新日期：2007-12-14 00:00:00
abstract：BACKGROUND:Previous experimental work using in situ zymography has shown very early increased plasminogen activation in ischemic regions after 3 h of ischemia with and without reperfusion. The objective of the present study was to evaluate the time course and extent of plasminogen activation in long-term permanent foca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02769-4
更新日期：2000-11-03 00:00:00
abstract：:A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91218-0
更新日期：1983-03-14 00:00:00
abstract：:Mice with reduced expression of the NR1 subunit of the NMDA receptor (NR1 hypomorphic mice) display altered behavioral phenotypes that may relate to behavioral characteristics of schizophrenia. Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical behavioral interactions in tests of socia...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.002
更新日期：2009-04-10 00:00:00
abstract：:The accumulation of amyloid-β (Aβ) peptides in the brain of Alzheimer disease patients is associated to cognitive deficit, increased oxidative stress, and alterations in the circadian rhythms. Brain-derived neurotrophic factor (BDNF) and Neurogranin (RC3), play an important role in the synaptic plasticity underlying m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.01.033
更新日期：2017-04-01 00:00:00
abstract：:To investigate the possible GABAergic nature of somatostatin-immunoreactive neurons of the larval tiger salamander retina, somatostatin immunocytochemistry was combined with either gamma-aminobutyric acid (GABA) immunocytochemistry or autoradiography of GABA high-affinity uptake. A total of 1,062 somatostatin cells we...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90623-u
更新日期：1993-07-16 00:00:00
abstract：:Honokiol, a major bioactive constituent of the bark of Magnolia officinalis has been confirmed to have the neuroprotective effect on ischemic stroke in rats. This study was designed to observe the therapeutic time window of honokiol microemulsion on cerebral ischemia-reperfusion injury to support its potential for fut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.004
更新日期：2013-01-23 00:00:00
abstract：:Nasal and temporal microexplants from the retina of the chicken embryo (E6; White Leghorn) were cultured on a collagen gel in the presence of extract from anterior or posterior E18 optic tectum. After 4 days of incubation maximum neurite lengths were measured as a function of protein concentration (1-500 micrograms/ml...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90085-x
更新日期：1987-01-01 00:00:00
abstract：:The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.010
更新日期：2015-06-22 00:00:00
abstract：:The central nervous system of the snail Helisoma duryi contains porcine insulin-immunoreactive cells. Most of these cells are known as neurosecretory mediodorsal cells (MDC), and are involved in regulation of growth. There are about 25-40 large and small MDC in each cerebral ganglion near the commissure. Besides the M...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90933-z
更新日期：1992-05-15 00:00:00
abstract：:Both clinical and experimental studies have indicated that depression and depression-like animal conditions are associated with disruption of the intrinsic plasticity of the brain, resulting in neuronal atrophy. However, little is known about the brain glia in these conditions. Early life stress in the form of infant ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.039
更新日期：2007-04-20 00:00:00
abstract：:Microinjections of the substance P (SP) antagonist (D-pro2,D-phe7,D-trp9)-SP, or the gamma-aminobutyric acid (GABA) agonist, muscimol, into the entopeduncular nucleus reduced muscle tone in genetically spastic rats in a dose- and time-dependent manner. Similar injections into the ventral thalamus, zona incerta or amyg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90564-r
更新日期：1990-02-19 00:00:00
