Abstract：
:Nitric oxide (NO) is a neuronal messenger that it is thought to be involved in the nociceptive transmission modulation. The activity of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d) was shown to be identical to NOS activity in the brain. Since the periaqueductal gray matter (PAG) plays an important role in pain perception and antinociception this study was carried out to monitor the expression of NADPH-d in PAG after nociceptive visceral stimulation. Our data showed that the noxious visceral stimulation significantly increased NADPH-d positive neurons and that these neurons were localized in the ventrolateral areas of the PAG. These findings suggest that NO in the PAG may play a role in pain modulation and antinociception.
journal_name
Brain Resjournal_title
Brain researchauthors
Rodella L,Rezzani R,Agostini C,Bianchi Rdoi
10.1016/s0006-8993(98)00255-8subject
Has Abstractpub_date
1998-05-18 00:00:00pages
333-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00255-8journal_volume
793pub_type
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