Dopamine modulates neuronal activities related to motor performance in the monkey prefrontal cortex.

abstract：:The involvement of the dopaminergic pathway from the ventral tegmental area (VTA) to the nucleus accumbens (NAcc) in the reinforcing properties of many drugs of abuse is well established. Though the prefrontal cortex (PFC) exhibits significant influence over activity in this pathway, its role in drug abuse is less def...

journal_title：Brain research

authors： Olsen CM,Duvauchelle CL

更新日期：2006-02-23 00:00:00

abstract：:We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde trans...

journal_title：Brain research

authors： Kuo H,Ingram DK,Crystal RG,Mastrangeli A

更新日期：1995-12-24 00:00:00

abstract：:Cortical projection areas and distribution and response characteristics of masseteric nerve-driven neurons (MDN) were studied by recording surface-evoked potentials and single neuronal activities elicited by stimulation of the contralateral masseteric nerve in cats. Neuronal activities of MDNs could be recorded in two...

journal_title：Brain research

authors： Iwata K,Itoga H,Ikukawa A,Hanashima N,Sumino R

更新日期：1985-09-02 00:00:00

abstract：:We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 microM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose-dependent manner (I...

journal_title：Brain research

authors： Hennings EC,Kiss JP,Vizi ES

更新日期：1997-06-13 00:00:00

abstract：:Choline molecules are needed for the synthesis of acetylcholine and phospholipids in the mammalian brain. An enzymatic activity capable of forming lecithin (phosphatidylcholine) from the step-by-step methylation of phosphatidylethanolamine is identified in the bovine brain. This enzyme(s), phosphatidylethanolamine-N-m...

journal_title：Brain research

authors： Blusztajn JK,Zeisel SH,Wurtman RJ

更新日期：1979-12-28 00:00:00

abstract：:Congenitally anophthalmic mice (ZRDCT-AN) have circadian rhythms which 'free-run' and are not light modulated. Their rhythms differ from those of controls in: duration of circadian period, length of active phase, and pattern/intensity of activity. Three different populations have been described based upon wheel-runnin...

journal_title：Brain research

authors： Laemle LK,Hori N,Strominger NL,Tan Y,Carpenter DO

更新日期：2002-10-25 00:00:00

abstract：:We sought to further elucidate signal transduction pathways for the I(1)-imidazoline receptor in PC12 cells and their interaction with the well-characterized signaling events triggered by nerve growth factor (NGF) in these cells. Stimulation of the I(1)-imidazoline receptor with moxonidine, a centrally acting antihype...

journal_title：Brain research

authors： Edwards L,Ernsberger P

更新日期：2003-08-01 00:00:00

abstract：:Regulation of the intracellular calcium concentration ([Ca(2+)](i)) is of critical importance for synaptic function. Therefore, neurons buffer [Ca(2+)](i) using intracellular Ca(2+)-binding proteins (CaBPs). Previous evidence suggests that Calbindin-D(28K) (CB), an abundantly expressed endogenous fast CaBP, plays an i...

journal_title：Brain research

authors： Westerink RH,Beekwilder JP,Wadman WJ

更新日期：2012-04-23 00:00:00

abstract：:In behaving cats, a cholinergic agonist, carbachol, or Ringer's solution were infused into the pontine reticular formation (PRF). Extracellular microelectrode recordings were obtained from single neurons located 1-4 mm from the infusion site. Sleep polygraphic variables were also recorded. Carbachol microinfusions int...

journal_title：Brain research

authors： Shiromani PJ,McGinty DJ

更新日期：1986-10-29 00:00:00

abstract：:We examined the effect of CP-154,526 on cardiovascular changes elicited in conscious rabbits by stressful stimuli (loud sound, cage move, pinprick, formaldehyde vapour and air-jet stress). CP-154,526 substantially reduced pressor and heart rate responses to these stimuli (both vagally and sympathetically mediated), an...

journal_title：Brain research

authors： Nalivaiko E,Blessing WW

更新日期：2004-08-13 00:00:00

abstract：:Activating transcription factor 3 (ATF3) has been proposed as a marker for injured neurons. Thus, while undetectable normally in sensory, motor, or sympathetic neurons, ATF3-like immunoreactivity (ATF3-IR) is readily detectable in such cells after axotomy. Here we examined ATF3-IR in the superior cervical ganglion (SC...

journal_title：Brain research

authors： Zigmond RE,Vaccariello SA

更新日期：2007-07-23 00:00:00

abstract：:Synaptosomes assemble an equatorial coil of microtubules during incubation at 37 degrees C. Stimulation of synaptosomes by veratridine or A23187 for 5 min results in disassembly of the microtubules. The role of microtubule disassembly in neurotransmitter release was investigated using the microtubule-stabilizing drug ...

journal_title：Brain research

authors： Burgoyne RD,Cumming R

更新日期：1983-11-28 00:00:00

abstract：:Gonadal steroids have previously been shown to enhance neuritic outgrowth from mouse preoptic area explants in vitro. To examine effects within the explant proper, dendritic fields of Golgi-stained neurons of estradiol-treated and untreated cultures were compared quantitatively. Neurons of gonadal steroid-treated cult...

journal_title：Brain research

authors： Toran-Allerand CD,Hashimoto K,Greenough WT,Saltarelli M

更新日期：1983-03-01 00:00:00

abstract：:The organization of neuronal cell bodies in the caudal preoptic area (POA) and rostral anterior hypothalamic area (AH) was studied in Nissl-stained brain sections from adult male and female ferrets. Computer-assisted image-analysis procedures were developed to help estimate the areas of cellular density and the sizes ...

journal_title：Brain research

authors： Tobet SA,Zahniser DJ,Baum MJ

更新日期：1986-02-05 00:00:00

abstract：:Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be...

journal_title：Brain research

authors： Sánchez-Alavez M,Gómez-Chavarín M,Navarro L,Jiménez-Anguiano A,Murillo-Rodríguez E,Prado-Alcalá RA,Drucker-Colin R,Prospéro-García O

更新日期：2000-03-06 00:00:00

abstract：:Eleven beta-carbolinium compounds (beta C+s) and MPP+ were stereotaxically injected (40-200 nmol in 5 microliter of vehicle) unilaterally into the substantia nigra of anesthetized adult male Sprague-Dawley rats. The rats were sacrificed after three weeks. The ipsilateral striatum was analyzed for dopamine and DOPAC le...

journal_title：Brain research

authors： Neafsey EJ,Albores R,Gearhart D,Kindel G,Raikoff K,Tamayo F,Collins MA

更新日期：1995-03-27 00:00:00

abstract：:Dopaminergic psychostimulants produce behavioral responses of greater magnitude with repeated, intermittent administration, than a single, acute dose, a phenomenon known as 'sensitization'. Alterations in regional neuronal activity produced by quinpirole, a D(2)/D(3) agonist, in quinpirole-naive and quinpirole-sensiti...

journal_title：Brain research

authors： Carpenter TL,Pazdernik TL,Levant B

更新日期：2003-02-28 00:00:00

abstract：:Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morph...

journal_title：Brain research

authors： McNeill TH,Brown SA,Rafols JA,Shoulson I

更新日期：1988-07-05 00:00:00

abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...

journal_title：Brain research

authors： Shirasaka T,Kunitake T,Tsuneyoshi I

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Intermittent hypoxia during sleep (IH), as occurs in sleep disordered breathing (SDB), induces spatial learning deficits associated with regulation of transcription factors associated with learning and memory in the hippocampal CA1 region in rats. high fat refined carbohydrate diet (HF/RC) can induce similar...

journal_title：Brain research

authors： Goldbart AD,Row BW,Kheirandish-Gozal L,Cheng Y,Brittian KR,Gozal D

更新日期：2006-05-23 00:00:00

abstract：:We examined in the present study alterations in cerebral blood flow (CBF) and blood-brain barrier (BBB) permeability following intrastriatal transplantation of mouse bone marrow stromal cells (BMSCs) or saline infusion in adult Sprague-Dawley rats. Laser Doppler revealed that transplanted animals exhibited near normal...

journal_title：Brain research

authors： Borlongan CV,Lind JG,Dillon-Carter O,Yu G,Hadman M,Cheng C,Carroll J,Hess DC

更新日期：2004-05-29 00:00:00

abstract：:Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino a...

journal_title：Brain research

authors： Lehmann A,Hagberg H,Jacobson I,Hamberger A

更新日期：1985-12-16 00:00:00

abstract：:Although nitric oxide (NO) has been shown to play an important role in the pathophysiology of cerebral ischemia, its contribution to the pathogenesis of experimentally induced thromboembolic stroke is unknown. In this study, we pharmacologically manipulated NO levels in the acute post-thrombotic stage and determined t...

journal_title：Brain research

authors： Stagliano NE,Dietrich WD,Prado R,Green EJ,Busto R

更新日期：1997-06-06 00:00:00

abstract：:This study investigated the effects of the calcium channel blockers nicardipine, calcicludine, omega-conotoxin GVIA, omega-agatoxin IVA, SNX-482, and NiCl on spontaneous muscle action potential of a rat spinal cord-muscle co-culture system. Spontaneous muscle action potential of the innervated muscle cells was blocked...

journal_title：Brain research

authors： Taguchi K,Shiina M,Shibata K,Utsunomiya I,Miyatake T

更新日期：2005-02-09 00:00:00

abstract：:The present paper addresses the question of whether a decline of central noradrenergic activity is associated with aging and memory loss in mice. Receptor binding techniques were utilized to compare alpha 2-adrenoceptor density in the brains of aged and young mice. Using [3H]rauwolscine, a selective alpha 2-adrenocept...

journal_title：Brain research

authors： Leslie FM,Loughlin SE,Sternberg DB,McGaugh JL,Young LE,Zornetzer SF

更新日期：1985-12-16 00:00:00

abstract：:A study of complex I (NADH:ubiquinone oxidoreductase) activity in Parkinson's disease (PD) brain has identified loss of activity only in substantia nigra although loss of activity of this enzyme has been identified in a number of non-brain tissues. We investigated this paradox by studying complex I and other complexes...

journal_title：Brain research

authors： Parker WD Jr,Parks JK,Swerdlow RH

更新日期：2008-01-16 00:00:00

abstract：:Much evidence suggests that the neuropeptide cholecystokinin (CCK) functions as a neurotransmitter or neuromodulator in the central nervous system. The CCKa receptor subtype in the nucleus accumbens has been demonstrated to potentiate the behavioral and neurophysiological effects of dopamine. Since the mesolimbic dopa...

journal_title：Brain research

authors： Markowski VP,Hull EM

更新日期：1995-11-20 00:00:00

abstract：:Regeneration of descending supraspinal projections were identified in adult goldfish following administration of HRP to different levels of the spinal cord. While in the untreated normal fish 17 nuclei were shown to project into the spinal cord, only 11 of them seem to have participated in the process of regeneration....

journal_title：Brain research

authors： Sharma SC,Jadhao AG,Rao PD

更新日期：1993-08-27 00:00:00

abstract：:We have previously described a rodent model of brief (30 min) middle cerebral artery occlusion followed by reperfusion, in which infarction develops gradually, reaching completion more than 3 days after ischemia, accompanied by morphological, biochemical, and pharmacological evidence of apoptosis. In the present study...

journal_title：Brain research

authors： Snider BJ,Du C,Wei L,Choi DW

更新日期：2001-11-02 00:00:00

abstract：:The expression of the calcium-binding protein calretinin (CR) in the chick cochlear nucleus, nucleus magnocellularis (NM), was examined after unilateral cochlea removal in hatchlings and 3-week-old birds. Following survival times of 3, 6 or 12 h or 1, 3 or 7 days, CR mRNA was localized by in situ hybridization using a...

journal_title：Brain research

authors： Stack KE,Code RA

更新日期：2000-08-04 00:00:00