Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies.

abstract：:Aquaporin-4 (AQP4), the prominent water channel in the brain, is particularly concentrated in astrocytic endfeet membranes lining the capillaries and the pia. This localisation pattern makes it well suited to regulate the flow of water and the homeostasis of the interstitial fluid surrounding the neurons. Using immuno...

journal_title：Brain research

authors： Medici V,Frassoni C,Tassi L,Spreafico R,Garbelli R

更新日期：2011-01-07 00:00:00

abstract：:The bed nucleus of the stria terminalis (BNST) receives dense noradrenergic projections from the brainstem and has been claimed to play a role in expression of a variety of stress responses. Fear-related stimuli suppress vasopressin and facilitate oxytocin release from the neurohypophysis and induce behavioral suppres...

journal_title：Brain research

authors： Onaka T,Yagi K

更新日期：1998-03-30 00:00:00

abstract：:The effects of chronic treatment of rats with RWJ 37796, a novel aryl-piperazine containing antipsychotic drug, on brain monoamine receptors were studied. Rats were treated daily with RWJ 37796 (1.3 mg/kg), the typical antipsychotic haloperidol (1 mg/kg) or vehicle (control) for 21 days, and were sacrificed 3 days aft...

journal_title：Brain research

authors： Shapiro LA,Offord SJ,Ordway GA

更新日期：1995-04-24 00:00:00

abstract：:Inflammation and immunity play a crucial role in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). Recently, a growing body of evidence indicates that Toll-like receptor (TLR) 4 is vital for inflammation and immunity. Therefore, this study aimed to detect the expression of TLR4 in the basilar...

journal_title：Brain research

authors： Zhou ML,Wu W,Ding YS,Zhang FF,Hang CH,Wang HD,Cheng HL,Yin HX,Shi JX

更新日期：2007-10-10 00:00:00

abstract：:The morphological basis of how visceral information from the nucleus of the solitary tract (NTS) is relayed from the parabrachial nucleus (PBN) to the central nucleus of the amygdala (Ce) was studied at the light and electron microscopic levels using the anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L), ...

journal_title：Brain research

authors： Jia HG,Rao ZR,Shi JW

更新日期：1994-11-14 00:00:00

abstract：:Ethanol caused a concentration-dependent loss of PC12 cells over a 24 h interval, accompanied by an increase in intracellular calcium. The specific alpha7 nicotinic receptor partial agonist DMXB attenuated both of these ethanol-induced actions at a concentration (3 microM) found previously to protect against apoptotic...

journal_title：Brain research

authors： Li Y,King MA,Grimes J,Smith N,de Fiebre CM,Meyer EM

更新日期：1999-01-16 00:00:00

abstract：:Intraventricular injections of kainic acid were used to destroy the hippocampal CA3-CA4 cells, thus denervating the inner third of the molecular layer of the fascia dentata and stratum radiatum and stratum oriens of area CA1. The responses of intact afferents to such lesions were then examined histologically. The hipp...

journal_title：Brain research

authors： Nadler JV,Perry BW,Cotman CW

更新日期：1980-01-20 00:00:00

abstract：:We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats. This finding indicates that enhanced function of the PPI-coupled excitatory amino acid (EAA...

journal_title：Brain research

authors： Akiyama K,Daigen A,Yamada N,Itoh T,Kohira I,Ujike H,Otsuki S

更新日期：1992-01-08 00:00:00

abstract：:Transforming growth factor beta (TGFbeta) modulates a variety of growth related functions following traumatic injury. The cellular response to TGFbeta is predominantly mediated through TGFbeta receptor I (TGFbetaRI) and receptor II (TGFbetaRII) on the cell surface and SMAD proteins intracellularly. We investigated the...

journal_title：Brain research

authors： Fee DB,Sewell DL,Andresen K,Jacques TJ,Piaskowski S,Barger BA,Hart MN,Fabry Z

更新日期：2004-06-25 00:00:00

abstract：:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...

journal_title：Brain research

authors： Kojima T,Matsumoto M,Togashi H,Tachibana K,Kemmotsu O,Yoshioka M

更新日期：2003-01-03 00:00:00

abstract：:Met5-enkephalin- (Met-ENK), Leu5-enkephalin-, Met5-enkephalin-Arg6-Phe7-, metorphamide- and BAM 22P-like peptides could be detected in the lumbar spinal cord of the chicken by immunocytochemistry and/or high performance liquid chromatography. However, a peptide identical to Met5-enkephalin-Arg6-Gly7-Leu8 could not be ...

journal_title：Brain research

authors： Maderdrut JL,Merchenthaler I,Sundberg DK,Okado N,Oppenheim RW

更新日期：1986-07-02 00:00:00

abstract：:As life spans increased, neurodegenerative disorders that affect aging populations have also increased. Progressive neuronal loss in specific brain regions is the most common cause of neurodegenerative disease; however, key determinants mediating neuron loss are not fully understood. Using a model of mitochondrial mem...

journal_title：Brain research

authors： Nam MK,Shin HA,Han JH,Park DW,Rhim H

更新日期：2013-04-10 00:00:00

abstract：:We have shown earlier that nicotinic agonists induce the release of noradrenaline from chick sympathetic neurons in culture in two ways: (a) by activating the postsynaptic nicotinic receptors on nerve cell bodies, giving rise to spreading electrical activity and opening of voltage operated calcium channels in neuronal...

journal_title：Brain research

authors： Dolezal V,Lee K,Schobert A,Hertting G

更新日期：1996-11-18 00:00:00

abstract：:Several studies have reported transient expression of tyrosine hydroxylase in a subpopulation of neurons in the bed nucleus of stria terminalis of preadolescent rats. The tyrosine hydroxylase immunoreactive (TH) neurons, which are of small to medium size and often display a typical bipolar configuration, are confined ...

journal_title：Brain research

authors： Beltramino CA,Forbes MS,Swanson DJ,Alheid GF,Heimer L

更新日期：1996-01-08 00:00:00

abstract：:The effects of exo- and endogenous cGMP on the resting activity (RA) of afferent crista fibers were studied in isolated preparations of the statocysts of the cuttlefish Sepia officinalis and the squid Sepioteuthis lessoniana. Bath application of the membrane-permeable cGMP analogs 8-bromo-cGMP (B-cGMP) and N(2),2'-o-d...

journal_title：Brain research

authors： Tu Y,Budelmann BU

更新日期：2000-10-13 00:00:00

abstract：:Electrical activities of thin hippocampal sections of the guinea pig were studied in vitro during and after administration of black widow spider venom (BSV). In CA3 neurons, BSV induced spontaneous discharges which were suppressed by Co2+ or Mn2+. During BSV administration, trains of potential changes resembling excit...

journal_title：Brain research

authors： Yamamoto C,Matsui H

更新日期：1982-07-29 00:00:00

abstract：:The conditioned place preference paradigm was used to study the reinforcing properties of D-amphetamine. Rats were injected (i.p.) with D-amphetamine sulphate (0.5, 1.0 or 5.0 mg/kg) and 10 min later confined for 30 min to one side of a shuttle box in which each of the two compartments had distinctive features. On alt...

journal_title：Brain research

authors： Spyraki C,Fibiger HC,Phillips AG

更新日期：1982-12-16 00:00:00

abstract：:The electrical property of delayed K+ currents (IKD) was studied in pyramidal neurones freshly isolated from the rat hippocampal CA1 region. The IKD was separated pharmacologically from other membrane currents. Activation and inactivation processes of the IKD were highly voltage-dependent in the potential range betwee...

journal_title：Brain research

authors： Oyama Y,Harata N,Akaike N

更新日期：1991-12-24 00:00:00

abstract：:Corticotropin-releasing factor (CRF) in the brain plays an important role in regulations of physiological and behavioral processes, yet CRF distribution in tree shrew brain has not been thoroughly and systematically reported. Here we examined the distribution of CRF immunoreactivity in the brain of tree shrews (Tupaia...

journal_title：Brain research

authors： Shu YM,Ni RJ,Sun YJ,Fang H,Zhou JN

更新日期：2015-08-27 00:00:00

abstract：:Nitric oxide (NO) has been proposed as an intercellular messenger mediating postsynaptic to presynaptic information transfer in the induction of long-term potentiation. A number of studies support the possible involvement of NO in synaptic plasticity. NO may have a role in synaptogenesis and synaptic plasticity in dev...

journal_title：Brain research

authors： Won Sohn N,Greenberg JH,Hand PJ

更新日期：1999-01-23 00:00:00

abstract：:The anesthetic-sedative barbiturate pentobarbital (PB) and the anticonvulsant barbiturate phenobarbital (PhB) were applied to mammalian spinal cord neurons in primary dissociated cell culture to assess their effects on: (1) postsynaptic GABA-responses; (2) paroxysmal activity produced by the convulsant bicuculline; (3...

journal_title：Brain research

authors： Schulz DW,Macdonald RL

更新日期：1981-03-23 00:00:00

abstract：:We examined how adjective ordering is used in language comprehension by crossing order preference and concreteness in phrases consisting of two adjectives and a noun. We used both more typical phrases in which the preferred order has a concrete second adjective ("exhaustive hardback encyclopedia") and those with a con...

journal_title：Brain research

authors： Huang HW,Federmeier KD

更新日期：2012-09-26 00:00:00

abstract：:Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...

journal_title：Brain research

authors： Xaio H,Banks WA,Niehoff ML,Morley JE

更新日期：2001-03-30 00:00:00

abstract：:The double-labeling, fluorescent dye technique was used in order to demonstrate the extent to which the central processes of renal afferent neurons directly project to the brainstem. One injection of a fluorescent dye was placed in the cortex of the left kidney of male rats, and a second injection of a different dye w...

journal_title：Brain research

authors： Wyss JM,Donovan MK

更新日期：1984-04-23 00:00:00

abstract：:In recent years estradiol has emerged as a potential regulator of transient receptor potential vanilloid (TRPV) cationic channels in the peripheral tissues and sensory neurons, however, its analogous role in the CNS is poorly understood. TRPV channels modulate Ca2+ signalling, neurotransmission and behaviour, and expr...

journal_title：Brain research

authors： Kumar S,Singh O,Singh U,Goswami C,Singru PS

更新日期：2018-12-15 00:00:00

abstract：:p-Chlorophenylalanine was administered to rats to inhibit hepatic phenylalanine hydroxylase activity. Two days later, phenylalanine injection was noted to produce substantial increases in serum phenylalanine levels, and relatively modest increments in serum tyrosine levels. Rats injected with p-chlorophenylalanine 2 d...

journal_title：Brain research

authors： Fernstrom MH,Baker RL,Fernstrom JD

更新日期：1989-10-16 00:00:00

abstract：:The rat medial prefrontal cortex is known to have diverse brain functions such as learning and memory, attention, and behavioral flexibility. Although these functions are affected by monoamines (dopamine (DA), noradrenaline (NA) and serotonin (5-HT)) and acetylcholine (ACh), the detailed mechanisms remain unclear. The...

journal_title：Brain research

authors： Imai H,Matsukawa M,Okado N

更新日期：2004-06-25 00:00:00

abstract：:17β-estradiol (E2 or estrogen) is an endogenous steroid hormone that is well known to exert neuroprotection. Along these lines, one mechanism through which E2 protects the hippocampus from cerebral ischemia is by preventing the post-ischemic elevation of Dkk1, a neurodegenerative factor that serves as an antagonist of...

journal_title：Brain research

authors： Scott EL,Brann DW

更新日期：2013-06-13 00:00:00

abstract：:In order to identify fixed versus flexible aspects of swallowing and oromotor control, we developed a method for the concurrent analysis of swallow frequency, swallow volume, and the temporal correlation between swallowing and rhythmic orolingual movements during prolonged bouts of fluid ingestion in unanesthetized, u...

journal_title：Brain research

authors： Kaplan JM,Grill HJ

更新日期：1989-10-09 00:00:00

abstract：:The effects of injecting cholecystokinin (CCK) into the third ventricle or into selected hypothalamic sites on electrical firing rate of sympathetic nerves to interscapular brown fat (IBAT) has been investigated in anesthetized rats. The hypothesis for these experiments was that there was a reciprocal relationship bet...

journal_title：Brain research

authors： Yoshimatsu H,Egawa M,Bray GA

更新日期：1992-12-04 00:00:00