Abstract：
:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by the 5-HT(4) receptor antagonist GR 113808 (20 microg/rat, i.c.v.) and the 5-HT(7) receptor antagonist DR 4004 (10 microg/rat, i.c.v.). These data suggest that the inhibitory effect of fluvoxamine on LTP induction is mediated via 5-HT(1A) receptors.
journal_name
Brain Resjournal_title
Brain researchauthors
Kojima T,Matsumoto M,Togashi H,Tachibana K,Kemmotsu O,Yoshioka Mdoi
10.1016/s0006-8993(02)03756-3subject
Has Abstractpub_date
2003-01-03 00:00:00pages
165-8issue
1eissn
0006-8993issn
1872-6240pii
S0006899302037563journal_volume
959pub_type
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