Abstract：
:The effects of propylthiouracil (PTU)-induced thyroid deficiency on [14C]acetylcholine synthesis and 14CO2 production from [U-14C]glucose in vitro, by fine prisms of the corpus striatum were investigated in developing rats. Consistent with deficits in choline uptake and choline acetyltransferase activity (Kalaria et al.17), PTU-treatment from two days after birth significantly impaired (27-39%) [14C]acetylcholine synthesis in striatal tissue taken from 3- or 6-week-old animals. In the thyroid-deficient (Tx) animals, 14CO2 production from [14C]glucose was unchanged in incubations in the presence of 5 mM K+ but was significantly reduced (33%) in medium with 31 mM K+ concentration. The addition of 10 mM DL-3-hydroxybutyrate in incubations with 5 mM K+ persistently inhibited 14CO2 production by striatal samples from the Tx rats. The fraction acetylated of [3H]choline accumulated by striatal prisms was unaffected by the PTU-induced thyroid deficiency. These findings suggest the development of fewer cholinergic nerve terminals in striatum during neonatal thyroid deficiency. Cholinergic nerve terminals that develop seem unaffected in their capacity for K+-stimulation and in their ability to acetylate transported [3H]choline.
journal_name
Brain Resjournal_title
Brain researchauthors
Kalaria RN,Prince AKdoi
10.1016/0165-3806(85)90114-2subject
Has Abstractpub_date
1985-06-01 00:00:00pages
271-9issue
2eissn
0006-8993issn
1872-6240journal_volume
352pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The distribution of calcitonin gene-related peptide (CGRP) and its binding sites in the bulbocavernosus, a striated muscle, are reported. We used immunohistochemistry and [125I]CGRP autoradiography. The pattern of [125I]CGRP binding was restricted to a discrete band that coincides with the distribution of end-plates i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91064-0
更新日期：1989-09-04 00:00:00
abstract：:Male rats were treated with barbital in their drinking fluid for about 40 weeks (daily dose 200 mg/kg). The treatment was stopped on day 0 and the number of muscarinic binding sites was measured in 3 brain parts (striatum; cortex and hippocampus; medulla oblongata and midbrain) during the abstinence with labeled quinu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90146-9
更新日期：1982-08-19 00:00:00
abstract：:Beta-amyloid(1-42) peptide (betaAP) was injected into the right nucleus basalis magnocellularis (nbm) of rats. After a 14-day survival time, the acetylcholinesterase and choline acetyltransferase activities and the number of muscarinic receptors were found biochemically to be significantly reduced in the ipsilateral f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00823-9
更新日期：1995-10-09 00:00:00
abstract：:This study determined whether macrophage inflammatory protein-1beta (MIP-1beta) plays a role in the hyperthermia caused by prostaglandin E2 (PGE2) given intracerebroventricularly (i.c.v.) in the rat. In these experiments, anti-murine MIP-1beta antibody (anti-MIP-1beta) was micro-injected in the anterior hypothalamic, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01362-5
更新日期：1997-02-14 00:00:00
abstract：:This paper reports studies on the biotransformation of the nonapeptide arginine-vasotocin (AVT) by both rat and chicken brain synaptic membranes. The fragments which were formed during digestion of AVT1-9, were isolated by high pressure liquid chromatography (HPLC) and chemically characterized by amino acid compositio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90419-5
更新日期：1983-09-19 00:00:00
abstract：:Following a mild cortical impact injury delivered by a piston to the right sensorimotor cortex of the anesthetized rat, we evaluated mantle loss, neuronal changes, and fiber track degeneration by deOlmos silver stains up to 8 weeks after injury. Darkened neurons indicating damage (chromatolysis) occurred widely throug...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00107-3
更新日期：1998-05-25 00:00:00
abstract：:Acute hyperammonemia is associated with motor disturbances that are thought to involve striatal dopaminergic dysfunction. Discharge of striatal dopaminergic neurons is controlled by N-methyl-D-aspartate (NMDA) receptors, the excessive activation of which contributes to ammonia neurotoxicity. Here we show that ammonium...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02777-x
更新日期：2003-07-11 00:00:00
abstract：:The object of this study was to quantify and compare the degree of control monkeys may assert over firing patterns of normal and epileptic neurons. Thirty-seven epileptic and 70 normal neurons were studied in detail. The operant task was for the monkey to generate specified consecutive interspike intervals (ISI). The ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90884-3
更新日期：1978-08-04 00:00:00
abstract：:Subcommissural organ (SCO) is a highly specialized ependymal gland located in the roof of the third ventricle. The secretory products of the SCO, which condense to form Reissner's fiber (RF), were recently found to cross-react with the anti-calcitonin antibody. To understand the mechanisms regulating the formation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02144-7
更新日期：2000-01-10 00:00:00
abstract：:Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90995-y
更新日期：1993-03-26 00:00:00
abstract：:Recently we have reported that methamphetamine (METH) neurotoxicity in rats depends on the environmental temperature. Here, we evaluate whether a cold environment (4 degrees C) or drugs which chloride and glutamate ion channel function block METH neurotoxicity in mice. Adult male CD mice received METH i.p. (4 x 10 mg/...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(09)90007-5
更新日期：1994-09-26 00:00:00
abstract：:Dehydroepiandrosterone (DHEA) modulates neurogenesis, neuronal function, neuronal survival and metabolism, enhancing mitochondrial oxidative capacity. Glucose deprivation and hypometabolism have been implicated in the mechanisms that mediate neuronal damage in neurological disorders, and some studies have shown that t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.05.014
更新日期：2016-08-01 00:00:00
abstract：:Axon-to-myelin transfer of lipids precursors have been studied in the rabbit optic system by intraocular injection of [32P]orthophosphate, [14C]glycerol and [3H]glycerol. Choline and ethanolamine phosphoglycerides and myelin showed increasing [32P]-radioactivity between 7 and 21 days following injection, while [3H]- a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90136-1
更新日期：1983-06-20 00:00:00
abstract：:The effects of the dopamine transporter (DAT) inhibitors cocaine and GBR12909 on DAT and dopamine D(2) receptors were evaluated in the brains under awake and isoflurane-anesthetized monkeys using high-resolution positron emission tomography (PET) in combination with microdialysis. The striatal DAT availability and dop...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02018-1
更新日期：1999-12-04 00:00:00
abstract：:Sardinian ethanol-preferring (sP), non-preferring (sNP), and Wistar rats show similar dopaminergic response to vanilla sugar consumption in nucleus accumbens shell (NAcS) and medial prefrontal cortex (mPFC), and similarly learn a vanilla sugar-sustained appetitive behavior. In this study we investigated whether in sat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.043
更新日期：2004-04-23 00:00:00
abstract：:The relationship between placental antigen X-P2 (PAX)-immunoreactive glomeruli and intensely acetylcholinesterase-reactive (IAE) patchy regions was evaluated by comparison of neighboring cryostat sections of the rat olfactory bulb. Both groups of distribution show similar necklace patterns. Each IAE region consists of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90440-x
更新日期：1993-07-30 00:00:00
abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.041
更新日期：2015-05-22 00:00:00
abstract：:The discovery of glucagon biosynthesis and receptors within mammalian brain has led one to suspect a neurotransmitter role for glucagon. In order to address this hypothesis in birds, we investigated the existence of glucagon receptors in duck brain by radioligand binding on fresh tissue sections and radioautography. S...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90469-3
更新日期：1994-11-07 00:00:00
abstract：:Effects of intracranial self-stimulation of central 'punishment areas' were studied on an operant conditioning of vertical eye movements in the midpontine pretrigeminal cats as well as in the encéphale isolé cats. In 36 pretrigeminal cats, the ventromedial hypothalamus (VMH), basal amygdaloid nuclei (AMY), dorsal cent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91008-8
更新日期：1981-12-21 00:00:00
abstract：:In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.063
更新日期：2007-09-05 00:00:00
abstract：:ASIC3-immunoreactivity (ir) was examined in the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal and nodose ganglia, 24.8%, 30.8% and 20.6% of sensory neurons, respectively, were immunoreactive for ASIC3. These neurons were observed throughout the ganglia. A double immunofluorescence method dem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.039
更新日期：2006-04-07 00:00:00
abstract：:We screened anti-Aβ1-42 antibodies from a human Alzheimer's disease (AD) specific single chain variable fragment (scFv) phage display library and assessed their effects in APP/PS1 transgenic mice. Reverse transcription-PCR was used to construct the scFv phage display library, and screening identified 11A5 as an anti-A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.01.028
更新日期：2016-03-15 00:00:00
abstract：:The Reelin signaling pathway controls radial neuronal migration and maturation in the developing brain. The platelet activating factor (PAF) acetyl hydrolase 1b (Pafah1b) complex is also involved in multiple aspects of brain development. We previously showed that the Reelin pathway and the Pafah1b complex interact gen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.02.059
更新日期：2009-04-24 00:00:00
abstract：:The morphological and physiological identification of the cells in the inner retina of Japanese dace was made by means of intracellular single cell recording and dye injection techniques. Our flat mounts and physiological classification revealed that 97 out of 102 sample cells were amacrine cells except for 3 transien...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91140-6
更新日期：1986-05-07 00:00:00
abstract：:Zif268 transcription factor is expressed throughout Cebus apella visual cortex at high basal levels. Monocular eyelid suture alters the levels of Zif268 on neurons connected to the deprived eye, revealing ocular dominance columns in the striate cortex of Cebus as previously demonstrated in Old World monkeys (Chaudhuri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00590-2
更新日期：1996-09-02 00:00:00
abstract：:Release of Ca(2+) from intracellular Ca(2+) stores (ICS) is involved in age-related changes in the induction of long-term potentiation. However, the role of this Ca(2+) source for the increased susceptibility to long-term depression (LTD) with advanced age is unknown. Extracellular excitatory postsynaptic field potent...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.10.023
更新日期：2005-01-07 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.058
更新日期：2010-01-14 00:00:00
abstract：:The dopamine transporter from rat caudate-putamen was photolabeled with [125I]DEEP as previously described. Treatment of photolabeled membranes with neuraminidase and N-glycanase reduced the molecular weight of the [125I]DEEP photolabeled dopamine transporter complex, whereas treatment with alpha-mannosidase had no ef...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91627-d
更新日期：1991-01-25 00:00:00
abstract：:Diabetes mellitus (DM) may lead to gastrointestinal motility disorders. Rodent models of DM indicate the presence of morpho-functional abnormalities of the enteric nervous system. Here, we evaluated whether experimental DM can cause changes in the excitatory cholinergic fibers, neuronal density, and voltage-gated sodi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.11.041
更新日期：2019-04-01 00:00:00
abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91065-4
更新日期：1982-06-10 00:00:00
