Abstract:
:Neonatal destruction of nigrostriatal dopamine neurons by cerebroventricular injection of 6-hydroxydopamine (6-OHDA) results in a serotonin (5-HT) hyperinnervation of the rostral neostriatum in adult rat. Quantitative ligand-binding autoradiography was used to compare the density of various 5-HT receptor subtypes in the adult brain of control and neonatally 6-OHDA-lesioned rats. 5-HT1A, 5-HT1B, 5HT1nonAB and 5-HT2 sites were labeled with [3H]8-OH-DPAT, [125I]cyanopindolol, [3H]5-HT and [125I]DOI, respectively, and measured in the rostral and caudal halves of neostriatum and selected forebrain or midbrain regions. 5-HT1A binding, measured after 6 months, was unchanged in all regions examined including the dorsal raphe nucleus. Three months after the lesion, 5-HT1B binding was increased throughout the neostriatum (30%), but also in the substantia nigra (50%) and globus pallidus (30%), suggesting an up-regulation and an increased axonal transport of these receptors in neostriatal projection neurons. 5-HT1nonAB binding was also increased throughout the neostriatum (40%) and in the substantia nigra (50%), but unchanged in the globus pallidus, as if this up-regulation preferentially involved striatonigral as opposed to striatopallidal neurons. 5-HT2 binding showed an even greater increase (60%), which was restricted to the rostral half of neostriatum and also seemed imputable to an up-regulation as heteroreceptors. Even though the exact cause(s) of these receptor increases could not be determined, their anatomical distribution suggested that they were somehow related to the initial dopamine denervation in the case of the 5-HT1B and 5-HT1nonAB receptors, and more tightly linked to the 5-HT hyperinnervation in the case of the 5-HT2 receptors. Such receptor changes could participate in adaptive mechanisms implicating other transmitters and behavioral disturbances observed in this particular experimental model. Interestingly, they could also account for an enhancement of neostriatal 5-HT function even in a condition where extracellular levels of 5-HT apparently remain normal because of increased uptake.
journal_name
Brain Resjournal_title
Brain researchauthors
Radja F,Descarries L,Dewar KM,Reader TAdoi
10.1016/0006-8993(93)90995-ysubject
Has Abstractpub_date
1993-03-26 00:00:00pages
273-85issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90995-Yjournal_volume
606pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The lateral geniculate nucleus (LGN) of a fetal rat was transplanted to the visual cortex (VC) of a neonatal rat. A current source-density analysis of field potentials and an intracellular study of neuronal responses were conducted in slice preparations by electrical stimulation of transplanted LGN and host VC. The re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90554-3
更新日期:1987-09-29 00:00:00
abstract::The present study was designed to test the hypothesis that a major excitatory mechanism for the expression of feline defensive rage behavior involves the medial nucleus of the amygdala which utilizes substance P as a neurotransmitter in a direct output pathway that supplies the medial hypothalamus. In phase I of the e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91070-9
更新日期:1993-10-22 00:00:00
abstract::The retinotopic organization of the expanded projection to the ipsilateral colliculus was studied electrophysiologically in 12 adult albino rats with one eye removed at birth. For comparison, the contralateral projection was rather variable in the representation of the nasotemporal axis of the retina along the rostroc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90200-2
更新日期:1984-11-12 00:00:00
abstract::Visual acuity was measured by determining the highest spatial acuity at which chickens aged 1-25 days jumped consistently to a physically supported grating instead of to an unsupported homogeneous field. In contrast to the gradual visual development found for kittens, monkeys, and humans, the chicken exhibits asymptot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90967-7
更新日期:1981-05-04 00:00:00
abstract::Electrical stimulation of the mesencephalic locomotor region (MLR) in the precollicular-postmammillary transected cat is known to induce controlled locomotion on a treadmill. We have been able to induce and block locomotion in this preparation by using localized infusions of transmitters and their agonists and antagon...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90006-x
更新日期:1985-03-18 00:00:00
abstract::Cerebellar explants derived from neonatal mice were exposed to cytosine arabinoside, an inhibitor of DNA synthesis. Following such exposure, the cortical regions of the explants contained numerous closely packed large neurons with few intervening elements and without lamination. The surviving large cortical neurons in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90984-1
更新日期:1980-03-31 00:00:00
abstract::In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00687-l
更新日期:1995-09-25 00:00:00
abstract::The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.03.024
更新日期:2019-07-15 00:00:00
abstract::Calretinin and calbindin-D28k are two calcium-binding proteins which are present in separate populations of interneurons in cerebral cortex and hippocampus. To identify these cells with the populations expressing different transmitters, two-colour immunofluorescence was done with antibodies against the calcium-binding...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91439-l
更新日期:1992-07-31 00:00:00
abstract::Levels of somatostatin-like immunoreactivity (SLI) were measured in the rat retina by radioimmunoassay during prenatal and postnatal development. SLI-containing cells were visualized by immunocytochemistry throughout this time period. SLI is present as early as embryonic day 15 (E15) and by E16 at concentrations 10-fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90209-4
更新日期:1987-08-01 00:00:00
abstract::Brain and anterior pituitary growth hormone (GH), thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) were measured during fetal, neonatal, and pubertal life and into adulthood. Immunoassayable GH and TSH could be found in the fetal whole brain before their detection in the fetal pituitary. Developmental pa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(82)90186-9
更新日期:1982-08-01 00:00:00
abstract::L-[35S]Methionine was injected into the dorsal root ganglion (L5) of the adult rat, and migration of the neurofilament polypeptides (the triplet with molecular weights of 200,000, 160,000 and 68,000 daltons), alpha- and beta-tubulins and actin in the sciatic nerve and the dorsal root was quantitatively determined and ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)90292-9
更新日期:1980-05-26 00:00:00
abstract::We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90142-x
更新日期:1990-11-26 00:00:00
abstract::Synapsin I is believed to be involved in regulating neurotransmitter release and in synapse formation. Its interactions with the actin filaments and synaptic vesicles are regulated by phosphorylation. Because exocytosis and synapsin I phosphorylation are a Ca(2+)-dependent process, it is possible that an ischemic insu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.069
更新日期:2004-01-16 00:00:00
abstract::The nictitating membrane response to periocular electrostimulation was investigated in anesthetized and paralyzed rabbits. Recordings from the abducens nerve, which carries the fibers innervating retractor bulbi muscles that are primarily involved in this reflex, showed two distinct volleys to effective stimulation: a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)91143-5
更新日期:1983-01-10 00:00:00
abstract::Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate wheth...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2015.04.038
更新日期:2015-07-30 00:00:00
abstract::High affinity D-[3H]aspartate uptake and amino acid concentrations were examined in synaptosome-enriched preparations of microdissected rat ventral tegmental area 6-7 days following N-methyl-D-aspartate lesions confined to medial prefrontal cortex. Specific reductions were observed in the high affinity uptake of D-[3H...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90140-4
更新日期:1985-04-29 00:00:00
abstract::Prolonged seizures have long been known to be associated with cell injury and cell death in brain. Such seizure-related neuronal injury has been assumed to be mediated by glutamate, the same excitatory amino acid in the central nervous system which propagates the seizure itself. Elevated extracellular concentrations o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00658-0
更新日期:1996-10-21 00:00:00
abstract::These studies examined whether posttraining activation of alpha1-noradrenergic receptors in the nucleus tractus solitarius (NTS) influences neural processes that are involved in encoding information into memory. Different groups of male Sprague-Dawley rats were trained in two separate learning tasks. In experiment 1, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03323-7
更新日期:2003-10-17 00:00:00
abstract::The regulation of circadian rhythms changes with age. In humans, changes in the timing of sleep and wakefulness are especially common. In Syrian hamsters Mesocricetus auratus the free running period of the activity/rest rhythm shortens with age. The present study tested the hypothesis that critical age-related changes...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00423-n
更新日期:1995-07-17 00:00:00
abstract::Intermediate filament aggregation within motor neurons is a hallmark of ALS pathogenesis. Changes to intermediate filament stoichiometry due to altered mRNA steady-state levels of NEFL, PRPH and INA is thought to drive protein aggregation, yet the exact cause of these changes is unknown. MicroRNAs (miRNAs)-master regu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.10.032
更新日期:2019-03-01 00:00:00
abstract::We electrically stimulated individual Mauthner (M-) cells to determine their motor contribution to C-starts of swimming goldfish. In comparison with sensory-evoked C-starts, M-reflexes triggered by electrical stimulation of single M-cells were significantly weaker and less variable. Stage 1 turns were both longer in d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91012-6
更新日期:1990-05-28 00:00:00
abstract::There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.09.056
更新日期:2015-01-30 00:00:00
abstract::A recent physiological report suggested that neurotensin could inhibit the vasopressin releasing from vasopressin-producing neurons in the hypothalamic paraventricular nucleus but not in the supraoptic nucleus. In the present study, the synaptic relationship between the neurotensin-like immunoreactive and vasopressin-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01455-9
更新日期:1999-07-10 00:00:00
abstract::The ganglion cells are the output neurons of the retina. There is, however, relatively little known about the neurotransmitters used by these cells. In the present study, ganglion cells identified with a ganglion cell-specific monoclonal antibody (AB5) are shown in separate double-label experiments to be gamma-aminobu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91498-9
更新日期:1988-01-26 00:00:00
abstract::Zinc ions seem to be important to several neurological functions and have been connected to the pathophysiology of epilepsy, neuronal cell death after seizure or stroke, and Alzheimer's disease. Both epilepsy and Alzheimer's disease are clinical conditions believed to involve the olfactory bulb. The mammalian olfactor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03544-8
更新日期:2002-11-29 00:00:00
abstract::The effect of intraocular injection of the neurotoxin, kainic acid, on the retinofugal pathway has been examined by anterograde transport of horseradish peroxidase. Although less peroxidase was present in all the primary optic centers after the intraocular injection of kainic acid than in the controls, the area occupi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90939-9
更新日期:1984-01-09 00:00:00
abstract::Bilateral intraventricular injections of 6-hydroxydopamine depleted dopamine (DA) in striatal tissue of rats by 88%. Tail shock increased DA in striatal extracellular fluid of these rats from 10 to 17 pg/20 microliters as measured by microdialysis, values less than half those seen in normal striatum. The increase was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91158-d
更新日期:1990-09-17 00:00:00
abstract::Previous studies using the spin trapping agent N-tert-butyl-alpha-phenylnitrone (PBN) and the antioxidant vitamin E established the involvement of free radicals in kainic acid (KA)-induced neurotoxicity. In the present study, we examined the effects of the neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03034-8
更新日期:2003-08-15 00:00:00
abstract::This study examined the effect of feeding either a bland cornstarch-based diet (BCD) or a highly palatable, high fat diet containing sucrose (HPD) on hypothalamic arcuate nucleus (ARC) gene expression for neuropeptide-Y (NPY). Male Sprague-Dawley rats received either BCD ad libitum, HPD ad libitum, HPD pair-fed to the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00755-0
更新日期:1998-09-21 00:00:00