Abstract：
:Levels of somatostatin-like immunoreactivity (SLI) were measured in the rat retina by radioimmunoassay during prenatal and postnatal development. SLI-containing cells were visualized by immunocytochemistry throughout this time period. SLI is present as early as embryonic day 15 (E15) and by E16 at concentrations 10-fold (4.4 +/- 1.4 pg/micrograms protein) higher than the adult retina, and the SLI is confined to cells in the inner neuroblastic layer. As the inner plexiform layer (IPL) develops (E17-18), the level of SLI falls (2.0 pg/micrograms protein) and distinct SLI neurites are seen throughout the inner neuroblastic layer. At birth (P0), the SLI level continues to decline at a time when cells are migrating. Few immunoreactive cells are seen in the developing ganglion cell layer (GCL), presumably as a result of this migration. At postnatal day 4 (P4), the amount of SLI continues to decline, and very few immunoreactive cells are noted. At P8, distinct cells contain SLI both in the GCL and inner nuclear layer (INL). SLI then increases as the retina matures postnatally. After eye opening, the amount of SLI approaches adult levels and the immunocytochemical pattern is similar to that reported for the adult rat retina; i.e. SLI is confined to two subpopulations of cells, one in the INL and one in the GCL. The early prenatal appearance of SLI suggests that it may play a role in retinal development.
journal_name
Brain Resjournal_title
Brain researchauthors
Ferriero DM,Sagar SMdoi
10.1016/0165-3806(87)90209-4subject
Has Abstractpub_date
1987-08-01 00:00:00pages
207-14issue
2eissn
0006-8993issn
1872-6240journal_volume
431pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.003
更新日期：2004-07-02 00:00:00
abstract：:The mesolimbic dopamine (DA) system has long been known to be involved in reward behaviors. As with other substances of abuse, it has been extensively reported that ethanol influences the dopaminergic system. The present study examined whether selectively bred Sardinian-alcohol-preferring (sP) and Sardinian alcohol no...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03296-6
更新日期：2002-01-11 00:00:00
abstract：:Tyrosine hydroxylase (TH) in freshly prepared 45,000 g supernatant from rat striatum was fractionated by DEAE-cellulose chromatography. The elution was made with 2 vols. of buffer (50 mM Tris, pH 7.4; 2 mM dithiothreitol) followed by 4 vols. of a linear NaCl gradient (0 0.3 M) in the same buffer. TH activity was elute...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90397-9
更新日期：1983-05-23 00:00:00
abstract：:A role for glutamatergic signaling in the nucleus accumbens (NA) in both the expression and extinction of cocaine seeking has been suggested. The effects of extinction following cocaine self-administration on the expression and synaptosomal distribution of GluR1 and NMDAR1 glutamate receptor subunits in the NA shell a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.01.047
更新日期：2009-04-24 00:00:00
abstract：:Vagus nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. In the present study, the effect of different stimulation protocols of VNS on the hippocampal formation (HPC) type II theta field potentials were evaluated in anesthetized rats. The following theta parameters were ana...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.08.030
更新日期：2017-11-15 00:00:00
abstract：:Rat cerebral cortex slices were incubated in small volumes of medium in order to study the bidirectional movements of gamma-aminobutyric acid (GABA) between tissue and medium, and to measure the extent of release of endogenous amino acids of interest as potential neurotransmitters. The apparent uptake, real uptake, an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90558-4
更新日期：1979-04-13 00:00:00
abstract：:Stimulation of a region within the parvocellular medullary reticular formation (PcRF) that contains somas of premotor interneurons produces short latency inhibitory synaptic potentials (IPSPs) in cat trigeminal motoneurons. The present study was undertaken to determine whether glycinergic synapses are responsible for ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90818-g
更新日期：1991-12-20 00:00:00
abstract：:Previous studies showed that hyperbaric oxygen (HBO) promoted cell proliferation in hypoxic-ischemic (HI) neonate rats. Neural stem cells (NSC) existed in the brain lifelong and can be activated. This study was undertaken to assess whether HBO treatment promoted the proliferation of NSC and repaired the brain damage r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.016
更新日期：2008-07-30 00:00:00
abstract：:Abecarnil is a recently described beta-carboline which acts at central benzodiazepine receptors (BZR) and has anxioselective/anticonvulsant properties. While it may be classified provisionally as a partial agonist at BZR, there is also evidence that its pharmacological profile may be due to a selective action at BZR s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90862-4
更新日期：1992-12-18 00:00:00
abstract：BACKGROUND:Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction. AIM:To assess OCM metabolites as predictors of 5-year cognitive prognosis in patients...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146519
更新日期：2020-01-01 00:00:00
abstract：:[d-Ala(2)-d-Leu(5)]-Enkephalin (DADLE) has shown promising results in protecting neurons from damages. However, the mechanism for this protection is still under investigation. The current study was carried out to test the hypothesis that DADLE may regulate cellular transcription in neurons. SH-SY5Y cells and primary c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.04.007
更新日期：2014-05-27 00:00:00
abstract：:Single unit discharges in the superior secondary gustatory nucleus of the carp, Cyprinus carpio L., were studied electrophysiologically in response to chemical stimulation of the external chemoreceptors of the facial skin surface. Of 36 gustatory neurons recorded, 80.6% were facilitated by taste stimuli and 19.4% were...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90184-0
更新日期：1981-07-27 00:00:00
abstract：:Parkinson's disease (PD) is characterized by progressive degeneration of nigrostriatal dopaminergic neurons. Several factors such as inhibition of the mitochondrial respiration, generation of hydroxyl radicals and reduced free radical defense mechanisms causing oxidative stress, have been postulated to contribute to t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02994-2
更新日期：2001-02-23 00:00:00
abstract：:Spinally-projecting A5 neurons were studied with anatomical and electrophysiological techniques in the rat. A detailed study of the number and distribution of spinally-projecting catecholaminergic (CA) and non-catecholaminergic neurons present in a defined area of ventrolateral pontine reticular formation was performe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90206-3
更新日期：1984-06-11 00:00:00
abstract：:Primary cultures of astrocytes exhibit a polygonal morphology, but on treatment with agents that increase cAMP they change to stellate cells. We found that astrocyte stellation also occurred on replacing the culture medium with saline buffered with HEPES. However, stellation did not occur when the medium was replaced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02819-6
更新日期：2002-08-09 00:00:00
abstract：:Six cats were trained to eat while partially restrained and while thermal pulse stimuli (43-60 degrees C, 5 s duration) were delivered to the upper hindlimbs. Food and stimulus delivery were under programmed electronic control. The probability and latency of 3 natural, unlearned nocifensive behaviors were electronical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91036-6
更新日期：1989-10-30 00:00:00
abstract：:The sublaminar binding profiles of (D-Ala-NMe-Phe-Gly-ol)-enkephalin (DAGO), (2-D-penicillamine), 5-D-penicillamine)-enkephalin (DPDPE), and dynorphin A(1-8) (DYN) were studied in the CA1 subfield and dentate gyrus of rat hippocampal formation. Binding was assayed on cryomicrotome sections using coverslip autoradiogra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91215-2
更新日期：1988-09-13 00:00:00
abstract：:Calretinin and calbindin-D28k are two calcium-binding proteins which are present in separate populations of interneurons in cerebral cortex and hippocampus. To identify these cells with the populations expressing different transmitters, two-colour immunofluorescence was done with antibodies against the calcium-binding...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91439-l
更新日期：1992-07-31 00:00:00
abstract：:gamma-L-Glutamyl-L-aspartic acid (gamma-LGLA) has been isolated from Datura stramonium; its structure has been determined and it was then synthesized. In male Swiss mice intraperitoneal administration of the natural peptide (125 nmol/kg) or of the synthetic peptide (25-2500 nmol/kg) 24 h after acquisition of a Y-maze ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90878-5
更新日期：1988-04-19 00:00:00
abstract：:The in vitro capacity of sympathetic superior cervical ganglia (SCG) to take up [3H]choline from the extracellular medium, to synthesize acetylcholine from [3H]choline, and to release [3H]acetylcholine in response to a high K+ concentration, were examined in rats throughout a 24-h cycle. Both the release of [3H]acetyl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91015-4
更新日期：1994-02-14 00:00:00
abstract：:Injury of peripheral nerves often results in hyperalgesia (an increased sensitivity to painful stimuli). This hyperalgesia is mediated in part by sympathetic neurotransmitters. We examined the effect of neuropeptide Y (NPY), specific Y1 and Y2 agonists, and an NPY antagonist on peripheral hyperalgesia in rats whose sc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01265-j
更新日期：1995-01-16 00:00:00
abstract：:Metabolites formed from testosterone in the brain, their neuroanatomical distribution and the kinetic properties of the enzymes were studied in male and female Japanese quail chicks and compared with the adult brain using an in vitro radioassay. Oestradiol-17 beta. 5 alpha-dihydrotestosterone, 5 beta-dihydrotestostero...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90149-5
更新日期：1986-02-01 00:00:00
abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91253-w
更新日期：1991-09-27 00:00:00
abstract：:PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90184-7
更新日期：1984-11-12 00:00:00
abstract：:The primary mechanism of action of bupropion, a smoking cessation drug, is commonly believed to involve the dopaminergic system although evidence exists that bupropion also has effects at nicotinic acetylcholine receptors (nAChRs). This study evaluated the disruptive effects of nicotine on response rates in the presen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.110
更新日期：2006-10-30 00:00:00
abstract：:Increased permeability of the brain-blood barrier (BBB) in the piriform cortex (PC) has been reported in various animal models of temporal lobe epilepsy. Since BBB disruption induced by epileptogenic insult has not fully clarified, we attempted to determine whether changes in BBB-related molecules are associated with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.10.080
更新日期：2011-01-19 00:00:00
abstract：:Intracellular recordings were made from Renshaw cells in the cat. Recurrent excitatory postsynaptic potentials (EPSPs) were elicited by antidromic stimulation of the ventral roots. These EPSPs had a simple monophasic time course without a spike-like peak reported by previous authors. No hyperpolarization could be dete...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90818-0
更新日期：1981-10-26 00:00:00
abstract：:Respiratory neurons were recorded with microelectrodes in the medullary dorsal respiratory group of pentobarbital-anesthetized cats. The animals were ventilated with a phrenic-driven servorespirator that allowed manipulation of phasic volume feedback. By increasing or decreasing the gain of the servorespirator, graded...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90924-5
更新日期：1980-11-03 00:00:00
abstract：:We previously reported that brain angiotensin II type 2 (AT2) receptors contribute to the hyperthermia induced by intrahypothalamic (intrapreoptic (i.p.o.)) administration of prostaglandin E2 (PGE2) in rats. The present study was carried out to investigate the role of angiotensin II (ANG II) receptors in the cardiovas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02218-0
更新日期：2000-01-03 00:00:00
abstract：:The activity of the septo-hippocampal and nucleus basalis-cortical cholinergic pathways was investigated by measuring changes in the extracellular acetylcholine levels in the hippocampus and parietal cortex, by means of transversal microdialysis, during the acquisition and recall of a positively reinforced operant beh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00292-2
更新日期：1996-06-10 00:00:00
