Daily changes in presynaptic cholinergic activity of rat sympathetic superior cervical ganglion.


:The in vitro capacity of sympathetic superior cervical ganglia (SCG) to take up [3H]choline from the extracellular medium, to synthesize acetylcholine from [3H]choline, and to release [3H]acetylcholine in response to a high K+ concentration, were examined in rats throughout a 24-h cycle. Both the release of [3H]acetylcholine and the synthesis of [3H]acetylcholine from [3H]choline exhibited significant diurnal variations, showing maxima during the first half of the night. After these maxima, nocturnal acetylcholine release and synthesis decayed to daytime levels and remained low until the end of the night. [3H]Choline uptake by rat SCG did not vary significantly throughout a 24-h period. A 1.5-h exposure of rats to darkness at the 5th hour of light phase of the daily photoperiod did not change significantly any parameter studied. A 20-min, 5-Hz, electrical stimulation of the preganglionic trunk of SCG excised from rats at noon increased significantly subsequent K(+)-induced [3H]acetylcholine release but did not change [3H]acetylcholine synthesis. In decentralized SCG of rats subjected to a unilateral SCG decentralization and a contralateral sham-operation 7 days earlier, [3H]acetylcholine release and synthesis were highly reduced or abolished at the decentralized side, while [3H]choline uptake remained unaltered. The present results suggest that an activation of preganglionic rat SCG neurons takes place during the first half of the scotophase.


Brain Res


Brain research


González Burgos GR,Rosenstein RE,Cardinali DP




Has Abstract


1994-02-14 00:00:00














  • Characterization of the binding of [3H]CGP54626 to GABAB receptors in the male bullfrog (Rana catesbeiana).

    abstract::Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Asay MJ,Boyd SK

    更新日期:2006-06-13 00:00:00

  • After-effects of fusimotor stimulation on spindle la afferents' dynamic sensitivity, revealed during slow movements.

    abstract::After-effects of fusimotor action on dynamic sensitivity of spindle primary afferents from soleus resulted from low rate stimulation of both static and dynamic gamma-axons. Sensitivity to small sinusoidal stretches superimposed on triangles was enhanced during triangular lengthening but not during shortening. These af...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Baumann TK,Emonet-Dénand F,Hulliger M

    更新日期:1982-01-28 00:00:00

  • Longitudinal variation in cell density and mossy fiber reorganization in the dentate gyrus from temporal lobe epileptic patients.

    abstract::Variation in cell loss and mossy fiber reorganization was examined along the longitudinal axis of the dentate gyrus from temporal lobe epileptic (TLE) patients. Previous evidence has indicated that the anterior hippocampus is prone to seizure activity. We compared granule and hilar cell number in addition to Timm stai...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Masukawa LM,O'Connor WM,Lynott J,Burdette LJ,Uruno K,McGonigle P,O'Connor MJ

    更新日期:1995-04-24 00:00:00

  • GFAP mRNA levels following stab wounds in rat brain.

    abstract::We previously reported that glial fibrillary acidic protein (GFAP) levels increased significantly at 3 days after stab wounds, relative to sham-operated controls, reaching a maximum of 200% of control value at 5-7 days. They then fell to near-normal values by 21 days. To determine whether these protein changes correla...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Hozumi I,Aquino DA,Norton WT

    更新日期:1990-11-26 00:00:00

  • Dopamine protects cerebral autoregulation and prevents hippocampal necrosis after traumatic brain injury via block of ERK MAPK in juvenile pigs.

    abstract::Traumatic brain injury (TBI) contributes to morbidity in children, and more boys experience TBI. Cerebral autoregulation is impaired after TBI, contributing to poor outcome. Cerebral Perfusion Pressure (CPP) is often normalized by use of vasoactive agents to increase mean arterial pressure (MAP). In prior studies of n...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Curvello V,Hekierski H,Pastor P,Vavilala MS,Armstead WM

    更新日期:2017-09-01 00:00:00

  • Single neuron cultivation of embryonic and perinatal rabbit or rat brains based on plasma clot technique.

    abstract::Isolated neuronal cells dissociated from the brain of embryonic rabbits on the sixteenth day of gestation and of perinatal rats (eighteenth embryonic day, to E18, thirteenth day postnatum, p.n. 13) were selectively cultured using a plasma clot technique. The cells grown were shown to be neurons by means of the neuron-...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Buse E,Matthaei H

    更新日期:1983-04-01 00:00:00

  • Intracerebroventricular arginine vasopressin causes intracranial pressure to rise in conscious goats.

    abstract::The effects of intracerebroventricular (i.c.v.) infusion of arginine vasopressin (AVP) on intracranial pressure (ICP), blood pressure (BP) and plasma AVP were investigated in conscious goats. The animals were implanted with ventricular (V) and cisternal (C) cannulae under halothane anaesthesia and allowed to recover p...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Seckl JR,Lightman SL

    更新日期:1987-10-13 00:00:00

  • Rapidly transported proteins released from nerve and isolated with myelin.

    abstract::An in vitro preparation was used to determine if rapidly transported radiolabeled protein which is isolated with the myelin fraction of frog sciatic nerves is similar to rapidly transported radiolabeled protein released from sciatic nerves. Sciatic nerves along with their eighth and ninth dorsal root ganglia were plac...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Edwards JA,Hines JF

    更新日期:1982-05-13 00:00:00

  • Spontaneous activity in rat vestibular nuclei in brain slices and effects of acetylcholine agonists and antagonists.

    abstract::Extracellular recording was used to investigate spontaneously active neurons in all four major nuclei of the rat vestibular nuclear complex (VNC) in brainstem slices. The density of spontaneously active neurons was highest in the medial vestibular nucleus (MVN), slightly lower in the superior (SuVN) and spinal (SpVN) ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Sun Y,Waller HJ,Godfrey DA,Rubin AM

    更新日期:2002-04-26 00:00:00

  • Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients.

    abstract::We assessed muscarinic M(1), M(2) and M(4) receptor subtypes in the hippocampus of Alzheimer's and control brains by receptor autoradiography using ligands such as [(125)I]muscarinic toxin-1 ([(125)I]MT-1, M(1) selective), [(3)H]AFDX-384 (M(2) partially selective) and [(125)I]muscarinic toxin 4 ([(125)I]M(4) toxin-1, ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Mulugeta E,Karlsson E,Islam A,Kalaria R,Mangat H,Winblad B,Adem A

    更新日期:2003-01-17 00:00:00

  • Electrophysiological evidence for the nomenclature of the pudendal nerve and sacral plexus in the male rat.

    abstract::Surgical microscopy and electrophysiological techniques were used to standardize the nomenclature for the pudendal nerve and sacral plexus according to their somatic axonal composition in the male rat. We conclude that the pudendal nerve is the segment running from the L6-S1 trunk to the sacral plexus, carrying effere...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pacheco P,Camacho MA,García LI,Hernández ME,Carrillo P,Manzo J

    更新日期:1997-07-25 00:00:00

  • Theta and alpha oscillatory responses differentiate between six-to seven-year-old children and adults during successful visual and auditory memory encoding.

    abstract::The healthy maturation of the brain is one of the intriguing topics that need to be investigated to understand human brain and child development. The present study aimed to investigate the development of memory processes both for auditory and visual memory using electroencephalography (EEG)-Brain Dynamics methodologie...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Güntekin B,Uzunlar H,Çalışoğlu P,Eroğlu-Ada F,Yıldırım E,Aktürk T,Atay E,Ceran Ö

    更新日期:2020-11-15 00:00:00

  • Muscarinic cholinergic receptors: autoradiographic localization of high and low affinity agonist binding sites.

    abstract::Previous studies have shown that muscarinic cholinergic agonists bind to 3 distinct receptor sites in brain, each being distinguished by their affinity for the agonists. Antagonists, on the other hand, bind to these sites with the same high affinity. The relative concentrations of the two high and the low affinity ago...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wamsley JK,Zarbin MA,Birdsall NJ,Kuhar MJ

    更新日期:1980-10-27 00:00:00

  • The avian somatosensory system: connections of regions of body representation in the forebrain of the pigeon.

    abstract::In order to establish the basic connectivity of physiologically identified somatosensory regions of the thalamus and telencephalon in the pigeon, injections of wheatgerm agglutinin-horseradish peroxidase were made under electrophysiological control and the projections were charted following conventional neurohistochem...

    journal_title:Brain research

    pub_type: 杂志文章,评审


    authors: Wild JM

    更新日期:1987-06-02 00:00:00

  • A re-evaluation of the role of superior colliculus in turning behaviour.

    abstract::There is much debate on the role of the superior colliculus (SC) in turning behaviour. In order to clarify this issue, unilateral kainate lesions were made by infusing 0.25 microgram of kainate at two different anterior planes (0.8 mm apart), in the lateral or in the medial aspects of the deep collicular layers (DLSC)...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Di Chiara G,Morelli M,Imperato A,Porceddu ML

    更新日期:1982-04-08 00:00:00

  • Radioligand-binding study of noribogaine, a likely metabolite of ibogaine.

    abstract::Radioligand-binding studies were performed to ascertain the actions of noribogaine, a suspected metabolite of ibogaine, on opioid receptors. Consistent with previous results, ibogaine showed highest affinity for kappa opioid receptors (Ki = 3.77 +/- 0.81 microM), less affinity for mu receptors (Ki = 11.04 +/- 0.66 mic...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pearl SM,Herrick-Davis K,Teitler M,Glick SD

    更新日期:1995-03-27 00:00:00

  • Coexistence of the stigmoid body and estrogen receptor in some neuronal groups involved in rat reproductive functions.

    abstract::Recent immunohistochemical studies have suggested that the forebrain distribution of stigmoid bodies, marked by an antibody against placental aromatase-associated antigen X-P2 (PAX), overlaps with that of the common binding sites of androgen and estrogen. In the present light- and electron-microscopy study the coexist...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Nagano M,Shinoda K

    更新日期:1994-01-21 00:00:00

  • Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat.

    abstract::To determine the mechanisms underlying the depolarization induced by anoxia in brainstem neurons, we studied single neurons in brainstem slices using conventional micro-electrodes and freshly dissociated hypoglossal and vagal cells using patch clamp techniques (whole-cell configuration). Since glutamate concentration ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haddad GG,Jiang C

    更新日期:1993-10-22 00:00:00

  • Localization of putative dopamine D2-like receptors in the chick retina, using in situ hybridization and immunocytochemistry.

    abstract::The actions of dopamine are mediated by 5 or more receptor subtypes, any of which may be coupled by G-proteins to adenylate cyclase (D1-family: stimulatory, D2-family: inhibitory or no action). Postnatal ocular growth in the chick is a vision-dependent mechanism which involves D2-type receptors in either the retina or...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rohrer B,Stell WK

    更新日期:1995-10-16 00:00:00

  • Facilitation of baroreflex-induced bradycardia by stimulation of specific hypothalamic sites in the rat.

    abstract::Hypothalamic stimulation generally inhibits baroreflex-induced bradycardia. However, we have noted discrete areas of the rat hypothalamus which facilitate reflex bradycardia. The effects of hypothalamic stimulation on baroreflex-induced changes in heart rate were investigated in urethane-anesthetized rats (1.2 g/kg, i...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pardini BJ,Patel KP,Schmid PG,Lund DD

    更新日期:1986-10-08 00:00:00

  • Intracerebroventricularly infused [D-Arg1]angiotensin III, is superior to [D-Asp1]angiotensin II, as a pressor agent in rats.

    abstract::Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wright JW,Roberts KA,Cook VI,Murray CE,Sardinia MF,Harding JW

    更新日期:1990-04-23 00:00:00

  • Role of prostacyclin in the response of cerebral blood flow to CO2.

    abstract::The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Uyama O,Nagatsuka K,Fukunaga R,Kusunoki M,Takano T,Yoneda S,Kimura K,Abe H

    更新日期:1983-01-24 00:00:00

  • Effect of adrenalectomy and dexamethasone on neuropeptide content of dorsal root ganglia in the rat.

    abstract::Neuropeptides, including substance P (SP), calcitonin gene-related peptide (CGRP) and somatostatin (SS) in dorsal root ganglia (DRG) may play a role in neurogenic inflammation and pain transmission. Adrenal corticosteroids regulate neuropeptide synthesis in some areas of the CNS and may modulate neurogenic inflammatio...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Smith GD,Seckl JR,Sheward WJ,Bennie JG,Carroll SM,Dick H,Harmar AJ

    更新日期:1991-11-08 00:00:00

  • Pharmacokinetics of L-dopa in plasma and extracellular fluid of striatum in common marmosets.

    abstract::L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Zhang J,Qu FR,Nakatsuka A,Nomura T,Nagai M,Nomoto M

    更新日期:2003-12-12 00:00:00

  • Plasma nerve growth factor access to the postnatal central nervous system.

    abstract::The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve growth factor (NGF), is thought to be unable to cross the blood-brain barrier in postnatal mammals. In this stu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Fabian RH,Hulsebosch CE

    更新日期:1993-05-14 00:00:00

  • Myelination of the corpus callosum in male and female rats following complex environment housing during adulthood.

    abstract::Myelination is an important process in brain development, and delays or abnormalities in this process have been associated with a number of conditions including autism, developmental delay, attention deficit disorder, and schizophrenia. Myelination can be sensitive to developmental experience; however, although the ad...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Markham JA,Herting MM,Luszpak AE,Juraska JM,Greenough WT

    更新日期:2009-09-08 00:00:00

  • Dissociation of IGF2 and H19 imprinting in human brain.

    abstract::The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in norma...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pham NV,Nguyen MT,Hu JF,Vu TH,Hoffman AR

    更新日期:1998-11-09 00:00:00

  • Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord.

    abstract::The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ninkovic M,Hunt SP,Kelly JS

    更新日期:1981-12-28 00:00:00

  • Serotonin-dependent cerebral activation: effects of methiothepin and other serotonergic antagonists.

    abstract::In scopolamine-treated (5.0 mg/kg, s.c.) rats hippocampal rhythmical slow activity (RSA) and neocortical low voltage fast activity (LVFA) occur only in close correlation with head movements, spontaneous changes in posture, or locomotion (Type I behavior). Previous work indicates that such scopolamine-resistant RSA and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Watson NV,Hargreaves EL,Penava D,Eckel LA,Vanderwolf CH

    更新日期:1992-11-27 00:00:00

  • A comparison of spinal Iba1 and GFAP expression in rodent models of acute and chronic pain.

    abstract::The treatment of acute and chronic pain is still deficient. The modulation of glial cells may provide novel targets to treat pain. We hypothesize that astrocytes and microglia participate in the initiation and maintenance of both, acute surgical and chronic neuropathic pain. Rats underwent paw incision, L5 nerve expos...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Romero-Sandoval A,Chai N,Nutile-McMenemy N,Deleo JA

    更新日期:2008-07-11 00:00:00