Abstract：
:The use of two different radioligands, [125I]Leu8, D-Tryp22,Tyr25-somatostatin-28 and the stable somatostatin octapeptide analog [125I]204-090, D-Phe-Cys[125I]Tyr-D-Trp-Lys-Thr-Cys-Thr(ol), allowed to differentiate between two somatostatin receptor subpopulations in the human cortex. In homogenates, octapeptide somatostatin analogs displaced only part of the somatostatin-28 radioligand with high affinity. Autoradiography showed that the receptor subpopulation labelled with [125I]204-090, which we named SS1, was preferentially localized in layers V and VI, whereas the subpopulation having low affinity for somatostatin octapeptides (named SS2), measured with somatostatin-28 radioligand, was concentrated in the superficial cortical layers (I-IV) and particularly enriched in parts of lamina IV.
journal_name
Brain Resjournal_title
Brain researchauthors
Reubi JC,Probst A,Cortés R,Palacios JMdoi
10.1016/0006-8993(87)90813-4subject
Has Abstractpub_date
1987-03-17 00:00:00pages
391-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90813-4journal_volume
406pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Mouse brain expresses three principal glucose transporters. Glut1 is an endothelial marker and is the principal glucose transporter of the blood-brain barrier. Glut3 and Glut6 are expressed in glial cells and neural cells. A mouse line with a null allele for Glut3 has been developed. The Glut3(-/-) genotype is intraut...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.014
更新日期：2011-04-12 00:00:00
abstract：:We have established a cell line (TB) from a cerebrospinal fluid (CSF) specimen of a patient with a primary leptomeningeal melanomatosis. TB cell line was immunoreactive with the antibodies for low molecular weight neurofilament protein, vimentin, neuron-specific enolase, chromogranin, synaptophysin and HMB-45 (an anti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01197-x
更新日期：1999-05-08 00:00:00
abstract：:Various chemical and physical lesions were employed to elucidate the cellular localization of cholecystokinin (CCK) receptors in the rat caudate nucleus. A wide knife cut severing all caudal afferents reduced caudate CCK receptors by approximately 25%, indicating that some receptors lie on axons and (or) terminals of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90284-5
更新日期：1981-08-24 00:00:00
abstract：:Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00743-3
更新日期：1996-10-28 00:00:00
abstract：:Injection of a potent, cholinergic muscarinic antagonist, [3H]3-quinuclidinyl benzilate ([3H]QNB), results in a localization of the drug to muscarinic receptors in rat brain. The distribution of these drug receptors was examined in various brain regions previously thought to contain cholinergic neurons. They were loca...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90399-1
更新日期：1976-07-09 00:00:00
abstract：:To determine the involvement of vasoactive intestinal polypeptide (VIP) in the development of kindling in rats, VIP or antibody to VIP (anti-VIP) was injected into the third ventricle after the daily stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling was sign...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91082-c
更新日期：1991-02-08 00:00:00
abstract：:Although dendritic release was first proposed in the 1970s, the mechanism of release is still subject to debate. We have used in vivo microdialysis to study the acute effects of botulinum toxin A, B and tetanus toxin injected in the substantia nigra or striatum of freely moving rats. Spontaneous and evoked dopamine re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03047-0
更新日期：2002-09-20 00:00:00
abstract：:Neurons with intrinsic pacemaker activity and presumed sympathoexcitatory function were recorded in rat tissue slices within the confines of the rostroventrolateral reticular nucleus (RVL). These cells were excited in dose-dependent fashion by arginine vasopressin (AVP, 10(8)-10(6) M) but not by oxytocin (up to 10(7) ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90909-8
更新日期：1989-07-17 00:00:00
abstract：:Choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities were measured in various visual structures of the pigeon brain after long-term monocular deprivation followed by short-term binocular presence or absence of light stimulation. The short-term phase (45 min) was coupled with a 2-deoxygluco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91253-7
更新日期：1982-09-16 00:00:00
abstract：:The influence of the cortico-geniculate pathway on identified X and Y lateral geniculate cells was studied by reversibly cooling visual cortical areas 17 and 18. The majority (86.5%) of cells changed their response to visual stimulation when cortex was inactivated, and both X- and Y-cells were modulated by the cortica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90568-0
更新日期：1981-03-16 00:00:00
abstract：:The overall volume of the three main inferior olivary (ION) subnuclei increases four-fold between the day of birth (PO) and P21. The rate of this increase is uneven; between P10 and P15 there is an abrupt acceleration which parallels the period of intense synaptogenesis and maturation of the neuropil. The growth of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90029-4
更新日期：1984-11-01 00:00:00
abstract：:An experiment was performed in order to determine the role of the amygdala and surrounding cortex in quiet biting attack elicited from electrical stimulation of the hypothalamus. Stimulation of basal, cortical, and anterior amygdala as well as pyriform cortex and parahippocampal gyrus resulted in a suppression of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90433-3
更新日期：1980-09-15 00:00:00
abstract：:The aetiology of the sporadic form of amyotrophic lateral sclerosis (ALS) is poorly understood although abnormalities in glutamate and glycine transport have been implicated which both could contribute to a neurodegenerative process mediated through the N-methyl-D-aspartate (NMDA) receptor. In this study we have used ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00052-r
更新日期：1995-04-03 00:00:00
abstract：:The core neuropsychological processes underlying post-traumatic stress disorder (PTSD) have yet to be elucidated, and the association between anatomical and functional deficits in PTSD remains largely unknown. The aim of our study was to investigate the alterations in cortical thickness and amplitude of low-frequency ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.048
更新日期：2013-01-15 00:00:00
abstract：:The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the froze...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90869-0
更新日期：1980-08-11 00:00:00
abstract：:Mammalian transglutaminases (TGs) catalyze the irreversible post-translational modifications of proteins, the most prominent of which is the calcium-dependent formation of covalent acyl transfers between the γ-carboxamide group of glutamine and the ε-amino-group of lysine (GGEL-linkage). In the central nervous system,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.11.027
更新日期：2016-01-15 00:00:00
abstract：:The effect of isradipine, a dihydropyridine calcium antagonist, on morphine-induced place preference and analgesia in rats and mice was studied. Isradipine (0.6-5.0 mg/kg s.c.) inhibited an acquisition of morphine-induced place preference in rats and mice in a dose-related manner. Isradipine did not affect or strength...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91311-2
更新日期：1992-10-16 00:00:00
abstract：:In anesthetized rats, out of 48 paraventricular (PaV) and 19 periventricular (PeV) neurosecretory cells, 12 PaV and 6 PeV cells increased and 10 PaV cells decreased the electrical activities statically in response to preoptic and anterior hypothalamic warming. Four PaV and 2 PeV cells responded dynamically to the ther...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90036-7
更新日期：1983-12-19 00:00:00
abstract：:In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsive...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.062
更新日期：2004-01-02 00:00:00
abstract：:The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined. The effects of RTX treatment on the nociceptive flexor reflex and activity-dependent increase in spinal excitability af...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01444-8
更新日期：1997-03-28 00:00:00
abstract：:Rat central nervous system (CNS) tissue sections were immunostained by the peroxidase-anti-peroxidase (PAP) method using a rabbit serum directed against rat liver 5'-nucleotidase. In paraffin sections from the brains of 60-day-old rats 5'-nucleotidase immunoreactivity occurred in the same white-matter regions as myeli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90090-2
更新日期：1985-05-01 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke often modelled in rats. Isoflurane anesthetic, commonly used in preclinical research, affects general physiology (e.g., blood pressure) and electrophysiology (e.g., burst suppression) in many ways. These physiological changes may detract from the clinical relevanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146593
更新日期：2020-02-01 00:00:00
abstract：:High-resolution positron emission tomography (microPET) allows for repeated observations of brain function in the same animal. In a previous study, using [(18)F] fluorodeoxyglucose (FDG) microPET, we demonstrated diminished glucose metabolism and subsequent recovery in the Neostriatum and thalamus ipsilateral to corti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.12.006
更新日期：2004-03-26 00:00:00
abstract：:Previous immunocytochemical, physiological, and molecular studies have reported that the Syrian hamster lacks a shortwave-sensitive (S) cone photopigment but retains circadian responses to ultraviolet (UV) light. Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02267-9
更新日期：2002-03-01 00:00:00
abstract：:Bismuth (Bi) can produce neurotoxic effects in both humans and animals under certain dosing conditions, but little else is known about the effects of Bi in the brain. In the present study we determined the distribution of Bi in the brains of adult female Swiss-Webster mice 4, 7, 14, 21 and 28 days after a single 2500 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00146-1
更新日期：1996-07-01 00:00:00
abstract：:The protective activity of trimetazidine (TMZ) against cochlear neurotoxicity induced by intraperitoneal and intracochlear administration of kainic acid (KA) has been analyzed. The amplitude of the CAP N1 wave was significantly higher in KA rats pretreated with TMZ, independently of the administration route, than in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01258-5
更新日期：1999-04-24 00:00:00
abstract：:The monoclonal antibody E/C8 was originally generated against chicken dorsal root ganglia. The antigen detected by E/C8, NAPA-73, is an intermediate filament-associated protein. NAPA-73 was shown to be one of the earliest neuronal markers to appear during development since it appears in some neuronal precursor cells o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91289-3
更新日期：1987-09-22 00:00:00
abstract：:Previous studies in this laboratory have demonstrated that cholinergic receptors within the spinal cord play an important role in the expression of naloxone-precipitated withdrawal symptoms in the morphine-dependent rat. Related cardiovascular studies in non-dependent animals have demonstrated that this spinal choline...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00203-3
更新日期：1995-05-15 00:00:00
abstract：:One hour after long-term potentiation (LTP) in the intact hippocampus, a selective increase in protein F1 in vitro phosphorylation was observed in homogenate prepared from dorsal hippocampus. Protein F1 phosphorylation was directly related to the magnitude and persistence of potentiation. No other phosphoprotein studi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91510-6
更新日期：1986-12-10 00:00:00
abstract：:One hundred and four visual units of the (ventral) lateral geniculate nucleus (GL) of chicks (Gallus domesticus) were studied with extracellular microelectrodes. Most were extremely responsive to moving targets even at low speeds (0.1 degrees/sec). They were classified as follows. (1) movement-sensitive units with uni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90823-0
更新日期：1979-05-11 00:00:00
