Abstract：
:Choline acetyltransferase (ChAT) and glutamic acid decarboxylase (GAD) activities were measured in various visual structures of the pigeon brain after long-term monocular deprivation followed by short-term binocular presence or absence of light stimulation. The short-term phase (45 min) was coupled with a 2-deoxyglucose experiment in order to select the adequate brain samples. After mononuclear deprivation during the first 6-11 months, ChAT activity was higher by 40-60% in the dorsolateral visual Wulst contralateral to the deprived eye, as compared to the other side. In the same structure, animals, either monocularly deprived or undeprived and exposed binocularly to environmental light for 45 min, had higher ChAT activities on both sides than those maintained in the dark. Mononuclear deprivation performed in adult animals did not affect the ChAT activity in visual Wulst. GAD activity was bilaterally decreased in the visual Wulst after early monocular deprivation. These results suggest that early monocular deprivation has an effect on biochemical systems involved in synaptic transmission at selected relays of the visual pathways.
journal_name
Brain Resjournal_title
Brain researchauthors
Bagnoli P,Burkhalter A,Vischer A,Henke H,Cuénod Mdoi
10.1016/0006-8993(82)91253-7subject
Has Abstractpub_date
1982-09-16 00:00:00pages
289-302issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(82)91253-7journal_volume
247pub_type
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