Presynaptic inhibition by noradrenaline of the EPSC evoked in neonatal rat sympathetic preganglionic neurons.

abstract：:Only recently, d-amino acids have been identified in mammals. Of these, d-serine has been most extensively studied. d-Serine was found to play an important role as a neurotransmitter in the human central nervous system (CNS) by binding to the N-methyl-d-aspartate receptor (NMDAr), similar to glycine. Therefore, d-seri...

journal_title：Brain research

authors： Fuchs SA,Berger R,de Koning TJ

更新日期：2011-07-15 00:00:00

abstract：:Postnatal development of the K+-stimulated release of [3H]GABA in rat cortex slices was compared to the density of Gray type 2 synapses (which correlate with GABAergic synapses in rat cortex). The [3H]GABA release system develops earlier than the inhibitory synapses which suggests that, at least in the young cortical ...

journal_title：Brain research

authors： Balcar VJ,Dammasch I,Wolff JR

更新日期：1983-11-01 00:00:00

abstract：:Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...

journal_title：Brain research

authors： Bregman BS,Goldberger ME

更新日期：1983-08-01 00:00:00

abstract：:The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-...

journal_title：Brain research

authors： Shippenberg TS,Bals-Kubik R,Herz A

更新日期：1987-12-15 00:00:00

abstract：:The effect of haloperidol administration on lipid peroxidation and glutathione/protein thiol homeostasis in the brain was examined 4 h following subcutaneous administration of a single dose of haloperidol; 1.0, 1.5, 2.0 or 2.5 mg/kg b.wt. Glutathione (GSH) levels decreased significantly in cortex, striatum and midbrai...

journal_title：Brain research

authors： Shivakumar BR,Ravindranath V

更新日期：1992-11-13 00:00:00

abstract：:The alpha7 nicotinic acetylcholine receptor (nAChR) plays an important role in cognitive processes and has generated recent interest as a potential drug target for treating neurodegenerative disorders such as Alzheimer's disease (AD). The property of Ca(2+) permeation associated with alpha7 nAChR agonism may lead to C...

journal_title：Brain research

authors： Bitner RS,Nikkel AL,Markosyan S,Otte S,Puttfarcken P,Gopalakrishnan M

更新日期：2009-04-10 00:00:00

abstract：:Transport of fragmented DNA in apical dendrites of the CA1 pyramidal neurons of gerbil hippocampus is observed in the apoptotic process following transient forebrain ischemia. The time-course of specific DNA fragmentation was examined after the ischemic insult by in situ nick-end-labeling method and fluorescence detec...

journal_title：Brain research

authors： Hara A,Niwa M,Iwai T,Nakashima M,Yano H,Uematsu T,Yoshimi N,Mori H

更新日期：1998-09-28 00:00:00

abstract：:C57BL/6J (B6) and DBA/2J (D2) mice have been characterized previously as seizure-resistant and seizure-sensitive, respectively, a distinction based primarily upon a differential response to the convulsant effects of various drugs. In the present study, electroconvulsive shock (ECS) was used to assess maximal electrosh...

journal_title：Brain research

authors： Ferraro TN,Golden GT,Snyder R,Laibinis M,Smith GG,Buono RJ,Berrettini WH

更新日期：1998-11-30 00:00:00

abstract：:We suggested previously that increases in the extracellular [Ca2+] or [Mg2+] lengthen miniature end-plate currents (m.e.p.c.s.) because the divalent cations decrease the negative surface potential on the end-plate, and thereby increase the voltage drop within the membrane. The increased voltage drop would lengthen the...

journal_title：Brain research

authors： Cohen I,Van der Kloot W

更新日期：1982-06-10 00:00:00

abstract：:Previous studies have indicated that amyloid precursor protein (APP) might be a trophic agent in the nervous system, possibly through the regulation of cell adhesion and the protease/protease inhibitor activity. Additionally, APP is upregulated during the development of the nervous system. In order to further study th...

journal_title：Brain research

authors： Masliah E,Mallory M,Ge N,Saitoh T

更新日期：1992-10-16 00:00:00

abstract：:The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...

journal_title：Brain research

authors： Alonso-Matielo H,Gonçalves ES,Campos M,Oliveira VRS,Toniolo EF,Alves AS,Lebrun I,de Andrade DC,Teixeira MJ,Britto LRG,Hamani C,Dale CS

更新日期：2021-01-02 00:00:00

abstract：:A significant fall in the number of GABA-immunoreactive cells in laminae I-III of the rat spinal cord occurred in the somatotopic area of projection of the sciatic nerve after nerve transection. The decrease started at 2 weeks post-neurectomy, and at 4 weeks ipsilateral mean cell numbers were approximately 72% of cont...

journal_title：Brain research

authors： Castro-Lopes JM,Tavares I,Coimbra A

更新日期：1993-08-27 00:00:00

abstract：:Peripheral nerve fascicles are deliberately impaled during microneurography experiments. We have assessed conduction block under these circumstances. First we recorded compound action potentials (CAP) in the sural nerve following stimulation of the sciatic nerve. The insertion of injection and microneurography electro...

journal_title：Brain research

authors： Rice AS,McMahon SB,Wall PD

更新日期：1993-12-24 00:00:00

abstract：:The discriminative stimulus properties of ethanol are functionally regulated by ionotropic GABA(A) and NMDA receptors in specific limbic brain regions including the nucleus accumbens, amygdala, and hippocampus, as determined by microinjection studies. The purpose of the present work was to further investigate potentia...

journal_title：Brain research

authors： Besheer J,Schroeder JP,Stevenson RA,Hodge CW

更新日期：2008-09-26 00:00:00

abstract：:Diabetes mellitus can lead to functional and structural deficits in both the peripheral and central nervous system. The pathogenesis of these deficits is multifactorial, probably involving, among others, microvascular dysfunction and alterations in intracellular calcium homeostasis. The present study examined the effe...

journal_title：Brain research

authors： Biessels GJ,ter Laak MP,Kamal A,Gispen WH

更新日期：2005-02-21 00:00:00

abstract：:The cholinergic innervation of the mediodorsal (MD) nucleus of the thalamus was visualized immunohistochemically in human brain postmortem, using an antibody against human choline acetyltransferase (ChAT). The ChAT staining of the MD nucleus was more intense than in the surrounding thalamic nuclei but weaker than that...

journal_title：Brain research

authors： Brandel JP,Hirsch EC,Hersh LB,Javoy-Agid F

更新日期：1990-05-07 00:00:00

abstract：:The pretectal olivary nucleus of the squirrel monkey was examined in both normal and autoradiographic material. In the Nissl- and fiber-stained tissue the nucleus appears as a laminated structure. The distribution of retinal terminals within the nucleus was examined by the autoradiographic tracing method. These data r...

journal_title：Brain research

authors： Weber JT,Young R,Hutchins B

更新日期：1981-11-09 00:00:00

abstract：:Acetylcholinesterase (AchE) is an important peripheral membrane-bound enzyme, crucial for cholinergic neurotransmission. Changes in AchE activity, kinetic and thermotropic properties were studied in hepatic encephalopathy (HE) associated with acute liver failure induced experimentally by the administration of the hepa...

journal_title：Brain research

authors： Swapna I,SathyaSaikumar KV,Murthy ChR,Gupta AD,Senthilkumaran B

更新日期：2007-06-11 00:00:00

abstract：:The effects of target and non-target cells on the growth and function of intrastriatal grafts of mesencephalic dopamine neurons have been studied in rats with unilateral 6-hydroxydopamine-induced lesions of the nigrostriatal dopamine pathway. Cell suspensions of ventral mesencephalon from 14-15-day-old rat fetuses (ri...

journal_title：Brain research

authors： Brundin P,Isacson O,Gage FH,Björklund A

更新日期：1986-01-01 00:00:00

abstract：:The suspected functional role of dendritic spines as loci of neuronal plasticity (possibly memory and learning) is greatly enriched when active membrane properties are assumed at the spine head. Computations with reasonable electrical and structural parameter values (corresponding to an optimal range for spine stem re...

journal_title：Brain research

authors： Miller JP,Rall W,Rinzel J

更新日期：1985-01-28 00:00:00

abstract：:The ependymocytes lining the central canal of the spinal cord in rats have prominent F-actin networks in the apical cytoplasm, exhibiting significant regional heterogeneity between differing spinal levels. It is not clear when and how this regional heterogeneity develops. We examined F-actin in the central canal durin...

journal_title：Brain research

authors： Li YC,Bai WZ,Hashikawa T

更新日期：2008-11-06 00:00:00

abstract：BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...

journal_title：Brain research

authors： Zhang J,Fu B,Zhang X,Chen L,Zhang L,Zhao X,Bai X,Zhu C,Cui L,Wang L

更新日期：2013-08-28 00:00:00

abstract：:Whereas the role of the hippocampus for spatial learning and long-term memory is largely undisputed, there is less evidence for a participation of hippocampal structures in spatial working memory operations. In an fMRI study (functional magnetic resonance imaging), we therefore examined the role of the hippocampus dur...

journal_title：Brain research

authors： Toepper M,Markowitsch HJ,Gebhardt H,Beblo T,Thomas C,Gallhofer B,Driessen M,Sammer G

更新日期：2010-10-01 00:00:00

abstract：:The globus pallidus plays a critical role in movement regulation. Morphological studies have shown that group I mGluRs including mGluR1 and mGluR5 are expressed in the globus pallidus. Up to now, little is known about the in vivo electrophysiological effects of group I mGluRs on the pallidal neurons. The present study...

journal_title：Brain research

authors： Sun XR,Chen L,Chen WF,Yung WH

更新日期：2012-10-05 00:00:00

abstract：:Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other parts of the brain. Cerebral blood flow mapping was performed using [...

journal_title：Brain research

authors： Wang Z,Guo Y,Mayer EA,Holschneider DP

更新日期：2019-08-15 00:00:00

abstract：:The alpha-2 adrenergic agonist dexmedetomidine (Dex), 3-300 microg/kg, i.p., decreased cerebellar cGMP in a dose-dependent manner. Fentanyl (F), an opioid agonist, increased cerebellar cGMP at 0.3 mg/kg, s.c., and decreased it at doses >/=1 mg/kg. The inhibitory effect was receptor specific, that of Dex being blocked ...

journal_title：Brain research

authors： Vulliemoz Y,Virag L,Whittington RA

更新日期：1998-11-30 00:00:00

abstract：:Horseradish peroxidase (HRP) in slow-release gel was unilaterally implanted in the transected dorsolateral funiculus (DLF) of either cervical, midthoracic, lumbar or sacral spinal cord levels of adult male rats. Cell mappings were made of all brain areas projecting through the DLF. Following cervical implants, dense l...

journal_title：Brain research

authors： Watkins LR,Griffin G,Leichnetz GR,Mayer DJ

更新日期：1981-11-02 00:00:00

abstract：:Proechimys, a rodent living in the Amazon region, has shown resistance to developing chronic epilepsy when submitted to different experimental models. Recently, many studies have attributed a potent anticonvulsant action to cannabinoid receptor CB1. This study investigated the distribution and expression of the CB1 re...

journal_title：Brain research

authors： Araujo BH,Torres LB,Cossa AC,Naffah-Mazzacoratti Mda G,Cavalheiro EA

更新日期：2010-06-04 00:00:00

abstract：:The GABA agonist muscimol, injected into the depressor area of the caudal ventrolateral medulla, increased blood pressure and increased the expression of the immediate early gene c-fos in the rostral ventral medulla (RVM) of the rat. The number of Fos-immunoreactive (Fos-IR) neurons seen in the RVM was increased 3-fol...

journal_title：Brain research

authors： Minson JB,Llewellyn-Smith IJ,Arnolda LF,Pilowsky PM,Oliver JR,Chalmers JP

更新日期：1994-05-16 00:00:00

abstract：:Cortical Spreading Depression (CSD) is a well-studied model of preconditioning that provides a high degree of tolerance to a subsequent ischemic event in the brain. The present study was undertaken in order to determine whether the release of ATP during CSD could contribute to the induction of ischemic tolerance. Dire...

journal_title：Brain research

authors： Schock SC,Munyao N,Yakubchyk Y,Sabourin LA,Hakim AM,Ventureyra EC,Thompson CS

更新日期：2007-09-07 00:00:00