Abstract：
:Transport of fragmented DNA in apical dendrites of the CA1 pyramidal neurons of gerbil hippocampus is observed in the apoptotic process following transient forebrain ischemia. The time-course of specific DNA fragmentation was examined after the ischemic insult by in situ nick-end-labeling method and fluorescence detection technique by DAPI. Although the role of the fragmented DNA movement is unclear, the transport mechanism of fragmented DNA is still active in the late phase of apoptotic process.
journal_name
Brain Resjournal_title
Brain researchauthors
Hara A,Niwa M,Iwai T,Nakashima M,Yano H,Uematsu T,Yoshimi N,Mori Hdoi
10.1016/s0006-8993(98)00753-7subject
Has Abstractpub_date
1998-09-28 00:00:00pages
274-7issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00753-7journal_volume
806pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:These studies investigated autoregulation of glucocorticoid receptor (GR) protein expression and activation in rat brain using western blot methodology. By comparing GR immunoblot reactivity present in various tissue subcellular preparations we were able to discriminate between corticosterone-induced changes in GR act...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02341-6
更新日期：2000-06-23 00:00:00
abstract：:The C-terminal flanking peptide of preprocholecystokinin (preproCCK) has been identified in extracts of rat brain using a novel radioimmunoassay. There is a single form of immunoreactive material on gel filtration, ion exchange and reversed-phase HPLC. The C-terminal preproCCK immunoreactivity had a similar pattern of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90921-2
更新日期：1986-06-18 00:00:00
abstract：:Pretreatment with recombinant human interleukin-1 alpha (rhIL-1 alpha) 20 h before irradiation attenuates radiation-induced hyperthermia. Experiments were conducted to determine the role of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) in rhIL-1 alpha-induced attenuation of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91576-e
更新日期：1993-03-19 00:00:00
abstract：:Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets (LDs) consisting of neutral- and phospho-lipids increase in the brains of patients with neurodegenerative diseases, such as Alzheimer'...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146484
更新日期：2019-12-15 00:00:00
abstract：:Neurofibrillary tangles (NFT) are pathological cytoskeletal structures composed of paired helical filaments (PHF), and are found in neurons of patients afflicted with many neurodegenerative disorders, including Alzheimer's disease (AD). We previously found that an antiserum against casein kinase II (CK-II) stained NFT...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90121-o
更新日期：1992-02-21 00:00:00
abstract：:We have previously shown that systemic administration of non-selective dopamine agonists results in a pronounced expression of the proto-oncoprotein Fos within the lateral habenula. In the current study we examined the effects of selective D1 and D2 dopamine receptor agonists on habenular Fos expression. Rats were inj...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01353-4
更新日期：1997-03-07 00:00:00
abstract：:Pentobarbital reversibly increased Na+-dependent GABA binding to bovine cerebral cortex membranes. This effect was chloride-dependent. Kinetic analysis of [3H]GABA binding revealed an increase of the apparent number of binding sites. Pretreatment of the membranes with Triton X-100 extremely diminished the effect of pe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90333-4
更新日期：1981-11-23 00:00:00
abstract：:A selective 5-HT reuptake inhibitor, fluvoxamine (10 and 30 mg/kg, i.p.) suppressed long-term potentiation (LTP) in the hippocampal CA1 field of anesthetized rats. Fluvoxamine (30 mg/kg, i.p.)-induced suppression of LTP was completely reversed by the 5-HT(1A) receptor antagonist NAN-190 (0.5 mg/kg, i.p), but not by th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03756-3
更新日期：2003-01-03 00:00:00
abstract：:Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01154-3
更新日期：1999-03-27 00:00:00
abstract：:Amphetamine-induced locomotion and stereotypy were concurrently evaluated in order to determine if pretreatment with para-chlorophenylalanine (PCPA) (which is reported to facilitate some of the effects of amphetamine) results in a behavioral pattern similar to the augmentation previously reported to occur with repeate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90904-5
更新日期：1976-11-05 00:00:00
abstract：:We examined the effect of nitric oxide (NO) on the expression of phosphorylated cAMP response element binding (pCREB) protein and on the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), in the hippocampus of the adult rat, by administering 7-nitroindazole (7-NI) for 5 days, to block neuronal nitric...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.055
更新日期：2004-05-15 00:00:00
abstract：:The myosin S-1 subfragment was used to label actin filaments in the developing rat brain. The results show actin filaments present throughout the dendritic region with highest concentrations within growth cones and regions of spine development. Between 6 and 25 days postnatal, spines became more complex and actin fila...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90253-1
更新日期：1986-06-01 00:00:00
abstract：:Axonal injury of the dorsal root ganglion (DRG) neurons may alter the synthesis of certain membrane proteins that are responsible for the development of abnormal hyperexcitability. The external domains of most of these membrane proteins are sialylated. Because sialic acid carries heavy negative charges, the increase o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.07.075
更新日期：2004-11-12 00:00:00
abstract：:Six experimental and 3 unoperated cats were trained with a go, no-go shock avoidance procedure to discriminate increases from decreases in the rate of presentation of all auditory cortex between the suprasylvian sulcus and rhinal fissure while 3 cats had bilateral auditory cortex lesions plus ablation of the cortex of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90249-3
更新日期：1976-10-29 00:00:00
abstract：:Fetal exposure to diazepam (DZ), a positive modulator of GABA(A) receptors and an agonist at mitochondrial benzodiazine receptors, induces long-term neural and behavioral effects. This study evaluated whether the early manipulation influenced the normal development of brain levels of neurosteroids or altered steroid a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.10.039
更新日期：2006-01-05 00:00:00
abstract：:The immunocytochemical localization of the enzyme choline acetyltransferase (ChAT) was examined in the guinea pig organ of Corti to determine if both lateral and medial systems of efferents would show immunoreactive labeling for this specific enzyme marker of cholinergic neurons. Cochleae were also examined after lesi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90242-2
更新日期：1985-07-08 00:00:00
abstract：:Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90697-t
更新日期：1991-01-18 00:00:00
abstract：:Magnetoencephalography (MEG) was used to investigate the response to speech sounds that differ in onset dynamics, parameterized as words that have initial stop consonants (e.g., /b/, /t/) or do not (e.g., /m/, /f/). Latency and amplitude of the M100 auditory evoked neuromagnetic field, recorded over right and left aud...
journal_title：Brain research
pub_type： 临床试验,杂志文章
doi：10.1016/s0006-8993(98)01058-0
更新日期：1998-12-14 00:00:00
abstract：:The inhibitory potency of ethanol upon excitatory amino acid induced depolarizations of rat hippocampal CA1 pyramidal cells was assessed in the presence and absence of magnesium (Mg2+) using the grease-gap technique. Ethanol shifted the N-methyl-D-aspartate (NMDA) dose-response curves to the right in a non-parallel ma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91486-k
更新日期：1991-04-19 00:00:00
abstract：:Several human tumour cell lines were screened for secretion of proenkephalin-derived peptides with an antiserum directed to its N-terminus, Met-enkephalin-Arg6,Phe7 and for proopiomelanocortin-derived peptides with an antiserum to beta-endorphin. The neuroblastoma SK-N-MC cell line secreted Met-enkephalin-Arg6,Phe7-im...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0169-328x(88)90060-5
更新日期：1988-04-01 00:00:00
abstract：:The effect of perinatal androgen exposure on the sexually dimorphic distribution of serotonin (5-HT)-immunoreactive fibers in the medial preoptic nucleus (MPN) of the rat was evaluated with an indirect immunohistochemical method. Female animals treated with testosterone propionate (TP) perinatally, postnatally or with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90777-2
更新日期：1985-08-05 00:00:00
abstract：:Immunohistochemistry for Kv1.2, a subunit of voltage-gated K(+) channels, was performed on the trigeminal ganglion (TG). Immunoreactivity (ir) was detected in half (48%) the TG neurons. These neurons were mostly medium-sized to large (range 137.6-2664.8 microm(2), mean+/-S.D. 892.6+/-413.3 microm(2)). A double immunof...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02583-6
更新日期：2003-06-06 00:00:00
abstract：:The chemokines CCL2 and CCL7 are upregulated in the brain during several neurodegenerative and acute diseases associated with infiltration of peripheral leukocytes. Astrocytes can respond to inflammatory cytokines like IL-1beta and TNF-alpha by producing chemokines. This study aims to test the ability of IL-1beta and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.081
更新日期：2009-09-01 00:00:00
abstract：:The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.016
更新日期：2010-01-15 00:00:00
abstract：:In the course of studies on the responsiveness of mediobasal hypothalamic neurons to the iontophoretic application of cortisol, it was found that positive currents applied to a sodium chloride (1 M) barrel alone, but not to a choline chloride (1 M) barrel, frequently increased the firing of these neurons. Subsequently...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91091-0
更新日期：1983-08-22 00:00:00
abstract：UNLABELLED:Although corticotropin-releasing factor (CRF) receptors have been identified throughout the brain, relatively little is known about the regulation of CRF receptors. Recent investigations aimed at developing an in vitro model for studying the regulation of CRF receptors demonstrated CRF binding in brain cell ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90357-5
更新日期：1988-07-19 00:00:00
abstract：:The projections to the striatum from two cytoarchitectonically and functionally distinct subdivisions of the cat precruciate motor cortex were studied using anatomical and electrophysiological techniques. Our results indicate that the medial precruciate cortex (stimulation of which leads to movements of the axial and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90960-0
更新日期：1979-07-20 00:00:00
abstract：:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91444-6
更新日期：1991-12-13 00:00:00
abstract：:We have developed a computer-assisted method for analyzing the 2-deoxyglucose (2-DG) autoradiograms of mice olfactory bulbs. The purpose of the study was to numerize the maps of glomerular activation in order to achieve a statistical comparison of the glomerular patterns evoked by different stimuli. The spatial distri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90173-9
更新日期：1987-08-04 00:00:00
abstract：:In the present paper immunocytochemical analysis at the fluorescence microscopical level has been performed of neural cell adhesion. molecule (NCAM) immunoreactivity in the adult rat tel- and diencephalon in order to further substantiate the highly selective neuronal localization of NCAM immunoreactivity, using an aff...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01130-4
更新日期：1997-01-23 00:00:00
