Extensive loss of brain dopamine and serotonin induced by chronic administration of MPTP in the marmoset.

Abstract:

:Common marmosets were given a subcutaneous injection of MPTP (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. The parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine and, to a lesser extent, of its metabolites in the striatum and in some extrastriatal regions. There was also a profound loss of serotonin in the striatum and in all of the extrastriatal regions analyzed, which was still highly significant 6 months after discontinuation of MPTP treatment. The results suggest that the selected dosage schedule produces a widespread and lasting neuronal degeneration closely resembling the neurochemical pathology of Parkinson's disease.

journal_name

Brain Res

journal_title

Brain research

authors

Pérez-Otaño I,Herrero MT,Oset C,De Ceballos ML,Luquin MR,Obeso JA,Del Río J

doi

10.1016/0006-8993(91)91444-6

subject

Has Abstract

pub_date

1991-12-13 00:00:00

pages

127-32

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(91)91444-6

journal_volume

567

pub_type

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