Abstract:
:Horseradish peroxidase (HRP) in slow-release gel was unilaterally implanted in the transected dorsolateral funiculus (DLF) of either cervical, midthoracic, lumbar or sacral spinal cord levels of adult male rats. Cell mappings were made of all brain areas projecting through the DLF. Following cervical implants, dense labelling was observed within a band along the dorsolateral border of the inferior olive, locus coeruleus, the paralemniscal reticular formation, the mesencephalic central gray, the red nucleus and the paraventricular nucleus of the hypothalamus. The DLF projection from the central gray consisted of a rostrocaudal line of cells extending from the level of the mesen-/diencephalic junction to the rostral red nucleus. The somatotopic organization of labelled nuclei was assessed by comparing the pattern of filled cells following HRP implants at various cord levels. The potential role of these areas in pain modulation was discussed in light of their descending projections through the DLF of the spinal cord.
journal_name
Brain Resjournal_title
Brain researchauthors
Watkins LR,Griffin G,Leichnetz GR,Mayer DJdoi
10.1016/0006-8993(81)91139-2subject
Has Abstractpub_date
1981-11-02 00:00:00pages
237-55issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(81)91139-2journal_volume
223pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The role of gangliosides in preventing neuronal degeneration was examined in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse parkinsonian model. Intraventricular injections of a ganglioside mixture prior to MPTP treatment reduced MPTP's toxicity on tyrosine hydroxylase-positive neurons in the subst...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91154-9
更新日期:1990-09-17 00:00:00
abstract::Depending on experimental conditions, chronic cocaine exposure can induce an increase in binding to the dopamine transporter (DAT). One possible mechanism for the cocaine-induced-upregulation in DAT binding sites is through stimulation of presynaptic D2 receptors by excess synaptic dopamine. To test this hypothesis, t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01033-5
更新日期:1996-12-02 00:00:00
abstract::We found that local perfusion of COA-Cl (0.1, 0.4, or 1.0 mM) into the dorsal striatum of living mice produced a significant and dose-dependent increase in extracellular DA levels, with the highest dose of 1.0 mM COA-Cl producing an approximately 5-fold increase in DA. Consistent with in vivo findings, 0.1 and 0.2 mM ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.10.026
更新日期:2019-03-01 00:00:00
abstract::Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90528-5
更新日期:1982-05-13 00:00:00
abstract::Ovarian steroid hormones influence not only seizure phenomena, but also the neuronal cell death that follows. In the present study, we applied two models of ovarian steroid loss, ovariectomy and chemically-induced ovarian failure, to evaluate kainate-induced seizure activity and the susceptibility of hippocampal neuro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.02.023
更新日期:2009-04-10 00:00:00
abstract::The link between the state of energy balance and reproductive function is well known. Thus, signals denoting negative energy balance and the accompanying hyperphagic drive are likely to be factors in the suppression of gonadotropin releasing hormone (GnRH) activity. We have previously found that appetite-regulating sy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.11.066
更新日期:2005-04-18 00:00:00
abstract::The purpose of the current study is to investigate the functional connections between the central histaminergic and cholinergic systems at NTS level in hypotensive condition. Experiments were carried out in male Wistar Albino rats. The hypotension was achieved by withdrawing a total volume of 1.5ml blood/100g bodyweig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.06.047
更新日期:2016-10-15 00:00:00
abstract:BACKGROUND:Cerebral ischemia is a major leading cause of death and at the first place cause of disability all over the world. There are a lot of drugs that are in experimental stage for treatment of stroke. Among them are calcium channel blockers (CCBs) that have, in animal models, different effectiveness in healing of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.038
更新日期:2007-10-24 00:00:00
abstract::To test the hypothesis that presence of metalloproteases (MMPs), their inhibitors (TIMPs) and their substrate laminin-5 differs between the ischemic core and the surrounding tissue, we examined the impact of middle cerebral artery occlusion/reperfusion (MCA:O/R) on these molecules in different regions of the infarct. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)03088-9
更新日期:2003-09-12 00:00:00
abstract::The cat substantia nigra (SN) pars reticulata (SNR) has been observed electron microscopically after ibotenic acid injections into the caudate nucleus (Cd) and horseradish peroxidase injections into the nucleus tegmenti pedunculopontinus pars compacta (TPC). As a result, degenerating striatal terminals were found to m...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90683-5
更新日期:1989-04-17 00:00:00
abstract::The drug 6-hydroxydopamine (6-OHDA) has been reported to reduce hypothalamic norepinephrine (NE) content after administration into the lateral ventricle without altering the dopamine content of tubero-infundibular neurons. Serum prolactin levels in male rats injected with 2 X 250 mug 6-OHDA were significantly higher t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90647-8
更新日期:1976-03-05 00:00:00
abstract::Acetylcholinesterase (AChE) histochemical staining occurred in neurons of the dentate gyrus at the day of birth and steadily increased in intensity and distribution during the first 3 postnatal weeks until the adult pattern was reached. Granule cells failed to display AChE staining; however, the somata of most non-pri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(87)90072-1
更新日期:1987-11-01 00:00:00
abstract::Field potentials (FP) recorded from the surface of toad's optic tectum (OT) to electrical stimulation of the contralateral optic nerve (ON) show initial positive deflections P*, followed by negative wave N and positive wave P; the former result from axonal inputs, the latter two resemble excitatory and inhibitory post...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01260-o
更新日期:1995-01-09 00:00:00
abstract::The behaviour and cognitive abilities of marmosets with bilateral ablations of either the archicortex on the mediodorsal surface or the paleocortex on the ventrolateral surface of the frontal lobes were assessed in terms of the types of information being handled, the mode of action (inhibitory versus productive mechan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90937-i
更新日期:1993-11-19 00:00:00
abstract::Catecholamine-containing fibers have been examined in the cerebella of normal and hypocerebellar mutant mice using Falck-Hillarp and glyoxylic acid histofluorescence techniques. The amounts of norepinephrine and dopamine were also determined chemically in the same mutants. Green fluorescent fibers in cerebella of norm...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90349-2
更新日期:1975-08-08 00:00:00
abstract::The behavioral effects of lesions of the nucleus basalis magnocellularis (NBM) on two spatial discrimination tasks (place navigation and cross maze) were examined in the rat. These tasks were designed to test reference memory. Lesions by bilateral injection of ibotenic acid into the NBM led to a severe and permanent i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90079-0
更新日期:1988-07-12 00:00:00
abstract::Alcohols and volatile anesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site between transmembrane domains two and three. The extracellular linker between these two domains is important in the transduction of the gating signal from the glycine binding site to the channel ga...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.03.031
更新日期:2007-06-04 00:00:00
abstract::The present study examined the ability of antioxidant effects of angiotensin-converting enzyme (ACE) inhibitor, imidaprilat, on the synergistic effect of bisphenol A and 1-methyl-4-phenylpyridinium ion (MPP(+))-induced hydroxyl radical (*OH) formation and dopamine (DA) efflux in extracellular fluid of rat striatum. Bi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.11.100
更新日期:2006-02-03 00:00:00
abstract::Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodiu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90426-8
更新日期:1979-01-12 00:00:00
abstract::Wayfinding is a complex cognitive function involving different types of information, such as knowledge about landmarks and direction information. This variety of processes suggest that multiple neural mechanisms are involved, e.g., the hippocampal system, the posterior parietal and temporal cortical areas. Although pa...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.10.048
更新日期:2006-01-05 00:00:00
abstract::In the vertebrate retina excitatory transmission seems to be mediated mainly by excitatory amino acids; glutamate and/or aspartate are the most viable candidates to subserve this function. Postsynaptic receptors for N-methyl-D-aspartate (NMDA), kainate (KA), quisqualate (QA) and 2-amino-4-phosphonobutyric acid have be...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91330-8
更新日期:1987-06-23 00:00:00
abstract::Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) is a potent neuroexcitatory compound which acts at the quisqualate class of excitatory amino acid receptors. In this study we describe the pharmacological characteristics and anatomical distribution of [3H]AMPA binding sites in rat brain using quantitativ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90636-x
更新日期:1984-12-17 00:00:00
abstract::Recent studies suggest that apolipoprotein E (apoE) might play a neurotrophic function in the central nervous system and that altered functioning of this molecule could result in neurodegeneration. The main objective of this study was to determine if neurodegenerative and cognitive alterations in apoE-deficient mice a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01420-5
更新日期:1997-03-21 00:00:00
abstract:BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.032
更新日期:2013-08-28 00:00:00
abstract::Ventilated, chloralose anesthetized cats were subjected to 3.2 atmosphere fluid percussion injury and compared with sham operated controls. In both groups, global cerebral blood flow (CBF), cerebral metabolic rate of oxygen utilization (CMRO2), cerebral metabolic rate of glucose utilization (CMRG1), and 31P magnetic r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91205-s
更新日期:1992-07-10 00:00:00
abstract::Glioblastoma is the most common primary brain tumor in adults from which about 15,000 patients die each year in the United States. Despite aggressive surgery, radiotherapy and chemotherapy, median survival remains only 1 year. Here we evaluate growth of primary human brain tumor cells in a defined nutrient culture med...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.064
更新日期:2007-07-09 00:00:00
abstract::Intracerebral injection of kainic acid (KA) in rat brain was previously found to cause altered immunohistochemical recognition of connexin-43 (Cx43) epitopes (epitope masking) with different sequence-specific antibodies against this gap junction protein. We demonstrate here that similar alterations occur when nitrocel...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00337-p
更新日期:1995-06-12 00:00:00
abstract::The influence of osmotic stimulation on the density of beta-adrenoceptor binding sites in the rat supraoptic nucleus (SON) was studied by quantitative autoradiography using 125I-cyanopindolol (ICYP). Increased density of beta-adrenoceptor binding sites was observed in osmotically stimulated rats and also after the sup...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91592-3
更新日期:1992-08-21 00:00:00
abstract::The aim of this study was to determine if a prolonged period (7 or 14 days) of hypodynamia-hypokinesia (HH) affects the conduction of afferent input and the cortical and spinal responsiveness. Acute recordings of cortical and spinal somatosensory evoked potentials (SEPs) were performed after stimulation of the sciatic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02804-x
更新日期:2003-07-18 00:00:00
abstract::parkin is the most frequent causative gene among familial Parkinson's disease (PD). Although parkin deficiency induces autosomal recessive juvenile parkinsonism (AR-JP, PARK2) in humans, parkin knockout (PKO) mice consistently show few signs of dopaminergic degeneration. We aimed to directly measure evoked extracellul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.06.065
更新日期:2010-09-17 00:00:00