Abstract：
:The role of gangliosides in preventing neuronal degeneration was examined in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse parkinsonian model. Intraventricular injections of a ganglioside mixture prior to MPTP treatment reduced MPTP's toxicity on tyrosine hydroxylase-positive neurons in the substantia nigra. This raises the interesting possibility that early ganglioside administration may be beneficial in the treatment of neurodegenerative disorders.
journal_name
Brain Resjournal_title
Brain researchauthors
Gupta M,Schwarz J,Chen XL,Roisen FJdoi
10.1016/0006-8993(90)91154-9subject
Has Abstractpub_date
1990-09-17 00:00:00pages
330-4issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91154-9journal_volume
527pub_type
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