Abstract：
:Kernicterus is a bilirubin-induced encephalopathy in newborn. Its spectrum ranges from subtle extrapyramidal to acute encephalopathy and chronic posticteric sequelae. Current treatment of this serious problem is far from optimal. Taurine has been documented to have protective effects on neuronal cells against ischemia in vivo and in vitro. This study used primary neuronal culture to investigate the toxicological effects of unconjugated bilirubin (UCB) and the protection of taurine against UCB-mediated neuron damage. Dose-dependent reduction of cell viability was found. Changes in neurite outgrowth preceded the reduction of cell viability. The bilirubin-mediated neurotoxicity is mainly due to increased rate of cell apoptosis and higher levels of intracellular free calcium ion level. Taurine dramatically improved cell viability in cultured neurons exposed to 12.5microM UCB. Taurine pretreatment reduced UCB-mediated apoptotic cell death in primary cultured neurons in a concentration-dependent manner, which was associated with reversal of the increased intracellular free calcium ion levels caused by UCB. This study suggests the potential of taurine as a broad-spectrum agent for preventing and/or treating neuronal damage in neonatal jaundice.
journal_name
Brain Resjournal_title
Brain researchauthors
Zhang B,Yang X,Gao Xdoi
10.1016/j.brainres.2010.01.036subject
Has Abstractpub_date
2010-03-12 00:00:00pages
159-67eissn
0006-8993issn
1872-6240pii
S0006-8993(10)00106-Xjournal_volume
1320pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Maternal separation is known to exert long-term effects on both behavior and the neuroendocrine system. We investigated cocaine-induced locomotor activation as well as the locomotor and corticosterone response to forced novelty in maternally separated adolescent and adult rats. Maternal separation consisted of separat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.003
更新日期：2004-07-02 00:00:00
abstract：:Transplanted embryonic stem (ES) cells can be integrated into the retinas of adult mice as well-differentiated neuronal cells. However, the integrated ES cells also have a tumorigenic effect just because they have the ability for multipotential differentiation to various types of tissues. Thus, control of neoplastic p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.02.079
更新日期：2006-04-26 00:00:00
abstract：:The present study utilized the [14C]2-deoxyglucose (2-DG) cell labeling procedure to characterize a functional pathway from the prefrontal cortex (Pfc) and mediodorsal thalamic nucleus (MD) to the hypothalamus. Rats were injected with 2-DG prior to a 45 min experimental paradigm consisting of alternating 30 s on-off p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90151-3
更新日期：1984-09-24 00:00:00
abstract：:Chicks of 1-8 days after hatching were submitted to unilateral visual deprivation and, in both optic lobes, muscarinic receptors, labeled with L-[3H]quinuclidinyl benzylate [( 3H]L-QNB) and acetylcholinesterase (AChE) were assayed. Between 1 and 6 days the number of [3H]L-QNB binding sites was lower in the contralater...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90313-4
更新日期：1984-06-01 00:00:00
abstract：:By means of an immunohistochemical technique, we examined the neuronal induction of 72-kDa heat shock protein (HSP72) in response to methamphetamine-induced hyperthermia in the mouse hippocampus. Strong HSP72 immunoreactivity (ir) was found in the neurons of hippocampus proper, particularly in the CA1/2 and medical CA...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90602-j
更新日期：1993-10-29 00:00:00
abstract：:In order to obtain further insight into the interactions between the purinergic and dopaminergic pathways in the striatum, we studied both metabolisms simultaneously, using a microdialysis technique in 1-methyl-1,4-phenylpyridinium ion (MPP+) unilaterally-denervated conscious rats. In these rats the contralateral side...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90052-8
更新日期：1989-03-27 00:00:00
abstract：:Phospholipid extracts from 48 intracranial tumors were analyzed using 31P NMR. Phospholipids commonly identified in the tumor spectra included phosphatidylglycerol (PG), phosphatidic acid (PA), diphosphatidylglycerol (DPG), uncharacterized phospholipid (U), ethanolamine plasmalogen (EPLAS), phosphatidylethanolamine (P...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91041-3
更新日期：1994-06-27 00:00:00
abstract：:Rats with bilateral striatal cholinergic lesions induced by the neurotoxin AF64A were found to have increased spontaneous nocturnal locomotor activity as measured in terms of the amount of time spent moving, the total distance traveled and the number of episodes and time of stereotypic behaviors. No significant differ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90715-7
更新日期：1984-05-14 00:00:00
abstract：:To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91044-8
更新日期：1984-03-05 00:00:00
abstract：:In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.02.033
更新日期：2013-04-24 00:00:00
abstract：:The present study was designed to examine the trophic effect of sympathetic nerves on cerebrovascular hypertrophy in developmental hypertension. Unilateral superior cervical ganglionectomy was performed in spontaneously hypertensive rats at 4 weeks of age, and wall-to-lumen ratios of cerebral arteries were determined ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90772-9
更新日期：1986-08-06 00:00:00
abstract：:The present study examines the brain-level representation and composition of meaning in scalar quantifiers (e.g., some), which have both a semantic meaning (at least one) and a pragmatic meaning (not all). We adopted a picture-sentence verification design to examine event-related potential (ERP) effects of reading inf...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.042
更新日期：2013-01-15 00:00:00
abstract：:Neonatal treatment with gonadal steroids has been reported to alter morphological as well as functional development in various regions of the brain and spinal cord. Among the observed alterations are changes in numbers of neurons and in the organization and numbers of synapses. These regions have been found to be sexu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90001-9
更新日期：1983-06-01 00:00:00
abstract：:Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experimen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90327-6
更新日期：1992-06-05 00:00:00
abstract：:Behavioral responses to light tactile stimulation of the skin of the head of axolotls were variable in occurrence but were of a constant pattern. Retraction of the eyes and gills followed stimulation of dorsal but not ventral skin. Ventral skin yielded lowering of the head. Touching near the lips caused turning of the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(81)90037-7
更新日期：1981-09-01 00:00:00
abstract：:The neurotoxic effects of amyloid-beta(1-42) and amyloid-beta(25-35) (A beta) on cholinergic and acetylcholinesterase-positive neurons were investigated in primary cultures derived from embryonic 18-day-old rat basal forebrain. After various time intervals, the cultures were treated with 1, 5, 10 or 20 microM A beta f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.021
更新日期：2004-02-13 00:00:00
abstract：:The cortical afferents from individual laminae of the dorsal lateral geniculate nucleus (LGN) were studied using both light and electron microscope autoradiography. In area 17, the A geniculate laminae (A and A1) had two main bands of projection, one extending from the bottom of IVc to the deepest cells in layer III, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90002-0
更新日期：1976-08-20 00:00:00
abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2017.04.006
更新日期：2017-07-01 00:00:00
abstract：:We examined the effects of chronic social stress and social rank on monamine concentrations in the prefrontal cortex (PFC) in adult male cynomolgus macaques (Macaca fascicularis). Seventy-five animals were housed in five-member social groups for 28 months and were exposed to three experimental conditions. A 'no-stress...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01146-3
更新日期：1995-12-24 00:00:00
abstract：:The ontogeny of muscarinic cholinergic receptors was studied in primary cultures of dissociated rat hippocampal cells. The specific [3H]quinuclidinyl benzilate [( 3H]QNB) to intact cells was detected after two days in culture. Scatchard analysis revealed only a unique binding site at all of the days tested, with a ver...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(87)90019-8
更新日期：1987-09-01 00:00:00
abstract：:Brain oscillations provide a rich source of potentially useful endophenotypes (intermediate phenotypes) for psychiatric genetics, as they represent important correlates of human information processing and are associated with fundamental processes from perception to cognition. These oscillations are highly heritable, a...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.06.053
更新日期：2008-10-15 00:00:00
abstract：:Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects of their conditio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.05.021
更新日期：2011-07-11 00:00:00
abstract：:When nomifensine is employed to inhibit neuronal uptake, exposure to dopamine (DA) (0.1-0.3 microM) or apomorphine (0.01-0.1 microM) inhibited, in a concentration-dependent manner, the electrically evoked release of [3H]dopamine from slices of the rabbit caudate nucleus. Apomorphine inhibited transmitter release indep...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91605-1
更新日期：1985-06-24 00:00:00
abstract：:We have previously demonstrated that NMDA receptor-mediated extracellular adenosine accumulation in neuronal cultures is receptor-mediated and requires calcium influx. Because protein kinase C (PKC) is a calcium-dependent enzyme, we hypothesized that activation of PKC might be involved in NMDA-mediated adenosine accum...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.057
更新日期：2007-06-25 00:00:00
abstract：:Partial, unilateral olfactory nerve section was performed in mice, and the behavior of the olfactory marker protein (OMP) studied, after this experimental manipulation, with the peroxidase--antiperoxidase method. The protein, which in normal mice is present only in mature olfactory sensory neurons, after unilateral le...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90162-1
更新日期：1981-03-30 00:00:00
abstract：:Studies of potentials for dorsal spinal nerve root axons to regrow into the spinal cord involved placement of the tracer HRP/WGA-HRP on the cut end of the nerve root. Following this procedure, labeled neurons were found within the spinal dorsal gray matter. Analyses revealed that spinal neurons influenced by the prese...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00501-5
更新日期：1997-07-18 00:00:00
abstract：:Fos-like immunoreactivity (FLI) can indicate the location of neurons activated following expression of conditioned taste aversion (CTA). After one conditioning trial FLI has been identified in the intermediate nucleus of the solitary tract (iNTS) with little expression in other brain regions. The present study assesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03032-8
更新日期：2000-12-29 00:00:00
abstract：:In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01054-8
更新日期：1997-12-19 00:00:00
abstract：:We have investigated sensitivity to the conditioned fear procedure of mice is influenced by the genetic deletion of alpha2A adrenoceptors (ARs). We observed a heightened freezing response in the discrete cue memory test in alpha2A AR knockout (alpha2A AR KO) mice and in D79N mice, a transgenic mouse strain with functi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03248-7
更新日期：2003-10-03 00:00:00
abstract：:Blockade of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors with 6-nitro-7-sulfamoyl-benzo-[f]quinoxaline-2,3(1H,4H)-dione (NBQX) activates tuberoinfundibular (TIDA) and periventricular-hypophysial dopaminergic (PHDA) neurons suggesting that these neurons are tonically inhibited by endogenous...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91305-6
更新日期：1994-10-17 00:00:00
