Conversation effects on neural mechanisms underlying reaction time to visual events while viewing a driving scene: fMRI analysis and asynchrony model.

Abstract:

:This neuroimaging study investigated the neural mechanisms of the effect of conversation on visual event detection during a driving-like scenario. The static load paradigm, established as predictive of visual reaction time in on-road driving, measured reaction times to visual events while subjects watched a real-world driving video. Behavioral testing with twenty-eight healthy volunteers determined the reaction time effects from overt and covert conversation tasks in this paradigm. Overt and covert conversation gave rise to longer visual event reaction times in the surrogate driving paradigm compared to just driving with no conversation, with negligible effect on miss rates. The covert conversation task was then undertaken by ten right-handed healthy adults in a 4-Tesla fMRI magnet. We identified a frontal-parietal network that maintained event detection performance during the conversation task while watching the driving video. Increased brain activations for conversation vs. no conversation during such simulated driving was found not only in language regions (Broca's and Wernicke's areas), but also specific regions in bilateral inferior frontal gyrus, bilateral anterior insula and orbitofrontal cortex, bilateral lateral prefrontal cortex (right middle frontal gyrus and left frontal eye field), supplementary motor cortex, anterior and posterior cingulate gyrus, right superior parietal lobe, right intraparietal sulcus, right precuneus, and right cuneus. We propose an Asynchrony Model in which the frontal regions have a top-down influence on the synchrony of neural processes within the superior parietal lobe and extrastriate visual cortex that in turn modulate the reaction time to visual events during conversation while driving.

journal_name

Brain Res

journal_title

Brain research

authors

Hsieh L,Young RA,Bowyer SM,Moran JE,Genik RJ 2nd,Green CC,Chiang YR,Yu YJ,Liao CC,Seaman S

doi

10.1016/j.brainres.2008.10.002

subject

Has Abstract

pub_date

2009-01-28 00:00:00

pages

162-75

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(08)02494-3

journal_volume

1251

pub_type

杂志文章
  • Locomotor behavior following kindling in three different brain sites.

    abstract::Spontaneous and drug-induced interictal and post-ictal locomotor behavior of rats was investigated following electrical 'kindling' of different limbic structures at 3 brain sites which differ in the relative amount of innervation from dopamine cells of the ventral tegmentum: nucleus accumbens (N.Acc.), amygdala (AMYG)...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91385-x

    authors: Ehlers CL,Koob GF

    更新日期:1985-02-04 00:00:00

  • Apparent unilateral visual neglect in MPTP-hemiparkinsonian monkeys is due to delayed initiation of motion.

    abstract::Monkeys made hemiparkinsonian by infusion of a solution of MPTP into one carotid artery appeared to ignore food presented from the contralateral side. Initial observations suggested neglect of visual stimuli presented as fruit treats by automated delivery system in the half-field contralateral to MPTP treatment. Furth...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91080-k

    authors: Bankiewicz KS,Oldfield EH,Plunkett RJ,Schuette WH,Cogan DG,Hogan N,Zuddas A,Kopin IJ

    更新日期:1991-02-08 00:00:00

  • Effects of preoptic injections of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide and PHI on the secretion of luteinizing hormone and prolactin in ovariectomized estrogen-primed rats.

    abstract::The effects of intracerebral injections of brain-gut peptides in the preoptic region on the secretion of luteinizing hormone (LH) and prolactin (PRL) were examined in ovariectomized, estrogen-primed rats. Gastrin or cholecystokinin-octapeptide injection in the preoptic region induced a moderate increase of circadian r...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)90330-1

    authors: Kimura F,Mitsugi N,Arita J,Akema T,Yoshida K

    更新日期:1987-05-05 00:00:00

  • Pubertal stress decreases sexual motivation and supresses the relation between cerebral theta rhythms and testosterone levels in adult male rats.

    abstract::This study evaluated the effect of stress during puberty on sexual motivation and the correlation between serum testosterone levels (T) and the absolute power of the theta electroencephalographic rhythms, recorded in the medial prefrontal cortex (mPFC) and basolateral amygdala (BLA) of adult male rats. Thirty males of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2020.146937

    authors: Hernández-Arteaga E,Hernández-González M,Bonilla-Jaime H,Guevara MA,Ågmo A

    更新日期:2020-10-15 00:00:00

  • Serum and fibroblast growth factor stimulate quiescent astrocytes to re-enter the cell cycle.

    abstract::An in vitro model was used to study the cytokinetics of astroglial cells derived from neonatal rat cerebellum. Confluent monolayers of astrocytes (85% astroglial as assessed by GFAP immunoreactivity) were subcultured at low cell density and after 2-3 days growth were rendered quiescent by shifting them to low serum me...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91485-0

    authors: Kniss DA,Burry RW

    更新日期:1988-01-26 00:00:00

  • Cation permeability change caused by L-glutamate in cultured rat hippocampal neurons.

    abstract::The ionic mechanism of the membrane permeability changes caused by L-glutamate in hippocampal neurons prepared from 17- to 19-day-old fetal rat in dispersed cell cultures was studied with the whole-cell variation of the patch electrode voltage-clamp technique. The cultured hippocampal neurons became sensitive to gluta...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)91601-0

    authors: Ozawa S,Nakamura T,Yuzaki M

    更新日期:1988-03-08 00:00:00

  • The distribution of somatostatin-immunoreactive neurons in the visual cortex of adult rabbits and during postnatal development.

    abstract::In the adult rabbit, the somatostatin-immunoreactive neurons are seen in all visual cortical layers, with the majority of them being found in layers II-III, V and VI. During postnatal development, we can see labeled cells in layer VI at birth and in layers V and VI on the 3rd day. The labeled cells are seen in layers ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)91456-8

    authors: Ramón y Cajal-Agüeras S,Contamina P,Parra P,Martinez-Millán L,De Carlos JA,Ramo C

    更新日期:1985-12-16 00:00:00

  • Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment.

    abstract::Poly(ADP-ribose) polymerase (PARP) can initiate an energy-consuming and inefficient repair cycle following cerebral ischemia/reperfusion by transferring ADP ribose units to nuclear proteins eventually leading to cellular dysfunction and neuronal death. 3-Aminobenzamide (3-AB) is a selective inhibitor of PARP that can ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)02852-9

    authors: Ding Y,Zhou Y,Lai Q,Li J,Gordon V,Diaz FG

    更新日期:2001-10-12 00:00:00

  • Two types of protease-activated receptors (PAR-1 and PAR-2) mediate calcium signaling in rat retinal ganglion cells RGC-5.

    abstract::Protease-activated receptors (PARs), G-protein-coupled receptors, are widely expressed in various tissues, where they participate in physiological and pathological processes, such as hemostasis, proliferation, tissue repair, and inflammation. Recently, we found that PARs were upregulated in the rat retina following op...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.04.040

    authors: Luo W,Wang Y,Reiser G

    更新日期:2005-06-21 00:00:00

  • Morphological and electrophysiological properties of neurons in an area of the chick brain involved in learning.

    abstract::The intermediate, medial part of the hyperstriatum ventrale (IMHV) is an area of the avian forebrain which is essential for two forms of early learning in the domestic chick. We have developed an in vitro slice preparation which contains part of the IMHV and have found that the electrophysiological properties of the a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(96)00361-7

    authors: Bradley PM,Burns BD,King TM,Webb AC

    更新日期:1996-07-15 00:00:00

  • Differential alterations of cortical cholinergic and neurotensin markers following ibotenic acid lesions of the nucleus basalis magnocellularis.

    abstract::The present study determined whether cortical cholinergic neurons recover functionally following the loss of afferent projections from the nucleus basalis magnocellularis (nbm). At various time points following ibotenic acid lesions of the nbm, choline acetyltransferase (ChAT) activity or the capacity of cortical chol...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90904-2

    authors: Lapchak PA,Araujo DM,Pasinetti G,Hefti F

    更新日期:1993-06-11 00:00:00

  • Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.

    abstract::In the previous study, we reported increased NOS expression in the astrocytes in the spinal cord of the transgenic mice that are used as ALS animal model. In the present study, we performed immunocytochemical studies to investigate the changes of nitrotyrosine-immunoreactivity in the brains of the transgenic mice, and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)02302-1

    authors: Cha CI,Chung YH,Shin CM,Shin DH,Kim YS,Gurney ME,Lee KW

    更新日期:2000-01-17 00:00:00

  • Developmental immunohistochemistry of catalase in the human brain.

    abstract::The immunohistochemical studies on a peroxisomal enzyme, catalase, were done on brains from human fetuses to adults. The catalase-positive neurons appeared in the basal ganglia, thalamus and cerebellum at 27-28 weeks of gestation, and in the frontal cortex at 35 weeks. They then increased in number with gestational ag...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)90314-l

    authors: Houdou S,Kuruta H,Hasegawa M,Konomi H,Takashima S,Suzuki Y,Hashimoto T

    更新日期:1991-08-16 00:00:00

  • Effects of chronic stress on dendritic arborization in the central and extended amygdala.

    abstract::A differential role has been suggested for two important areas in the neural circuitry of stress, central nucleus of the amygdala (CeA) and bed nucleus of stria terminalis (BNST) in the extended amygdala, in regulating fear versus anxiety. Since chronic stress enhances anxiety and consolidation of aversive memories, w...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)04162-8

    authors: Vyas A,Bernal S,Chattarji S

    更新日期:2003-03-07 00:00:00

  • Explicit versus implicit gaze processing assessed by ERPs.

    abstract::Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.07.094

    authors: Itier RJ,Alain C,Kovacevic N,McIntosh AR

    更新日期:2007-10-26 00:00:00

  • The action of norepinephrine in the rat hippocampus: intracellular studies in the slice preparation.

    abstract::The ionic basis of norepinephrine (NE) action was studied with intracellular recording techniques in the rat hippocampal slice. Topical application of NE caused, in CA1 neurons, a 3-4 mV hyperpolarization associated with a 10-20% decrease in input resistance. This effect was accompanied by a decrease in spontaneous ac...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90104-9

    authors: Segal M

    更新日期:1981-02-09 00:00:00

  • Glycine-activated chloride currents of neurons freshly isolated from the prefrontal cortex of young rats.

    abstract::Strychnine-sensitive glycine receptors (GlyR) play a major role in the excitability of CNS neurons and are also a major target of many drugs including some general anesthetics and ethanol. The prefrontal cortex (PFC) is an important substrate responsible for cognitive function and for sedation, as well as hypnosis (un...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2011.03.073

    authors: Lu Y,Ye JH

    更新日期:2011-06-01 00:00:00

  • New dopamine D2 receptor polymorphisms in rats and association with apomorphine-induced stereotypies.

    abstract::Adult Wistar rats injected with the dopamine receptor agonist apomorphine display different types of motility patterns with respect to oral stereotypes and locomotor activities. It was tested whether phenotypes exhibiting either 'sniffing' or 'non-sniffing' behaviour differed in gene structures of dopamine receptors D...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03136-5

    authors: Germeyer S,Birke A,Schmitt U,Dahmen N,Hiemke C,Havemann-Reinecke U

    更新日期:2002-02-01 00:00:00

  • Electrophysiological effects of MK-801 on rat nigrostriatal and mesoaccumbal dopaminergic neurons.

    abstract::The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91091-r

    authors: Zhang J,Chiodo LA,Freeman AS

    更新日期:1992-09-11 00:00:00

  • Anterograde axoplasmic transport of peroxidase in the rat visual system after intraocular neurotoxin injection.

    abstract::The effect of intraocular injection of the neurotoxin, kainic acid, on the retinofugal pathway has been examined by anterograde transport of horseradish peroxidase. Although less peroxidase was present in all the primary optic centers after the intraocular injection of kainic acid than in the controls, the area occupi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90939-9

    authors: Gomez-Ramos P,Perez-Rico C,Reinoso-Suarez F

    更新日期:1984-01-09 00:00:00

  • Membrane contact regulates transmitter phenotypic expression.

    abstract::High cell density, with attendant aggregation, selectively increases expression of substance P (SP) and choline acetyltransferase (ChAT) in virtually pure neonatal sympathetic neuronal cultures. To investigate the specific role of cell contact in selective transmitter expression, SP content and ChAT activity were exam...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(86)80202-5

    authors: Adler JE,Black IB

    更新日期:1986-12-01 00:00:00

  • Topographical projection of the septal organ to the main olfactory bulb in rats: ontogenetic study.

    abstract::Using the horseradish peroxidase (HRP) retrograde tracing method, we have studied the topographical organization of the projection of the septal organ to the main olfactory bulb in rats varying in age from 22 fetal days up to 15 postnatal days. For all developmental stages studied, receptor cells of the septal organ h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(88)90248-9

    authors: Astic L,Saucier D

    更新日期:1988-08-01 00:00:00

  • Regional changes in spinal cord glucose metabolism in a rat model of painful neuropathy.

    abstract::Spinal cord patterns of metabolic activity in a model of neuropathic pain were assessed in unanesthetized rats by the [14C]-2-deoxyglucose (2-DG) technique. Rats used in this procedure had demonstrable thermal hyperalgesia ipsilateral to sciatic nerve ligation and ipsilateral hindpaws that were lifted in a guarded pos...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91468-g

    authors: Price DD,Mao JR,Coghill RC,d'Avella D,Cicciarello R,Fiori MG,Mayer DJ,Hayes RL

    更新日期:1991-11-15 00:00:00

  • Abnormal localization of iron regulatory protein in Alzheimer's disease.

    abstract::A role for altered iron metabolism in the pathogenesis of Alzheimer's disease has been suggested by several reports associating the cardinal neuropathologic lesions with markers of free radical-induced damage and redox-active iron. We hypothesized that the abnormal distribution of iron in Alzheimer brain might result ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00002-x

    authors: Smith MA,Wehr K,Harris PL,Siedlak SL,Connor JR,Perry G

    更新日期:1998-03-30 00:00:00

  • Indomethacin-induced antipyresis in the rat: role of vasopressin receptors.

    abstract::Infusion of 15 micrograms/microliters (approximately 120 micrograms/kg/h) of indomethacin within the ventral septal area of the rat brain significantly reduced a centrally induced prostaglandin E1 (PGE1) hyperthermia when compared with infusions of artificial cerebrospinal fluid. A bolus injection of a V1 receptor ant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)90599-4

    authors: Fyda DM,Cooper KE,Veale WL

    更新日期:1989-08-14 00:00:00

  • Spinal and trigeminal lamina I input to the locus coeruleus anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) in the cat and the monkey.

    abstract::Terminal fibers anterogradely labeled with Phaseolus vulgaris leucoagglutinin (PHA-L) were observed in the locus coeruleus in the brainstem of the cat and the cynomolgus monkey following injections in lamina I of the spinal or medullary dorsal horn. Thus, thermoreceptive- or nociceptive-specific lamina I cells that pr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90915-v

    authors: Craig AD

    更新日期:1992-07-03 00:00:00

  • Sumatriptan modifies cortical free radical release during cortical spreading depression. A novel antimigraine action for sumatriptan?

    abstract::Increases in concentration of brain NO are proposed to initiate and mediate migraine headache. Triggered by focal depolarisation, spreading depression (SD) represents a suitable mechanism for eliciting widespread release of nitric oxide. The current study examines the effect of sumatriptan, a 5-HT(1B/1D) agonist and e...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(00)02400-8

    authors: Read SJ,Parsons AA

    更新日期:2000-07-07 00:00:00

  • Enkephalins, substance P and acetylcholine microinjected into the nucleus ambiguus elicit vagal bradycardia in rats.

    abstract::Little is known about putative transmitters in the nucleus ambiguus (NA) mediating parasympathetic control of the heart, although Met-enkephalin (m-ENK), Leu-enkephalin (l-ENK), substance P (SP) and acetylcholine (Ach) have been detected in the cell bodies and fibers of this nucleus. The effects of these substances on...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(91)91534-8

    authors: Agarwal SK,Calaresu FR

    更新日期:1991-11-01 00:00:00

  • Opiate-like excitatory effects of steroid sulfates and calcium-complexing agents given cerebroventricularly.

    abstract::Intracerebroventricular administration of 10--20 microgram of steroid-O-sulfates induced hypermotility, agitation, salivation, EEG abnormalities, stereotypies, wet dog shakes and seizures. Equivalent effects resulted from 30--200 microgram morphine sulfate (H2SO4 salt), 50 microgram EGTA or 300--400 microgram of sodiu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90426-8

    authors: LaBella FS,Havlicek V,Pinsky C

    更新日期:1979-01-12 00:00:00

  • A retrograde transport method for mapping zinc-containing fiber systems in the brain.

    abstract::A method for selectively labeling the CNS neurons that give rise to zinc-containing axonal boutons is described. Focal intracerebral infusions of selenium anions are used to produce a precipitate (presumably ZnSe) in zinc-containing axonal boutons at the injection site, and within 24-48 h, the precipitate is transport...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90607-d

    authors: Howell GA,Frederickson CJ

    更新日期:1990-05-07 00:00:00