Increased excitability and reduced intracortical inhibition in the ipsilateral primary motor cortex during a fine-motor manipulation task.

Abstract:

:The effects of a sensorimotor task on ipsilateral primary motor cortex (ipsi-M1) excitability mediated via the transcallosal pathway, including the changes in short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF), were examined in ten right-handed subjects. Transcranial magnetic stimulation (TMS) was delivered to evoke a motor evoked potential (MEP) from the first dorsal interosseous (FDI). The test-TMS intensity was adjusted to around 120% of the resting motor threshold (rMT). For the paired-pulse TMS paradigm, the conditioning-TMS intensity was set to 80% of the rMT, and the interstimulus interval was fixed at 3 ms for SICI and 12 ms for ICF. As a sensorimotor task, a fine-motor manipulation (FM) task (using chopsticks to pick up, transport, and release glass balls) was adopted. In addition, a pseudo-FM (pFM) task was also performed as a control task. These tasks were carried out using each hand separately. The MEPs evoked during the FM task were markedly increased compared with those evoked during the pFM task, and these effects were not dependent on the electromyographic activity of the FDI performing these tasks. SICI was significantly decreased during the FM task, indicating disinhibition of the ipsi-M1, and these effects were also noted when the subjects used their non-dominant hand. The present findings suggest that the differences between the effects of the FM and pFM tasks on ipsi-M1 excitability were caused by their property.

journal_name

Brain Res

journal_title

Brain research

authors

Morishita T,Ninomiya M,Uehara K,Funase K

doi

10.1016/j.brainres.2010.11.049

subject

Has Abstract

pub_date

2011-01-31 00:00:00

pages

65-73

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(10)02562-X

journal_volume

1371

pub_type

杂志文章
  • Behavioral evidence for midbrain dopamine depolarization inactivation.

    abstract::High (2.5-5 micrograms) doses of ventral tegmental morphine, which normally facilitate brain stimulation reward, were found to cause a complete cessation of bar pressing for brainstem stimulation in animals pretreated with systemic pimozide (0.175-0.35 mg/kg). It was hypothesized that the behavioral failure was due to...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91402-9

    authors: Rompré PP,Wise RA

    更新日期:1989-01-16 00:00:00

  • Central amygdaloid axon terminals are in contact with retrorubral field neurons that project to the parvicellular reticular formation of the medulla oblongata in the rat.

    abstract::The retrorubral field (RRF) contains numerous dopaminergic neurons and projects to the parvicellular reticular formation (RFp) of the medullary and pontomedullary brainstem, where many premotor neurons project to the orofacial motor nuclei. To know how the amygdala affects the RRF-RFp pathway in the rat, we first exam...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2009.09.118

    authors: Tsumori T,Qin Y,Yokota S,Niu JG,Yasui Y

    更新日期:2010-01-08 00:00:00

  • Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord.

    abstract::The distributions of neurotensin and opiate receptors within the dorsal horn of the rat spinal cord were studied with quantitative autoradiographic techniques and compared with the immunohistochemical localizations of neurotensin and methionine-enkephalin-like immunoreactivity in this region. High densities of both ne...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90395-4

    authors: Ninkovic M,Hunt SP,Kelly JS

    更新日期:1981-12-28 00:00:00

  • CA1 ischemic injury does not affect the ability of Mongolian gerbils to solve response, direction, or place problems.

    abstract::Open field and T-maze paradigms are used to test the effects of hippocampal lesions on spatial memory in rodents. Place cells in the dorsal CA1 region of the hippocampus are known to be responsible for the formation of global place maps, while CA3 neurons respond to changes in local contexts. It is proposed here that ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.10.050

    authors: Walsh SJ,Harley CW,Corbett D,Skinner DM,Martin GM

    更新日期:2008-01-02 00:00:00

  • In vitro expression of in vivo learning by an isolated molluscan CNS.

    abstract::The associative learning functions of the central nervous system of Limax maximus have been established with behavioral experiments on intact animals (Sahley et al., J. comp. Physiol., 144 (1981) 1) and physiological experiments on the isolated CNS (Culligan and Gelperin, Brain Research, 266 (1983) 319). We now report...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90323-8

    authors: Gelperin A,Culligan N

    更新日期:1984-06-25 00:00:00

  • Pattern of fos activation in the ventral tegmental area (VTA) of male prairie vole's (Microtus ochrogaster) in response to infant-related stimuli.

    abstract::Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2019.02.023

    authors: Lang DY,Bamshad M,Dorcely R

    更新日期:2019-07-01 00:00:00

  • Fetal brain transplants induce recuperation of taste aversion learning.

    abstract::Rats showing disrupted taste aversion due to gustatory neocortex or amygdala lesions were transplanted into the lesioned area with homologous brain tissue obtained from 17-day-old fetuses. Comparisons of taste aversions scores before and after the graft, revealed that the grafted animals significantly recuperated tast...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(87)91507-1

    authors: Bermúdez-Rattoni F,Fernández J,Sánchez MA,Aguilar-Roblero R,Drucker-Colín R

    更新日期:1987-07-21 00:00:00

  • Light microscope differentiation of two populations of rat olfactory bulb granule cells.

    abstract::Examination of glycolmethacrylate embedded olfactory bulbs of normal rats revealed that the granule cells of the accessory olfactory bulb were dissimilar from the majority of main olfactory bulb granule cells. Cells from these structures can be discriminated on the basis of spherical form. nuclear diameter, nucleoplas...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90711-9

    authors: Struble RG,Walters CP

    更新日期:1982-03-25 00:00:00

  • Fluctuation of serum NO(x) concentration at stroke onset in a rat spontaneous stroke model (M-SHRSP). Peroxynitrite formation in brain lesions.

    abstract::Malignant stroke-prone spontaneously hypertensive rats (M-SHRSP) develop hypertension and stroke at earlier ages than do nonmalignant SHRSP. Our previous findings suggested that reactive oxygen species were involved in the development of stroke in this strain. Nitric oxide (NO) which is more released at ischemia, migh...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)02975-x

    authors: Tabuchi M,Umegaki K,Ito T,Suzuki M,Tomita I,Ikeda M,Tomita T

    更新日期:2002-09-13 00:00:00

  • Prefrontal unit activity and delayed response: relation to cue location versus direction of response.

    abstract::Two monkeys were trained to perform 3 kinds of spatial tasks (right-left DR, up-down DR, and conditional position discrimination with delay). In the conditional position task, the animal was required to respond to the right (left) choice key when the cue had been presented on the upper (lower) position. Single unit ac...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(76)90924-0

    authors: Niki H,Watanabe M

    更新日期:1976-03-19 00:00:00

  • Anticonvulsant effect of enhancement of noradrenergic transmission in the superior colliculus in genetically epilepsy-prone rats (GEPRs): a microinjection study.

    abstract::An expanding body of data has indicated that the seizure prone state in genetically epilepsy-prone rats (GEPRs) is partially caused by deficits in central nervous system noradrenergic transmission. Several lines of evidence suggest that the noradrenergic terminals in the superior colliculus (SC) may act as determinant...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)01139-6

    authors: Yan QS,Dailey JW,Steenbergen JL,Jobe PC

    更新日期:1998-01-12 00:00:00

  • alpha 4 beta 2 subunit combination specific pharmacology of neuronal nicotinic acetylcholine receptors in N1E-115 neuroblastoma cells.

    abstract::Pharmacological characteristics of native neuronal nicotinic acetylcholine receptor-mediated ion currents in mouse N1E-115 neuroblastoma cells have been investigated by superfusion of voltage clamped cells with known concentrations of the agonists acetylcholine, nicotine and cytisine, and the antagonists alpha-bungaro...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90493-6

    authors: Zwart R,Abraham D,Oortgiesen M,Vijverberg HP

    更新日期:1994-08-22 00:00:00

  • Effects of chronic dizocilpine on acute pain and on mRNA expression of neuropeptides and the dopamine and glutamate receptors.

    abstract::The mesocorticolimbic circuitry has been implicated in the pathophysiology of several neuropsychiatric syndromes like chronic pain and addiction. The aim of this study was to evaluate the effects of dizocilpine (MK-801), a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, on sensorimotor behaviors and t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(03)02988-3

    authors: Al-Amin HA,Saadé NE,Khani M,Atweh S,Jaber M

    更新日期:2003-08-15 00:00:00

  • Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats.

    abstract::In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomi...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2013.02.033

    authors: Zhang X,Wu J,Liu H,Zhang X

    更新日期:2013-04-24 00:00:00

  • Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract.

    abstract::The suprachiasmatic nuclei receive photic input information directly through a retinohypothalamic tract (RHT) and indirectly through a projection from the intergeniculate leaflet of the lateral geniculate complex, the geniculohypothalamic tract (GHT). Prior work has established that the RHT is sufficient for entrainme...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90374-5

    authors: Johnson RF,Moore RY,Morin LP

    更新日期:1988-09-20 00:00:00

  • Apparent sprouting of striatal serotonergic terminals after dopamine-depleting brain lesions in neonatal rats.

    abstract::Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90665-6

    authors: Stachowiak MK,Bruno JP,Snyder AM,Stricker EM,Zigmond MJ

    更新日期:1984-01-16 00:00:00

  • A rat model of focal embolic cerebral ischemia.

    abstract::We developed a new model of embolic cerebral ischemia in the rat which provides a reproducible and predictable infarct volume within the territory supplied by the middle cerebral artery (MCA). The MCA was occluded by an embolus in Wistar rats (n = 71). An additional three non-embolized rats were used as a control. Cer...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(97)00580-5

    authors: Zhang RL,Chopp M,Zhang ZG,Jiang Q,Ewing JR

    更新日期:1997-08-22 00:00:00

  • Long-lasting enhancement of metabotropic excitatory amino acid receptor-mediated polyphosphoinositide hydrolysis in the amygdala/pyriform cortex of deep prepiriform cortical kindled rats.

    abstract::We have previously demonstrated that ibotenate (IBO)-stimulated polyphosphoinositide (PPI) hydrolysis is increased for a long period in the amygdala/pyriform cortex (AM/PC) of amygdala (AM)- and hippocampal (HIPP)-kindled rats. This finding indicates that enhanced function of the PPI-coupled excitatory amino acid (EAA...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90370-o

    authors: Akiyama K,Daigen A,Yamada N,Itoh T,Kohira I,Ujike H,Otsuki S

    更新日期:1992-01-08 00:00:00

  • cAMP-dependent differential regulation of extracellular matrix (ECM) gene expression in cultured rat Schwann cells.

    abstract::cAMP-dependent regulation of the steady-state mRNA levels for the ECM components, laminin A, B1 and B2 chains, collagen types I, III and IV were examined by Northern blot analysis in cultured rat Schwann cells. ECM mRNAs of laminin B1 chain and collagen types I and IV were expressed at high levels in the control Schwa...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90409-x

    authors: Yamamoto M,Sobue G,Li M,Mitsuma T,Kimata K,Yamada Y

    更新日期:1994-08-08 00:00:00

  • Brain tyrosine availability and the depression of central nervous norepinephrine turnover in acute and chronic starvation in adult male rats.

    abstract::Norepinephrine (NE) and 3-methoxy-4-hydroxyphenylglycol (MOPEG) were determined in medio-basal hypothalamus of adult male rats using high-performance liquid chromatography to study nutritional modulation of noradrenergic turnover. Acute starvation, as well as 3 weeks of semistarvation with a low-protein high-carbohydr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90471-8

    authors: Schweiger U,Warnhoff M,Pirke KM

    更新日期:1985-06-03 00:00:00

  • Fluoxetine attenuates the DL-fenfluramine-induced increase in extracellular serotonin as measured by in vivo dialysis.

    abstract::Rats with hippocampal dialysis probes were treated with DL-fenfluramine (FEN), fluoxetine, or FEN with fluoxetine pre-treatment. FEN (12.5 mg/kg) increased extracellular serotonin (5-HT) from 0.4 +/- 0.04 to 25.2 +/- 4.16 pg/10 microliters. Fluoxetine (10.0 mg/kg) increased extracellular 5-HT levels from 0.4 +/- 0.05 ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)91249-e

    authors: Sabol KE,Richards JB,Seiden LS

    更新日期:1992-07-10 00:00:00

  • Salicylic acid protects against chronic L-DOPA-induced 6-OHDA generation in experimental model of parkinsonism.

    abstract::The present study evaluated the ability of salicylic acid (SA) to attenuate long-term L-DOPA-induced 6-hydroxydopamine (6-OHDA) formation in the striatum of mice, and to protect against the resulting dopaminergic neurotoxicity. The production of 6-OHDA from dopamine in vitro from ferrous-ascorbate-dopamine (FAD) hydro...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2010.05.010

    authors: Borah A,Mohanakumar KP

    更新日期:2010-07-16 00:00:00

  • Age-related changes in thyroid hormone responsive protein (THRP) expression in cerebral tissue of rats.

    abstract::To determine if aging in rats is associated with insensitivity of cerebral tissue to thyroid hormones (TH), the expression of a TH responsive protein or (THRP) in cerebral tissue was studied in male Fischer rats at 4, 12 and 24 months of age during euthyroid, hypothyroid and hyperthyroid states. The basal levels of TH...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(98)00144-9

    authors: Mooradian AD,Li J,Shah GN

    更新日期:1998-05-18 00:00:00

  • Immediate integration of novel meanings: N400 support for an embodied view of language comprehension.

    abstract::A substantial part of language understanding depends on our previous experiences, but part of it consists of the creation of new meanings. Such new meanings cannot be retrieved from memory but still have to be constructed. The goals of this article were: first, to explore the nature of new meaning creation, and second...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2007.09.014

    authors: Chwilla DJ,Kolk HH,Vissers CT

    更新日期:2007-12-05 00:00:00

  • Electroshock afterdischarges are related to neuronal oscillability: neuronal models of Aplysia.

    abstract::Identifiable giant neurons of Aplysia explored intracellularly behave differently at the offset of an intracellular electroshock (IES) or after a synaptic 'tetanization', according to their functional type: neurons of the stable type depolarize and fire at the offset of the IES, anodal or cathodal, thus eliciting an a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(82)90583-2

    authors: Chalazonitis N,Boisson M,Rome-Talbot D,Chagneux R

    更新日期:1982-09-30 00:00:00

  • Direct monosynaptic contacts between type-identified alpha-motoneurons in the cat.

    abstract::We have examined, at the light microscope level, putative direct synaptic interconnections, via motor axon collaterals, between type-identified triceps surae alpha-motoneurons labeled by intracellular injection of HRP. The results indicate that monosynaptic recurrent contacts can occur between synergist motoneurons (i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)90937-5

    authors: Cullheim S,Lipsenthal L,Burke RE

    更新日期:1984-08-06 00:00:00

  • Organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis and upper cervical spinal cord associated with orofacial neuropathic pain.

    abstract::The aim of this study was to evaluate spatial organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis (Vc) and upper cervical spinal cord (C1), and to clarify the involvement in mechanisms underlying orofacial secondary hyperalgesia following infraorbital nerve injury. We found that the h...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.02.023

    authors: Shibuta K,Suzuki I,Shinoda M,Tsuboi Y,Honda K,Shimizu N,Sessle BJ,Iwata K

    更新日期:2012-04-27 00:00:00

  • Mesenchymal stem cells as cellular vectors for pediatric neurological disorders.

    abstract::Lysosomal storage diseases are a heterogeneous group of hereditary disorders characterized by a deficiency in lysosomal function. Although these disorders differ in their etiology and phenotype those that affect the nervous system generally manifest as a profound deterioration in neurologic function with age. Over the...

    journal_title:Brain research

    pub_type: 杂志文章,评审

    doi:10.1016/j.brainres.2014.05.029

    authors: Phinney DG,Isakova IA

    更新日期:2014-07-21 00:00:00

  • Kainic acid responses and toxicity show pronounced Ca2+ dependence.

    abstract::Responses of pyramidal neurons to ionophoretic kainate, quisqualate and N-methyl aspartate were studied in a submerged rat piriform cortex slice as a function of Ca2+ and Mg2+ concentrations. The results suggest that the channel activated by kainate is unusually influenced by Ca2+, excitotoxicity is Ca2+-dependent and...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(85)90989-8

    authors: Hori N,Ffrench-Mullen JM,Carpenter DO

    更新日期:1985-12-09 00:00:00

  • Maturational changes of amino acid concentration in cerebrospinal fluid of the rat.

    abstract::The cisternal spinal fluid (CF), plasma, and brain stem concentrations of 6 amino acids were measured in suckling rats between birth and one months of age. Each of the amino acids studied had its distinctive maturational pattern of CF concentration. Presumably these amino acids have separate mechanisms of transport fr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90098-1

    authors: Korobkin RK,Cutler RW

    更新日期:1977-01-01 00:00:00