Abstract：
:Centrifugal fibers and their synaptic connections were studied in retinas of the lamprey Lampetra fluviatilis. The morphological analysis of retinofugal and retinopetal elements was performed after their horseradish peroxidase (HRP) filling through either the cut optic nerve in isolated retina preparations or after intracerebral HRP injections. In flat-mounted retinas, labeled ganglion cell bodies with their dendritic arborizations as well as centrifugal axons were found. The topography of labeled ganglion cell bodies and fibers in semi-thin plastic sections is described. The electron microscopic analysis revealed that the centrifugal terminals synapse either upon unlabeled somata or profiles containing synaptic vesicles (PCSVs). In more rare cases these boutons seem to establish synaptic contacts on ganglion cell dendrites. The target cell bodies were located within the inner part of the inner nuclear layer, whereas postsynaptic dendrites and PCSVs were mainly observed in the outer portion of the internal synaptic layer. Stimulation of the optic nerve in isolated retinas produced antidromic responses in 23 neurons and in 9 of these cells, an antidromic spike was followed by a postsynaptic potential (PSP). Ten cells yielded no antidromic response, but showed PSPs sometimes associated with spikes. The morphological and physiological evidence obtained indicate that these PSP-generating cells were activated synaptically by centrifugal fibers and that in the lamprey retina, these fibers make contacts either with dendrites or somata of amacrine cells and probably with ganglion cell dendrites.
journal_name
Brain Resjournal_title
Brain researchauthors
Vesselkin NP,Repérant J,Kenigfest NB,Rio JP,Miceli D,Shupliakov OVdoi
10.1016/0006-8993(89)90999-2subject
Has Abstractpub_date
1989-07-24 00:00:00pages
51-65issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)90999-2journal_volume
493pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of continuous clonidine infusion (10 micrograms/kg/h for 10 days) and the cessation of this infusion on the circadian body temperature rhythm of the spontaneously hypertensive (SH) rat were examined. This circadian rhythm was blunted significantly during the infusion of clonidine. The fall in body temperat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91088-7
更新日期：1986-10-22 00:00:00
abstract：:The hippocampal formation is a highly plastic brain region that is sensitive to stress. It receives extensive noradrenergic projections, and noradrenaline is released in the hippocampus in response to stressor exposure. The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.01.084
更新日期：2010-04-06 00:00:00
abstract：:Altered noradrenergic function is associated with alcoholism. Reduced brain norepinephrine (NE) concentrations and beta-adrenergic receptor supersensitivity following chronic alcohol consumption suggest a reduced level of noradrenergic neurotransmission. To further elucidate the reason for changes in noradrenergic fun...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90199-6
更新日期：1994-07-04 00:00:00
abstract：:After an intraventricular administration of colchicine, the arcuate nucleus of rat hypothalamus was examined light and electron microscopically by pre-embedding immunohistochemistry for somatostatin. The arcuate nucleus exhibited numerous immunoreactive cell bodies and dense networks of immunoreactive fibers. The fibe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90312-8
更新日期：1983-03-21 00:00:00
abstract：:Our previous studies have shown that there is a lower cGMP concentration in the aged brain as well as an alteration in the activity of cGMP-hydrolyzing phosphodiesterases (PDEs) and nitric oxide synthase (NOS). The aim of this study was to investigate the effect of specific inhibitors of selected PDEs on object recogn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.108
更新日期：2008-06-24 00:00:00
abstract：:The aim of this study was (i) to compare the immunocytochemical distribution of the calcium-binding protein calbindin-D28k (CB) in the hippocampus of rats with the pattern of neurodegeneration following adrenalectomy (ADX) using silver impregnation, and (ii) to investigate the CB-immunoreactivity in the hippocampus fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00783-m
更新日期：1995-10-23 00:00:00
abstract：:The Timm and selenium staining techniques, based on silver amplification of endogenous zinc, produce an electron-dense precipitate in boutons. The staining characteristics of the two methods were compared by examining two allocortical regions, prepiriform cortex and entorhinal cortex, in the brain of the European hedg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90361-0
更新日期：1985-11-25 00:00:00
abstract：:The present study describes the biochemical changes, morphological development and the cerebrospinal fluid dynamics of the kaolin-induced hydrocephalus in the adult rat. Two, 4 and 6 weeks after microsurgical kaolin instillation into the rat cisterna magna the basal intracranial pressure and the cerebrospinal fluid ou...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03320-0
更新日期：2002-02-08 00:00:00
abstract：:In the urethane-anesthetized rat both electrical stimulation (20 microA, 0.2 ms, 30 s) through micropipettes and glutamate injections (0.1 M, 100 nl) within an area including the dorsal lateral parabrachial nucleus, the adjacent central lateral parabrachial nucleus, the external lateral parabrachial nucleus, the Kölli...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90570-7
更新日期：1988-10-18 00:00:00
abstract：:The trisomy-16 mouse is considered to be a model of human trisomy-21 (Down syndrome). We have examined the electrical membrane properties of cultured dorsal root ganglion (DRG) neurons from normal and trisomy-16 fetuses. Trisomy-16 neurons had significantly accelerated rates of action potential depolarization and repo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90678-1
更新日期：1989-04-17 00:00:00
abstract：:Large neuronal perikarya isolated in bulk fractions from adult bovine ventral spinal cord and examined by electron microscopy have discontinuities in their plasma membrane. A systematic investigation of the possible causes of the membrane defects indicates that the act of mechanical dissociation of the neurons from th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90108-7
更新日期：1978-12-22 00:00:00
abstract：:Traumatic brain injury (TBI) affects 2.8 million people annually in the United States, with significant populations suffering from ongoing cognitive dysfunction. Impairments in decision-making can have major implications for patients and their caregivers, often enduring for years to decades, yet are rarely explored in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.004
更新日期：2019-02-01 00:00:00
abstract：:Regional brain glucose utilization was investigated in lean and fatty Zucker rats when feeding status was changed. Ad-lib-fed fat rats exhibited lower glucose utilization in the central amygdala than ad-lib-fed lean rats. Food deprivation for 72 h enhanced glucose utilization in the ventromedial hypothalamus, lateral ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90628-2
更新日期：1988-12-20 00:00:00
abstract：:Hypothalamic stimulation generally inhibits baroreflex-induced bradycardia. However, we have noted discrete areas of the rat hypothalamus which facilitate reflex bradycardia. The effects of hypothalamic stimulation on baroreflex-induced changes in heart rate were investigated in urethane-anesthetized rats (1.2 g/kg, i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91163-7
更新日期：1986-10-08 00:00:00
abstract：:The anatomical distribution of L-[3H]glutamate binding sites was determined in the presence of various glutamate analogues using quantitative autoradiography. The binding of L-[3H]glutamate is accounted for by the presence of 3 distinct binding sites when measured in the absence of Ca2+, Cl- and Na+ ions. The anatomic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90936-9
更新日期：1985-08-12 00:00:00
abstract：:Histochemical investigation by means of light and electron microscopy revealed the presence of dipeptidylpeptidase IV activity in Meissner corpuscles of macaque glabrous skin. The enzyme activity was found in fibroblast-like cells forming an incomplete capsule around the Meissner corpuscle. Distinct electron-dense rea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90739-1
更新日期：1988-09-27 00:00:00
abstract：:In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.030
更新日期：2015-11-02 00:00:00
abstract：:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90117-8
更新日期：1983-12-12 00:00:00
abstract：:The axonal arborizations of the basket cells in the cerebral neocortex have long been considered as the source of the presynaptic terminals contacting the cell bodies of pyramidal cells. Given that the concept of the cortical basket cell is based upon indirect evidence only, it was deemed worthwhile to re-investigate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90898-8
更新日期：1982-07-22 00:00:00
abstract：:The respiratory role of GABA(A), GABA(B) and glycine receptors within the Bötzinger complex (BötC) and the pre-Bötzinger complex (preBötC) was investigated in alpha-chloralose-urethane anesthetized, vagotomized, paralysed and artificially ventilated rabbits by using bilateral microinjections (30-50 nl) of GABA and gly...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.05.032
更新日期：2010-07-16 00:00:00
abstract：:The aim of this study was to assess the effect of Alzheimer's disease has on the functional integrity of several signal transduction proteins. The relative levels of the G-protein alpha subunits Gs alpha-L, Gs alpha-S, Gi alpha-2 and G(o) alpha were measured by western blotting and found to be unchanged in membranes p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90798-r
更新日期：1993-09-17 00:00:00
abstract：:The role of subcortical input and/or output pathways in the development of cortical networks was examined in organotypic tissue cultures derived from neonatal mouse brain. Comparisons were made between cultures of cerebral neocortex grown with large amounts of subcortical tissue and those that were completely isolated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91631-8
更新日期：1986-02-19 00:00:00
abstract：:Results from the application of a procedure that allows simultaneous estimation of the rates of glucose transport from blood and of glucose phosphorylation in discrete regions of the brain are given for groups of rats displaying chemically induced motor disturbances. The procedure is based on sequential injections of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90782-4
更新日期：1981-09-28 00:00:00
abstract：:Glial cells play a crucial role in the pathomechanism of perinatal hypoxic-ischemic brain injury (HI) and are involved in the maintenance of a chronic state of inflammation that causes delayed neuronal damage. Activation of astrocytes is one factor prolonging brain damage and contributing to the formation of a glial s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.05.066
更新日期：2012-12-03 00:00:00
abstract：:In synaptosomal preparations from rat cerebral cortex, ouabain-sensitive Rb+ uptake was stimulated by ethanol (20-80 mM). Based on differential sensitivity to ouabain, 80% of this Na+,K(+)-ATPase activity represented activity of the alpha 1 isozyme while 20% was due to the alpha 2 and/or alpha 3 isozymes (alpha 2/ alp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90386-7
更新日期：1994-08-08 00:00:00
abstract：:Brain capillaries form a selective interface, the blood-brain barrier (BBB), between the neural parenchyma and the blood. The factors which regulate this interface are poorly understood. Both the iris and retina possess vascular beds that express some BBB characteristics; therefore, they provide attractive models to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91323-k
更新日期：1993-12-03 00:00:00
abstract：:Unilateral nigrostriatal lesions were performed in rats by punctate injection of 6-hydroxydopamine. Lesioned animals exhibited anorexia and weight loss for 7-11 days after surgery. These animals then displayed normal rate of weight gain. However, there was a chronic depression of body weight in the lesioned animals re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90195-0
更新日期：1977-09-02 00:00:00
abstract：:Proliferating astrocytes and proliferating neuroblasts have been observed in the subgranular zone (SGZ) of the dentate gyrus (DG) in the hippocampus of adult rats under normal conditions. However, whether these proliferating cells are stimulated by running has not been determined. Using immunohistochemical techniques,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.066
更新日期：2006-08-09 00:00:00
abstract：:Rhesus monkeys were taught to make identical wrist flexion and extension movements in response to either a visual cue or to vibratory cues. Changes in firing rates that were not stimulus-associated but preceded the movements were measured for each primary somatosensory cortical neuron recorded under the two stimulus c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90346-6
更新日期：1989-04-10 00:00:00
abstract：:This study investigated the effects of morphine microinjection into the nucleus raphe magnus (RMg) on electrically evoked C-fiber activities of convergent neurons in the spinal trigeminal nucleus oralis (Sp5O), in halothane-anesthetized rats. Although the neurons could be depressed by systemic morphine (6 mg/kg, i.v.)...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00659-3
更新日期：1998-08-24 00:00:00
