Effect of food deprivation on regional brain glucose utilization in lean and fatty Zucker rats.

Abstract:

:Regional brain glucose utilization was investigated in lean and fatty Zucker rats when feeding status was changed. Ad-lib-fed fat rats exhibited lower glucose utilization in the central amygdala than ad-lib-fed lean rats. Food deprivation for 72 h enhanced glucose utilization in the ventromedial hypothalamus, lateral hypothalamic area of both phenotypes, hippocampus of fat rats, mammillary body and ventral tegmental area of leans. These results suggest association of the central amygdala with the development of genetic obesity and of the latter 5 areas with hunger-motivated behaviors.

journal_name

Brain Res

journal_title

Brain research

authors

Tsujii S,Nakai Y,Takahashi H,Usui T,Koh T,Yonekura Y,Konishi J,Imura H

doi

10.1016/0006-8993(88)90628-2

subject

Has Abstract

pub_date

1988-12-20 00:00:00

pages

371-5

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(88)90628-2

journal_volume

475

pub_type

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