Abstract：
:Despite a blood-brain barrier for norepinephrine, the concentration of norepinephrine in plasma and cerebrospinal fluid has been observed to be similar. This relationship between plasma and cerebrospinal fluid norepinephrine levels suggest that peripheral sympathetic neurons innervating blood vessels to brain and spinal cord may contribute significantly to cerebrospinal fluid norepinephrine levels, and questions the validity of cerebrospinal fluid norepinephrine as an index of central nervous system noradrenergic activity. We demonstrate that extensive destruction of the peripheral sympathetic nervous system and the adrenal medulla has no effect on rat cerebrospinal fluid norepinephrine. It is therefore unlikely that peripheral sources of norepinephrine contribute significantly to cerebrospinal fluid norepinephrine levels.
journal_name
Brain Resjournal_title
Brain researchauthors
Peskind ER,Raskind MA,Wilkinson CW,Flatness DE,Halter JBdoi
10.1016/0006-8993(86)91600-8subject
Has Abstractpub_date
1986-03-05 00:00:00pages
258-64issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(86)91600-8journal_volume
367pub_type
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