Differentiation of neurochemical basis of stress-induced analgesia in mice by selective breeding.

abstract：:We investigated whether somatostain modulates the generation of long-term potentiation (LTP) in rat perforant path-dentate gyrus synapse in vivo. When somatostatin was injected intracerebroventricularly (i.c.v.) 20 min prior to the tetanus, the intensity of LTP increased dose dependently. Synaptic potential evoked by ...

journal_title：Brain research

authors： Nakata A,Saito H,Nishiyama N

更新日期：1996-06-03 00:00:00

abstract：:Immunolabelling for synaptophysin and chromogranin A, two polypeptides associated with small clear and large dense core synaptic vesicles respectively, has been performed on tissue sections of the temporal cortex in Alzheimer's disease in combination with anti-A4 amyloid labelling. The dystrophic neurites in many seni...

journal_title：Brain research

authors： Brion JP,Couck AM,Bruce M,Anderton B,Flament-Durand J

更新日期：1991-01-18 00:00:00

abstract：:Previous studies we performed on the mdx mouse demonstrated marked central nervous system alterations in this model of human Duchenne muscular dystrophy, such as reduction in number and pathological changes of cortico-spinal neurons. Prompted by these findings we extended the survey of the mdx brain to the major brain...

journal_title：Brain research

authors： Carretta D,Santarelli M,Vanni D,Carrai R,Sbriccoli A,Pinto F,Minciacchi D

更新日期：2001-03-23 00:00:00

abstract：:Unilateral injections of 6-hydroxydopamine into the lateral hypothalamus or ventral tegmental area that damage extensively the mesotelencephalic dopaminergic projection result in significant hemispheric asymmetries in autoradiographic labeling after [14C]2-deoxy-D-glucose (2DG) administration. The incorporation of thi...

journal_title：Brain research

authors： Kozlowski MR,Marshall JF

更新日期：1980-09-15 00:00:00

abstract：:Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...

journal_title：Brain research

authors： Kessler M,Mutneja MS,Rogers G,Lynch G

更新日期：1998-02-02 00:00:00

abstract：:The mouse auditory neurons, hair cells and their supporting cells in the cochlea are considered to be generated mainly in the embryonic days and to be sustained throughout the whole life. In the present study, however, we observed that auditory ganglion cells in the spiral ganglia undergo apoptosis and mitosis in the ...

journal_title：Brain research

authors： Kamiya K,Takahashi K,Kitamura K,Momoi T,Yoshikawa Y

更新日期：2001-05-18 00:00:00

abstract：:The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats hav...

journal_title：Brain research

authors： Aravich PF,Sladek CD

更新日期：1986-10-22 00:00:00

abstract：:Repeated intermittent administration of amphetamines acutely increases appetitive and consummatory aspects of motivated behaviors as well as general activity and exploratory behavior, including voluntary running wheel activity. Subsequently, if the drug is withdrawn, the frequency of these behaviors decreases, which i...

journal_title：Brain research

authors： Kitanaka N,Kitanaka J,Hall FS,Uhl GR,Watabe K,Kubo H,Takahashi H,Tatsuta T,Morita Y,Takemura M

更新日期：2012-01-06 00:00:00

abstract：:In the present experiment we tested the hypothesis that early interference with noradrenaline transmission can have permanent consequences for brain function in adulthood. Neonatal depletion of noradrenaline by daily subcutaneous injections of clonidine results in supersensitivity to noradrenaline in adult hippocampal...

journal_title：Brain research

authors： Gorter JA,Kamphuis W,Huisman E,Bos NP,Mirmiran M

更新日期：1990-12-03 00:00:00

abstract：:Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...

journal_title：Brain research

authors： Long DA,Ghosh K,Moore AN,Dixon CE,Dash PK

更新日期：1996-04-22 00:00:00

abstract：:Lamprey retriculospinal neurons show phasic oscillations of their membrane potential during fictive locomotion. This modulation originates from the spinal cord locomotor networks. The aim of the present study was to elucidate the pattern of discharge of the spino-bulbar axons responsible for this modulation. Experimen...

journal_title：Brain research

authors： Vinay L,Grillner S

更新日期：1992-06-05 00:00:00

abstract：:In the present study we evaluated the role of NMDA receptors on the pressor and bradycardic responses to L-glutamate (L-Glu) microinjected into the nucleus tractus solitarius (NTS) of unanesthetized rats. L-Glu (1 nmol/100 nl) was microinjected into the NTS before and 10 min after microinjection of phosponovaleric aci...

journal_title：Brain research

authors： Colombari E,Bonagamba LG,Machado BH

更新日期：1997-02-28 00:00:00

abstract：:The effect of lead as a neurotoxic agent has been associated with alterations in calcium metabolism. On this line, the present study shows that lead alters the characteristics of [3H]nitrendipine ([ 3H]NDP) binding to rat striatal membranes. In vitro, lead shares the action of calcium in enhancing [3H]NDP binding alth...

journal_title：Brain research

authors： Rius RA,Lucchi L,Govoni S,Trabucchi M

更新日期：1984-11-19 00:00:00

abstract：:Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cy...

journal_title：Brain research

authors： De Montis MG,Gambarana C,Meloni D,Taddei I,Tagliamonte A

更新日期：1993-03-19 00:00:00

abstract：:Based on pharmacological evidence that inhibitory amino acids mediate vaginocervical mechano-stimulation produced analgesia (VSPA), we hypothesized that inhibitory amino acids would be released endogenously in the spinal cord in response to vaginocervical mechano-stimulation (VS). This hypothesis was tested by HPLC an...

journal_title：Brain research

authors： Masters DB,Jordan F,Beyer C,Komisaruk BR

更新日期：1993-09-10 00:00:00

abstract：:The ability to detect and cope with unpredictable novel events is fundamental for adapting to a rapidly changing environment and ensuring the survival of the organism. Despite knowledge of gender differences in emotional processing, little is currently known about the impact of gender on neural processing of emotion-i...

journal_title：Brain research

authors： Yuan J,Xu S,Li C,Yang J,Li H,Yuan Y,Huang Y

更新日期：2012-02-09 00:00:00

abstract：:Neonatal hypoxia-ischemia (HI) has been extensively studied in a rat model characterized by unilateral brain damage (Rice-Vannucci Model). However, as well as in humans, each rat brain hemisphere is distinctly involved in cognitive functions, as for example retrieval of emotionally based memory, and neurochemical asym...

journal_title：Brain research

authors： Arteni NS,Salgueiro J,Torres I,Achaval M,Netto CA

更新日期：2003-05-30 00:00:00

abstract：:In the present study, uptake of glutamine by rat cerebellar granule cells, a predominantly glutamatergic nerve cell population, has been investigated. Glutamine is taken up by granule cells via at least three transport systems, A, ASC and L. The L-type low affinity system (K(m) = 2.6 mM) is the major transport system ...

journal_title：Brain research

authors： Su TZ,Campbell GW,Oxender DL

更新日期：1997-05-16 00:00:00

abstract：:The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...

journal_title：Brain research

authors： Tan HS,van Neerven J,Collewijn H,Pompeiano O

更新日期：1991-10-25 00:00:00

abstract：:The effects of naltrexone, naltrindole (a selective delta opiate receptor antagonist) and beta-funaltrexamine (beta-FNA; a selective mu opiate receptor antagonist) on alcohol intake by C57BL/6 mice in a restricted access paradigm were examined. During the pretreatment baseline phase, mice consumed an average of 1.3 g/...

journal_title：Brain research

authors： Lê AD,Poulos CX,Quan B,Chow S

更新日期：1993-12-10 00:00:00

abstract：:To assess the role of androgen-dependent brain vasopressinergic transmission in the modulation of social recognition, castrated male rats which are deficient in vasopressin were implanted intracerebroventricularly with an Accurel collodion mini-device containing 10 micrograms vasopressin (AVP) whereas intact male rats...

journal_title：Brain research

authors： Bluthé RM,Dantzer R

更新日期：1992-02-14 00:00:00

abstract：:Altered dopamine regulation in the medial prefrontal cortex has been linked to drug abuse and disorders such as schizophrenia. Heterogeneous expression of the dopamine transporter, as well as the ability of the norepinephrine transporter to clear dopamine in the prefrontal cortex, delineates two potential sites for th...

journal_title：Brain research

authors： Mazei MS,Pluto CP,Kirkbride B,Pehek EA

更新日期：2002-05-17 00:00:00

abstract：:Cortistatin (CST) is a recently described neuropeptide with high structural homology with somatostatin. Its mRNA is restricted to gamma amino butyric acid (GABA)-containing cells in the cerebral cortex and hippocampus. CST modulates the electrophysiology of the hippocampus and cerebral cortex of rats; hence, it may be...

journal_title：Brain research

authors： Sánchez-Alavez M,Gómez-Chavarín M,Navarro L,Jiménez-Anguiano A,Murillo-Rodríguez E,Prado-Alcalá RA,Drucker-Colin R,Prospéro-García O

更新日期：2000-03-06 00:00:00

abstract：:Dopaminergic and glutamatergic afferents simultaneously innervate median spiny neurons (MSNs) and interact to mediate basal ganglia functions. However, the association between dopaminergic and glutamatergic axons is not clear. In the present study, nigrostriatal, corticostriatal, and thalamostriatal axons were anterog...

journal_title：Brain research

authors： Xu C,Zhao J,Liu Y,Zeng X,Jia Y,Wang Y,Jiang X,Xu Q

更新日期：2012-11-27 00:00:00

abstract：:Circular RNAs (circRNAs) are a class of covalently closed non-coding RNAs, and aberrant alteration of their expression patterns is studied in numerous diseases. This study aimed to investigate whether intracerebral hemorrhage (ICH) affected circRNA expression profiles in the rat brain. Adult male Sprague-Dawley rats w...

journal_title：Brain research

authors： Dou Z,Yu Q,Wang G,Wu S,Reis C,Ruan W,Yan F,Chen G

更新日期：2020-01-01 00:00:00

abstract：:Growth factor-dependent proliferation of neuronal progenitors is an essential stage in CNS development. Although several of these growth factors have been identified, high levels of neuregulin 1 (NRG1) mRNA and protein expression in the CNS during the time of neuronal progenitor expansion suggest NRG1 growth factors m...

journal_title：Brain research

authors： Edwards JM,Bottenstein JE

更新日期：2006-09-07 00:00:00

abstract：:We have investigated the role of NMDA receptors in the rat dorsal horn in mediating neuronal responses to noxious hindlimb ischemia, induced by acute occlusion of the femoral artery, as well as in the hyperalgesia evident when noxious mechanical stimuli were applied to the ischemic limb. Two specific NMDA antagonists,...

journal_title：Brain research

authors： Sher GD,Mitchell D

更新日期：1990-07-02 00:00:00

abstract：:Hormone-dependent sociosexual behaviors of the displaying individual regulate the abundance of estrogen receptor- and progesterone receptor-mRNA in sex steroid hormone-concentrating brain areas of the partner. This effect of behavior on gene expression in the brain is independent of the gonads. ...

journal_title：Brain research

authors： Hartman V,Crews D

更新日期：1996-11-25 00:00:00

abstract：:Repeated administration of subconvulsant doses of lidocaine or cocaine results in the development of an increased susceptibility to seizures induced by the two drugs (pharmacological kindling). It has been hypothesized that the local anesthetic properties of cocaine are responsible for its convulsant and epileptogenic...

journal_title：Brain research

authors： Marley RJ,Witkin JM,Goldberg SR

更新日期：1991-10-25 00:00:00

abstract：:Neurons located in the nucleus raphe magnus (NRM), a region important in the control of nociception, appear to be tonically inhibited by noradrenergic (NA) neurons. Anatomical studies have suggested that the A5 catecholamine nucleus may be the primary source of noradrenergic neurons whose terminals are located in the ...

journal_title：Brain research

authors： Sagen J,Proudfit HK

更新日期：1986-04-02 00:00:00