Abstract:
:Endothelins are potent vasoconstrictors and signaling molecules. Their effects are broad, impacting processes ranging from neurovascular and cardiovascular health to cell migration and survival. In stroke, traumatic brain injury or subarachnoid hemorrhage, endothelin-1 (ET-1) is induced resulting in cerebral vasospasm, ischemia, reperfusion and the activation of various pathways. Given the central role that ET-1 plays in these patients and to identify the downstream molecular events specific to transient vasoconstriction, we studied the consequences of ET-1-mediated vasoconstriction of the middle cerebral artery in a rat model. Our observations demonstrate that ET-1 can lead to increases in gene expression, including genes associated with the inflammatory response (Ifnb, Il6, Tnf) and oxidative stress (Hif1a, Myc, Sod2). We also observed inductions (>2 fold) of genes involved in eicosanoid biosynthesis (Pla2g4a, Pla2g4b, Ptgs2, Ptgis, Alox12, Alox15), heme metabolism (Hpx, Hmox1, Prdx1) and iron homeostasis (Hamp, Tf). Our findings demonstrate that mRNA levels for the hormone hepcidin (Hamp) are induced in the brain in response to ET-1, providing a novel target in the treatment of multiple conditions. These changes on the ipsilateral side were also accompanied by corresponding changes in a subset of genes in the contralateral hemisphere. Understanding ET-1-mediated events at the molecular level may lead to better treatments for neurological diseases and provide significant impact on neurological function, morbidity and mortality.
journal_name
Brain Resjournal_title
Brain researchauthors
Bickford JS,Ali NF,Nick JA,Al-Yahia M,Beachy DE,Doré S,Nick HS,Waters MFdoi
10.1016/j.brainres.2014.09.022subject
Has Abstractpub_date
2014-11-07 00:00:00pages
25-36eissn
0006-8993issn
1872-6240pii
S0006-8993(14)01233-5journal_volume
1588pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::Frequency modulation (FM) is an important building block of complex sounds that include speech signals. Exploring the neural mechanisms of FM coding with computer modeling could help understand how speech sounds are processed in the brain. Here, we modeled the single unit responses of auditory neurons recorded from th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.04.058
更新日期:2013-11-06 00:00:00
abstract::Three groups of rats, one with amygdala lesions, one with hippocampal lesions and a control group were trained on a brightness discrimination task under one of three different conditions, enhancement of the negative cue, enhancement of the positive cue or a non-enhanced condition. Animals with amygdala lesions showed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90621-7
更新日期:1977-04-15 00:00:00
abstract::The effects of infusing N-methyl-d-aspartate (NMDA) into the raphe nuclei on release of 5-HT in this brain region and also the frontal cortex of the same animal were studied using in vivo microdialysis in freely moving rats. Infusion of 25 microM NMDA into the raphe led to a substantial decrease in dialysate 5-HT in t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01333-4
更新日期:1998-02-09 00:00:00
abstract::Intracellular transport of newly synthesized proteins through organelles in the perikarya of regenerating goldfish retinal ganglion cells was studied using electron microscopic autoradiography. Retinas were removed 14 or 30 days after optic tract cut or sham operation, pulse-labeled in [3H]proline-containing medium fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90832-0
更新日期:1982-05-06 00:00:00
abstract::The neuroprotective effects of N-stearoyl-L-tyrosine (NSTyr) on cognitive function and neuronal plasticity during chronic cerebral hypoperfusion (CCH) in rats were investigated. After induction of CCH, NSTyr was administered daily for 3 months intraperitoneally. Cognitive functions were evaluated by Morris water maze ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.037
更新日期:2010-04-14 00:00:00
abstract::The second messenger cyclic GMP (cGMP) plays a role in the anxiolytic-like behavioral response of mice to nitrous oxide (N2O). This study was conducted to determine whether this behavioral effect of N2O is affected by inhibition of cGMP-dependent protein kinase (PKG). N2O-induced behavior in the light/dark exploration...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.01.015
更新日期:2005-03-15 00:00:00
abstract::Oxidative stress has been suggested to play a key role in the neuropathogenesis of HIV infection. HIV proteins (gp120, Tat) and proinflammatory cytokines can trigger the production of reactive oxygen species (ROS), resulting in DNA and RNA lesions. Among all the lesions induced by ROS, one of the most abundant lesions...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.001
更新日期:2012-06-06 00:00:00
abstract::Dynorphin and other kappa opioid agonists are thought to elicit aversive actions and changes in motor activity through direct or indirect modulation of dopamine neurons in ventral tegmental area (VTA) and substantia nigra (SN), respectively. We comparatively examined the immunoperoxidase localization of anti-dynorphin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90693-h
更新日期:1993-02-05 00:00:00
abstract::Brains of reptiles, Caiman crocodilus, were processed by standard immunocytochemical methodology using a polyclonal antibody to gamma-aminobutyric acid (GABA) raised in rabbit and a polyclonal antibody to glutamic acid decarboxylase (GAD) raised in sheep. No GABA(+) or GAD(+) cells or puncta were observed over any tha...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90068-6
更新日期:1988-08-02 00:00:00
abstract::After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.08.048
更新日期:2014-10-24 00:00:00
abstract::Previous work has shown that administration of corticotropin-releasing factor (CRF) into the lateral ventricle antagonizes the orexigenic effect of neuropeptide Y (NPY), and central injection of CRF antagonist, alpha-helical CRF(9-41) enhanced NPY-induced food intake in satiated rats. The aim of the present study was ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90431-l
更新日期:1993-07-30 00:00:00
abstract::Mutant Cu/Zn superoxide dismutase (SOD1) associated with familial amyotrophic lateral sclerosis (FALS) causes selective motor neuron loss through unknown mechanisms of cell damage. Damaged neurons frequently undergo apoptosis mediated by the p53 cell survival regulator. We therefore studied whether motor neuron diseas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02745-1
更新日期:2000-10-06 00:00:00
abstract::Metallothioneins (MTs) are metal-binding proteins that are expressed in many tissues including brain. MTs protect cells and organs against metal toxicity and oxidants. Among MTs, a brain-predominant subtype MT-III has prominent neuroprotective activity against various types of damage. Here we show that the expression ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02633-7
更新日期:2003-06-20 00:00:00
abstract::Using a double-labelling procedure, morphological relationships existing between dopaminergic and indoleaminergic neuronal systems in the rat brain were investigated. First, thanks to a tryptamine (T) antiserum, we visualized this indoleamine in all mesencephalic regions and showed that the T-immunoreactivity (IR) see...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91182-g
更新日期:1990-03-26 00:00:00
abstract::From measured effects of amino acids on synaptosomal tyrosine uptake and from published data on human CNS levels of amino acids hypothetical calculations were made to compare CNS tyrosine availability for catecholamine synthesis in the hyperphenylalaninemic and non-hyperphenylalaninemic condition. These calculations i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90380-3
更新日期:1983-08-01 00:00:00
abstract::Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91422-2
更新日期:1985-12-16 00:00:00
abstract::The amygdala is a bilateral temporal lobe brain region which plays an important role in emotional processing. Past studies on the amygdala have shown hemispheric differences in amygdalar processes and responses associated with specific pain and fear behaviors. Despite the functional differences in the amygdala, few st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.10.028
更新日期:2018-01-01 00:00:00
abstract::The present paper examines the hypothesis that the long latency EMG activity produced by muscle stretch is the result of long loop reflex pathways involved in the control of limb stiffness. We recorded the cerebral responses and late EMG activity in agonist and antagonist muscles following sudden stretch of the wrist ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91159-c
更新日期:1992-08-28 00:00:00
abstract::This study aimed at gaining insight into the role of the excitatory neurotransmitter glutamate in topographic map reorganization in the sensory systems of adult mammals after restricted deafferentations. Hereto, in vivo microdialysis was used to sample extracellular glutamate from sensory-deprived and non-deprived vis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)04047-7
更新日期:2003-02-07 00:00:00
abstract::Distribution of adult T cell leukemia derived factor (ADF/TRX), a human thioredoxin homologue, was studied by immunohistochemistry in gerbil brain during reperfusion after transient cerebral ischemia. In control brains, immunoreactivity was observed widely in the central nervous system, including the ependyma, tanycyt...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90130-f
更新日期:1993-10-15 00:00:00
abstract::The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91533-1
更新日期:1985-02-18 00:00:00
abstract::Combined amylin+leptin (AMN+LEP) can reduce diet induced obesity and is very effective in combating LEP resistance. The purpose of this study was to evaluate the effect of AMN+LEP on central histaminergic signaling in lean and obese rats. Male rats were administered LEP (300 μg/kg/d), AMN (100 μg/kg/d), AMN+LEP or veh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.12.022
更新日期:2012-03-09 00:00:00
abstract::Electrical stimulation of the chorda tympani nerve (CT; innervating taste buds on the rostral tongue) is known to initiate recurrent inhibition in cells in the nucleus of the solitary tract (NTS, the first central relay in the gustatory system). Here, we explored the relationship between inhibitory circuits and the br...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.03.069
更新日期:2009-06-12 00:00:00
abstract::The present study investigated the neuroprotective potential of two novel polyamine analogues, BU43b and BU36b, when administered 30 min prior to cerebral ischaemia. Neuroprotection in a permanent and a transient focal cerebral ischaemia mouse model (induced by intraluminal middle cerebral artery occlusion (MCAO)) was...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.097
更新日期:2006-03-03 00:00:00
abstract::Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.06.073
更新日期:2009-09-08 00:00:00
abstract::Rats exposed to inescapable tailshock exhibit deficits in learning a simple shuttlebox escape task 24 h later. This syndrome has been termed 'behavioral depression' or 'learned helplessness', and is a model of stress-induced depression. In the present study a significant (25%) decrease in GABA receptor-mediated chlori...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90938-4
更新日期:1989-05-15 00:00:00
abstract::Recent evidence has suggested that cholecystokinin (CCK) may act as a physiological opiate antagonist. Both the overlap of CCK and opiate systems within the central nervous system and the fact that exogenous CCK can antagonize opiate analgesia suggest that endogenous CCK systems interact with opiate-mediated pain inhi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91511-2
更新日期:1985-02-18 00:00:00
abstract::To elucidate the intracellular mechanism of seizure discharge, phosphorylation of cellular protein during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. PTZ markedly enhanced the phosphorylation of proteins of 34,000 and 50,000 molecular weight. Similar effects were observed by a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91395-8
更新日期:1986-01-01 00:00:00
abstract::A comparison of morphological and biochemical characteristics of the D1-type dopamine receptor has been assessed in two experimental tissues, the superior cervical ganglion (SCG) and caudate nucleus of the rat. Correlation of the distribution of this dopaminergic binding site using in vitro autoradiographic localizati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91294-7
更新日期:1987-09-22 00:00:00
abstract::The mitochondrial respiratory chain is a powerful source of reactive oxygen species (ROS) also in noise induced hearing loss (NIHL) and anti-oxidants and free-radicals scavengers have been shown to attenuate the damage. Coenzyme Q(10) (CoQ(10)) or ubiquinone has a bioenergetic role as a component of the mithocondrial ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.12.027
更新日期:2009-02-27 00:00:00