Abstract：
:Galectin-3 (Gal-3) is a member of a class of carbohydrate-binding proteins and plays a role in a number of cellular functions such as cell proliferation, angiogenesis and differentiation. We observed an up-regulated expression of Gal-3 in the ischemic brain following transient middle cerebral artery occlusion in rats. Compared to the brain of sham-operated rats, the expression of Gal-3 was increased in the ischemic striatum at day 1 of reperfusion. The number of Gal-3+ cells in the ischemic brain was further increased at day 2 and day 3, and peaked at day 7 of reperfusion. The up-regulated expression of Gal-3 persisted from day 14 to 2 months after reperfusion. Double staining showed co-localization of Gal-3 with OX-42+ cells, glial fibrillary acidic protein (GFAP)+ and ED1+ cells, suggesting that activated microglia/infiltrating macrophages and activated astrocytes are the primary source of Gal-3 in the ischemic brain. In the in vitro setting, Gal-3 treatment dose-dependently stimulated the proliferation of endothelial cells and neural progenitors. Blockade of Gal-3 activity by infusing a neutralizing antibody against Gal-3 into the ischemic striatum decreased ischemia-induced angiogenesis and the proliferation of neural progenitors. These results suggest that Gal-3 expressed by activated microglia/infiltrating macrophages and astrocytes in the ischemic brain may play a role in post-ischemic tissue remodeling by enhancing angiogenesis and neurogenesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Yan YP,Lang BT,Vemuganti R,Dempsey RJdoi
10.1016/j.brainres.2009.06.073subject
Has Abstractpub_date
2009-09-08 00:00:00pages
116-24eissn
0006-8993issn
1872-6240pii
S0006-8993(09)01288-8journal_volume
1288pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg6, Sar9, Met(O2)11]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00940-r
更新日期：1995-11-27 00:00:00
abstract：:A Rous Sarcoma virus transformed cerebellar cell line, BC6, secretes a factor which causes clonal glial cell lines to rapidly (1 h) extend processes. The factor shows a degree of specificity since only 3 out of 10 lines which exhibit either glial or combined glial and neuronal properties respond. The active factor app...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90214-6
更新日期：1983-12-01 00:00:00
abstract：:The neural connections from the ventral pallidum (VP) through the mediodorsal nucleus of the thalamus (MD) to the medial prefrontal cortex (MPC) were investigated. Extracellular recordings were made from 219 neurons in the medial and lateral portions of the MD and the VP and the MPC were stimulated. The most frequent ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90811-x
更新日期：1985-10-07 00:00:00
abstract：:Antibodies binding to the 150 kDa neurofilament protein NF150 have been purified from a serum raised by immunizing a rabbit with alpha-MSH. The NF150-binding antibodies were purified by affinity chromatography on a column of cytoskeletal proteins coupled to CNBr-activated Sepharose-4B. Immunocytochemical application o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91365-5
更新日期：1987-02-24 00:00:00
abstract：:We previously reported that the antinociceptive effect of morphine on the thermal tail withdrawal reflex (tail flick, TF) was reduced in rats that had practiced the TF response prior to morphine administration. This phenomenon, termed behavioral tolerance, was observed even when rats were spinally transected following...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90342-7
更新日期：1992-05-22 00:00:00
abstract：:Nocistatin, a product of the same precursor as nociceptin/orphanin FQ (N/OFQ), has been shown to antagonize effects of N/OFQ. N/OFQ stimulates feeding, most probably by inhibiting activation of neurons containing oxytocin (OT) and vasopressin (VP), peptides considered as satiety factors, and implicated in the developm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02535-x
更新日期：2000-07-28 00:00:00
abstract：:Although dendritic release was first proposed in the 1970s, the mechanism of release is still subject to debate. We have used in vivo microdialysis to study the acute effects of botulinum toxin A, B and tetanus toxin injected in the substantia nigra or striatum of freely moving rats. Spontaneous and evoked dopamine re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03047-0
更新日期：2002-09-20 00:00:00
abstract：:The syndrome of benign familial neonatal convulsions (BFNC) is characterized by seizures starting within the first days of life and disappearing within weeks to months. BFNC is caused by loss-of-function mutations in the potassium channels KCNQ2 and KCNQ3 which can well explain the resulting neuronal hyperexcitability...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.023
更新日期：2006-03-10 00:00:00
abstract：:Commissural and ipsilateral intrinsic connections of the vestibular nuclear complex of cats were investigated using retrograde transport of horseradish peroxidase (HRP). HRP was microiontophoretically injected into limited areas (0.2-0.5 mm in diameter) of the respective vestibular nuclei. In the commissural connectio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91474-x
更新日期：1985-08-19 00:00:00
abstract：:Williams Syndrome (WS) is a neurodevelopment disorder associated with a hemizygous deletion on chromosome 7. WS is characterized with mental retardation, severe visual-spatial deficits, relative language preservation, and excellent facial recognition. Distinctive auditory features include musical ability, heightened s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.11.038
更新日期：2005-03-10 00:00:00
abstract：:The nucleus of the solitary tract (NTS) is a critical structure involved in coordinating autonomic and visceral activities. Previous independent studies have demonstrated efferent projections from the NTS to the nucleus paragigantocellularis (PGi) and the central nucleus of the amygdala (CNA) in rat brain. To further ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.051
更新日期：2006-10-30 00:00:00
abstract：:Earlier studies showed that pretreatment (3 and 6 h) of rats with the glucocorticoid hormone, dexamethasone, potentiated the drinking response to either central or peripheral administration of angiotensin II (AII). In the present study the specificity and mechanisms of this potentiation were examined. Intraperitoneal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90093-b
更新日期：1991-06-28 00:00:00
abstract：:Previous studies employing systemic administration of the dopamine agonist apomorphine have shown that the dose response curves for apomorphine's effects on penile reflexes and seminal emission differ, suggesting that experimentally separable populations of dopamine receptors regulate these two responses. The present ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90328-4
更新日期：1989-10-23 00:00:00
abstract：:Lesions of the anterior hypothalamus-medial preoptic area (AH-MPOA) impair courtship and copulatory behavior in male Cnemidophorus inornatus, a sexually reproducing species of whiptail lizard, and male-like pseudosexual behaviors in C. uniparens, an all-female species. These results suggest that, since C. inornatus is...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90046-9
更新日期：1994-04-18 00:00:00
abstract：:The glial cell line-derived neurotrophic factor (GDNF) exerts trophic actions on a number of cell types, including mesencephalic dopaminergic (mDA) neurons. Using rat mesencephalic primary cultures enriched in mDA neurons, we show that protracted GDNF stimulation increases their survival and neurite outgrowth. It modu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.071
更新日期：2007-07-23 00:00:00
abstract：:Soluble epoxide hydrolase (sEH) is the major enzyme responsible for the metabolism and inactivation of epoxyeicosatrienoic acids (EETs). EETs are produced by the cytochrome P450 (CYP) epoxygenase pathway of arachidonic acid (AA) metabolism and tend to be anti-hypertensive, anti-inflammatory and protective against isch...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.07.060
更新日期：2009-09-29 00:00:00
abstract：:A recent physiological report suggested that neurotensin could inhibit the vasopressin releasing from vasopressin-producing neurons in the hypothalamic paraventricular nucleus but not in the supraoptic nucleus. In the present study, the synaptic relationship between the neurotensin-like immunoreactive and vasopressin-...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01455-9
更新日期：1999-07-10 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is the predominant isoform of cyclooxygenase in brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that have many injurious effects. COX-2 transcription is induced by synaptic activity; therefore, COX-2 activity could contribute to epileptic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.038
更新日期：2005-07-19 00:00:00
abstract：:Brain serotonin (5-HT) uptake sites were quantitated, by saturation binding of [3H]paroxetine, in 10 brain regions from 22 suicide victims and 20 control subjects. Suicide victims were restricted to those subjects in whom a firm retrospective diagnosis of depression was established and who had not recently been prescr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90244-6
更新日期：1990-08-27 00:00:00
abstract：:This neuroimaging study investigated the neural mechanisms of the effect of conversation on visual event detection during a driving-like scenario. The static load paradigm, established as predictive of visual reaction time in on-road driving, measured reaction times to visual events while subjects watched a real-world...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.002
更新日期：2009-01-28 00:00:00
abstract：:Our previous study reported that cathepsin L may contribute to the death of dopaminergic neurons in rodent model of Parkinson's disease (PD). In this study we detected the changes in the expression of lysosomal cathepsin L in cellular models of PD. In human neuroblastoma SH-SY5Y cells, treatment with 6-hydroxydopamine...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.092
更新日期：2011-04-28 00:00:00
abstract：:The effect of lactic acidosis on calcium influx, accumulation and efflux was studied in primary cultures of neonatal cortical rat astrocytes. Treatment of cultures with 20 mM sodium lactate, pH 6.0, for 10-60 min resulted in a 35% reduction of 45Ca2+ influx. The decrease in calcium influx was pH dependent because a si...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90371-s
更新日期：1993-02-26 00:00:00
abstract：:Movements of medium and large sized membranous organelles (0.5-1 microns in diameter) were visualized within segments of the crab walking leg nerve with Nomarski differential interference contrast optics and subjected to video contrast enhancement. Accessibility to the axoplasm was demonstrated by intra-axonal fluores...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91754-g
更新日期：1993-03-12 00:00:00
abstract：:Lesions of the insular cortex (IC) attenuate acquisition of conditioned taste aversions (CTAs). We have suggested that this impairment is the expected consequence of a failure of IC-lesioned (ICX) rats to recognize unfamiliar taste stimuli as novel. That is, ICX rats treat novel taste stimuli as if they are familiar a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.058
更新日期：2009-03-09 00:00:00
abstract：:Adaptive decision making in dynamic social settings requires frequent re-evaluation of choice outcomes and revision of strategies. This requires an array of multiple cognitive abilities, such as working memory and response inhibition. Thus, the disruption of such abilities in schizophrenia can have significant implica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.08.049
更新日期：2007-11-14 00:00:00
abstract：:Several neurodevelopmental disorders, including schizophrenia, autism, ADD/ADHD and dyslexia are believed to originate during gestation and involve white matter abnormalities. Modulation of glutamate environments and glutamate receptors has also been implicated in alteration of oligodendrocytes, the myelin forming cel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.126
更新日期：2008-10-09 00:00:00
abstract：:The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 microg/kg) and high dose (125 micro...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02418-x
更新日期：2000-03-06 00:00:00
abstract：:The tegmentopontine reticular nucleus (nucleus of Bechterew) plays a crucial role in the generation of horizontal saccades and smooth pursuit movement of the eyes. The evolution of Alzheimer's disease-related cytoskeletal pathology was studied of this nucleus was studied in 27 autopsy cases at different stages of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02598-7
更新日期：2001-07-27 00:00:00
abstract：:Male and female hooded rats were raised from weaning in either a complex or an isolated environment in two separate replications. After one month, the brains were Golgi-Cox stained and dendritic fields of dentate gyrus granule cells were quantified. There was a sex difference in response to the environment. Females ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90125-8
更新日期：1985-04-29 00:00:00
abstract：:Previous studies on the processing of fractions and proportions focused mainly on the processing of their overall magnitude information in the intraparietal sulcus (IPS). However, the IPS is also associated with domain-general cognitive functions beyond processing overall magnitude, which may nevertheless be involved ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.029
更新日期：2019-07-01 00:00:00
