Abstract：
:Antibodies binding to the 150 kDa neurofilament protein NF150 have been purified from a serum raised by immunizing a rabbit with alpha-MSH. The NF150-binding antibodies were purified by affinity chromatography on a column of cytoskeletal proteins coupled to CNBr-activated Sepharose-4B. Immunocytochemical application of these antibodies, followed by a FITC-coupled second antibody, labels axons in intact and regenerating nerves and provides a means of identifying and counting small regenerating sprouts from 48 h after nerve crush. We have been able to demonstrate that treatment with the neurotrophic melanocortin analog, Org.2766, increases the number of regenerating axons present in the nerve as early as 72 h after nerve crush.
journal_name
Brain Resjournal_title
Brain researchauthors
Verhaagen J,Edwards PM,Jennekens FG,Schotman P,Gispen WHdoi
10.1016/0006-8993(87)91365-5subject
Has Abstractpub_date
1987-02-24 00:00:00pages
142-50issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91365-5journal_volume
404pub_type
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