Effect of pentylenetetrazol treatment on cholecystokinin mRNA and peptide levels in rat hippocampus and cortex.

abstract：:Previous research with deafferented subjects suggests that efference copy can be used to update limb position. However, the contributions of efference copy to limb localization are currently unclear. We examined the performance of JDY, a woman with severe, longstanding proprioceptive deficits from a sensory peripheral...

journal_title：Brain research

authors： Medina J,Jax SA,Brown MJ,Coslett HB

更新日期：2010-10-08 00:00:00

abstract：:The enzyme in brain that hydrolyzes 2',3'-cyclic nucleotides to the 2'-mononucleotides has been found by several authors to be concentrated in the myelin fraction. To facilitate further study of the enzyme, one of our objectives has been to develop a method of solubilizing the enzyme without the use of detergents. Whe...

journal_title：Brain research

authors： Guha A,Moore S

更新日期：1975-05-23 00:00:00

abstract：:The adult rat retina was evaluated following surgical lesion and after transplantation of embryonic day 15 (E15) retinal tissue. While a surgical incision caused degeneration and ganglion cell death peripheral to lesion site, the addition of an embryonic retinal implant to the lesion site resulted in a reduction of th...

journal_title：Brain research

authors： Laedtke TW,Turner JE

更新日期：1989-10-23 00:00:00

abstract：:The postnatal development of soma size and cytochrome oxidase activity was examined in the perigeniculate nucleus (PGN) and reticular nucleus of the thalamus (RNT). Neurons in the PGN and RNT exhibited a rapid increase in soma size between 2 and 4 weeks of age. During this period of cell growth there is an increase in...

journal_title：Brain research

authors： Murakami DM,Condo GJ,Wilson PD

更新日期：1987-10-01 00:00:00

abstract：:Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In the present study effects of minocycline, an anti-inflammatory agent, alone or in combination with mild hypothermia, on focal embolic brain ischemia have been examined. Focal ischemic injury was induced by embolizing a ...

journal_title：Brain research

authors： Wang CX,Yang T,Shuaib A

更新日期：2003-02-14 00:00:00

abstract：:Purkinje cell dendritic arborizations were studied in HRP intracellularly stained mature neurons grown during 30-50 days in organotypic cerebellar cultures from newborn kittens. The effects of afferent fiber depletions on the final dendritic topological parameters were investigated by computer assisted methods. Three ...

journal_title：Brain research

authors： Calvet MC,Calvet J,Camacho R,Eude D

更新日期：1983-12-05 00:00:00

abstract：:This review summarizes the anatomical and functional organization of the frontal cortex of the rat in comparison to primates. Lesions of the primary motor or of the prefrontal cortex of both primates and rodents produce a consistent constellation of symptoms that are strikingly similar across species as diverse as rat...

journal_title：Brain research

authors： Kolb B

更新日期：1984-11-01 00:00:00

abstract：:Axonal loss and degeneration in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been suggested by brain imaging, pathological and axonal transport studies. Further elucidation of the processes and mechanisms of axonal degeneration in demyelinating diseases is therefore of potential impor...

journal_title：Brain research

authors： Zhu B,Moore GR,Zwimpfer TJ,Kastrukoff LF,Dyer JK,Steeves JD,Paty DW,Cynader MS

更新日期：1999-04-10 00:00:00

abstract：:Beta-amyloid peptide (Aβ) has a causal role in the pathophysiology of Alzheimer's disease (AD). Recent studies indicate that Aβ can disrupt excitatory glutamatergic synaptic function at synaptic level. However, the underlying mechanisms remain obscure. In this study, we recorded evoked and spontaneous EPSCs in hippoca...

journal_title：Brain research

authors： Yao W,Zou HJ,Sun D,Ren SQ

更新日期：2013-06-17 00:00:00

abstract：:The objective was to obtain detailed topographic determinations of cytochrome oxidase activity in the gerbil central auditory system at the light microscopic level. Quantitative techniques were developed using (1) tissue standards calibrated to express histochemical measures as actual enzyme activity units, (2) densit...

journal_title：Brain research

authors： Gonzalez-Lima F,Jones D

更新日期：1994-10-10 00:00:00

abstract：:Aromatization of testosterone in the preoptic area of the male ring dove is required for the expression of specific estrogen-sensitive sexual behavior. Estradiol metabolism and/or binding of the aromatization product(s) to the preoptic estrogen receptors (ER) could interfere with the apparent increase in estradiol for...

journal_title：Brain research

authors： Steimer T,Hutchison JB

更新日期：1989-02-20 00:00:00

abstract：:Fronto-limbic circuits in the primate brain are responsible for executive function, learning and memory, and emotions, including fear. Consequently, changes in gene expression in cortical and subcortical brain regions housing these circuits are associated with many important psychiatric and neurological disorders. Whi...

journal_title：Brain research

authors： Dalgard CL,Jacobowitz DM,Singh VK,Saleem KS,Ursano RJ,Starr JM,Pollard HB

更新日期：2015-03-10 00:00:00

abstract：:Neuromuscular patterns associated with the development of hindlimb stepping behaviors were studied from birth to postnatal day 60 in normal kittens. Hindlimb muscles were chronically implanted with EMG electrodes at birth to characterize interlimb coordination and intralimb synergies during development of overground a...

journal_title：Brain research

authors： Bradley NS,Smith JL

更新日期：1988-01-01 00:00:00

abstract：:Axonal projections of ganglion cells to the superior colliculus (SC) and to the nucleus of the optic tract (NOT) were re-examined physiologically in the cat's retina. Taking care to minimize current spreads around the stimulating electrodes placed in the NOT or the SC, we reached a conclusion that a substantial propor...

journal_title：Brain research

authors： Sawai H,Fukuda Y,Wakakuwa K

更新日期：1985-08-19 00:00:00

abstract：:Scratching elicited by the intrathecal (i.t.) administration of substance P (SP) into the lumbosacral spinal cord of rats was not reduced by spinalization or i.t. pretreatment with the analgesic morphine. Spinalization also did not affect scratching elicited by i.t. kainic acid and potentiated scratching elicited by i...

journal_title：Brain research

authors： Bossut D,Frenk H,Mayer DJ

更新日期：1988-07-12 00:00:00

abstract：:Cholecystokinins in rat cerebral cortex were studied by radioimmunoassay using an antiserum specific for the COOH-terminus of CCK8. Total concentrations of immunoreactive CCK in cortex were 3-4 fold higher than in jejunum. Rat cerebral CCK was purified by immuno-affinity adsorption to the IgG fraction of CCK antisera ...

journal_title：Brain research

authors： Dockray GJ

更新日期：1980-04-21 00:00:00

abstract：:Three weeks of hypoxic exposure results in a spectrum of systemic physiological and local brain tissue adaptations. Cytochrome oxidase histochemistry was used as an indicator of changes in energy demand in response to hypoxia. We found overall cytochrome oxidase activity decreased in hypoxic adapted rats as compared t...

journal_title：Brain research

authors： LaManna JC,Kutina-Nelson KL,Hritz MA,Huang Z,Wong-Riley MT

更新日期：1996-05-13 00:00:00

abstract：:Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra became briefly sedated and hypothermic after the acute injection of nicotine s.c. (0.4 or 0.8 mg/kg free base). When nicotine was repeated 5 days per week there was rapid tolerance for the sedation and slower tolerance for the hypothermia and the l...

journal_title：Brain research

authors： Lapin EP,Maker HS,Sershen H,Hurd Y,Lajtha A

更新日期：1987-03-31 00:00:00

abstract：BACKGROUND AND PURPOSE:The present study analyzed whether administration of sulindac, a non-steroidal anti-inflammatory drug (NSAID) would prevent, attenuate or repair ischemia induced brain injury and reverse functional impairment in a focal ischemia model of stroke. METHODS:Male Sprague-Dawley rats (weight 250-300 g...

journal_title：Brain research

authors： Modi JP,Gharibani PM,Ma Z,Tao R,Menzie J,Prentice H,Wu JY

更新日期：2014-08-12 00:00:00

abstract：:Traumatic brain injury (TBI) causes impairments of both motor and spatial memory performances. Research is only beginning to reveal the biochemical mechanism(s) underlying these deficits. It has been postulated that reactive oxygen species such as the superoxide and hydroxyl radicals, as well as the peroxynitrite anio...

journal_title：Brain research

authors： Long DA,Ghosh K,Moore AN,Dixon CE,Dash PK

更新日期：1996-04-22 00:00:00

abstract：:The serotonin agonist 8-hydroxy-di-propylaminotetralin (8-OH-DPAT), injected systemically or directly into the medial preoptic area (MPOA), reduces the ejaculatory threshold in male rats. While 8-OH-DPAT has been characterized as an agonist at the 5-HT1A receptor, it also acts at other receptor sites including the dop...

journal_title：Brain research

authors： Matuszewich L,Lorrain DS,Trujillo R,Dominguez J,Putnam SK,Hull EM

更新日期：1999-02-27 00:00:00

abstract：:Fast B neurons in bullfrog sympathetic ganglia were voltage clamped with two microelectrodes. Acetylcholine (ACh) was applied onto the soma membrane by iontophoresis. A rapid nicotinic inward current was followed by a slow muscarinic inward current. After an addition of scopolamine to Ringer solution so as to block th...

journal_title：Brain research

authors： Tokimasa T,North RA

更新日期：1984-03-19 00:00:00

abstract：:We have investigated the influence of central noradrenergic and dopaminergic systems on the susceptibility of rats to seizures in the kainic acid (KA)-model of epilepsy. In the dose range of 0.75 to 10 mg/kg s.c., KA dose-dependently induced characteristic behavioural changes. Partial depletion of noradrenaline (NA) a...

journal_title：Brain research

authors： Baran H,Hörtnagl H,Hornykiewicz O

更新日期：1989-08-28 00:00:00

abstract：:A possible role for neuropeptides in affective disorders is suggested by many investigators. Somatostatin-like immunoreactivity (SS-LI) and neuropeptide Y-like immunoreactivity (NPY-LI) concentrations are demonstrated to be reduced in cerebrospinal fluid from depressed patients. We have shown that long-term treatment ...

journal_title：Brain research

authors： Kakigi T,Maeda K

更新日期：1992-12-18 00:00:00

abstract：:The growth of corticospinal tract (CST) axons was studied quantitatively at the 7th cervical (C7) and the 4th lumbar (L4) spinal segments in the balb/cByJ mice at the ages of postnatal day (P) 0, 2, 4, 6, 8, 10, 14, and 28. The cross-sectional area of the CST increased progressively with time. Unmyelinated axons, the ...

journal_title：Brain research

authors： Hsu JY,Stein SA,Xu XM

更新日期：2006-04-21 00:00:00

abstract：:Single neurons in culture express a heterogeneity of neurotransmitter receptor subtypes. The study of the effects of neurotransmitters on neuronal function is complicated by this heterogeneity. It would therefore be useful to be able to identify live neurons that express the receptors of interest and then use these ne...

journal_title：Brain research

authors： Hoyt KR,Reynolds IJ

更新日期：1996-08-26 00:00:00

abstract：:Chronically demyelinated lesions of cat dorsal columns were created by focal injection of the glial toxin ethidium bromide. Freeze-fracture studies show that the center of the lesion, which is devoid of glial cells and processes, contains axons having neither node-like nor paranodal-type membrane specializations. Near...

journal_title：Brain research

authors： Rosenbluth J,Tao-Cheng JH,Blakemore WF

更新日期：1985-12-09 00:00:00

abstract：:The dorsal lateral geniculate nucleus of tree shrews is very susceptible to the neurotoxic effects of kainic acid. In addition to neuronal loss, there is a profound loss of retinal terminals that is manifested through a disruption of anterograde transport of WGA/HRP from the retina to the kainic acid-lesioned area of ...

journal_title：Brain research

authors： Horn KM,Carey RG

更新日期：1987-07-21 00:00:00

abstract：:We characterized acute intracerebral hemorrhage (ICH) in the rat by sequential magnetic resonance imaging (MRI) and correlated MRI findings with neurobehavior and histopathology. In addition, we investigated whether albumin treatment would reduce ICH-induced brain injury. ICH was produced in rats by a double-injection...

journal_title：Brain research

authors： Belayev L,Obenaus A,Zhao W,Saul I,Busto R,Wu C,Vigdorchik A,Lin B,Ginsberg MD

更新日期：2007-07-09 00:00:00

abstract：:To investigate the role of the amygdala in central regulation of pancreatic exocrine secretion, the effects of electrolytic lesions on pancreatic secretion were studied in rats. Small bilateral electrolytic lesions in amygdaloid body restricted to basolateral, medial and central nuclei were produced. Eight days after ...

journal_title：Brain research

authors： Mine K,Tsuruta N,Nakai Y,Kataoka Y,Fujiwara M,Ueki S,Nakagawa T

更新日期：1985-08-05 00:00:00