Abstract：
:Three weeks of hypoxic exposure results in a spectrum of systemic physiological and local brain tissue adaptations. Cytochrome oxidase histochemistry was used as an indicator of changes in energy demand in response to hypoxia. We found overall cytochrome oxidase activity decreased in hypoxic adapted rats as compared to normoxic control rats. Some regions, notably layer 3 of the frontal cerebral cortex, layer 4 of the parietal sensory barrel fields, lacunosum moleculare hippocampi, and specific nuclei of the rostral ventral medulla, though exhibiting cytochrome oxidase activity decreases of 16-27%, still retain their relatively higher levels of activity. We conclude that there is a hypometabolic component of the rat brain adaptation to continued hypoxia.
journal_name
Brain Resjournal_title
Brain researchauthors
LaManna JC,Kutina-Nelson KL,Hritz MA,Huang Z,Wong-Riley MTdoi
10.1016/0006-8993(95)01495-0subject
Has Abstractpub_date
1996-05-13 00:00:00pages
1-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(95)01495-0journal_volume
720pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of microinjection of alpha-noradrenergic agonists and antagonists in the flocculus on the basic gain and adaptibility of vestibulo-ocular and optokinetic responses were investigated. A complementary, previous investigation had shown that the adaptation, but not the basic performance, of compensatory oculom...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90623-4
更新日期：1991-10-25 00:00:00
abstract：:Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines woul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90454-4
更新日期：1991-01-11 00:00:00
abstract：:The feedback effect of activity of area 21a on orientation maps of areas 17 and 18 was investigated in cats using intrinsic signal optical imaging. A spatial frequency-dependent decrease in response amplitude of orientation maps to grating stimuli was observed in areas 17 and 18 when area 21a was inactivated by local ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.024
更新日期：2004-02-20 00:00:00
abstract：:The present experiments were performed to demonstrate in vivo the existence of a modulatory role of Na+ in the inhibitory control of prolactin (PRL) secretion. Groups of adult male rats were either adrenalectomized (adrenex) or sham-operated (normals) and implanted in the right atrium with a chronic cannula for the in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91158-9
更新日期：1987-01-13 00:00:00
abstract：:The effects of 5-hydroxytryptamine (5-HT) on lateral horn cells contained in thin in vitro slices of neonatal rat spinal cord were investigated by means of intracellular recording techniques. Superfusion of 5-HT (1-100 microM) to lateral horn cells caused a concentration-dependent membrane depolarization leading to, i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90176-8
更新日期：1986-01-01 00:00:00
abstract：:Brain edema is a serious consequence of hemispheric stroke and traumatic brain injury and contributes significantly to patient mortality. In the present study, we measured water contents in hippocampal slices as an in vitro model of edema formation. Excitotoxic conditions induced by N-methyl-D-aspartate (NMDA, 300 mic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.012
更新日期：2006-11-29 00:00:00
abstract：:The effect of perinatal androgen exposure on the sexually dimorphic distribution of serotonin (5-HT)-immunoreactive fibers in the medial preoptic nucleus (MPN) of the rat was evaluated with an indirect immunohistochemical method. Female animals treated with testosterone propionate (TP) perinatally, postnatally or with...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90777-2
更新日期：1985-08-05 00:00:00
abstract：:We have developed a sensitive enzymatic-immunoassay to quantify the level of gamma-enolase (a specific neuronal enzyme) which is released from cultured cells after exposure to various toxins. We show that this method can estimate selectively neuronal cell death without significantly interfering with glial cell death. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91264-f
更新日期：1992-10-09 00:00:00
abstract：:Cultured astrocytes contain immunologically specific aromatic L-amino acid decarboxylase (AADC) protein and express the AADC gene. Following incubation with L-Dopa, glial cultures synthesize and metabolize dopamine. The addition of pyridoxal 5-phosphate did not change the rate of dopamine synthesis. The formation of d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90592-b
更新日期：1993-10-29 00:00:00
abstract：:Rats exposed to inescapable tailshock exhibit deficits in learning a simple shuttlebox escape task 24 h later. This syndrome has been termed 'behavioral depression' or 'learned helplessness', and is a model of stress-induced depression. In the present study a significant (25%) decrease in GABA receptor-mediated chlori...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90938-4
更新日期：1989-05-15 00:00:00
abstract：:Primary rat neuronal cultures can be preconditioned against ischemic damage by several mechanisms. In the present study we established a new model system in order to characterize the "time window of protection' obtained by preconditioning of neurons with adenosine. Ischemia was simulated by exposure of the cultures to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00939-0
更新日期：1996-11-25 00:00:00
abstract：:In normal adult cats we measured the density of staining for the activity of succinate dehydrogenase (SDH staining) in ventral horn cells of different sizes. The measurements were restricted to that part of the lumbar ventral horn (L6-L7) which is known to contain motoneurones of the peroneal nerve. A statistically si...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91542-8
更新日期：1986-10-15 00:00:00
abstract：:6-[18F]Fluoro-L-DOPA (FDOPA) is an imaging agent used in the study of dopamine terminals in the living brain using positron emission tomography (PET). To better understand the role of tracer metabolism in dynamic FDOPA PET studies, the pharmacokinetics of individual FDOPA metabolites in extracellular space in the stri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02649-4
更新日期：2000-09-15 00:00:00
abstract：:Monkeys can gradually increase or decrease the amplitude of the segmentally mediated spinal stretch reflex (SSR) without change in initial muscle length or background EMG activity. Both increase (under the SSR increases mode) and decrease (under the SSR decreases mode) occur slowly, progressing steadily over weeks. Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90259-7
更新日期：1983-11-14 00:00:00
abstract：:This study examined the hypothesis that the subfornical organ (SFO), a circumventricular organ with both osmosensitive elements and dipsogenic receptors for circulating angiotensin (ANG) II, is important for the water drinking response that follows an intragastric (ig) load of hypertonic NaCl. A 2-ml saline load was a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00249-2
更新日期：1998-06-08 00:00:00
abstract：:Two D-amino acid substitution angiotensin analogues were compared against native angiotensin II (AII) and angiotensin III (AIII) for their resistance to brain tissue-induced degradation and for pressor potency when intracerebroventricularly (i.c.v.) infused in Sprague-Dawley rats. The in vitro results indicate that [D...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90428-e
更新日期：1990-04-23 00:00:00
abstract：:Extracellular recordings were made in vitro from 212 single units in the rat subfornical organ (SFO) and 54 single units in the rat medial preoptic area (MPO). Units were exposed to solutions made hyper-osmotic or hypo-osmotic by 1.4-11%. A reversible 30% or greater change in frequency followed the osmotic challenge i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90251-x
更新日期：1988-10-04 00:00:00
abstract：:We report here that following partial spinal transections in adult lampreys, the fibers of the spinal cords can regenerate and restore some intersegmental coordination to the central pattern generator for locomotion, as tested in the isolated cord preparation. However, the regeneration by this test is not successful i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91090-1
更新日期：1989-09-04 00:00:00
abstract：:This study compared patterns of Fos expression within the suprachiasmatic nucleus (SCN), the region immediately dorsal to the SCN (the lower subparaventricular zone, LSPV), and the supraoptic nucleus (SON) of grass rats (Arvicanthis niloticus) and lab rats (Rattus norvegicus). Among grass rats we also compared individ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02205-3
更新日期：2001-04-27 00:00:00
abstract：:Recent studies stressed the importance of comparing exemplars both for improving performance by artificial classifiers as well as for explaining human category-learning strategies. In this report we provide a theoretical analysis for the usability of exemplar comparison for category-learning. We distinguish between tw...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.079
更新日期：2008-08-15 00:00:00
abstract：:The specific benzodiazepine antagonist, Ro14-7437, in nanomolar concentrations, caused depolarization, increased spontaneous spiking, and conductance decrease when applied to CA1 cells in vitro. These effects were resistant to intracellularly injected Cl- ions or synaptic blockade by TTX, were prevented in Ca2+-free m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91370-7
更新日期：1983-07-18 00:00:00
abstract：:Serotonin 1A receptor (5-HT(1A)R) agonists have emerged as valuable supplements to l-DOPA therapy, demonstrating that they can decrease side effects and enhance motor function in animal models of Parkinson's disease (PD) and human PD patients. The precise mechanism by which these receptors act remains unknown and ther...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.05.005
更新日期：2007-07-16 00:00:00
abstract：:Accumulating evidence indicates that extensive microglia activation-mediated local inflammation contributes to neuronal injury in cerebral ischemia. We have previously shown that 4-(2-butyl-6, 7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid (DCPIB), a potent volume-regulated anion channel (VRAC) inhibitor, s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.10.026
更新日期：2014-01-13 00:00:00
abstract：:In larval lamprey 4 weeks after a spinal transection locomotor patterns were usually complete along the body in whole animals. In in vitro preparations locomotor activity was restricted to a few millimeters below the transection. Retrograde labeling indicated that descending axons from a few brainstem neurons had grow...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90252-i
更新日期：1993-01-29 00:00:00
abstract：:Specific binding of [3H]naloxone to rat brain tissue in vitro was inhibited by the excitant organochlorinated insecticides (OCI), by ether (E) and octanol (OCT), and by the convulsant indoklon (IND) and its anesthetic isomer, isoindoklon (ISO). In the presence of 100 mM NaCl the inhibition of naloxone binding by E, OC...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90277-8
更新日期：1981-08-24 00:00:00
abstract：:In the diseased central nervous system, astrogliosis is accompanied by microglial activation. Depending on the context of their activation, reactive astrocytes are involved in neuronal survival and regeneration in an either protective or impedimental way. Major reactive changes of astrocytes in vivo are the upregulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.10.057
更新日期：2007-01-19 00:00:00
abstract：:A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three G...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03282-1
更新日期：2002-10-25 00:00:00
abstract：:Hypothalamic nuclei close to the third ventricle (VIII) represent key structures in avian osmoregulation concerned with the control of salt gland activity and release of the antidiuretic hormone [Arg8]vasotocin (AVT). Nitric oxide (NO) acting as a paracrine transmitter in the hypothalamus has been shown to contribute ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01205-6
更新日期：1999-04-17 00:00:00
abstract：:The frequency-dependent effect of various anticonvulsant drugs on the conduction in central axons was studied in the corpus callosum of rat and guinea pig brain slices from the parietal region. Extracellularly recorded compound action potentials (CAPs) were evoked by either single stimulus or high frequency stimulatio...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91636-s
更新日期：1992-07-24 00:00:00
abstract：:Amphetamine withdrawal is associated with heightened anxiety-like behavior, which is directly driven by blunted stress-induced glucocorticoid receptor-dependent serotonin release in the ventral hippocampus. This suggests that glucocorticoid availability in the ventral hippocampus during stress may be reduced during am...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.05.030
更新日期：2016-08-01 00:00:00
