Abstract:
:A gentle long-lasting handling produces persistent neurochemical and behavioural changes and attenuates the impairment in the behavioural reactivity to novelty induced by the prenatal exposure to diazepam (DZ) in adult male rat progeny. This study investigated the consequences of a late prenatal treatment with three GABA/BDZ R agonists (DZ) alprazolam (ALP) and zolpidem (ZOLP)), on different stress-related behavioural patterns, in non-handled (NH), short-lasting handled (SLH) and long-lasting handled (LLH) adult male rats exposed to forced swim test (FST), acoustic startle reflex (ASR) and Vogel test (VT). The effects on motor activity were evaluated in the open field and in the Skinner box. The seizure sensitivity to picrotoxin (PTX) was investigated as an index of the functional state of GABA/BDZ Rs. A single daily s.c. injection of DZ (1.25-2.50 mg/kg) and ALP (0.125-0.250 mg/kg) over gestational days 14-20 induced a decrease in immobility time in the FST in NH rats, no change in SLH rats and an increase in LLH rats; DZ induced an increase in the peak amplitude of the ASR in NH rats, no change in SLH rats and a reduction in LLH rats; ALP was ineffective in all groups. DZ and ALP reduced the number of punished licks in the VT in NH, SLH and LLH rats while the unpunished licks were not modified. DZ decreased locomotion and the lever pressing responses while ALP increased them. DZ and ALP increased the seizure sensitivity to PTX (2.5-4.0 mg/kg i.p.). These findings indicate a convergence on anxiety-related behaviours in the effects of prenatal exposure to DZ and ALP and a differentiation on motor activity. Long-lasting handling was able to overcompensate the increased behavioural stress reactivity induced by the prenatal exposure to DZ and ALP.
journal_name
Brain Resjournal_title
Brain researchauthors
Cannizzaro C,Martire M,Steardo L,Cannizzaro E,Gagliano M,Mineo A,Provenzano Gdoi
10.1016/s0006-8993(02)03282-1subject
Has Abstractpub_date
2002-10-25 00:00:00pages
170-80issue
1-2eissn
0006-8993issn
1872-6240pii
S0006899302032821journal_volume
953pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (T...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.11.032
更新日期:2013-02-01 00:00:00
abstract::The ontogeny of adenosine receptors was studied in rat brain and spinal cord using the specific ligand [3H]cyclohexyladenosine [( 3H]CHA). The [3H]CHA affinity constant (Kd) and the maximum receptor binding capacity (Bmax) were analyzed at all ages and in all CNS regions studied. Throughout development the Kd of [3H]C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90080-4
更新日期:1984-03-01 00:00:00
abstract::Detailed quantitative information on catecholamines and 5-hydroxytryptamine (serotonin) in the human thalamus is much needed because of increasing interest in norepinephrine and serotonin as modulators of thalamic behavioral state control and overall information processing. This study provides three-dimensional distri...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00404-6
更新日期:1997-07-18 00:00:00
abstract::Intrinsic membrane properties, voltage-dependent sodium and voltage-dependent potassium currents of area postrema neurons in culture have been characterized with respect to their voltage dependence, time dependence and sensitivity to specific blocking agents. The area postrema is a hindbrain circumventricular organ wh...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01159-5
更新日期:1995-12-24 00:00:00
abstract::Several human tumour cell lines were screened for secretion of proenkephalin-derived peptides with an antiserum directed to its N-terminus, Met-enkephalin-Arg6,Phe7 and for proopiomelanocortin-derived peptides with an antiserum to beta-endorphin. The neuroblastoma SK-N-MC cell line secreted Met-enkephalin-Arg6,Phe7-im...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0169-328x(88)90060-5
更新日期:1988-04-01 00:00:00
abstract::Motor behavior not seen in newborn cats can be revealed by spinal transection and is therefore normally suppressed. Motor performance of these spinal kittens after reaching adulthood surpasses that of chronic adult-operated spinal cats but the latter display a significant improvement when GABAergic inhibition is block...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90879-0
更新日期:1985-11-04 00:00:00
abstract::Our recent study has shown that many afferent fibers in the ventral root are third branches of dorsal root ganglion cells in addition to their processes in the peripheral nerve and the dorsal root. From results of this study, we hypothesized that most of the afferent fibers in the normal ventral root are extra process...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91030-5
更新日期:1989-10-30 00:00:00
abstract::One-day-old chicks were exposed for 60 min to either an imprinting stimulus or a dark-box. They were killed at 0, 1, 6 or 12 h after the end of this treatment, and the activities of acetylcholinesterase (AChE) and choline acetyltransferase (ChAc) assayed in the forebrain roof, forebrain base and midbrain. The activity...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90271-1
更新日期:1975-07-11 00:00:00
abstract::Previous work has suggested that the rewarding effect of hippocampal stimulation develops only as a consequence of neuroplastic change resulting from repeated stimulation experience: naive rats will not initiate self-stimulation for several days, but a prior program of hippocampal kindling greatly facilitates acquisit...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91706-m
更新日期:1990-06-18 00:00:00
abstract::L-3, 4-Dihydroxyphenylalanine (L-dopa) has been widely used for the treatment of Parkinson's disease (PD), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. In this study, we examined the concentration of L-dopa in plasma and in the extracellular fluid (ECF) of the striatu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.08.065
更新日期:2003-12-12 00:00:00
abstract::With the use of [3H]p-aminoclonidine (PAC), alpha 2-adrenergic binding sites were mapped in the brain of the Japanese quail (Coturnix coturnix japonica). The sites were labeled with the use of in vitro quantitative autoradiography. Special attention was given to areas implicated in the control of sexually dimorphic re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90088-7
更新日期:1989-07-03 00:00:00
abstract::It is now well known that dopamine (DA) receptors agonists can reduce striatal DA release. These compounds are generally thought to produce short-term effects. However, in a recent in vivo study we have reported that the D1/D2 receptor agonist apomorphine might induce decrements in striatal DA release that lasted seve...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90922-9
更新日期:1994-04-11 00:00:00
abstract::Local circuit neurons in the human anterior thalamus (AT) were identified on the basis of glutamic acid decarboxylase immunoreactivity (GAD-IR). GAD-IR neurons of the AT displayed small diameter somas with thin, sparsely-branching dendrites, consistent with the morphological characteristics of local circuit neurons fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03194-8
更新日期:2001-12-27 00:00:00
abstract::The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90784-7
更新日期:1992-02-28 00:00:00
abstract::The present study using near-infrared spectroscopy (NIRS) examined prefrontal activation associated with maze-solving performance in adult humans. The participants were required to solve a plus-shaped maze, comparable to the one used for pigeons and human children to behaviorally assess planning processes, by moving a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.12.047
更新日期:2011-02-16 00:00:00
abstract::Microtubule organization in type I hair cells has been investigated during the synaptogenesis of vestibular receptors in mammals. The different steps in the maturation of the synapse between the hair cell and the nerve chalice were: a slight symmetrical membrane densification; the appearance of synaptic bodies alongsi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90161-6
更新日期:1986-02-01 00:00:00
abstract::SC1 is an extracellular matrix glycoprotein that is related to the multifunctional protein SPARC. These matricellular members play regulatory roles in modulating cellular interactions. SC1 expression is enriched in the central nervous system during embryonic and postnatal development as well as in the adult brain. In ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02270-9
更新日期:2002-03-29 00:00:00
abstract::The potential shifts (delta Vo) associated with spreading depression (SD) were analysed with the help of multiple extracellular recording and ion-selective microelectrodes in the CA1 region of the dorsal hippocampus of anesthetized rats. Recurrent waves of SD were induced by perfusing high K+ solution through microdia...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91412-l
更新日期:1993-05-07 00:00:00
abstract::The aim of the present study was to determine differences in cortical processing of consonant-vowel syllables and acoustically matched non-speech sounds, as well as novel human and nonhuman sounds. Event-related potentials (ERPs) were recorded to vowel, vowel duration, consonant, syllable intensity, and frequency chan...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.052
更新日期:2010-04-23 00:00:00
abstract::Cannabinoids are promising therapies to support neurogenesis and decelerate disease progression in neuroinflammatory and degenerative disorders. Whether neuroprotective effects of cannabinoids are sustainable during persistent viral infection of the CNS is not known. Using a rodent model of chronic viral encephalitis ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.08.032
更新日期:2013-11-06 00:00:00
abstract::The excitatory amino acid L-glutamate injected into the nucleus of the solitary tract (NTS) in unanesthetized rats similar to peripheral chemoreceptor activation increases mean arterial pressure (MAP) and reduces heart rate. In this study, we investigated the effects of acute (1 day) and chronic (15 days) electrolytic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.08.006
更新日期:2004-10-29 00:00:00
abstract::The effects of hyperbaric oxygen have been studied on synaptic transmission in the hippocampal brain slice. Oxygen enhances both the prevolley and postsynaptic potential of extracellularly recorded responses following focal stimulation of afferent fiber bundles, but synaptic efficiency is reduced. It is suggested that...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90775-8
更新日期:1983-01-31 00:00:00
abstract::The acute stroke phase is a critical time frame used to evaluate stroke severity, therapeutic options, and prognosis while also serving as a major tool for the development of diagnostics. To further understand stroke pathophysiology and to enhance the development of treatments, our group developed a translational pig ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.146778
更新日期:2020-06-01 00:00:00
abstract::Programmed cell death has been implicated in the loss of neurons that occurs in many neurodegenerative diseases. This has led to an increased interest in the types of stimuli that can initiate neurons to undergo programmed cell death. Previously, we have shown that cross-linking of membrane receptors with the lectin c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00309-6
更新日期:1998-06-15 00:00:00
abstract::Wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP) was used to study transneuronal transport in the developing rat visual pathways. Intraocular injections of WGA-HRP were made in neonatal albino rat pups at different ages from the day of birth, postnatal day 0 (P0), to one month of age. Transneuronal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(88)90087-9
更新日期:1988-01-01 00:00:00
abstract::We have developed and tested the biological activity and specificity of a novel fluorescent dextran-Texas Red-nerve growth factor (DTR-NGF) conjugate. DTR-NGF was found to promote survival and neurite outgrowth in cultured dissociated sympathetic neurons similarly to native NGF. The conjugate was taken up and transpor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03099-2
更新日期:2001-11-30 00:00:00
abstract::During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.11.010
更新日期:2014-01-16 00:00:00
abstract::Inoculation of the tail base of rats with Mycobacterium butyricum led to an arthritic swelling and inflammation of the limbs which displayed a hyperalgesia to noxious pressure: these effects peaked at 3 weeks postinoculation. In vitro autoradiography of coronal sections of rat brain was used for a parallel determinati...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90917-6
更新日期:1987-07-28 00:00:00
abstract::The BE (2)-M17 human neuroblastoma has previously been shown to express corticotropin-releasing factor (CRF) mRNA following retinoic acid treatment. It is demonstrated in this report that both cell extracts and cell incubation medium of retinoic acid-treated BE (2)-M17 cells were shown to contain CRF-like immunoreacti...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91583-0
更新日期:1994-08-15 00:00:00
abstract::Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.094
更新日期:2007-09-07 00:00:00