Abstract：
:The mammalian circadian clock in the suprachiasmatic nuclei (SCN) can be phase-shifted in vitro by the serotonin agonist quipazine. Here we show that quipazine resets the SCN clock in the presence of tetrodotoxin or 10 mM Mg2+, treatments that block Na+ action potentials and Ca2+ channels, respectively. These results support the hypothesis that quipazine resets the clock by stimulating receptors located on clock elements rather than on cells afferent to the clock.
journal_name
Brain Resjournal_title
Brain researchauthors
Prosser RA,Heller HC,Miller JDdoi
10.1016/0006-8993(92)90784-7subject
Has Abstractpub_date
1992-02-28 00:00:00pages
336-40issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(92)90784-7journal_volume
573pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Several forebrain areas have been shown to project to the parabrachial nucleus (PBN) and exert inhibitory and excitatory influences on taste processing. The neurochemicals by which descending forebrain inputs modulate neural taste-evoked responses remain to be established. This study investigated the existence of soma...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.038
更新日期：2009-11-17 00:00:00
abstract：:Previous studies suggested the existence of two populations of cells in the mammalian sympathetic nervous system which differ in their ability to express phenylethanolamine N-methyltransferase (PNMT), the enzyme which specifically subserves the biosynthesis of epinephrine: (1) sympathoblasts and their progeny, the nor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(84)90163-9
更新日期：1984-04-01 00:00:00
abstract：:Locally applied ciliary neurotrophic factor (CNTF) has a powerful effect on retrograde axonal reaction following facial nerve crush in neonatal rats. We examined whether it also exerts a strong effect on retrograde axonal reaction in young adult rats when administered subcutaneously. The dose was 1 mg/kg body weight, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01512-4
更新日期：1996-04-22 00:00:00
abstract：:Using site-specific antibodies, we assessed the effect of aggregation of various length forms of A beta on the immunoreactive profile of the peptides. All of the antibodies tested reacted with monomeric/dimeric forms of A beta 1-42 and its further aggregates. However, antibodies directed against the 1-24 region of A b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01195-1
更新日期：1995-12-12 00:00:00
abstract：:Ramified microglial cells were investigated in primary cultures of dissociated cerebral cortical tissue from rats. The identification of these cells was confirmed through immunohistochemical staining with 7 monoclonal antibodies selective for microglia. While there was significant variation in staining intensity with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91118-k
更新日期：1991-05-10 00:00:00
abstract：:Whereas the role of the hippocampus for spatial learning and long-term memory is largely undisputed, there is less evidence for a participation of hippocampal structures in spatial working memory operations. In an fMRI study (functional magnetic resonance imaging), we therefore examined the role of the hippocampus dur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.065
更新日期：2010-10-01 00:00:00
abstract：:Among 235 histologically identified cells of the ventral lateral geniculate nucleus (LGV) in the cat, 66 responded antidromically to electrical stimulation of the pretectum (PT) and/or superior colliculus (SC): 22 projected to PT, 22 to SC and 22 to both sites. The LGV cells were innervated by optic tract fibers corre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90993-x
更新日期：1985-12-09 00:00:00
abstract：:The pedunculopontine nucleus (PPN) located in the mesopontine tegmentum is innervated by descending projections from nuclei in the basal ganglia. The present study was performed to determine whether nigrostriatal dopaminergic neuron degeneration is associated with changes in PPN metabolic activity. Unilateral nigrostr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01268-8
更新日期：1999-05-15 00:00:00
abstract：:Fos expression in vestibular brainstem and cerebellar regions was evaluated during vestibular adaptation in the Mongolian gerbil. In addition, vestibular adaptation was evaluated in both normal and compensated animals, as vestibular compensation reorganizes the vestibular pathway constraining adaptive processes. Behav...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.029
更新日期：2005-07-19 00:00:00
abstract：:The afferent connections of the eye of Python reticulatus have been studied with HRP, Nuclear yellow and Granular blue. It appeared that in this snake the eye receives afferent connections from basal telencephalic areas both ipsi- and contralaterally. Following experiments in which Granular blue was injected into one ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91257-9
更新日期：1981-05-25 00:00:00
abstract：:Depolarizing actions of 4 conformationally restricted L-glutamate analogues, (2S,3S,4S) isomer (L-CCG-I), (2S,3R,4R) isomer (L-CCG-II), (2S,3S,4R) isomer (L-CCG-III) and (2S,3R,4S) isomer (L-CCG-IV) of L-alpha-(carboxycyclopropyl)-glycine (L-CCG), were investigated in the isolated rat spinal cord by extracellular reco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90207-2
更新日期：1989-02-20 00:00:00
abstract：:The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretrea...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02331-3
更新日期：2000-07-28 00:00:00
abstract：:The effects of postnatal thyroidectomy (on day 8 after birth) and 131I treatment (on day 10) on the development of the vomeronasal organ (VO) has been studied In the rat. Thyroidectomized rats showed decrements in the overall VO volume, volume of the neurosensorial epithelium, neuronal population and nuclear size of n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90159-6
更新日期：1982-10-01 00:00:00
abstract：:In 22 squirrel monkeys (Saimiri sciureus) vocalization-eliciting electrodes were implanted into the amygdala and along the trajectory of the stria terminalis. Then, lesions were placed in the stria terminalis, its bed nucleus, the ventral amygdalofugal pathway and several di- and mesencephalic structures in order to f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91055-1
更新日期：1982-06-10 00:00:00
abstract：:The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.03.010
更新日期：2015-06-22 00:00:00
abstract：:The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging. Field excitatory postsynaptic potentials (fEPSPs) were recorded in the CA1 region in slices from young and aged Fischer 344 rats. Peptide toxin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01234-6
更新日期：1997-01-16 00:00:00
abstract：:In alert cats, extracellular spikes of neurons in the medial pontine tegmentum were recorded simultaneously with whole nerve discharges of the abducens and medial rectus nerves during horizontal vestibular nystagmus. Nystagmus-related neurons were classified by their firing patterns in relation to the abrupt cessation...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90941-0
更新日期：1981-10-05 00:00:00
abstract：:The horizontal and vertical vestibulo ocular reflex (VOR) of head tilted (het) mutant mice was compared to C57BL/6 controls. Eye movements were recorded in darkness using a temporarily attached search coil. Contributions of semicircular canal versus otolith organ signals were investigated by providing a canal only (ve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02505-8
更新日期：2003-05-16 00:00:00
abstract：:Norepinephrine (NE), acting on brain adrenoceptors, plays an important role in barrel field neuronal activity and plasticity. For this reason, the distribution of alpha 1- and alpha 2-adrenoceptors in the somatosensory cortex barrel field was studied by autoradiographic techniques in rats undergoing plastic change or ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90005-8
更新日期：1993-09-24 00:00:00
abstract：:Neurons in the polymorph layer of the hippocampal dentate hilus were found to be the cells of origin for ipsilateral association and commissural projections to the dentate gyrus. Both afferent systems terminate in the proximal one-third of the stratum moleculare. The polymorph layer is the primary target for noradrene...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90512-6
更新日期：1981-06-29 00:00:00
abstract：:The in vitro release of luteinizing hormone-releasing hormone (LHRH), prostaglandin (PG) E2 and leukotriene (LT) C4 from male rat median eminences (ME), was estimated by radioimmunoassay (RIA) in the presence of the catecholamines (CA), norepinephrine (NE) and dopamine (DA). NE increased the release of PGE2 in the pre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90697-5
更新日期：1989-05-29 00:00:00
abstract：:Previous studies have suggested that substance P (SP) plays a critical role in the development of brain oedema and functional deficits following traumatic brain injury and that SP receptor antagonism may improve outcome. No studies have described such a role in ischemic stroke. The present study characterized the effe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.066
更新日期：2011-06-01 00:00:00
abstract：:Tyrosine hydroxylase immunohistochemical examination of the mesencephalon of severely parkinsonian MPTP-treated macaque fascicularis monkeys revealed a marked loss of substantia nigra pars compacta (SNc) neurons in both medial and central portions of the nucleus with a relative sparing of neurons in the dorsal-most po...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90691-3
更新日期：1987-05-12 00:00:00
abstract：:Emerging evidence that autophagy serves as a sweeper for toxic materials in the brain gives us new insight into the pathophysiology of neurodegenerative diseases. Autophagy is important for maintaining cellular homeostasis associated with metabolism. Some neurodegenerative diseases such as Alzheimer׳s and Parkinson׳s ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.02.049
更新日期：2016-10-15 00:00:00
abstract：:Oxidative stress in brain tissue was measured experimentally in situ using microdialysis to sample the extracellular environment for a lipid peroxidation breakdown product and antioxidants. The extracellular concentrations of the lipid peroxidation product malonaldehyde (MDA) and the antioxidants ascorbic acid (AA) an...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01540-x
更新日期：1996-03-11 00:00:00
abstract：:Nerve growth factor (NGF) and neurotrophin-3 (NT-3) are target-derived proteins that regulate innervating sympathetic neurons. Here, we used western blot analysis to investigate changes in NGF and NT-3 protein in several peripheral tissues following loss of sympathetic input. Following removal of the superior cervical...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.099
更新日期：2007-05-04 00:00:00
abstract：:Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.08.040
更新日期：2015-11-02 00:00:00
abstract：:Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02110-7
更新日期：2000-04-28 00:00:00
abstract：:The expression of two embryonic intermediate filaments, nestin and vimentin, in the rat brain at days 0 (control), 1, 4, 7 and 14 post-cryoinjury was studied to elucidate their roles in brain injury. Western blot analysis showed that both nestin and vimentin expressions in the ipsilateral cerebral cortex were signific...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.09.022
更新日期：2004-12-03 00:00:00
abstract：:Long-term exposure to different antidepressant treatments induces increased motor response to central stimulants, due to a selective supersensitivity of dopamine D2 receptors in the limbic areas. Such an effect is accompanied by down-regulation of dopamine D1 receptor number, and by a decreased response of adenylyl cy...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91570-i
更新日期：1993-03-19 00:00:00
