Abstract:
:The role of calcium and protein kinases in rhythmic activity induced by muscarinic receptor activation in the CA1 area in rat hippocampal slices was investigated. Extracellular recording showed that carbachol (20 microM) induced synchronized field potential activity with a dominant frequency of 7.39+/-0.68 Hz. Pretreatment with the membrane permeable Ca(2+) chelator BAPTA-AM (50 microM) or with thapsigargin (1 microM), a compound which depletes intracellular calcium stores, reduced the dominant power of carbachol-induced theta-like activity by 83% and 78%, respectively. Inhibition of calmodulin-dependent protein kinase II (CaMKII) by the cell permeable inhibitor KN-93 (10 microM) reduced the power of carbachol-induced theta-like activity by 80%. In contrast the protein kinase C (PKC) inhibitor calphostin C did not significantly (P>0.05) affect the effect of carbachol. Whole-cell recording indicated that KN-93 also blocked carbachol-induced suppression of slow I(AHP) and strongly inhibited the carbachol-induced plateau potential. Our data suggest that activation of CaMKII by carbachol is crucial for local theta-like activity in the CA1 area of the rat hippocampus in vitro. Furthermore, involvement of CaMKII in carbachol-induced suppression of the slow I(AHP) and the induction of plateau potentials could play a role in the induction of theta-like rhythmic activity by carbachol.
journal_name
Brain Resjournal_title
Brain researchauthors
Alberi S,Boeijinga PH,Raggenbass M,Boddeke HWdoi
10.1016/s0006-8993(00)02331-3subject
Has Abstractpub_date
2000-07-28 00:00:00pages
11-9issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(00)02331-3journal_volume
872pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::To test the hypothesis that neurons in the hypothalamic paraventricular nucleus (PVN) may be under both direct and indirect regulation by alpha melanocyte-stimulating hormone (alpha-MSH)-synthesizing neurons of the arcuate nucleus, we determined whether the retrogradely transported marker substance, cholera toxin beta...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.09.023
更新日期:2005-12-07 00:00:00
abstract::In order to better understand the neuroleptic-like effects of neurotensin in vivo, the effects of neurotensin in vitro on dopamine D2 and D1 agonist and antagonist binding sites were characterized in membranes from the neostriatum and the subcortical limbic area. Neurotensin increased the KD but not the Bmax value of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90753-i
更新日期:1991-10-04 00:00:00
abstract::Axons in the adult mammalian CNS normally do not regenerate following axotomy even though they retain the capacity for growth under certain experimental conditions. Although this implies that the regeneration of adult axons is under regulative control, very little is known about the signaling pathways "responsible" fo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01468-3
更新日期:1996-04-01 00:00:00
abstract::The experimental evidence linking glutamate to ischemic neuronal injury is derived from in vitro or in vivo animal stroke models. We, therefore, developed an in vitro preparation to determine whether glutamate contributes to early neuronal swelling in oxygen and glucose deprived (OGD) human neocortical slices. In orde...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01286-9
更新日期:1998-01-26 00:00:00
abstract::Two-month-old male offspring of rats injected intravenously on day 19 of gestation with antiserum to synaptic membrane fraction showed marked behavioral deficits on a DRL (differential reinforcement at low rates) training paradigm. These behavioral deficits included perseveration, slow acquisition rates, and poor rete...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90325-x
更新日期:1975-07-18 00:00:00
abstract::Injury to the central or peripheral nervous systems leads to the loss of cognitive and/or sensorimotor capabilities that still lack an effective treatment. Although injury to the nervous system involves multiple and complex molecular factors, alteration to protein homeostasis is emerging as a relevant pathological mec...
journal_title:Brain research
pub_type: 杂志文章,评审
doi:10.1016/j.brainres.2016.04.053
更新日期:2016-10-01 00:00:00
abstract::To determine the involvement of vasoactive intestinal polypeptide (VIP) in the development of kindling in rats, VIP or antibody to VIP (anti-VIP) was injected into the third ventricle after the daily stimulation of the basolateral amygdala. The number of stimulations required to reach full amygdaloid kindling was sign...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91082-c
更新日期:1991-02-08 00:00:00
abstract::Light-microscopical measurements have been made on teased pulpal nerve fibers from young adult cat canine teeth. In the root canal portion (apical to first branching point) the mean internodal length was approximately 250 micron. In the pulpal chamber portion (coronal to the first branching point) the pulpal nerve fib...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90221-x
更新日期:1984-06-11 00:00:00
abstract::The kinetic properties of the testosterone-metabolizing enzymes were studied in the hypothalamus of adult and young zebra finches of both sexes. Estradiol, 5 alpha-dihydrotestosterone, 5 beta-dihydrotestosterone and 5 beta-androstane-3 alpha,17 beta-diol were identified as metabolites of testosterone in males and fema...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90406-4
更新日期:1988-11-01 00:00:00
abstract::This study determined whether macrophage inflammatory protein-1beta (MIP-1beta) plays a role in the hyperthermia caused by prostaglandin E2 (PGE2) given intracerebroventricularly (i.c.v.) in the rat. In these experiments, anti-murine MIP-1beta antibody (anti-MIP-1beta) was micro-injected in the anterior hypothalamic, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01362-5
更新日期:1997-02-14 00:00:00
abstract::In vitro quantitative autoradiography of high-affinity [3H]desmethylimipramine (DMI) binding sites was performed on 24 human brains postmortem. Highest densities of binding sites were found in portions of the amygdala, the granular layer of the dentate gyrus, the pyramidal layer of CA4. Next, in descending order were ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90353-8
更新日期:1988-07-19 00:00:00
abstract::Traumatic brain injury (TBI) is a major public health problem with long-term neurobehavioral sequela. The evidences have revealed that TBI is a risk factor for later development of neurodegenerative disease and both the single and repetitive brain injury can lead to the neurodegeneration. But whether the effects of ac...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.11.028
更新日期:2017-02-15 00:00:00
abstract::Manipulations of either discrete emotions (e.g. happiness) or affective dimensions (e.g. positivity) have a long tradition in emotion research, but interactive effects have never been studied, based on the assumption that the two underlying theories are incompatible. Recent theorizing suggests, however, that the human...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.03.045
更新日期:2014-05-20 00:00:00
abstract::Subcutaneous administration of rotenone has recently attracted attention because of its convenience, simplicity and efficacy in replicating features of Parkinson's disease (PD) in animal models. However, the wide range of doses reported in the literature makes it difficult to evaluate the effectiveness of this techniq...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2016.11.020
更新日期:2017-01-15 00:00:00
abstract::The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91739-6
更新日期:1994-03-14 00:00:00
abstract::Locally applied ciliary neurotrophic factor (CNTF) has a powerful effect on retrograde axonal reaction following facial nerve crush in neonatal rats. We examined whether it also exerts a strong effect on retrograde axonal reaction in young adult rats when administered subcutaneously. The dose was 1 mg/kg body weight, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01512-4
更新日期:1996-04-22 00:00:00
abstract::Symbolic visual cues indicating the location of an upcoming target are believed to invoke endogenous shifts of attention to cued locations. In the present study, we investigated how visual attention is shifted during such cuing paradigms by recording event-related potentials (ERPs). We focused on a component known to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.08.011
更新日期:2009-11-10 00:00:00
abstract::The ontogenic development of neurophysin has not been investigated so far. To study this problem, electron microscopic immunohistochemistry was performed on ultrathin sections of the posterior pituitary of foetal and newborn rats. A concomitant appearance of secretory granules and neurophysin was first noted in the po...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90007-5
更新日期:1977-07-01 00:00:00
abstract::Strychnine-sensitive, inhibitory glycine receptors have not until lately been considered to play a significant role in neurotransmission in mammalian forebrain regions. In order to investigate the role of glycine as a neurotransmitter in brain we have measured glycine induced chloride fluxes in different adult rat for...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01484-5
更新日期:1996-03-11 00:00:00
abstract::Several reports during the last three decades have indicated that biosynthesis of N-acetylaspartate (NAA) occurs primarily in the mitochondria. But a recent report by Lu et al. in this journal [2004; 122: 71-78] and subsequent two reports that cited those data suggested a predominant microsomal localization of the NAA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.06.040
更新日期:2008-08-28 00:00:00
abstract::Nesfatin-1, an 82-amino acid peptide encoded by the secreted precursor nucleobinin-2 (NUCB2), exerts potent anorexigenic action independently of leptin signaling. This propensity has propelled this peptide and its analogues as potential anti-obesity drug candidates. However, a more extensive comprehension of its biolo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.01.032
更新日期:2019-05-15 00:00:00
abstract::Repeated intracerebroventricular (i.c.v.) administration of angiotensin II (AII) and angiotensin III (AIII) induced dipsogenic tachyphylaxis in the Sprague-Dawley rat. AIII caused a rapid suppression of drinking, whereas AII showed a progressive decline of water consumption with repeated injections. Tachyphylaxis due ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90010-8
更新日期:1988-06-14 00:00:00
abstract::Retinotectal projections were studied in 33 different species of Actinopterygii, the ray-finned fishes, with horseradish peroxidase and cobalt tracing techniques. The distribution of retinorecipient layers in the contralateral optic tectum was analyzed. In addition, the degree of differentiation of the stratum periven...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91248-0
更新日期:1987-09-15 00:00:00
abstract::Horseradish peroxidase injections into the medulla of tadpoles demonstrate, by back-filling, efferent neurons in the torus semicircularis which project to the ipsilateral superior olive. This projection, as well as one to the vicinity of the efferent neurons of the contralateral VIII and lateral line nerves, is confir...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90774-1
更新日期:1984-02-06 00:00:00
abstract::The recent development of rodent models of bone cancer pain has started to provide the basis for demonstrating the particular neurochemical and behavioral entity of cancer pain. Behaviourally, both spontaneous pain and hyperalgesia related to mechanical, but not thermal, noxious stimuli have been described in cancer-b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02284-4
更新日期:2003-04-18 00:00:00
abstract::Whilst the brain-specific benzodiazepine receptor has been assumed to show a late evolutionary appearance, we present evidence for the presence of a central benzodiazepine binding site in sharks, which shows a high affinity for [3H]Ro 15-1788. However, the receptor density and the affinities of several benzodiazepine ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90884-0
更新日期:1988-04-19 00:00:00
abstract::The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90894-6
更新日期:1983-05-16 00:00:00
abstract::Olfactory nerve input is required for the normal expression of tyrosine hydroxylase (TH) by dopaminergic neurons in the glomerular region of the rodent main olfactory bulb. To determine whether the olfactory nerve exerts a similar influence on neurons in other brain regions, we performed unilateral bulbectomies in rat...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90977-3
更新日期:1989-09-11 00:00:00
abstract::Thyrotropin-releasing hormone (TRH; Protirelin) is an endogenous neuropeptide known to have anticonvulsant effects in several seizure models and in intractable epileptic patients. Like most neuropeptides, its duration of action may be limited by a lack of sustained site-specific bioavailability. To attempt to provide ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00860-9
更新日期:1998-11-02 00:00:00
abstract::Gaze processing was investigated using event-related potentials in two different tasks in which front-view and 3/4-view faces were presented, with eyes gazing straight ahead or averted. Task alternated between an explicit gaze direction judgment and a judgment on head orientation where gaze was irrelevant. Accuracy an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.07.094
更新日期:2007-10-26 00:00:00