Glucocorticoid modification of spinal dopamine receptor activation by apomorphine.

Abstract:

:The effects of an intensive short-term glucocorticoid (e.g. triamcinolone) regimen in cats have been studied on the actions of the dopamine (DA) receptor agonist apomorphine (APO) on spinal lumbar primary afferent excitability (dorsal root reflex or DRR) and monosynaptic reflex (MSR) transmission. Glucocorticoid dosing significantly decreased the APO-induced depression of the spinal DRR, but not the similar action of APO on the MSR. This complex effect of triamcinolone on spinal dopaminergic activation by APO may represent a differential action of glucocorticoid on two types of spinal DA receptors with one type, but not the other, undergoing partial desensitization.

journal_name

Brain Res

journal_title

Brain research

authors

Hall ED,Tyler CV Jr

doi

10.1016/0006-8993(83)90894-6

subject

Has Abstract

pub_date

1983-05-16 00:00:00

pages

380-3

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(83)90894-6

journal_volume

267

pub_type

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