Abstract：
:Nitric oxide synthase (NOS) activity was examined in forebrain, cerebellum and optic lobes of adult domestic fowl, having a hereditary primary generalized convulsive disorder. NOS was approximately 2-fold higher in only the forebrain of adult epileptic fowl compared to non-epileptic (carrier) hatchmates. A significant increase in NOS was also evident in forebrains of 1-day-old epileptic chicks. Ca(2+)-dependency experiments confirmed that these increments were principally due to type I NOS (NOS-I). Induction of convulsions by intermittent photic stimulation did not affect pre-existing forebrain NOS-I activity. The present data suggest that an enhanced NO signaling may ensue in selected regions of the brain as an adaptive response to hereditary epileptogenesis.
journal_name
Brain Resjournal_title
Brain researchauthors
Sandirasegarane L,Mikler JR,Tuchek JM,Sulakhe PVdoi
10.1016/0006-8993(96)00595-1subject
Has Abstractpub_date
1996-10-07 00:00:00pages
311-3issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(96)00595-1journal_volume
735pub_type
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