Abstract：
:In this study, the neuromodulatory effects of progesterone were tested in an intact neuronal circuit of a model extrahypothalamic CNS area. Spontaneous discharge and responses of single cerebellar Purkinje neurons to microiontophoretically applied gamma-aminobutyric acid (GABA) and glutamate were monitored before, during and after either systemic injection, at physiologic doses, or local application of the steroid. By both means of administration, progesterone significantly enhanced inhibitory responses of Purkinje cells to GABA and suppressed glutamate excitation within 3-10 min post-steroid. These results are consistent with the anxiolytic actions of the steroid.
journal_name
Brain Resjournal_title
Brain researchauthors
Smith SS,Waterhouse BD,Chapin JK,Woodward DJdoi
10.1016/0006-8993(87)90634-2subject
Has Abstractpub_date
1987-01-06 00:00:00pages
353-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90634-2journal_volume
400pub_type
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