Abstract：
:By means of the [14C]deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in the lateral geniculate nucleus and the superior colliculus of rats with a simultaneous double enucleation, animals with an enucleation of the right eye between neonatal and adult stages followed by an enucleation of the left eye some months later and adult control rats. The control animals show LCGU values within the limits published by other observers. The LCGU values of the simultaneously double-enucleated rats are reduced on both sides to the same extent by about 20%. The dorsal lateral geniculate nucleus shows the largest decrease. The LCGU values of the rats with the delayed double enucleation have decreased even more (up to 37%). The right sided visual brain regions have a significantly lower LCGU than the corresponding regions on the left side. These findings indicate that unilateral enucleation from neonatal to adult stages leads to adaptive changes resulting in a higher metabolic vulnerability, which is revealed by the second enucleation.
journal_name
Brain Resjournal_title
Brain researchauthors
Zilles K,Wree A,Petrovic-Minic B,Schleicher A,Beck Tdoi
10.1016/0006-8993(89)90688-4subject
Has Abstractpub_date
1989-05-29 00:00:00pages
14-21issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(89)90688-4journal_volume
488pub_type
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