Abstract：
:Maternal cocaine abuse has several deleterious effects in the newborn, including perinatal asphyxia, hypoxia, and hypercapnia. We hypothesized that chronic cocaine exposure during development may alter cerebral blood flow (CBF) regulation. We studied 16 neonatal rabbits that had received cocaine (20 mg/kg, i.p. b.i.d.) or saline since birth. Changes in CBF were measured by laser doppler flowmetry before (baseline), and during hypercapnia (FiCO2 = 7.5%), hypoxia (FiO2 = 12%), and asphyxia (apnea for 1 min). During hypercapnia, CBF increased less in cocaine than in control animals (28 +/- 3% vs. 69 +/- 10%, P < 0.05). During hypoxia, CBF increased similarly in both groups. During reventilation after asphyxia, CBF increased more in cocaine than in control animals (391 +/- 52% vs. 225 +/- 43%, P < 0.05). Chronic cocaine exposure during brain development appears to alter CBF regulation to hypercapnia and asphyxia, which may put the drug exposed newborn at risk for neurologic injury around birth.
journal_name
Brain Resjournal_title
Brain researchauthors
Feuer P,Loeb A,Monitto CL,O'Rourke M,Kurth CDdoi
10.1016/s0006-8993(97)00178-9subject
Has Abstractpub_date
1997-04-25 00:00:00pages
142-5issue
1eissn
0006-8993issn
1872-6240pii
S0006899397001789journal_volume
755pub_type
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