A consideration of sensory factors involved in motor functions of the basal ganglia.

Abstract:

:There is a sizeable literature concerning basal ganglia (BG) functioning that is based on data from experiments employing a method of analysis that is traditionally used with other motor areas. A brief review of this literature is presented and the following conclusion is reached: as compared to the success of traditional methodologies in elucidating the workings of other motor systems, their use in BG investigations has proven disappointing. A possible reason for the shortcomings of traditional analyses in BG research is discussed. The remainder of this review concerns an alternative approach to the study of the BG that follows from consideration of a variety of clinical and experimental findings. The literature suggests that sensory aspects of BG functioning must be taken into account to fully appreciate the role of this system in motor control. A review of the literature concerning the latter suggests two points: The BG function as sensory analyzer for motor systems. That is, the BG convert sensory data from a form that is receptor oriented to a form that is relevant for guiding movement. The BG ultimately affect movement by gating sensory inputs into other motor areas rather than by directly affecting these areas. This sensory-based model of BG functioning explains a number of apparent discrepancies in the literature. In addition, seemingly anomalous findings are reconciled with the overwhelming evidence that the BG are a motor system. In particular, the suggestions of a BG role in attention and cognition are viewed as being intrinsic rather than orthogonal to the role of the BG in movement.

journal_name

Brain Res

journal_title

Brain research

authors

Lidsky TI,Manetto C,Schneider JS

doi

10.1016/0165-0173(85)90010-4

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

133-46

issue

2

eissn

0006-8993

issn

1872-6240

journal_volume

356

pub_type

杂志文章,评审
  • Ethanol enhancement of GABA-activated chloride current in rat dorsal root ganglion neurons.

    abstract::The acute effects of ethanol on the gamma-aminobutyric acid (GABA)-activated current were studied with the rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. GABA produced an inward chloride current, which was composed of an initial transient and a subsequent sustained phas...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)90982-h

    authors: Nishio M,Narahashi T

    更新日期:1990-06-04 00:00:00

  • Properties of otolith-related vestibular nuclear neurons in response to bidirectional off-vertical axis rotation of the rat.

    abstract::In decerebrate rats, the responses of tilt-sensitive neurons in the lateral and descending vestibular nuclei were studied during constant velocity 10 degrees off-vertical axis rotations (OVAR) in the clockwise (VW) and counterclockwise (CCW) directions. Seventy three otolith-related units showed a sinusoidal position-...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(95)00687-l

    authors: Lai CH,Chan YS

    更新日期:1995-09-25 00:00:00

  • Event-related potential evidence of accessing gender stereotypes to aid source monitoring.

    abstract::Source memory for the speaker's voice (male or female) was investigated when semantic knowledge (gender stereotypes) could and could not inform the episodic source judgment while event-related potentials (ERPs) were recorded. Source accuracy was greater and response times were faster when stereotypes could predict the...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2012.11.013

    authors: Leynes PA,Crawford JT,Radebaugh AM,Taranto E

    更新日期:2013-01-23 00:00:00

  • Identification of recoverin-like immunoreactivity in mouse brain.

    abstract::Mouse brain was found by immunoblot analysis to have a protein of Mr 23,000 (P23k) that was clearly different from recoverin and was labeled with an antiserum raised against the NH2-terminus of recoverin. P23k could not be detected by an antiserum raised against the COOH-terminus of recoverin. Blots with 45Ca demonstr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(92)90676-z

    authors: Takamatsu K,Uyemura K

    更新日期:1992-02-07 00:00:00

  • Cholinergic modulation of the functional organization of the cat visual cortex.

    abstract::The cortex receives a cholinergic input which is considered to be involved in mediating the effects of arousal. The experiments reported here have examined the nature of the cholinergic influence on the neuronal organization of the cat visual cortex. Out of 83 cells studied, 92% exhibited a modification in their visua...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(83)90015-x

    authors: Sillito AM,Kemp JA

    更新日期:1983-12-19 00:00:00

  • Effect of small changes in temperature on CA1 pyramidal cells from rat hippocampal slices during hypoxia: implications about the mechanism of hypothermic protection against neuronal damage.

    abstract::Small reductions in temperature have been shown to improve neurologic recovery after ischemia. We have examined the effect of temperature on biochemical and physiological changes during hypoxia using rat hippocampal slices as a model system. The postsynaptic population spike recorded from the CA1 pyramidal cell region...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(99)01944-7

    authors: Amorim P,Cottrell JE,Kass IS

    更新日期:1999-10-09 00:00:00

  • Amantadine increases the extracellular dopamine levels in the striatum by re-uptake inhibition and by N-methyl-D-aspartate antagonism.

    abstract::This study was performed to investigate the mechanism how amantadine increases the extracellular dopamine (DA) levels in the striatum in vivo. Local application of amantadine (1 mM, 40 min) to the striatum through the dialysis membrane significantly increased the extracellular DA levels. Coadministration of nomifensin...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)90821-4

    authors: Mizoguchi K,Yokoo H,Yoshida M,Tanaka T,Tanaka M

    更新日期:1994-10-31 00:00:00

  • Medullary pathways involved in cardiac sympathoexcitatory reflexes in the cat.

    abstract::Stimulation of cardiac sympathetic afferents evokes excitatory cardiovascular reflexes. However, the exact regions in the brain that integrate these reflexes have not been identified. Expression of c-Fos in the neurons provides a useful marker of the activated neurons. In the present study, we examined the response of...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03259-0

    authors: Guo ZL,Lai HC,Longhurst JC

    更新日期:2002-01-18 00:00:00

  • gamma-L-glutamyl-L-aspartate induces specific deficits in long-term memory and inhibits [3H]glutamate binding on hippocampal membranes.

    abstract::gamma-L-Glutamyl-L-aspartic acid (gamma-LGLA) has been isolated from Datura stramonium; its structure has been determined and it was then synthesized. In male Swiss mice intraperitoneal administration of the natural peptide (125 nmol/kg) or of the synthetic peptide (25-2500 nmol/kg) 24 h after acquisition of a Y-maze ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90878-5

    authors: Ungerer A,Schmitz-Bourgeois M,Mélan C,Boulanger Y,Reinbolt J,Amiri I,de Barry J

    更新日期:1988-04-19 00:00:00

  • The effect of raphe lesion on sleep in the rat.

    abstract::The midbrain raphe nuclei (nucleus raphe dorsalis and nucleus raphe medialis) were destroyed by electrocoaggulation in rats. On the first few days following the lesion, a marked hyperactivity was observed in lesioned animals as well as in shame-operated controls. Between the 5th and 36th days after the lesion, sleep p...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(80)91218-4

    authors: Juvancz P

    更新日期:1980-08-04 00:00:00

  • Amyloid beta-protein stimulates casein kinase I and casein kinase II activities.

    abstract::Amyloid beta-protein (A beta) is the major protein of cerebrovascular and plaque amyloid in Alzheimer's disease (AD). Extensive evidence has demonstrated abnormal protein phosphorylation in this disease. We investigated the effect of synthetic A beta with the amino-acid sequence corresponding to cerebrovascular A beta...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(93)90479-7

    authors: Chauhan A,Chauhan VP,Murakami N,Brockerhoff H,Wisniewski HM

    更新日期:1993-11-26 00:00:00

  • Increased [3H]glutamate receptor binding in aged rats.

    abstract::Na-independent [3H]glutamate binding to rat hippocampal membranes increases progressively as a function of age. The increased binding represents an increased number of binding sites without changes in their apparent affinity for glutamate. However, [3H]glutamate binding, measured with a saturating concentration of cal...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(81)90823-4

    authors: Baudry M,Arst DS,Lynch G

    更新日期:1981-10-26 00:00:00

  • Cholinergic binding sites in rat hippocampal formation: properties and ontogenesis.

    abstract::The hippocampal formation of the rat contains two types of membrane-bound cholinergic binding sites, as revealed by specific binding of [3H]quinuclidinyl benzilate (QNB) or of a-[125I]bungarotoxin (a-Btx). The sites differ in pharmacological profile, sensitivity to detergents and ontogenesis. The major binding site (a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(79)90211-7

    authors: Ben-Barak J,Dudai Y

    更新日期:1979-04-27 00:00:00

  • Respiratory and autonomic responses to microinjection of NMDA and AMPA into the commissural subnucleus of the NTS of awake rats.

    abstract::The changes in mean arterial pressure (MAP) and respiratory frequency (RF) in response to microinjection of NMDA or AMPA into the commissural subnucleus of the NTS (comNTS) at the calamus scriptorius level of awake rats were evaluated. Under tribromoethanol anesthesia, the rats received guide-cannulae in direction of ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.09.017

    authors: Almado CE,Machado BH

    更新日期:2005-11-23 00:00:00

  • Vasopressin and glucoprivic-feeding behavior: a new perspective on an 'old' peptide.

    abstract::The feeding responses induced by systemic administration of 2-deoxy-D-glucose (2-DG) and paraventricular hypothalamic injection of norepinephrine were assessed in Brattleboro rats deficient in vasopressin (VP). Controlling for the non-specific complications of diabetes insipidus, it was found that Brattleboro rats hav...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(86)91070-x

    authors: Aravich PF,Sladek CD

    更新日期:1986-10-22 00:00:00

  • Neuroprotective effects of the N-terminal tripeptide of IGF-1, glycine-proline-glutamate, in the immature rat brain after hypoxic-ischemic injury.

    abstract::Insulin growth factor 1 (IGF-1) has an important role in brain development and is strongly expressed during recovery after a hypoxic-ischemic injury. Some of its central actions could be mediated through the N-terminal tripeptide fragment of IGF-1: Gly-Pro-Glu (GPE). The neuroprotective properties of GPE given after a...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(01)03148-1

    authors: Sizonenko SV,Sirimanne ES,Williams CE,Gluckman PD

    更新日期:2001-12-13 00:00:00

  • Streptozotocin-induced diabetes produces a naltrexone-reversible lowering of self-stimulation threshold.

    abstract::Stimulation frequency thresholds for lateral hypothalamic self-stimulation were monitored for 3 weeks following the induction of diabetes with streptozotocin (STZ). In each of the 3 weeks following STZ treatment, thresholds of diabetic rats were significantly lower than their pre-STZ baseline while thresholds of contr...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)91973-9

    authors: Carr KD

    更新日期:1994-11-21 00:00:00

  • Neuroprotective properties of selective estrogen receptor agonists in cultured neurons.

    abstract::To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2005.03.032

    authors: Cordey M,Pike CJ

    更新日期:2005-05-31 00:00:00

  • Antidiabetic sulfonylureas: localization of binding sites in the brain and effects on the hyperpolarization induced by anoxia in hippocampal slices.

    abstract::The distribution of antidiabetic sulfonylurea [( 3H]glibenclamide) binding sites is heterogeneous in rat brain. Pyramidal and extrapyramidal motor system contain the highest densities of sites, particularly in the substantia nigra and in the globus pallidus. Only low levels are present in the hypothalamic nuclei and t...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(89)91288-2

    authors: Mourre C,Ben Ari Y,Bernardi H,Fosset M,Lazdunski M

    更新日期:1989-05-01 00:00:00

  • Neonatal testosterone treatment increases neuron and synapse numbers in male rat superior cervical ganglion.

    abstract::Neonatal treatment with gonadal steroids has been reported to alter morphological as well as functional development in various regions of the brain and spinal cord. Among the observed alterations are changes in numbers of neurons and in the organization and numbers of synapses. These regions have been found to be sexu...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0165-3806(83)90001-9

    authors: Wright LL,Smolen AJ

    更新日期:1983-06-01 00:00:00

  • Selective breeding for differences in cholinergic function: pre- and postsynaptic mechanisms involved in sensitivity to the anticholinesterase, DFP.

    abstract::To determine the contribution of presynaptic cholinergic mechanisms to the increased sensitivity of a genetically selected line of Sprague-Dawley rats (Flinders S-line) to the anticholinesterase, diisopropyl fluorophosphate (DFP), rats were sacrificed by focused microwave irradiation of the head 1 min after a pulse in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(84)91044-8

    authors: Overstreet DH,Russell RW,Crocker AD,Schiller GD

    更新日期:1984-03-05 00:00:00

  • A new densitometric procedure to measure protein levels in tissue slices used in quantitative autoradiography.

    abstract::A new quantitative staining technique for the assay of protein in tissue sections using the dye Coomassie brilliant blue G 250 is discussed. This densitometric procedure uses commercially available hardware and software employed in the quantitation of receptor autoradiographs. Rather than assuming a homogeneous distri...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(88)90965-1

    authors: Miller JA,Curella P,Zahniser NR

    更新日期:1988-04-26 00:00:00

  • Transport of cargo from periphery to brain by circulating monocytes.

    abstract::The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2015.06.047

    authors: Cintron AF,Dalal NV,Dooyema J,Betarbet R,Walker LC

    更新日期:2015-10-05 00:00:00

  • The Na+/K+ATPase activity is increased in the hippocampus after multiple status epilepticus induced by pilocarpine in developing rats.

    abstract::The effects of repetitive pilocarpine-induced status epilepticus (SE) in the hippocampal Na(+)/K(+)ATPase activity were studied in developing rat. Na(+)/K(+)ATPase is a membrane-bound enzyme responsible for the active transport of sodium and potassium ions through the membrane. It is necessary to maintain neuronal exc...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2006.12.068

    authors: Reime Kinjo E,Arida RM,Mara de Oliveira D,da Silva Fernandes MJ

    更新日期:2007-03-23 00:00:00

  • Diethyldithiocarbamate and dithizone augment the toxicity of kainic acid.

    abstract::Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(90)91273-j

    authors: Mitchell CL,Barnes MI,Grimes LM

    更新日期:1990-01-08 00:00:00

  • Different spatial organizations of saccade related BOLD-activation in parietal and striate cortex.

    abstract::Voluntary saccades performed in total darkness provide the opportunity to investigate the brain system active during saccades without confounding effects caused by the saccade induced shifts of the retinal image. Using this approach saccade related activation has been demonstrated not only in parietal but also in stri...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2008.07.108

    authors: Rieger JW,Schoenfeld MA,Heinze HJ,Bodis-Wollner I

    更新日期:2008-10-03 00:00:00

  • Role of excitatory amino-acids in diethyldithiocarbamate-induced cell death in mesencephalic cultures.

    abstract::The effects of diethyldithiocarbamate (DDC) and DDC plus glutamate on mesencephalic cell cultures were investigated. DDC 10 microM was toxic for cell cultures as assessed by observation under a phase-contrast microscope and the drop in [3H]dopamine uptake. Moreover, DDC 1 microM greatly potentiated cell death induced ...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(94)01457-s

    authors: Vaglini F,Pardini C,Maggio R,Corsini GU

    更新日期:1995-03-13 00:00:00

  • Stable long-term recordings from cat peripheral nerves.

    abstract::A procedure has been developed for the stable long-term recording of nerve signals in unanesthetized mammals, which should have wide application in basic research on the nervous system and also in clinical areas such as the derivation of control signals for powered prostheses. Methods are fully described for construct...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/0006-8993(77)90233-5

    authors: Stein RB,Nichols TR,Jhamandas J,Davis L,Charles D

    更新日期:1977-06-03 00:00:00

  • NO-sGC-cGMP signaling influence the anxiolytic like effect of lithium in mice in light and dark box and elevated plus maze.

    abstract::Glutamate is an excitatory neurotransmitter implicated in the pathogenesis of psychiatric disorders. Glutamate results in the activation of an enzyme called glycogen synthase kinase-3 (GSK-3) acting through N-methyl-d-aspartate (NMDA) receptors. Impaired expression of GSK-3 affects behavior and neurochemicals level in...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/j.brainres.2018.10.002

    authors: Walia V,Garg C,Garg M

    更新日期:2019-02-01 00:00:00

  • The role of cyclo-oxygenase 1 and 2 activity in prostaglandin E(2) secretion by cultured human adult microglia: implications for Alzheimer's disease.

    abstract::Microglial cyclo-oxygenase (COX) expression is considered to be important in the pathogenesis of Alzheimer's disease (AD) and, therefore, constitutes a key target for therapeutic intervention. We investigated the influence of AD plaque associated factors on COX-1 and COX-2 expression and activity in adult human microg...

    journal_title:Brain research

    pub_type: 杂志文章

    doi:10.1016/s0006-8993(02)03164-5

    authors: Hoozemans JJ,Veerhuis R,Janssen I,van Elk EJ,Rozemuller AJ,Eikelenboom P

    更新日期:2002-10-04 00:00:00