Abstract：
:Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may be useful tools for investigating the role of zinc in central nervous system excitatory transmission and/or convulsive phenomena.
journal_name
Brain Resjournal_title
Brain researchauthors
Mitchell CL,Barnes MI,Grimes LMdoi
10.1016/0006-8993(90)91273-jsubject
Has Abstractpub_date
1990-01-08 00:00:00pages
327-30issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(90)91273-Jjournal_volume
506pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Echo-planar magnetic resonance imaging (EP-MRI), which is novel variant of MRI, is thought to have antidepressant properties in humans and animal models. Using the forced swimming test (FST), we investigated which monoaminergic system in mice is affected by EP-MRI. The short- and long-term effects of EP-MRI on immobil...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.08.011
更新日期：2008-10-21 00:00:00
abstract：:Eye and head movements during tracking of a smoothly moving visual target were recorded in trained monkeys. The head movement clearly followed the target, although with considerable variability from cycle to cycle. The eye stayed relatively near the primary position and moved in an apparently irregular fashion; howeve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91127-7
更新日期：1978-09-15 00:00:00
abstract：:The effects of pituitary adenylate cyclase activating polypeptides (PACAPs: PACAP27, PACAP38) on glutamate-induced neurotoxicity were examined using cultured retinal neurons obtained from 3- to 5-day old Wistar rats. Cell viability was evaluated by double staining with fluorescein diacetate and propidium iodide. Effec...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01690-x
更新日期：1999-08-21 00:00:00
abstract：:The present study utilized the [14C]2-deoxyglucose (2-DG) cell labeling procedure to characterize a functional pathway from the prefrontal cortex (Pfc) and mediodorsal thalamic nucleus (MD) to the hypothalamus. Rats were injected with 2-DG prior to a 45 min experimental paradigm consisting of alternating 30 s on-off p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90151-3
更新日期：1984-09-24 00:00:00
abstract：:Sardinian ethanol-preferring (sP), non-preferring (sNP), and Wistar rats show similar dopaminergic response to vanilla sugar consumption in nucleus accumbens shell (NAcS) and medial prefrontal cortex (mPFC), and similarly learn a vanilla sugar-sustained appetitive behavior. In this study we investigated whether in sat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.043
更新日期：2004-04-23 00:00:00
abstract：:The objective was to determine if corticopetal basal forebrain neurons could co-synthesize different transmitters. Histochemical labeling of a molecular marker of connectivity (wheat germ agglutinin lectin-bound horseradish peroxidase [HRP]; axonal uptake and retrograde transport from neocortex) and immunohistochemica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90099-1
更新日期：1989-07-03 00:00:00
abstract：:This study was designed to describe renal afferent information with respect to its intraspinal projections, convergence with cutaneous inputs, ascending projections, and modulation by descending fiber tracts. Extracellular recordings were made from neurons in the spinal gray while electrically stimulating the renal ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91292-9
更新日期：1988-04-12 00:00:00
abstract：BACKGROUND:Toll-like receptor 4 (TLR4) is an important mediator of the innate immune response. It significantly contributes to neuroinflammation and may be involved in ischemic tolerance. It is unknown how cerebral ischemia in the cortex and postconditioning might affect inflammatory reactions in the hippocampus or whe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.02.005
更新日期：2011-04-12 00:00:00
abstract：:The contribution of motor and intralaminar thalamic nuclei to the changes of [3H]GABA release evoked in both caudate nuclei (CN) and both substantia nigra (SN) by a unilateral nigral application of muscimol (10(-6) M) was investigated on halothane-anaesthetized cats. Acute lesions were performed on one side of the tha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91206-x
更新日期：1984-06-15 00:00:00
abstract：:Chick neural cultures were used to study effects of insulin, thyrotropin releasing hormone, growth hormone and glucagon on myelin lipid synthesis in vitro. The incorporation of [3H]galactose into myelin associated lipids such as cerebroside and sulfatide was used as an index for various hormonal effects on myelination...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90831-0
更新日期：1986-04-16 00:00:00
abstract：:Ultrastructural examination of the region near the olfactory epithelial surface of leopard frogs revealed the presence of nerve terminals just proximal to the zonula adherens between adjacent sustentacular cells, and between sustentacular cells and olfactory receptor neurons. Terminal varicosities, located about 20 nm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90920-7
更新日期：1989-07-17 00:00:00
abstract：:ASIC3-immunoreactivity (ir) was examined in the rat vagal and glossopharyngeal sensory ganglia. In the jugular, petrosal and nodose ganglia, 24.8%, 30.8% and 20.6% of sensory neurons, respectively, were immunoreactive for ASIC3. These neurons were observed throughout the ganglia. A double immunofluorescence method dem...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.01.039
更新日期：2006-04-07 00:00:00
abstract：:Using the hippocampal slice preparation, extracellular recordings of CA3 field excitatory postsynaptic potentials (fEPSPs) were performed to assess the effects of adenosine on the induction of mossy fiber long-term potentiation (LTP). When present during tetanization, adenosine (50 microM) significantly suppressed mos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91061-5
更新日期：1991-03-08 00:00:00
abstract：:The localization of the receptor for apamin, a specific toxin for one class of sensitive Ca2+-dependent K+ channel, was studied in rat brain using an in vitro autoradiographic technique. Radiolabeled monoiodoapamin binds specifically to rat brain sections with a high affinity (Kd = 25 pM) to a single class of sites. A...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91333-8
更新日期：1986-09-24 00:00:00
abstract：:Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved in ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and neurological deficits in a standardized model of transient focal cerebra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.078
更新日期：2004-05-08 00:00:00
abstract：:Memory and perception are two tightly interrelated cognitive processes, but the neural level of their interaction remains a matter of debate. Proponents of a late interaction emphasize feedback memory effects on visual processing, whereas others suggest that feed forward processing is affected by memory. In the visual...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.087
更新日期：2009-08-18 00:00:00
abstract：:Prostaglandin E2 (PGE2) is a lipid mediator which plays a role in the generation of inflammatory and neuropathic pain. In the peripheral nervous system, PGE2 sensitizes nociceptive afferent neurons through E-prostanoid (EP) receptors. In the central nervous system, PGE2 modulates pain sensitivity and contributes to th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147153
更新日期：2021-01-01 00:00:00
abstract：:A study was undertaken of the possible relationship of the binding affinity of a series of anticholinergic psychotomimetic drugs to their psychopharmacological and anticholinergic effects. Binding was measured to brain homogenates and nerve endings using [3H]quinuclidinyl benzilate (QB), a highly potent psychotomimeti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90889-7
更新日期：1977-03-25 00:00:00
abstract：:Superfusion of the hepatic portal vein with hypertonic saline solutions increases the electrical activity of the hypothalamo-neurohypophysial tract. Bilateral cervical vagotomy had no effect on this response in all rats studied. Section of the hepatic branch of the vagus abolished the hypothalamic response in only two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90850-2
更新日期：1982-05-06 00:00:00
abstract：:Glial-derived monocarboxylate lactate is thought to be an important energy source for neurons during brain activation or in hypoxia-ischemia. Treatment with alpha-cyano-4-hydroxycinnamate (4-CIN), a monocarboxylate transporter inhibitor, has been recently reported to exacerbate delayed neuronal damage in a rat model o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)03375-4
更新日期：2003-10-31 00:00:00
abstract：:The retrograde transport of fluorescent substances was used in order to investigate divergent axon collaterals of neurons in the nucleus prepositus hypoglossi (Ph). Fast blue (FB) was injected into the flocculus, paraflocculus and/or the vermis, while nuclear yellow (NY) was injected into the oculomotor nucleus alone ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90150-0
更新日期：1982-08-19 00:00:00
abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.10.058
更新日期：2010-01-14 00:00:00
abstract：:The extraction and utilization of sound level changes in acoustic-autonomic reflex systems were studied on a vasoconstriction response in the tail of nonanesthetized rats. The vasoconstriction was found to depend on sound level and changes of level in the following ways. (a) It increased as a linear function of sound ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90555-7
更新日期：1980-04-21 00:00:00
abstract：:Excitatory and inhibitory synapses may control neuronal output through a push-pull mechanism--that is, increases in excitation are coupled to simultaneous decreases in inhibition or vice versa. This pattern of activity is characteristic of excitatory and inhibitory vestibulospinal axons that mediate vestibulocollic re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.03.065
更新日期：2010-05-28 00:00:00
abstract：:In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to c...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2021.147277
更新日期：2021-01-07 00:00:00
abstract：:Zebrafish as a neurogenetic model system depends on the correct neuroanatomical understanding of its brain organization. Here, we address the unresolved question regarding a possible zebrafish homologue of the dorsal pallial division, the region that in mammals gives rise to the isocortex. Analyzing the distributions ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.12.089
更新日期：2011-03-24 00:00:00
abstract：:Microinjection of the indirect GABAA antagonist, picrotoxin, or the mu opioid agonist, Tyr-D-Ala-Gly-NMe-Phe-Gly-ol (DAGO), into the ventral pallidum and substantia innominata (VP/SI) increases locomotor activity in rats. The VP/SI has direct and indirect projections to the region of the ventral mesencephalon containi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91005-l
更新日期：1991-02-22 00:00:00
abstract：:Using gold-labelled somatostatin, somatostatin binding sites were predominantly found in laminae I-III, X and on motorneurones of the rat lumbar spinal cord. A comparison with immunohistochemical staining using antisera against somatostatin receptor sequences revealed that the marked binding in laminae I-III coincided...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01226-8
更新日期：1999-01-16 00:00:00
abstract：:The responses of single neurons in the insular cortex to electrical stimulation of the chorda tympani (CT), lingual-tonsillar branch of the glossopharyngeal (LT-IXth) nerve, pharyngeal branch of the glossopharyngeal (PH-IXth) nerve, and superior laryngeal (SL) nerve were recorded in anaesthetized and paralyzed rats. N...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00483-6
更新日期：1997-07-25 00:00:00
abstract：:The search for the neural substrate of a state of consciousness has led to the expectation that there may be neurons which discharge tonically and rhythmically during that state alone. We have now recorded in the cat the first evidence of neurons whose rhythmic discharge is consistent with the hypothesis of a tonicall...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(77)90900-3
更新日期：1977-01-21 00:00:00
