Transmitter cosynthesis by corticopetal basal forebrain neurons.

Abstract:

:The objective was to determine if corticopetal basal forebrain neurons could co-synthesize different transmitters. Histochemical labeling of a molecular marker of connectivity (wheat germ agglutinin lectin-bound horseradish peroxidase [HRP]; axonal uptake and retrograde transport from neocortex) and immunohistochemical labeling of molecular markers of transmitter synthesis (glutamic acid decarboxylase [GAD]: choline acetyltransferase [ChAT]) were combined in adult cats and examined by light microscopy. Adjoining partial profiles of the same neurons in the basal forebrain co-localized GAD + HRP and ChAT + HRP in adjacent faces of serial tissue sections. GAD + ChAT were also co-localized within individual profiles of neurons in the basal forebrain from single tissue sections. The results indicate that infrequent corticopetal neurons in the basal forebrain can produce both gamma-aminobutyric acid and acetylcholine.

journal_name

Brain Res

journal_title

Brain research

authors

Fisher RS,Levine MS

doi

10.1016/0006-8993(89)90099-1

subject

Has Abstract

pub_date

1989-07-03 00:00:00

pages

163-8

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(89)90099-1

journal_volume

491

pub_type

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