SH-SY5Y cells as a model for sigma receptor regulation of potassium-stimulated dopamine release.

abstract：:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...

journal_title：Brain research

authors： Amir S,Meyerovitch J,Shechter Y

更新日期：1987-09-01 00:00:00

abstract：:In rats under urethane or pentobarbitone anesthesia, Ca2+ -sensitive microelectrodes were inserted into CA3 and CA1 hippocampal cells. In 23 neurons with a mean resting membrane potential (Vm) of -56.9 mV, the Ca potential (VCa) fell below Vm by an average of -22.1 mV (S.D. +/- 19.1 mV), indicating a mean intracellula...

journal_title：Brain research

authors： Krnjević K,Morris ME,Ropert N

更新日期：1986-05-21 00:00:00

abstract：:The hypothalamic response area for electrically induced locomotion was determined using moveable electrodes and discriminant analysis as an appropriate statistical technique. At 241 out of 641 stimulated sites locomotion was induced. The distribution of locomotion sites is relatively diffuse. Discriminant analysis of ...

journal_title：Brain research

authors： Lammers JH,Kruk MR,Meelis W,van der Poel AM

更新日期：1988-05-24 00:00:00

abstract：:Two pathways that have been shown to mediate cerebral ischemic damage are the MEK/ERK cascade and the pro-apoptotic deltaPKC pathway. We investigated the relationship between these pathways in a rat model of focal ischemia by observing and modifying the activation state of each pathway. The ERK1/2 inhibitor, U0126, in...

journal_title：Brain research

authors： Castañeda D,Zhao H,Mochly-Rosen D,Steinberg GK

更新日期：2009-01-28 00:00:00

abstract：:In adolescence, gender differences in rates of affective disorders emerge. For both adolescent boys and girls, peer relationships are the primary source of life stressors though adolescent girls are more sensitive to such stressors. Social stressors are also powerful stressors for non-human social species like rodents...

journal_title：Brain research

authors： Weintraub A,Singaravelu J,Bhatnagar S

更新日期：2010-07-09 00:00:00

abstract：:It has been previously observed that taurine inhibits PKC-activated phosphorylation of specific proteins including a approximately 20k Mr protein in rat cortical synaptosomes. In the present study, the mechanism of the above effects of taurine were investigated. In an intrasynaptosomal cytosol fraction obtained by sub...

journal_title：Brain research

authors： Li YP,Lombardini JB

更新日期：1991-07-05 00:00:00

abstract：:The ventral tegmental area (VTA) is a brain region centrally involved in the development and expression of a variety of behaviors associated with drug use. Orexin/hypocretin (ox/hcrt) and corticotropin releasing factor (CRF) are both peptides released into the VTA, and an increasing number of studies show that both ox...

journal_title：Brain research

authors： Borgland SL,Ungless MA,Bonci A

更新日期：2010-02-16 00:00:00

abstract：:Prolidase deficiency is characterized by chronic ulcerative dermatitis, mental retardation, and frequent infections. In the present study we examined the characteristics of rat brain prolidase isoenzymes. Prolidase isoenzymes (PD I and PD II) were isolated from the rat brain using DEAE cellulose column chromatography....

journal_title：Brain research

authors： Chi H,Lu J,Liu G,Tong J,Nakayama K,Yamashita K,Kitaoka N,Kodama H

更新日期：2009-12-15 00:00:00

abstract：:Signaling pathways underlying the cognitive deficit of the Alzheimer's disease (AD) are not completely understood. Protein kinase C (PKC), a major neuronal protein plays a critical role in cellular signal transduction and it is known to be subjected to modulation in AD. We showed previously that, chronic infusion of b...

journal_title：Brain research

authors： Olariu A,Yamada K,Mamiya T,Hefco V,Nabeshima T

更新日期：2002-12-13 00:00:00

abstract：:The relationship between carotid body chemoreceptor activity and flow was studied in preparations superfused in vitro. The carotid bodies were excised from pentobarbitone-anesthetized cats and superfused with modified Tyrode's solution, buffered with HEPES-NaOH to pH 7.41. The bath temperature was kept constant at 37....

journal_title：Brain research

authors： Alcayaga J,Iturriaga R,Zapata P

更新日期：1988-07-05 00:00:00

abstract：:Saccadic eye tracking was studied in a monkey given i.v. injections of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The Parkinson-like symptoms which appeared in the animal's general motor behavior (akinesia, bradykinesia, hypokinesia) were also observed in its eye tracking. Similar oculomotor deficits are see...

journal_title：Brain research

authors： Brooks BA,Fuchs AF,Finocchio D

更新日期：1986-09-24 00:00:00

abstract：:Depolarizing actions of 4 conformationally restricted L-glutamate analogues, (2S,3S,4S) isomer (L-CCG-I), (2S,3R,4R) isomer (L-CCG-II), (2S,3S,4R) isomer (L-CCG-III) and (2S,3R,4S) isomer (L-CCG-IV) of L-alpha-(carboxycyclopropyl)-glycine (L-CCG), were investigated in the isolated rat spinal cord by extracellular reco...

journal_title：Brain research

authors： Shinozaki H,Ishida M,Shimamoto K,Ohfune Y

更新日期：1989-02-20 00:00:00

abstract：:Central administration of CRH results in endocrinological, cardiovascular, and behavioral effects that suggest stress or anxiety. Among these is a marked pressor response. Parenteral administration of CRH, however, results in hypotension. We used parenteral administration of antalarmin, a novel, small molecule CRH1 re...

journal_title：Brain research

authors： Briscoe RJ,Cabrera CL,Baird TJ,Rice KC,Woods JH

更新日期：2000-10-27 00:00:00

abstract：:Excitatory amino acid neurotoxicity and the inflammatory response are suspected as mediators of some of the pathological sequelae occurring as a result of spinal cord injury. Here we report temporal and regional increases of the NMDA receptor agonist, quinolinic acid (QUIN), in an experimental model of spinal contusio...

journal_title：Brain research

authors： Popovich PG,Reinhard JF Jr,Flanagan EM,Stokes BT

更新日期：1994-01-07 00:00:00

abstract：:Extended incubation of hippocampus slices in the presence of fatty acid-free bovine serum albumin (FAF-BSA) strongly enhanced the release of D-[3H]aspartate and [14C]GABA induced by veratridine. Saturation of the FAF-BSA with oleic acid abolished the enhancing effect. Spontaneous release and K+-induced release were no...

journal_title：Brain research

authors： Minc-Golomb D,Eimerl S,Levy Y,Schramm M

更新日期：1988-08-09 00:00:00

abstract：:It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (T...

journal_title：Brain research

authors： Zhang JL,Yang JP,Zhang JR,Li RQ,Wang J,Jan JJ,Zhuang Q

更新日期：2013-02-01 00:00:00

abstract：:An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...

journal_title：Brain research

authors： Miles R

更新日期：1983-07-25 00:00:00

abstract：:The purpose of this study was to determine whether treatment with high-dose human serum albumin (HSA) would offer protection in a model of high-grade transient forebrain ischemia. Twenty-six fasted Wistar rats underwent bilateral common carotid artery occlusion and severe hypotension (50 mmHg) for 10 min. The agent (2...

journal_title：Brain research

authors： Belayev L,Saul I,Huh PW,Finotti N,Zhao W,Busto R,Ginsberg MD

更新日期：1999-10-16 00:00:00

abstract：:The distribution of melanin-concentrating hormone-like immunoreactivity (MCH-LI) in 41 microdissected brain and spinal cord regions was determined using radioimmunoassay with antibodies to salmon MCH. The highest concentration of MCH-LI was detected just ventral to the zona incerta (subzona incerta) (2923.2 fmol/mg pr...

journal_title：Brain research

authors： Zamir N,Skofitsch G,Jacobowitz DM

更新日期：1986-05-14 00:00:00

abstract：:Humans flexibly adapt their behavior using feedback from their environment. This ability is impaired in old age, but recent research suggests this mainly concerns processing of negative feedback and that positive feedback might be spared. The aim of this study was to test this idea of an age-related positivity bias ag...

journal_title：Brain research

authors： Ferdinand NK

更新日期：2019-08-15 00:00:00

abstract：:The immunocytological study of LH-RH producing neurons was carried out on 3 newborns and 14 fetuses (from 10 to 36 weeks of age). Perikarya and fibers which were immunoreactive to anti-LH-RH IS were revealed by IF or IE in all the hypothalamus beginning with the 13th week. Important variations in neurons staining may ...

journal_title：Brain research

authors： Bugnon C,Bloch B,Fellmann D

更新日期：1977-06-10 00:00:00

abstract：:Diurnal changes in the intranuclear release of vasopressin (VP) and oxytocin (OT) in the suprachiasmatic (SCN), paraventricular (PVN) and supraoptic nuclei (SON) of the rat were studied by means of brain microdialysis. A significant diurnal variation in VP release in the SCN was detected, with the highest levels occur...

journal_title：Brain research

authors： Kalsbeek A,Buijs RM,Engelmann M,Wotjak CT,Landgraf R

更新日期：1995-06-05 00:00:00

abstract：:The retinohypothalamic tract, a monosynaptic retinal projection to the suprachiasmatic nucleus (SCN), is the path by which light entrains the circadian system to the external photoperiod. Serotonergic neurons in the mesencephalic median raphe nucleus (MnR) also give rise to a major SCN afferent projection. The present...

journal_title：Brain research

authors： Muscat L,Tischler RC,Morin LP

更新日期：2005-05-17 00:00:00

abstract：:A double-labeling immunofluorescence technique was employed to investigate the co-localization of the functionally antagonistic neuropeptides, substance P and enkephalins, within intraspinal neurons of the rat. Anti-Met-enkephalin-Arg6-Gly7-Leu8 (Enk-8) antiserum was used as a marker of the preproenkephalin A neuron s...

journal_title：Brain research

authors： Senba E,Yanaihara C,Yanaihara N,Tohyama M

更新日期：1988-06-21 00:00:00

abstract：:Pharmacological studies have documented that altered drug responses, particularly to benzodiazepines, are common in elderly populations. While numerous factors may contribute to changes in drug response, age-related alterations in the molecular composition of GABA(A) receptors may be a key factor in regulating these r...

journal_title：Brain research

authors： Rissman RA,Nocera R,Fuller LM,Kordower JH,Armstrong DM

更新日期：2006-02-16 00:00:00

abstract：:The time-course of intracellular glutathione (GSH) values after incubation with L-buthionine-(S,R)-sulfoximine (BSO), a selective inhibitor of gamma-glutamylcysteine synthetase, showed that glutathione turns over with a half-life of 5 h. Intracellular GSH was assayed by flow cytometry using three different methods. As...

journal_title：Brain research

authors： Devesa A,O'Connor JE,Garciá C,Puertes IR,Viña JR

更新日期：1993-08-06 00:00:00

abstract：:Motor-related regions of parietal and prefrontal cortices have been shown to selectively activate when observers passively view objects that afford manual grasping. Yet, it remains unknown whether these cortical responses depend on prior motor-related experience with the object being observed. To address this question...

journal_title：Brain research

authors： Handy TC,Tipper CM,Schaich Borg J,Grafton ST,Gazzaniga MS

更新日期：2006-06-30 00:00:00

abstract：:N-desmethylclozapine (NDMC), a major circulating metabolite of the atypical antipsychotic drug, clozapine, and has M(1) muscarinic receptor partial agonistic property. The purpose of the present study was to examine whether in vivo behavioral effects of NDMC were elicited through the activation of muscarinic receptors...

journal_title：Brain research

authors： Maehara S,Hikichi H,Ohta H

更新日期：2011-10-18 00:00:00

abstract：:The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h afte...

journal_title：Brain research

authors： Itagaki S,Kimura H

更新日期：1986-08-27 00:00:00

abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...

journal_title：Brain research

authors： Galvez R,Gopal AR,Greenough WT

更新日期：2003-05-02 00:00:00